The price of gold is on the rise, but one piece of currency that can be extremely valuable in this department is the gold certificate. These certificates were first issued during the Civil War and were meant to be a placeholder for the owner. They reflected the value in gold that the owner had at that time, and the denominations came in dollar bills amounts ranging from $10 to $100,000. If you own a gold certificate, you should know that the value is likely going to be much higher than the original printed amount. The antique currency professionals at Antique Money Buyers ...

This Thursday the London Underground, the first underground railway in the world, celebrates its 150th anniversary and a commemorative service retracing the first journey from Paddington to Farringdon, is one of a number of events planned to commemorate the important birthday. LondonTown.com, where there's a wide range of cheap London hotels available to book Steam and heritage train outings, talks, tours, a large scale poster art exhibition and theatrical events in the disused Aldwych tube station are all part of the celebrations marking the 150th anniversary of the ...

Corcentric, a leading provider of Accounts Payable automation and electronic invoicing solutions, announced today the launch of a new blog site. This blog is designed as a knowledge center for accounts payable professionals to explore automation best practices Every week, Corcentric will focus on the ways companies can improve performance, optimize financial operations, and streamline invoice processes in their own finance departments, regardless of the industry sector (retail, manufacturing, healthcare, entertainment, transportation, construction, and others), There ...

It's been said that a picture is worth a thousand words. When it comes to reputation management, a damaging picture could mean losses in the millions, rather than the thousands. To help reduce the impact a compromising image could have on a person's employment, health and happiness, InternetReputation.com is proud to announce a new image reputation management program. As Web images have become more pervasive, and image-sharing sites have become more popular in the process, the need for image reputation management has become more apparent, the company claims. "Anytime ...

Nearly 1 in 4 Alabama motorists do not currently carry any auto liability insurance. To put Alabama's uninsured motorist problem in context, the state ranks 6th in the nation for the highest number of uninsured drivers and 5th for most fatal traffic accidents per capita. When those two statistics are combined, Alabama becomes one of the most dangerous states for drivers. As with many public safety laws, Alabama's growing dilemma with uninsured motorists stems from a lack of enforcement of its mandatory auto liability insurance law. Although state law requires a motorist ...

AgilQuest Corporation released a new version of OnBoard, their hoteling and conference room management technology, continuing features and capabilities which increase their lead in the workplace optimization market for large commercial firms and federal government agencies. "Our customers asked for help shifting their culture from day-at-a-time to hour-by-hour and to support the location-aware phones everyone has, so we are delivering that and more in version 5.5." says Torrance Houlihan, VP of Product Management. As the leader in hoteling technology for ...

Getting Smart released a report on the Automated Student Assessment Prize (ASAP). The case study illustrates a powerful philanthropic use of prizes to drive focused innovation with the goal of promoting deeper learning. The first two phases of ASAP were sponsored by the William and Flora Hewlett Foundation to promote focused innovation in student writing assessment. "ASAP was designed to answer a basic question: Can a computer grade a student-written response on a state-administered test as well as or better than a human grader?" explained co-author Jaison ...

MBA Rankings are used to assess the quality of programs and schools. Depending on the publisher, however, rankings follow different methodologies. The platform Master of Business Administration Compass explored internationally recognized full-time MBA rankings from Businessweek, Financial Times, Economist, Forbes, and US News using three dimensions: Ranking criteria: Which topics are covered by the ranking? Sources of information: Who provides the information? Influence: Which groups and topics are given the highest weighting and have greatest impact on the ranking? ...

Newly released NASA Hubble Space Telescope images of a vast debris disk encircling the nearby star Fomalhaut and a mysterious planet circling it may provide forensic evidence of a titanic planetary disruption in the system. Astronomers are surprised to find the debris belt is wider than previously known, spanning a section of space from 14 to nearly 20 billion miles from the star. Even more surprisingly, the latest Hubble images have allowed a team of astronomers to calculate the planet follows an unusual elliptical orbit that carries it on a potentially destructive ...

In mammals such as rodents that raise their young as a group, infants will nurse from their mother as well as other females, a dynamic known as allosuckling. Ecologists have long hypothesized that allosuckling lets newborns stockpile antibodies to various diseases, but the experimental proof has been lacking until now. An in-press report in the journal Mammalian Biology found that infant Mongolian gerbils that suckled from females given separate vaccines for two different diseases wound up with antibodies for both illnesses. The findings not only demonstrate the potential ...

A University of Arizona-led team of astronomers for the first time has used NASA's Spitzer and Hubble space telescopes simultaneously to peer into the stormy atmosphere of a brown dwarf, creating the most detailed "weather map" yet for this class of strange, not-quite-star-and-not-quite-planet objects. The forecast shows wind-driven, planet-sized clouds enshrouding these strange worlds. Brown dwarfs form out of condensing gas like stars but fail to accrue enough mass to ignite the nuclear fusion process necessary to turn them into a star. Instead, they pass their lives ...

Vega, the second brightest star in northern night skies, has an asteroid belt much like our sun, discovered by a University of Arizona-lead team of astronomers. A wide gap between the dust belts in nearby bright stars is a strong hint of yet-undiscovered planets orbiting the stars. The findings from the Infrared Space Telescopes are the first to show an asteroid-like belt ringing Vega. The discovery of an asteroid belt around Vega makes it more similar to its twin, a star called Fomalhaut, than previously known. Both stars now are known to have inner, warm asteroid belts ...

Small peptide ameliorates autoimmune skin blistering disease in mice Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke ...

Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, ...

WASHINGTON — Scientists have long wondered how nerve cell activity in the brain's hippocampus, the epicenter for learning and memory, is controlled — too much synaptic communication between neurons can trigger a seizure, and too little impairs information processing, promoting neurodegeneration. Researchers at Georgetown University Medical Center say they now have an answer. In the January 10 issue of Neuron, they report that synapses that link two different groups of nerve cells in the hippocampus serve as a kind of "volume control," keeping neuronal activity throughout ...

Chronic kidney disease (CKD) patients frequently suffer from mineral bone disorder, which causes vascular calcification and, eventually, chronic heart failure. Similar to patients with CKD, mice with low levels of the protein klotho (klotho hypomorphic mice) also develop vascular calcification and have shorter life spans compared to normal mice. In this issue of the Journal of Clinical Investigation, Florian Lang and colleagues at the University of Tübingen in Germany, found that treatment with the mineralocorticoid receptor antagonist spironolactone reduced vascular calcification ...

Fusion genes are common chromosomal aberrations in many cancers, and can be used as prognostic markers and drug targets in clinical practice. In this issue of the Journal of Clinical Investigation, researchers led by Matti Annala at Tampere University of Technology in Finland identified a fusion between the FGFR3 and TACC3 genes in human glioblastoma samples. The protein produced by this fusion gene promoted tumor growth and progression in a mouse model of glioblastoma, while increased expression of either of the normal genes did not alter tumor progression. Ivan Babic ...

Extremely loud noise can cause irreversible hearing loss by damaging sound sensing cells in the inner ear that are not replaced. But researchers reporting in the January 9 issue of the Cell Press journal Neuron have successfully regenerated these cells in mice with noise-induced deafness, partially reversing their hearing loss. The investigators hope the technique may lead to development of treatments to help individuals who suffer from acute hearing loss. While birds and fish are capable of regenerating sound sensing hair cells in the inner ear, mammals are not. Scientists ...

San Diego, California – January 9, 2013 – How does mathematics improve our understanding of weather and climate? Can mathematicians determine whether an extreme meteorological event is an anomaly or part of a general trend? Presentations touching on these questions will be given at the annual national mathematics conference in San Diego, California. New results will also be presented on the MJO (pronounced "mojo"), a tropical atmospheric wave which governs monsoons and also impacts rainfall in North America, and yet does not fit into any current computer models of the ...

NEW YORK (January 9, 2013) – Exposure to a chemical once used widely in plastic bottles and still found in aluminum cans appears to be associated with a biomarker for higher risk of heart and kidney disease in children and adolescents, according to an analysis of national survey data by NYU School of Medicine researchers published in the January 9, 2013, online issue of Kidney International, a Nature publication. Laboratory studies suggest that even low levels of bisphenol A (BPA) like the ones identified in this national survey of children and adolescents increase oxidative ...

WASHINGTON—Video games have been blamed for contributing to the epidemic of childhood obesity in the United States. But a new study by researchers at the George Washington University School of Public Health and Health Services (SPHHS) suggests that certain blood-pumping video games can actually boost energy expenditures among inner city children, a group that is at high risk for unhealthy weight gain. The study, "Can E-gaming be Useful for Achieving Recommended Levels of Moderate to Vigorous-Intensity Physical Activity in Inner-City Children," will appear January 9 in ...

PASADENA, Calif., January 9, 2013 – The presence of microscopic hematuria – blood found in urine that can't be seen by the naked eye – does not necessarily indicate the presence of cancer, according to a Kaiser Permanente Southern California study published in the journal Mayo Clinic Proceedings. The study suggests that tests routinely done on patients with this condition could be avoided and has led to the creation of a screening tool to better diagnose certain types of cancers. The observational study examined the electronic health records of more than 4,000 patients ...

DURHAM, N.C. -- Two years of painstaking observation on the social interactions of a troop of free-ranging monkeys and an analysis of their family trees has found signs of natural selection affecting the behavior of the descendants. Rhesus macaques who had large, strong networks tended to be descendants of similarly social macaques, according to a Duke University team of researchers. And their ability to recognize relationships and play nice with others also won them more reproductive success. "If you are a more social monkey, then you're going to have greater reproductive ...

Boston (Jan. 9, 2013) — Hearing loss is a significant public health problem affecting close to 50 million people in the United States alone. Sensorineural hearing loss is the most common form and is caused by the loss of sensory hair cells in the cochlea. Hair cell loss results from a variety of factors including noise exposure, aging, toxins, infections, and certain antibiotics and anti-cancer drugs. Although hearing aids and cochlear implants can ameliorate the symptoms somewhat, there are no known treatments to restore hearing, because auditory hair cells in mammals, ...

Scientists at the University of Granada and Alcalá de Henares University have found out that not all isolated stem cells are equally valid in regenerative medicine and tissue engineering. In a paper recently published in the prestigious journal Tissue Engineering the researchers report that, contrary to what was thought, only a specific group of cord blood stem cells (CB-SC) maintained in culture are useful for therapeutic purposes. At present, CB-SCs are key to regenerative medicine and tissue engineering. From all types of CB-SC those called "Wharton's jelly stem cells ...