MAY 16, 2013—An ad hoc coalition of unlikely insurgents—scientists, journal editors and publishers, scholarly societies, and research funders across many scientific disciplines—today posted an international declaration calling on the world scientific community to eliminate the role of the journal impact factor (JIF) in evaluating research for funding, hiring, promotion, or institutional effectiveness. The San Francisco Declaration on Research Assessment, or DORA, was framed by a group of journal editors, publishers, and others convened by the American Society for Cell ...

HOUSTON – (May 16, 2013) – In a paper published in Science Express, a group of experts led by bioethicists in the Center for Medical Ethics and Health Policy at Baylor College of Medicine provide a framework for the new American College of Medical Genetics and Genomics (ACMG) recommendations on reporting incidental findings in clinical exome and genome sequencing. In March 2013, the ACMG recommended that all laboratories conducting clinical sequencing seek and report pathogenic and expected pathogenic mutations for a short list of carefully chosen genes and conditions. ...

This news release is available in German. Once introduced for biological pest control, Asian lady beetle Harmonia axyridis populations have been increasing uncontrollably in the US and Europe since the turn of the millennium. The species has been proliferating rapidly in Germany; conservationists fear that the Asian lady beetle will out-compete native beetle species. Scientists from the University of Giessen and the Max Planck Institute for Chemical Ecology in Jena, Germany, have now found the reason why this animal is so successful. Apart from a strongly antibiotic ...

Depressed middle-aged women have almost double the risk of having a stroke, according to research published in Stroke: Journal of the American Heart Association. In a 12-year Australian study of 10,547 women 47-52 years old, researchers found that depressed women had a 2.4 times increased risk of stroke compared to those who weren't depressed. Even after researchers eliminated several factors that increase stroke risks, depressed women were still 1.9 times more likely to have a stroke. "When treating women, doctors need to recognize the serious nature of poor mental health ...

Science publishes the article in Science Express, which facilitates rapid publication of select studies. "This study is a breakthrough for our research group after years of work. When we reduce the production of the enzyme in mice, the development of all the clinical symptoms of progeria is reduced or blocked. We have also studied cultured cells from children with progeria, and can see that when the enzyme is inhibited, the growth of the cells increases by the same mechanism as in mouse cells," says Martin Bergö, Professor at the Sahlgrenska Academy, University of Gothenburg ...

DETROIT – If you're a left-brain thinker, chances are you use your right hand to hold your cell phone up to your right ear, according to a newly published study from Henry Ford Hospital in Detroit. The study – to appear online in JAMA Otolaryngology-Head & Neck Surgery – shows a strong correlation between brain dominance and the ear used to listen to a cell phone. More than 70% of participants held their cell phone up to the ear on the same side as their dominant hand, the study finds. Left-brain dominant people – who account for about 95% of the population and have ...

Promotion of influenza vaccines is one of the most visible and aggressive public health policies today, writes Doshi. Today around 135 million doses of influenza vaccine annually enter the US market, with vaccinations administered in drug stores, supermarkets - even some drive-throughs. This enormous growth has not been fuelled by popular demand but instead by a public health campaign that delivers a straightforward message: influenza is a serious disease, we are all at risk of complications from influenza, the flu shot is virtually risk free, and vaccination saves lives. Yet, ...

MINNEAPOLIS/ST. PAUL (05/15/2012)—Informed consent is the backbone of patient care. Genetic testing has long required patient consent and patients have had a "right not to know" the results. However, as 21st century medicine now begins to use the tools of genome sequencing, an enormous debate has erupted over whether patients' rights will continue in an era of medical genomics. Recent recommendations from the American College of Medical Genetics and Genomics (ACMG) suggest no. On March 22, the ACMG released recommendations stating that when clinical sequencing is undertaken ...

Boston, MA – Bicycle engineering guidelines often used by state regulators to design bicycle facilities need to be overhauled to reflect current cyclists' preferences and safety data, according to a new study from Harvard School of Public Health (HSPH) researchers. They say that U.S. guidelines should be expanded to offer cyclists more riding options and call for endorsing cycle tracks – physically separated, bicycle-exclusive paths adjacent to sidewalks – to encourage more people of all ages to ride bicycles. The study appears online May 16, 2013 and will appear in ...

While 99 percent of Earth's land ice is locked up in the Greenland and Antarctic ice sheets, the remaining ice in the world's glaciers contributed just as much to sea rise as the two ice sheets combined from 2003 to 2009, says a new study led by Clark University and involving the University Colorado Boulder. The new research found that all glacial regions lost mass from 2003 to 2009, with the biggest ice losses occurring in Arctic Canada, Alaska, coastal Greenland, the southern Andes and the Himalayas. The glaciers outside of the Greenland and Antarctic sheets lost an ...

How much all glaciers contribute to global sea-level rise has never been calculated before with this accuracy. An international group of researchers involving two geographers from the University of Zurich has confirmed that melting of glaciers caused about one third of the observed sea-level rise, while the ice sheets and thermal expansion of sea water account for one third each. So far, estimates on the contribution of glaciers have differed substantially. Now 16 scientists from nine countries have compared the data from traditional measurements on the ground with satellite ...

Amsterdam, May 17, 2013 - Elsevier, a world-leading provider of scientific, technical and medical information products and services, today announced the publication of a recent study in Reproductive BioMedicine Online on 5-day old human blastocysts showing that those with an abnormal chromosomal composition can be identified by the rate at which they have developed to blastocysts, thereby classifying the risk of genetic abnormality without a biopsy. In a new study the same group has undertaken a retrospective study, using their predictive model to assess the likelihood ...

Men experience a higher burden of disease and lower life expectancy than women, but policies focusing on the health needs of men are notably absent from the strategies of global health organisations, according to a Viewpoint article in this week's Lancet. The article reinterprets data from the 'Global Burden of Disease: 2010' study which shows that all of the top ten causes of premature death and disability, and top ten behavioural risk factors driving rates of ill-health around the world, affect men more than they affect women (see tables in Notes to Editors). In every ...

ORLANDO, Fla., May 16, 2013 — The hardening of arteries is a hallmark of atherosclerosis, an often deadly disease in which plaques, excessive connective tissue, and other changes build up inside vessel walls and squeeze off the flow of oxygen-rich blood throughout the body. Now, researchers at Sanford-Burnham Medical Research Institute have described the molecular and cellular pathway that leads to this hardening of the arteries—and zeroed in on a particularly destructive protein called Dkk1. Their study was published online today by Arteriosclerosis, Thrombosis, and ...

For decades, scientists have used ancient shorelines to predict the stability of today's largest ice sheets in Greenland and Antarctica. Markings of a high shoreline from three million years ago, for example – when Earth was going through a warm period – were thought to be evidence of a high sea level due to ice sheet collapse at that time. This assumption has led many scientists to think that if the world's largest ice sheets collapsed in the past, then they may do just the same in our modern, progressively warming world. However, a new groundbreaking study now challenges ...

Philadelphia, Pa. (May 16, 2013) – Like the general public, health care professionals may hold certain stereotypes regarding sexual activity and childbearing among women with disabilities. But a new study finds that women with chronic physical disabilities are about as likely as nondisabled women to say they are currently pregnant, after age and other sociodemographic factors are taken into account. The findings are reported in the June issue of Medical Care, published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Health care professionals can expect—and ...

"Spring is like a perhaps hand," wrote the poet E. E. Cummings: "carefully / moving a perhaps / fraction of flower here placing / an inch of air there... / without breaking anything." With the hand of nature trained on a beaker of chemical fluid, the most delicate flower structures have been formed in a Harvard laboratory—and not at the scale of inches, but microns. These minuscule sculptures, curved and delicate, don't resemble the cubic or jagged forms normally associated with crystals, though that's what they are. Rather, fields of carnations and marigolds seem to ...

In the wake of the sobering news that atmospheric carbon dioxide is now at its highest level in at least three million years, an important advance in the race to develop carbon-neutral renewable energy sources has been achieved. Scientists with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have reported the first fully integrated nanosystem for artificial photosynthesis. While "artificial leaf" is the popular term for such a system, the key to this success was an "artificial forest." "Similar to the chloroplasts in green plants ...

Philadelphia, PA— The answer is yes, according to a paper in the SIAM Journal on Discrete Mathematics. In a paper published in the journal last month, authors Anthony Bonato, Dieter Mitsche, and Pawel Pralat describe a mathematical model to disrupt flow of information in a complex real-world network, such as a terrorist organization, using minimal resources. Terror networks are comparable in their structure to hierarchical organization in companies and certain online social networks, where information flows in one direction from a source, which produces the information ...

Northwestern University scientists have shown a gene involved in neurodegenerative disease also plays a critical role in the proper function of the circadian clock. In a study of the common fruit fly, the researchers found the gene, called Ataxin-2, keeps the clock responsible for sleeping and waking on a 24-hour rhythm. Without the gene, the rhythm of the fruit fly's sleep-wake cycle is disturbed, making waking up on a regular schedule difficult for the fly. The discovery is particularly interesting because mutations in the human Ataxin-2 gene are known to cause ...

HOUSTON ­­– African-American adults living closer to a fast food restaurant had a higher body mass index (BMI) than those who lived further away from fast food, according to researchers at The University of Texas MD Anderson Cancer Center, and this association was particularly strong among those with a lower income. A new study published online in the American Journal of Public Health indicates higher BMI associates with residential proximity to a fast food restaurant, and among lower-income African-Americans, the density, or number, of fast food restaurants within two ...

(Santa Barbara, Calif.) –– When UC Santa Barbara doctoral student Seeta Sistla and her adviser, environmental studies professor Josh Schimel, went north not long ago to study how long-term warming in the Arctic affects carbon storage, they had made certain assumptions. "We expected that because of the long-term warming, we would have lost carbon stored in the soil to the atmosphere," said Schimel. The gradual warming, he explained, would accelerate decomposition on the upper layers of what would have previously been frozen or near-frozen earth, releasing the greenhouse ...

Whether we're listening to Bach or the blues, our brains are wired to make music-color connections depending on how the melodies make us feel, according to new research from the University of California, Berkeley. For instance, Mozart's jaunty Flute Concerto No. 1 in G major is most often associated with bright yellow and orange, whereas his dour Requiem in D minor is more likely to be linked to dark, bluish gray. Moreover, people in both the United States and Mexico linked the same pieces of classical orchestral music with the same colors. This suggests that humans ...

In today's virtual world, it's easy to downplay the significance of place. Yet when it comes to regional prosperity, geography matters. Income and job growth is not random but rather spill over from one region to another, meaning that merely being next to a prosperous region will make your own economy more vibrant. This may sound like a no-brainer, but until recently it's been hard to prove from a statistical perspective. Yet by using new models that factor in location and blending microeconomic ideas with macro ones, researchers at the Edward Lowe Foundation's Institute ...

Frustration led to revelation when Rice University scientists determined how graphene might be made useful for high-capacity batteries. Calculations by the Rice lab of theoretical physicist Boris Yakobson found a graphene/boron anode should be able to hold a lot of lithium and perform at a proper voltage for use in lithium-ion batteries. The discovery appears in the American Chemical Society's Journal of Physical Chemistry Letters. The possibilities offered by graphene get clearer by the day as labs around the world grow and test the one-atom-thick form of carbon. Because ...