SAN FRANCISCO (March 10, 2013) — The new Sapien XT aortic valve showed a non-significantly lower rate of death and strokes at 30 days than the original model, and both valves demonstrated notably better short-term outcomes than seen with the Sapien system in PARTNER I, according to the first results from the PARTNER II study presented today at the American College of Cardiology's 62nd Annual Scientific Session. PARTNER II is the first randomized clinical trial involving the Sapien XT valve and the only one that compares the new device to the original FDA-approved Sapien ...

SAN FRANCISCO (March 10, 2013) — In a match-up of Japan's top drug-releasing stent and a new device featuring a biodegradable coating, the newcomer delivered statistically comparable one-year results, according to data from the NEXT trial presented today at the American College of Cardiology's 62nd Annual Scientific Session. Drug-eluting stents are structures placed inside narrowed coronary arteries to restore proper blood flow. A polymer coating on these devices slowly releases a drug designed to prevent restenosis—another blockage at the same site—and prevent a second ...

SAN FRANCISCO (March 10, 2013) — Patients with a type of coronary lesion linked with poor prognosis fared significantly better with the stent technique known as double kissing crush than with culotte stenting, according to data from the DKCRUSH-III trial presented today at the American College of Cardiology's 62nd Annual Scientific Session. DKCRUSH-III is the first head-to-head comparison of double kissing (DK) crush and culotte stent techniques in coronary artery disease. The study focused on bifurcation lesions, which involve a main branch and a smaller side branch ...

SAN FRANCISCO (March 10, 2013) — The experimental anti-clotting drug cangrelor solidly outperformed commonly used clopidogrel in a large global trial of patients who underwent coronary stent procedures, according to data from the phase III CHAMPION PHOENIX study presented today at the American College of Cardiology's 62nd Annual Scientific Session. Cangrelor and clopidogrel interfere with the P2Y12 receptor, a platelet-surface protein that helps regulate blood clotting. Currently approved drugs in this class are effective in cutting down ischemic events—blood-flow reductions ...

A new and experimental anti-clotting drug, cangrelor, proved better than the commonly used clopidogrel and was significantly more effective at preventing blood clots in a large trial of patients who underwent coronary stent procedures. These data, from the phase III CHAMPION PHOENIX study, were presented at the American College of Cardiology's 62nd Annual Scientific Session and published simultaneously in the New England Journal of Medicine. Researchers report that the new drug, which is administered intravenously, reduced the odds of complications from stenting procedures. ...

Physicians and parents must be aware of the growing danger of magnet ingestion by children because magnets can adhere to each other and cause life-threatening problems such as bowel perforations, a new case study illustrates in CMAJ. "Modern magnet technology has transformed what was once an esoteric subtype of foreign-body ingestion into a common and lethal threat," writes Dr. Daniel Rosenfield, Department of Paediatrics, The Hospital for Sick Children (SickKids), with coauthors. In the past, magnet ingestion generally could be treated with a wait-and-see approach, ...

Two University of Colorado Cancer Center studies show that the protein receptor Mer is overexpressed in many leukemias, and that inhibition of this Mer receptor results in the death of leukemia cells – without affecting surrounding, healthy cells. The first study, published today in the journal Oncogene, worked with acute myeloid leukemia (AML), for which current chemotherapies offer a cure rate of only about 55 percent. "In about 2/3 of all AML patients and about 90 percent of adult AML patients, we found that the Mer receptor was upregulated. Mer receptor protein ...

Alexandria, VA – Much like our voices create sound waves with a variety of low and high pitches, or frequencies, earthquakes produce seismic waves over a broad spectrum. The seismic waves' frequencies determine, in part, how far they travel and how damaging they are to human-made structures. However, the inaccessibility of fault zones means that very little is known about why and how earthquakes produce different frequencies. With the help of a new tabletop model, scientists have now identified how a process known as fault healing can shape seismic waves and potentially ...

Shenzhen, China, March 11, 2013- BGI Tech Solutions Co., Ltd., also referred to as "BGI Tech", introduced today its novel assembly solution for facilitating heterozygous genomes research. This marks another technological breakthrough for BGI in heterozygous genome assembly after the completed genome sequencing of oyster, diamondback moth and pear. The availability of a reference genome for a species is the cornerstone for the in-depth understanding of its biological secrets and commercial values. However, a major obstacle that prevents scientists to easily crack the genome ...

(SACRAMENTO, Calif.) —A scientific survey of more than 1,600 gun retailers in the U.S. has found that gun buyers frequently try to make illegal purchases and that gun retailers take a dim view of fellow sellers who engage in illegal activity — regardless of whether they are actively breaking the law or simply looking the other way. The survey, conducted in 2011 by Garen Wintemute, professor of emergency medicine and director of the UC Davis Violence Prevention Research Program, is believed to be the first scientific study of a large group of gun retailers to determine ...

Researchers of five European universities have developed a cloud-computing platform for robots. The platform allows robots connected to the Internet to directly access the powerful computational, storage, and communications infrastructure of modern data centers - the giant server farms behind the likes of Google, Facebook, and Amazon - for robotics tasks and robot learning. With the development of the RoboEarth Cloud Engine the team continues their work towards creating an Internet for robots. The new platform extends earlier work on allowing robots to share knowledge ...

For years, researchers have developed thin films of bismuth telluride (Bi2Te3) – which converts heat into electricity or electricity to cooling – on top of gallium arsenide (GaAs) to create cooling devices for electronics. But while they knew it could be done, it was not clear how – because the atomic structures of those unlikely pair of materials do not appear to be compatible. Now researchers from North Carolina State University and RTI International have solved the mystery, opening the door to new research in the field. "We've used state-of-the-art technology to solve ...

Vegetation growth at Earth's northern latitudes increasingly resembles lusher latitudes to the south, according to a NASA-funded study based on a 30-year record of land surface and newly improved satellite data sets. An international team of university and NASA scientists examined the relationship between changes in surface temperature and vegetation growth from 45 degrees north latitude to the Arctic Ocean. Results show temperature and vegetation growth at northern latitudes now resemble those found 4 degrees to 6 degrees of latitude farther south as recently as 1982. "Higher ...

Massachusetts General Hospital (MGH) investigators have described what may be a newly identified disease that appears to explain some cases of widespread chronic pain and other symptoms in children and young adults. Their report that will appear in the April issue of the journal Pediatrics, and has received early online release, finds that most of a group of young patients seen at the MGH for chronic, unexplained pain had test results indicating small-fiber polyneuropathy, a condition not previously reported in children. The MGH investigators call this new syndrome juvenile-onset ...

In recent years, a body of pub­li­ca­tions in the micro­bi­ology field has chal­lenged all pre­vious knowl­edge of how antibi­otics kill bac­teria. "A slew of papers came out studying this phe­nom­enon, sug­gesting that there is a gen­eral mech­a­nism of killing by antibi­otics," said Kim Lewis, Northeastern Uni­ver­sity Dis­tin­guished Pro­fessor in the Depart­ment of Biology and director of Northeastern's Antimi­cro­bial Dis­covery Center. The stan­dard thinking at the time was that the three main classes of bac­te­ri­cidal antibi­otics each had a unique way of killing ...

The current international climate policy framework is mainly based on the national and regional level of macroscopic carbon emissions data, such as the regional per capita carbon emissions are often used as the indicator to measure the fairness of carbon emission rights. However, the per capita emissions based on regional macro data can not accurately reveal the low carbon emissions of the poor within the region, and cover up the emission differences among people intra-country and intra-region, the household carbon emission data based on field surveys could compensate for ...

In a long-term study, Prof. Dr. Jürgen Margraf, Alexander von Humboldt Professor for Clinical Psychology and Psychotherapy at the RUB, investigated the psychological effects of plastic surgery on approximately 550 patients in cooperation with colleagues from the University of Basel. Patients demonstrated more enjoyment of life, satisfaction and self-esteem after their physical appearance had been surgically altered. The results of the world's largest ever study on this issue are reported by the researchers in the journal "Clinical Psychological Science". The aim of the ...

Extensive shell fishing and sewerage discharge in river estuaries could have serious consequences for the rare Icelandic black-tailed godwits that feed there. But it is the males that are more likely to suffer, according to new research from the University of East Anglia. Research published today in the journal Ecology and Evolution reveals very different winter feeding habits between the sexes. Both males and females mainly consume bivalve molluscs, sea snails and marine worms, probing vigorously into soft estuary mud with their long beaks. But the study shows that ...

Drinking just two cups of coffee a day is associated with the risk of low birth weight. Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have conducted a study on 59,000 women in collaboration with the Norwegian Institute of Public Health. Expectant mothers who consume caffeine, usually by drinking coffee, are more likely to have babies with lower birth weight than anticipated, given their gestational age. Researchers at Sahlgrenska Academy, University of Gothenburg, conducted a study on 59,000 pregnant Norwegian women in collaboration with the Norwegian ...

This press release is available in German. Immune system B cells play a crucial role in the defence of pathogens; when they detect such an intruder, they produce antibodies that help to combat the enemy. They concurrently and continuously improve these molecules to more precisely recognize the pathogens. A team of scientists with participation of the Helmholtz Centre for Infection Research (HZI) has discovered that during this process the cells are able to advance their own evolution themselves by increasing the selection pressure through previously-produced antibodies. ...

Philadelphia, Pa. (March 11, 2013) - Patients with neck injuries incur increased health and social costs—which also affect their spouses and may begin years before the initial injury, reports a study in the March 1 issue of Spine. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Some individuals and families seem more susceptible to experiencing socioeconomic consequences of neck injury, according to the new research by Dr Poul Jennum of University of Copenhagen and colleagues. Particularly for patients who develop chronic ...

A team of researchers from the National University of Singapore (NUS) led by Professor Loh Kian Ping, Head of the Department of Chemistry at the NUS Faculty of Science, has successfully altered the properties of water, making it corrosive enough to etch diamonds. This was achieved by attaching a layer of graphene on diamond and heated to high temperatures. Water molecules trapped between them become highly corrosive, as opposed to normal water. This novel discovery, reported for the first time, has wide-ranging industrial applications, from environmentally-friendly degradation ...

AMHERST, Mass. – For hundreds of years, naturalists and scientists have identified new species based on an organism's visible differences. But now, new genetic techniques are revealing that different species can show little, to no visible differences. In a just-published study, evolutionary biologists at the University of Massachusetts Amherst and the American Museum of Natural History (AMNH) combine traditional morphological tests plus genetic techniques to describe new species. Groups of morphologically similar organisms that show very divergent genetics are generally ...

Many Europeans are fretting these days over what they eat, and whether horse meat might have adulterated their pork chops. Food fraud has been dominating headlines globally - calling for new policies in law enforcement and more robust methods for successful food identification and authentication. As companies and manufacturers resort to fraudulent practices to extract more cash from the gullible public, it is estimated that up to 7% of the consumer supply chain contains hidden ingredients (i.e. – not disclosed on the label). And while all too often policymakers seem oblivious ...

These findings are the result of a new study carried out at the Norwegian Institute of Public Health. In the study, women who took folic acid supplements from four weeks before conception to eight weeks into pregnancy had a 40 per cent lower risk of giving birth to children with childhood autism (classic autism). "It appears that the crucial time interval is from four weeks before conception to eight weeks into pregnancy," states Pål Surén, MD and doctoral fellow at the Norwegian Institute of Public Health. The study is based on the Norwegian Mother and Child Cohort ...