Non-invasive 'liquid biopsies' can find metastatic or recurrent prostate cancer, in a low cost assay suitable for most healthcare systems, finds research published in BioMed Central's open access journal Genome Medicine. Genomic signatures of prostate cancer, isolated from plasma DNA, display abnormal copy numbers of specific areas of chromosomes. It is even possible to separate out patients who develop resistance against hormone deprivation therapy, which is the most common form of treatment in men with metastatic prostate cancer. Prostate cancer is the most common cancer ...

Up to 2009 there is no statistically significant evidence of any reduction in smoking amongst men – and very little evidence of a reduction in smoking amongst women – resulting from the introduction of EU minimum tax legislation in Spain in 2006. This is despite the price of cigarettes rising up to three times faster than before the legislation came into effect, according to a new study published online in the journal Nicotine and Tobacco Research. The World Health Organization's Framework Convention on Tobacco Control exhorts Parties to implement tax policies aimed ...

Cutting down on salt and, at the same time, increasing levels of potassium in our diet will have major health and cost benefits across the world, according to studies published on bmj.com today. Such a strategy will save millions of lives every year from heart disease and stroke, say experts. Much evidence shows that reducing salt intake lowers blood pressure and thereby reduces the risk of stroke and heart disease. Less is known about the potential benefits of increasing potassium intake, but lower potassium consumption has been linked with elevated blood pressure. The ...

Cambridge, Mass. – April 4, 2013 – Agios Pharmaceuticals, Inc., the leading biopharmaceutical company focused on discovering and developing novel drugs in the fields of cancer metabolism and rare metabolic genetic diseases, announced today the publication of two articles in the journal Science by Agios scientists and their collaborators demonstrating the effects of the company's small molecule isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) mutant specific inhibitors in primary human tumor models. These data add to a growing body of scientific research demonstrating the ...

There are cells in your brain that recognize very specific places, and have that as one of their main jobs. These cells, called place cells, are found in an area behind your temple called the hippocampus. While these cells must be sent information from nearby cells to do their job, so far no one has been able to determine exactly what kind of nerve cells, or neurons, work with place cells to craft the code they create for each location. Neurons come in many different types with specialized functions. Some respond to edges and borders, others to specific locations, others ...

Experts from The University of Manchester have revealed their findings from the most in-depth study ever to take place in the UK into the tragic instances of child killing by parents, known as filicide. The research, published in the journal PLOS ONE, found 37 per cent of parents and step-parents who killed their children were suffering from some form of mental illness and 12% had been in contact with mental health services within a year of the offence. Academics from the University's Institute of Brain Behaviour and Mental Health analysed 297cases of convicted filicide ...

COLUMBIA, Mo. -- Crocodilians have nerves on their faces that are so sensitive, they can detect a change in a pond when a single drop hits the water surface several feet away. Alligators and crocodiles use these "invisible whiskers" to detect prey when hunting. Now, a new study from the University of Missouri has measured the nerves responsible for this function, which will help biologists understand how today's animals, as well as dinosaurs and crocodiles that lived millions of years ago, interact with the environment around them. "The trigeminal nerve is the nerve responsible ...

Gordon, the unique supercomputer launched last year by the San Diego Supercomputer Center (SDSC) at the University of California, San Diego, recently completed its most data-intensive task so far: rapidly processing raw data from almost one billion particle collisions as part of a project to help define the future research agenda for the Large Hadron Collider (LHC). Under a partnership between a team of UC San Diego physicists and the Open Science Grid (OSG), a multi-disciplinary research partnership funded by the U.S. Department of Energy and the National Science Foundation, ...

Some thirty million years ago, Ganges river dolphins diverged from other toothed whales, making them one of the oldest species of aquatic mammals that use echolocation, or biosonar, to navigate and find food. This also makes them ideal subjects for scientists working to understand the evolution of echolocation among toothed whales. New research, led by Frants Havmand Jensen, a Danish Council for Independent Research | Natural Sciences postdoctoral fellow at Woods Hole Oceanographic Institution, shows that freshwater dolphins produce echolocation signals at very low sound ...

ANN ARBOR—One of the major obstacles to growing new organs—replacement hearts, lungs and kidneys—is the difficulty researchers face in building blood vessels that keep the tissues alive, but new findings from the University of Michigan could help overcome this roadblock. "It's not just enough to make a piece of tissue that functions like your desired target," said Andrew Putnam, U-M associate professor of biomedical engineering. "If you don't nourish it with blood by vascularizing it, it's only going to be as big as the head of a pen. "But we need a heart that's this ...

Jupiter's moon Io is the most volcanically active world in the Solar System, with hundreds of volcanoes, some erupting lava fountains up to 250 miles high. However, concentrations of volcanic activity are significantly displaced from where they are expected to be based on models that predict how the moon's interior is heated, according to NASA and European Space Agency researchers. Io is caught in a tug-of-war between Jupiter's massive gravity and the smaller but precisely timed pulls from two neighboring moons that orbit further from Jupiter – Europa and Ganymede. Io ...

TORONTO, ON, April 5, 2013 — Only half of people with arthritis who had a hip or knee replacement reported a significant improvement in pain and mobility after surgery, according to a new study led by Women's College Hospital and the Institute for Clinical and Evaluative Sciences (ICES). "Many patients with hip and knee arthritis have the condition in more than one of their hip or knee joints," said the study's lead author Dr. Gillian Hawker. "So it's not surprising that replacing a single joint doesn't alleviate all their pain and disability — patients may need subsequent ...

Mothers suffering from postpartum depression after a high-risk pregnancy would turn to online interventions if available anonymously and from professional healthcare providers, according to researchers from Case Western Reserve University's Frances Payne Bolton School of Nursing and College of Arts and Sciences. Postpartum depression, a moderate to severe depression that can occur after a woman has given birth, affects about 7 to 15 percent of new mothers. The effects can be felt soon after delivery to as long as a year later. The Case Western Reserve study, which recruited ...

Astronomers using the Atacama Large Millimeter/submillimeter Array (ALMA) telescope have discovered signs of star formation perilously close to the supermassive black hole at the center of the Milky Way Galaxy. If confirmed, this would be the first time that star formation was observed so close to the galactic center. The center of our galaxy, 27,000 light-years away in the direction of the constellation Sagittarius, is home to a monstrous black hole with a mass of four million suns. Extending outward from this gravitational behemoth for many light-years is a turbulent ...

Osmosis – the flow of a solvent across a semipermeable membrane from a region of lower to higher solute concentration – is a well-developed concept in physics and biophysics. The problem is that, even though the concept is important to plant and human physiology, osmosis is understood in biology and chemistry in a much simpler – and often incorrect – way. "A range of surprising misconceptions about osmosis continue to appear in papers, web sites and textbooks," says Eric Kramer, professor of physics at Bard College at Simon's Rock in Great Barrington, Mass. "Wrong ideas ...

LOS ALAMOS, N.M., April 4, 2013—Observing the evolution of a particular type of antibody in an infected HIV-1 patient, a study spearheaded by Duke University, including analysis from Los Alamos National Laboratory, has provided insights that will enable vaccination strategies that mimic the actual antibody development within the body. The kind of antibody studied is called a broadly cross-reactive neutralizing antibody, and details of its generation could provide a blueprint for effective vaccination, according to the study's authors. In a paper published online in Nature ...

Employment and health problems rather than the xenophobia in their new country, are the biggest reasons that migrants feel less happy than average, a new study says. The British Sociological Association's annual conference in London heard today [Friday 5 April 2013] that economic factors such as unemployment and low income, and their own health problems were the most powerful causes of a lowered wellbeing. Professor Andreas Hadjar and Susanne Backes analysed data from the European Social Survey on 32,000 first or second generation migrants and 164,700 non-migrants in ...

Researchers at Moffitt Cancer Center predict that advancements in breast cancer screening will need a personalized touch because mammography is not a "one strategy fits all" technology. Their review "Beyond Mammography: New Frontiers in Breast Cancer Screening" appears in the April 4 issue of The American Journal of Medicine. "Although mammography remains the gold standard for breast cancer screening, there is increasing awareness that there are subpopulations of women for whom mammography is limited because of its reduced sensitivity based on an individual's breast ...

Adults -- not only teens -- are guilty of careless driving Article provided by Brown, Paindiris & Scott, L.L.P. Visit us at http://www.bpslawyers.com More than nine people are killed and 1,060 others injured in crashes caused by inattentive driving every day, according to the Centers for Disease Control and Prevention. The Department of Transportation reports that in 2011, 3,331 people lost their lives in car accidents involving a distracted driver. Many laws around the country aim to address the problem, with a primary focus on teen motorists. However, while ...

Florida-based company seeks to terminate multiple franchised restaurants Article provided by Usher Law Firm, P.A. Visit us at http://www.usherlawfirm.com/ Burger King Corporate in Miami, Florida has sued the owners of five Burger King franchises, claiming they violated the terms of their franchise agreements. Early this year, BKC sent letters to the owners terminating their franchise agreements for allegedly failing to submit required payments. The litigation is still pending and it has yet to be determined whether the restaurants will continue with the same owners ...

Military divorce often complicated by overlap of federal and state laws Article provided by Law Office of Shawn P Hammond Visit us at http://www.hammondlaw.org Military divorces often come with added complexities. For a couple who has moved frequently, it can be a challenge to determine the correct state in which to file for divorce. Pay calculations for child support or alimony may also be more complicated for an active-duty spouse especially if there is Basic Allowance for Subsistence (BAS) and Basic Allowance for Housing (BAH). Most divorce laws vary state-by-state, ...

During divorce, debt division is just as important as property division Article provided by The Law Office of J. Kevin Clark P.C. Visit us at http://www.fortworth-civil-attorney.com/ When it comes to divorce, dividing shared debts is just as important as dividing money and property -- particularly in today's tough economic climate, when many couple's debts outnumber their assets. The laws that determine how debts and property are divided during divorce vary by state. Texas property division In Texas, family courts follow a system known as "community property" ...

A plea deal may keep a Washington DUI conviction off your record Article provided by Charles H. Williams, Attorney and Counselor at Law, P.S. Visit us at http://www.dui-defense-seattle.com/ An office happy hour with two-for-one drink specials or an evening out and several drinks with a meal could be enough to push a breath or blood alcohol reading above the legal .08 limit. For those charged for the first time with impaired driving or a DUI, it can be difficult to know how to proceed. A case that recently made local news provides some insights into alternative options ...

Teen driver deaths up nationwide, down in New York Article provided by The Law Offices of Daniel A. Kalish Visit us at http://www.personalinjurylawnewyork.com/ According to the "Teenage Driver Fatalities by State: 2012 Preliminary Data" report that was recently released by the Governors Highway Safety Association, teenage driver deaths are on the rise nationwide. The report analyzed fatal car accident data, excluding pedestrian and bicycle accidents, from all 50 states and the District of Columbia. The data showed that the number of 16 and 17-year-olds ...

House Bill 259 extends DUI statute to off-highway vehicles Article provided by Law Offices of Thomas A. Foley Visit us at http://www.tomfoleylaw.com/ A new act passed by the Delaware legislature expands the application of the DUI statute to include off-highway vehicles operated on public roadways. Off-highway vehicles, or OHVs as defined by state law, include vehicles such as ATVs and lawn mowers. Previously, an intoxicated person who travelled by an OHV was out of reach of the DUI statute. As a result, habitual DUI offenders who lost their vehicles or licenses ...