St. Jude Children's Research Hospital scientists have discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. Researchers also found evidence that the same mechanism may operate in humans. The study was published today in the advance online edition of Nature. The findings provide a new target for ongoing efforts to develop immunotherapies to harness the immune system to fight cancer and other diseases. The work focused on white blood cells called regulatory T cells. These specialized cells serve as the ...

PITTSBURGH, Aug. 4, 2013 – Not only does practice make perfect, it also makes for more efficient generation of neuronal activity in the primary motor cortex, the area of the brain that plans and executes movement, according to researchers from the University of Pittsburgh School of Medicine. Their findings, published online today in Nature Neuroscience, showed that practice leads to decreased metabolic activity for internally generated movements, but not for visually guided motor tasks, and suggest the motor cortex is "plastic" and a potential site for the storage of motor ...

By borrowing a tool from bacteria that infect plants, scientists have developed a new approach to eliminate mutated DNA inside mitochondria—the energy factories within cells. Doctors might someday use the approach to treat a variety of mitochondrial diseases, including the degenerative eye disease Leber hereditary optic neuropathy (LHON). The research, published online today in Nature Medicine, was funded by the National Eye Institute (NEI), a part of the National Institutes of Health (NIH). Mitochondria convert fuel from food into a form of energy that cells can use. ...

(Santa Barbara, Calif.) — Oceans cover 71 percent of the Earth's surface, yet our knowledge of the impact of climate change on marine habitats is a mere drop in the proverbial ocean compared to terrestrial systems. An international team of scientists set out to change that by conducting a global meta-analysis of climate change impacts on marine systems. Counter to previous thinking, marine species are shifting their geographic distribution toward the poles and doing so much faster than their land-based counterparts. The findings were published in Nature Climate Change. The ...

VIDEO: The structure of NatA, an n-terminal acetyltransferase, is described in a paper published Aug. 4, 2013, in Nature Structural & Molecular Biology. Click here for more information. A team of researchers from Philadelphia and Norway has determined the structure of an enzyme complex that modifies one end of most human proteins and is made at elevated levels in numerous forms of cancer. A study in Nature Structural & Molecular Biology, led by researchers at The Wistar Institute, ...

Cambridge-- As anyone who has traveled with young children knows, maintaining focus on distant goals can be a challenge. A new study from MIT suggests how the brain achieves this task, and indicates that the neurotransmitter dopamine may signal the value of long-term rewards. The findings may also explain why patients with Parkinson's disease — in which dopamine signaling is impaired — often have difficulty in sustaining motivation to finish tasks. The work is described this week in the journal Nature. Previous studies have linked dopamine to rewards, and have shown ...

Chemically modified inhibitors of the COX-2 enzyme relieve anxiety behaviors in mice by activating natural "endocannabinoids" without gastrointestinal side effects, Vanderbilt University scientists will report next week. Endocannabinoids are natural signaling molecules that activate cannabinoid receptors in the brain, the same receptors turned on by the active ingredient in marijuana. These receptors are also found in the gastrointestinal system and elsewhere in the body, and there is evidence that they play a role in wide range of physiological and pathological processes, ...

In a loud, crowded restaurant, having the ability to focus on the people and conversation at your own table is critical. Nerve cells in the brain face similar challenges in separating wanted messages from background chatter. A key element in this process appears to be oxytocin, typically known as the “love hormone” for its role in promoting social and parental bonding. In a study appearing online August 4 in Nature, NYU Langone Medical Center researchers decipher how oxytocin, acting as a neurohormone in the brain, not only reduces background noise, but more importantly, ...

Scientists at the University of East Anglia have shown that sequencing the DNA of crushed up creepy crawlies can accelerate the monitoring and cataloguing of biodiversity around the world. Research published today in the journal Ecology Letters shows that a process known as 'metabarcoding' is much faster than and just as reliable as standard biodiversity datasets assembled with traditional labour-intensive methods. The breakthrough means that changing environments and endangered species can be monitored more easily than ever before. It could help researchers find endangered ...

HONOLULU – Vulnerability to alcohol and drug abuse may begin in the womb and be linked to how much fatty and sugary foods a mother eats during pregnancy, according to findings from animal lab experiments presented at APA's 121st Annual Convention. "The majority of women in the U.S. at child-bearing age are overweight, and this is most likely due to overeating the tasty, high-fat, high-sugar foods you find everywhere in our society. The rise in prenatal and childhood obesity and the rise in number of youths abusing alcohol and drugs merits looking into all the possible ...

HONOLULU – Multiracial people may be misidentified more often as being white than black and may value being accurately identified more so than single-race individuals, according to research presented at APA's 121st Annual Convention. "Today, the distinctions among white, black, Latino and Asian people are becoming blurred by the increasing frequency and prominence of multiracial people," said Jacqueline M. Chen, PhD, of the University of California, Davis. "Still, average Americans have difficulty identifying multiracial people who don't conform to the traditional single-race ...

A person playing a first-person shooter video game like Halo or Unreal Tournament must make decisions quickly. That fast-paced decision-making, it turns out, boosts the player's visual skills but comes at a cost, according to new research: reducing the person's ability to inhibit impulsive behavior. This reduction in what is called "proactive executive control" appears to be yet another way that violent video games can increase aggressive behavior. "We believe that any game that requires the same type of rapid responding as in most first-person shooters may produce similar ...

VIDEO: The SLIPS coating makes glass so slippery that droplets of liquids slip off quickly even at a shallow angle. Here, from top to bottom, a droplet of octane, an ingredient... Click here for more information. August 2, 2013 – A new transparent, bioinspired coating makes ordinary glass tough, self-cleaning and incredibly slippery, a team from the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard School of Engineering and Applied Sciences ...

Sacramento, CA (August 2, 2013) – In a new observational study published in the Journal of Food Science, researchers looked at the association of grape consumption, in the non-alcoholic forms most commonly consumed – fresh grapes, raisins and 100% grape juice – with the diet quality of a recent, nationally representative sample of U.S. children and adults. Their findings suggest that, among adults and children, consumption of grapes and grape products is associated with healthier dietary patterns and improved nutrient intakes. Researchers analyzed the diets of more than ...

By differentiating monkey stem cells into liver cells and inducing successful infection, researchers from the Icahn School of Medicine at Mount Sinai have shown for the first time that the hepatitis C virus (HCV) can replicate in monkeys, according to research published in the journal Gastroenterology. The new findings may lead to the first new animal model and provide new avenues for developing treatments and vaccines for this disease, which impacts more than three million people in the United States. Scientists have tried for decades to develop animal models to study ...

WASHINGTON — Prothrombin complex concentrates (PCCs) are faster and more effective than fresh frozen plasma at reversing hemorrhage caused by the anti-coagulant warfarin, despite plasma being the most commonly used therapy. A literature review published last month in Annals of Emergency Medicine suggests that physicians in the United States should join those around the world in following recommendations of multiple specialty organizations to use PCCs as the first line of defense in this common and life-threatening emergency ("Rapid Reversal of Warfarin-Associated Hemorrhage ...

RICHLAND, Wash. -- Chemists have unexpectedly made two differently colored crystals – one orange, the other blue – from one chemical in the same flask while studying a special kind of molecular connection called an agostic bond. The discovery, reported in Angewandte Chemie International Edition on July 29, is providing new insights into important industrial chemical reactions such as those that occur while making plastics and fuels. "We were studying agostic bonds in a project to make liquid fuels like methanol from carbon dioxide to replace fuels we get from oil," said ...

Research from the University of Copenhagen has revealed the effects of a decade of decentralised wage negotiations in the private sector. In an article in the Journal of Labor Economics, researchers conclude that wages have risen for all employees and that companies are now better able to retain key personnel. "Average wages rise when employees and managers negotiate on an individual basis, without a collective-bargaining agreement dictating fixed rates for all," explains Jakob Roland Munch, professor of economics at the University of Copenhagen. For the first time, ...

At NASA's White Sands Test Facility in Las Cruces, N.M., a sounding rocket is being readied for flight. Due to launch on Aug. 8, 2013, the VERIS rocket, short for Very high Resolution Imaging Spectrometer, will launch for a 15-minute trip carrying an instrument that can measure properties of the structures in the sun's upper atmosphere down to 145 miles across, some eight times clearer than any similar telescope currently in space. When it comes to observing the sun, different instruments and techniques must be used to study different temperatures of material or different ...

Most aircraft carrying Doppler radar look like they've grown a tail, developed a dorsal fin, or sprouted a giant pancake on their backs. But when the unmanned Global Hawk carries a radar system this summer, its cargo will be hard to see. The autonomous and compact High-altitude Imaging Wind and Rain Profiler, or HIWRAP, a dual-frequency conical-scanning Doppler radar, will hang under the aircraft's belly as it flies above hurricanes to measure wind and rain and to test a new method for retrieving wind data. HIWRAP is one of the instruments that will fly in this summer's ...

On July 31, NASA's TRMM satellite saw Tropical Storm Gil intensifying and the storm became a hurricane. NASA's Aqua satellite and NOAA's GOES-15 satellite captured views of Gil on Aug. 1 as it was being chased by another developing tropical system. The Atmospheric Infrared Sounder or AIRS instrument aboard NASA's Aqua satellite captured an infrared image of Hurricane Gil on August 1 at 10:11 UTC or 6:11 a.m. EDT. Strongest storms and heaviest rains appear around the center where cloud top temperatures exceed -63F/-52. Microwave imagery on Aug. 1 from NASA's Aqua satellite ...

Tropical Storm Jebi developed on July 31 and NASA satellite data on Aug. 1 shows the storm filling up at least half of the South China Sea. The Atmospheric Infrared Sounder or AIRS instrument aboard NASA's Aqua satellite captured an infrared image of Tropical Storm Jebi on August 1 at 6:11 UTC or 2:11 a.m. EDT when it passed overhead from space. Strongest storms and heaviest rains appeared south of the center and in a large band of thunderstorms wrapping into the center from the southwest. Additionally, fragmented bands of thunderstorms are also east of the center of ...

Chicago, IL (August 1, 2013): A novel interactive 3-dimensional(3-D) simulation platform offers surgical residents a unique opportunity to hone their diagnostic and patient management skills, and then have those skills accurately evaluated according to a new study appearing in the August issue of the Journal of the American College of Surgeons. The findings may help establish a new tool for assessing and training surgical residents. Previous research studies have shown that the management of patient complications following operations is an extremely important skill ...

ASTRO Chairman Michael L. Steinberg, MD, FASTRO, called attention to the Government Accountability Office's (GAO) striking report released today, "Medicare: Higher Use of Costly Prostate Cancer Treatment by Providers Who Self-Refer Warrants Scrutiny," that details clear mistreatment of patients who trusted their physicians to care for their prostate cancer. Dr. Steinberg and radiation oncologists nationwide called on Congress to pass the "Promoting Integrity in Medicare Act of 2013" (PIMA), introduced earlier today by Rep. Jackie Speier (D-Calif.) and Rep. Jim McDermott ...

The seasonal influence of aerosols on Australia's tropical climate can now be included in climate models following completion of the first long-term study of fine smoke particles generated by burning of the savanna open woodland and grassland. Australia's biomass burning emissions comprise about eight per cent of the global total, ranking third by continent behind Africa (48 per cent) and South America (27 per cent). Lead researcher, CSIRO's Dr Ross Mitchell, said fine particles generated by burning of the tropical savanna of Northern Australia are a globally significant ...