PHILADELPHIA — Neuroblastoma, the most common malignant tumor of early childhood, is frequently associated with the presence of MYCN amplification, a genetic biomarker associated with poor prognosis. Researchers have determined that tumors containing MYCN amplification are sensitive to a new class of drugs, BET bromodomain inhibitors. The researchers made this discovery in a preclinical study, which was funded in part by a Stand Up To Cancer Innovative Research Grant and was published in Cancer Discovery, a journal of the American Association for Cancer Research. "BET ...

If a genome is the blueprint for life, then the chief architects are tiny slices of genetic material that orchestrate how we are assembled and function, Yale School of Medicine researchers report Feb. 21 in the journal Developmental Cell. The study pinpoints the molecular regulators of epigenetics – the process by which unchanging genes along our DNA are switched on and off at precisely right time and place. "Our genome is like a landscape with lakes, mountains, and rivers, but it is not yet a community or a city full of buildings," said Haifan Lin, director of the ...

WORCESTER, MA – Each fall millions of monarch butterflies from across the eastern United States begin a southward migration in order to escape the frigid temperatures of their northern boundaries, traveling up to 2,000 miles to an overwintering site in a specific grove of fir trees in central Mexico. Surprisingly, a new study by scientists at the University of Massachusetts Medical School published in Current Biology, suggests that exposure to coldness found in the microenvironment of the monarch's overwintering site triggers their return north every spring. Without this ...

IRVINE, Calif. (February 20, 2013) – New analysis of data from the National Health and Nutrition Examination Survey (NHANES) , a program of the Centers for Disease Control and Prevention (CDC), indicates that consuming avocados may be associated with better diet quality and nutrient intake level, lower intake of added sugars, lower body weight, BMI and waist circumferences, higher "good cholesterol" levels and lower metabolic syndrome risk. These results were published in the January 2013 issue of Nutrition Journal. Specifically, the survey data (NHANES 2001-2008, ...

DENVER (Feb. 21, 2013) – A new study from the University of Colorado Denver shows that the earliest human burial practices in Eurasia varied widely, with some graves lavish and ornate while the vast majority were fairly plain. "We don't know why some of these burials were so ornate, but what's striking is that they postdate the arrival of modern humans in Eurasia by almost 10,000 years," said Julien Riel-Salvatore, Ph.D., assistant professor of anthropology at CU Denver and lead author of the study. "When they appear around 30,000 years ago some are lavish but many aren't ...

Disruption in the body's circadian rhythm can lead not only to obesity, but can also increase the risk of diabetes and heart disease. That is the conclusion of the first study to show definitively that insulin activity is controlled by the body's circadian biological clock. The study, which was published on Feb. 21 in the journal Current Biology, helps explain why not only what you eat, but when you eat, matters. The research was conducted by a team of Vanderbilt scientists directed by Professor of Biological Sciences Carl Johnson and Professors of Molecular Physiology ...

Flower colors that contrast with their background are more important to foraging bees than patterns of colored veins on pale flowers according to new research, by Heather Whitney from the University of Cambridge in the UK, and her colleagues. Their observation of how patterns of pigmentation on flower petals influence bumblebees' behavior suggests that color veins give clues to the location of the nectar. There is little to suggest, however, that bees have an innate preference for striped flowers. The work is published online in Springer's journal, Naturwissenschaften - ...

Scientists from the University of Southampton have identified the molecular system that contributes to the harmful inflammatory reaction in the brain during neurodegenerative diseases. An important aspect of chronic neurodegenerative diseases, such as Alzheimer's, Parkinson's, Huntington's or prion disease, is the generation of an innate inflammatory reaction within the brain. Results from the study open new avenues for the regulation of the inflammatory reaction and provide new insights into the understanding of the biology of microglial cells, which play a leading ...

A new study shows that children who are exposed to bullying during childhood are at increased risk of psychiatric disorders in adulthood, regardless of whether they are victims or perpetrators. Professor William E. Copeland of Duke University Medical Center and Professor Dieter Wolke of the University of Warwick led a team in examining whether bullying in childhood predicts psychiatric problems and suicidality in young adulthood. While some still view bullying as a harmless rite of passage, research shows that being a victim of bullying increases the risk of adverse outcomes ...

AUGUSTA, Ga. – Early life stress like that experienced by ill newborns appears to take an early toll of the heart, affecting its ability to relax and refill with oxygen-rich blood, researchers report. Rat pups separated from their mothers a few hours each day, experienced a significant decrease in this basic heart function when – as life tends to do – an extra stressor was added to raise blood pressure, said Dr. Catalina Bazacliu, neonatologist at the Medical College of Georgia and Children's Hospital of Georgia at Georgia Regents University. Bazacliu worked under the ...

Kyoto, Japan – Working with a group from Nagasaki University, a research group at the Center for iPS Cell Research and Application (CiRA) at Japan's Kyoto University has announced in the Feb. 21 online publication of Cell Stem Cell has successfully modeled Alzheimer's disease (AD) using both familial and sporadic patient-derived induced pluripotent stem cells (iPSCs), and revealed stress phenotypes and differential drug responsiveness associated with intracellular amyloid beta oligomers in AD neurons and astrocytes. In a study published online in Cell Stem Cell, Associate ...

People who are at greater genetic risk of schizophrenia are more likely to see a fall in IQ as they age, even if they do not develop the condition. Scientists at the University of Edinburgh say the findings could lead to new research into how different genes for schizophrenia affect brain function over time. They also show that genes associated with schizophrenia influence people in other important ways besides causing the illness itself. The researchers used the latest genetic analysis techniques to reach their conclusion on how thinking skills change with age. They ...

Brussels and Geneva, 20th February 2013 --- Major progress has been made in the past 30 years in the knowledge and management of liver disease, yet approximately 29 million Europeans still suffer from a chronic liver condition. The European Association for the Study of the Liver (EASL) today unveiled its new publication The burden of liver disease in Europe: a review of available epidemiological data. Key findings in the report suggest that alcohol consumption, viral hepatitis B and C and metabolic syndromes related to overweight and obesity are the leading causes of ...

A lifelong diet rich in omega-3 fatty acids can inhibit growth of breast cancer tumours by 30 per cent, according to new research from the University of Guelph. The study, published recently in the Journal of Nutritional Biochemistry, is believed to be the first to provide unequivocal evidence that omega-3s reduce cancer risk. "It's a significant finding," said David Ma, a professor in Guelph's Department of Human Health and Nutritional Sciences, and one of the study's authors. "We show that lifelong exposure to omega-3s has a beneficial role in disease prevention ...

Scientists from the Bonn University Hospital successfully tested a method in mice allowing the morphological and functional sequelae of a myocardial infarction to be reduced. Tiny gas bubbles are made to oscillate within the heart via focused ultrasound - this improves microcirculation and decreases the size of the scar tissue. The results show that the mice, following myocardial infarction, have improved cardiac output as a result of this method, as compared to untreated animals. The study is now being presented in the professional journal PLOS ONE. Every year in Germany, ...

Philadelphia, Pa. (February 21, 2013) - A routine step in preparing for cleft palate surgery in a child led to an unusual—but not unprecedented—case of lung inflammation (pneumonitis), according to a report in the The Journal of Craniofacial Surgery. The journal, edited by Mutaz B. Habal, MD, FRCSC, is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. The complication resulted from accidental inhalation of povidone-iodine (PI), or Betadine—an antiseptic widely used before surgery. The rare complication led to new surgical "prep" steps to reduce ...

The walls of the human heart are a disorganised jumble of tissue until relatively late in pregnancy, despite having the shape of a fully functioning heart, according to a pioneering study. Experts from the University of Sheffield's Medical School collaborated on research to create the first comprehensive model of human heart development using observations of living foetal hearts. The results showed surprising differences from existing animal models. Although scientists saw four clearly defined chambers in the foetal heart from the eighth week of pregnancy, they did ...

This press release is available in German. Motor development in children under five years of age can now be tested reliably: Together with colleagues from Lausanne, researchers from the University Children's Hospital Zurich and the University of Zurich have determined normative data for different exercises such as hopping or running. This enables parents and experts to gage the motor skills of young children for the first time objectively and thus identify abnormalities at an early stage. My child still can't stand on one leg or walk down the stairs in alternating ...

An international team of scientists has discovered how an important natural antibiotic called dermcidin, produced by our skin when we sweat, is a highly efficient tool to fight tuberculosis germs and other dangerous bugs. Their results could contribute to the development of new antibiotics that control multi-resistant bacteria. Scientists have uncovered the atomic structure of the compound, enabling them to pinpoint for the first time what makes dermcidin such an efficient weapon in the battle against dangerous bugs. Although about 1700 types of these natural antibiotics ...

WASHINGTON - Feeling good about spending money on someone else rather than for personal benefit may be a universal response among people in both impoverished countries and rich nations, according to new research published by the American Psychological Association. "Our findings suggest that the psychological reward experienced from helping others may be deeply ingrained in human nature, emerging in diverse cultural and economic contexts," said lead author Lara Aknin, PhD, of Simon Fraser University in Canada. The findings provide the first empirical evidence that "the ...

Cell therapy is a promising alternative to tissue and organ transplantation for diseases that are caused by death or poor functioning of cells. Considering the ethical discussions surrounding human embryonic stem cells, a lot is expected of the so-called 'induced pluripotent stem cells' (iPS cells). However, before this technique can be applied effectively, a lot of research is required into the safety and efficacy of such iPS cells. VIB scientists associated to the UGent have developed a mouse model that can advance this research to the next step. Lieven Haenebalcke ...

Philadelphia, Pa. (February 21, 2013) - The Veterans Health Administration (VHA) is aiming to become a leader in using health information technology (HIT) to change the way patients experience medical care, to decrease medical mistakes, and to improve health outcomes. A special March supplement of Medical Care highlights new research into the many and varied types of HIT projects being explored to improve the quality of patient care throughout the VHA system. Medical Care is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. The special issue ...

On the front lines of our defenses against bacteria is the protein calprotectin, which "starves" invading pathogens of metal nutrients. Vanderbilt investigators now report new insights to the workings of calprotectin – including a detailed structural view of how it binds the metal manganese. Their findings, published online before print in the Proceedings of the National Academy of Sciences, could guide efforts to develop novel antibacterials that limit a microbe's access to metals. The increasing resistance of bacteria to existing antibiotics poses a severe threat to ...

Why certain catalyst materials work more efficiently when they are surrounded by water instead of a gas phase is unclear. RUB chemists have now gleamed some initial answers from computer simulations. They showed that water stabilises specific charge states on the catalyst surface. "The catalyst and the water sort of speak with each other" says Professor Dominik Marx, depicting the underlying complex charge transfer processes. His research group from the Centre for Theoretical Chemistry also calculated how to increase the efficiency of catalytic systems without water by ...

Researchers at the University of Warwick and The Royal Marsden NHS Foundation Trust have completed a study that may lead to clinicians being able to more accurately predict which patients will suffer from the side effects of radiotherapy. Gastrointestinal side effects are commonplace in radiotherapy patients and occasionally severe, yet there is no existing means of predicting which patients will suffer from them. The results of the pilot study, published in the journal Sensors, outline how the use of an electronic nose and a newer technology, FAIMS (Field Asymmetric ...