AMHERST, Mass. – University of Massachusetts Amherst researchers, experts in revealing molecular structure by X-ray crystallography, have identified two new small "chaperone" molecules that may be useful in treating the inherited metabolic disorder known as Schindler/Kanzaki disease. This offers hope for developing the first ever drug treatment for this very rare disease. Findings are reported in the current issue of Proceedings of the National Academy of Sciences. First author Nathaniel Clark conducted this work for his doctoral degree at UMass Amherst with his advisor, ...

Rosemont, Ill. – Wearing a knee brace following anterior cruciate ligament (ACL) surgery has no effect on a person's recovery. However, strength, range-of- motion, and functionality exercises provide significant benefits, and other new therapies may show promise. In a new literature review recently published in the Journal of Bone and Joint Surgery (JBJS), a team of orthopaedic surgeons reviewed 29 studies regarding treatment following reconstructive ACL surgery. They found that physical therapy, begun shortly after surgery, can bring about very good outcomes for patients. ...

URBANA – University of Illinois professor of agricultural law A. Bryan Endres and his wife are both lawyers so, between the two of them, they've read a lot of legal documents, but when they became members of their local Community Supported Agriculture (CSA), even they struggled to understand the agreement they were asked to sign. Endres's experience as a consumer led him to develop simple contracts that can clarify expectations, avoid misunderstandings, and protect farmers and their customers. CSAs create a partnership between local farmers and consumers who become members ...

Scientists affiliated with VIB and UGent have discovered a mechanism used by the protein A20 to combat inflammation. This could be a very important point of focus in the search for a treatment for autoimmune diseases such as Rheumatoid Arthritis, in which the patient suffers from chronic, uncontrolled inflammation. Rudi Beyaert (VIB –UGent): We hope that our research can eventually contribute to the development of new therapies against Rheumatoid Arthritis and other auto-immune conditions." Friday 12 October is "World Arthritis Day". A20, a protein involved in Rheumatoid ...

A new study provides evidence that gamblers interpret near-misses as frustrating losses rather than near-wins. This frustration stimulates the reward systems in the brain to promote continued gambling, according to Mike Dixon from the University of Waterloo in Canada, and his colleagues. This, in turn, may contribute to addictive gambling behavior. Their work is published online in Springer's Journal of Gambling Studies. Dr. Dixon comments, "Our findings support the hypothesis that these types of near-misses are a particularly frustrating form of loss, and contradict ...

ESA's Herschel space observatory has discovered enough water vapour to fill Earth's oceans more than 2000 times over, in a gas and dust cloud that is on the verge of collapsing into a new Sun-like star. Stars form within cold, dark clouds of gas and dust – 'pre-stellar cores' – that contain all the ingredients to make solar systems like our own. Water, essential to life on Earth, has previously been detected outside of our Solar System as gas and ice coated onto tiny dust grains near sites of active star formation, and in proto-planetary discs capable of forming alien ...

MELBOURNE, FLA.—Marine diseases are killing coral populations all over the world, threatening the livelihoods of millions of people who depend on reefs for food and protection from storms. Are these diseases new and unprecedented infections, or do they erupt from the stresses of environmental change? Florida Institute of Technology biologist Robert van Woesik and his former student Erinn Muller—now a researcher at the Mote Marine Lab in Sarasota, Fla.—used a mapping technique to examine disease clustering and determine what might have caused the recent ...

UNIVERSITY OF CALIFORNIA, BERKELEY'S HAAS SCHOOL OF BUSINESS –When Madeleine Albright became the first female U.S. Secretary of State, she led high-level negotiations between mostly male foreign government leaders. In 2009, comedian Bill Maher asked Albright if she ever flirted on the job and she replied, "I did, I did." Flirtatiousness, female friendliness, or the more diplomatic description "feminine charm" is an effective way for women to gain negotiating mileage, according to a new study by Haas School of Business Professor Laura Kray. "Women are uniquely confronted ...

Many drugs work by "fixing" a particular biological pathway that's gone awry in a disease. But sometimes drugs affect other pathways too, producing undesirable side effects that can be severe enough to outweigh the drug's benefits. Such is the case for the thiazolidinedione drugs (also known as TZDs), which are used to treat type 2 diabetes. These are highly effective in controlling blood glucose levels and have an added benefit of lowering blood pressure in some patients. However, TZDs cause unrelated but potentially severe side effects in some patients, including heart ...

NEW YORK (Oct. 09, 2012) -- A new study by Weill Cornell Medical College researchers, published in the Journal of General Internal Medicine, provides compelling evidence that electronic health records (EHRs) enhance the quality of patient care in a community-based setting with multiple payers, which is representative of how medicine is generally practiced across the United States. The use of EHRs is on the rise, in part because the federal government has invested up to $29 billion in incentives promoting the meaningful use of these systems, with the aim of tracking and ...

WINSTON-SALEM, N. C. – Oct. 9, 2012 – The high rate of non-diabetic kidney disease in African-Americans is strongly associated with variations in a particular gene. Yet, not everyone who inherits these variations develops the disease. Researchers at Wake Forest Baptist Medical Center are working to find out why. In a study published in the October issue of the journal Kidney International, the research team evaluated children and siblings of African-Americans on dialysis to determine why some develop kidney disease and others don't. These relatives of the dialysis patients ...

Everyone wants to have beautiful teeth. After all, a perfect set of teeth symbolizes health and youthfulness, and can even influence career prospects. If having pristine teeth calls for thorough oral hygiene, then how well or badly does a given toothpaste clean? How effective is it? What should it contain in order not to damage the structure of the teeth? Such questions are primarily of interest to manufacturers of dental hygiene products, and answers are being delivered by researchers from the Fraunhofer Institute for Mechanics of Materials IWM in Halle. Through close ...

The Sun blazes down from a deep blue sky – and rooftop solar cells convert this solar energy into electricity. Not all of it, however: Around a quarter of the Sun's spectrum is made up of infrared radiation which cannot be converted by standard solar cells – so this heat radiation is lost. One way to overcome this is to use black silicon, a material that absorbs nearly all of the sunlight that hits it, including infrared radiation, and converts it into electricity. But how is this material produced? "Black silicon is produced by irradiating standard silicon with femtosecond ...

LOS ANGELES (Oct. 9, 2012) – Approximately 14 percent of individuals suffering from depression and other mental health issues in the United States are minorities in underserved communities, yet very few medications or psychosocial interventions have been developed utilizing the participation of these groups. This year, Bowen Chung, M.D. - principal investigator at The Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center (LA BioMed) - will change that when two unique studies are initiated: the first study will utilize intervention that focuses on families ...

An SGH study has revealed that considering all osteoporotic patients as having simple osteoporosis and treating all of them alike by putting them on potent long term medication without finding out the cause of their osteoporosis may be ineffective and in most cases downright harmful. Secondary osteoporosis is a rather common but lesser known type of osteoporosis that affects men and women of any age. It is caused by certain medical conditions that result in bone loss or interfere with development of peak bone mass. Contributors of secondary osteoporosis include conditions ...

Patients who drank coffee, rather than water, after bowel surgery to remove a part of their colon experienced a quicker return to bowel movements and tolerance of solid food. Those are two of the key findings of a comparative study of 80 patients, carried out at University Hospital Heidelberg, Germany, and published in the surgical journal BJS. "Post-operative bowel obstruction is a common problem after abdominal surgery and the aim of this study was to test our theory that coffee would help to alleviate this" says lead author Dr Sascha Müller, who is now based at ...

Links to publications: http://pubs.acs.org/doi/abs/10.1021/nn302633q http://pubs.acs.org/doi/abs/10.1021/ac201903n ...

ROCHESTER, Minn. -- Mayo Clinic researchers have identified a new therapy for patients with neuromyelitis optica that appears to stop inflammation of the eye nerves and spinal cord. NMO is a debilitating central nervous system disorder that is often misdiagnosed as multiple sclerosis (MS). In the study, patients with severe symptoms of the disease, also known as NMO, were given eculizumab, a drug typically used to treat blood disorders. While not a cure, the therapy Mayo Clinic researchers used in the study to halt attacks could potentially lead to longer attack-free ...

Scientists at the National Physical Laboratory (NPL) and the University of Leicester have been commissioned by the European Space Agency (ESA) to investigate the feasibility of using dead stars to navigate spacecraft in deep space. The findings of the research will advise ESA strategy and if feasible this technique may in future revolutionise the way spacecraft navigate in the outer Solar System and beyond. Spacecraft navigation currently relies on radio transmissions between a distant craft and a network of ground-stations on Earth. This means that the craft has to ...

This press release is available in German. The iron-sulfur protein IspH plays a central role in the terpene metabolism of several pathogens. The mechanism of the reaction provides an approach for developing new antibiotics, particularly against malaria and tuberculosis. While researching this enzyme, biochemists at the Technische Universitat Munchen discovered a previously unknown reaction: IspH accepts two completely different classes of molecules as partners. This surprising insight, published in Nature Communications, opens up new perspectives in combating infectious ...

Scientists at the Montreal Neurological Institute and Hospital – The Neuro, McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders. Using a new technique that has revolutionized genetic studies, the teams determined that mutations in the RMND1 gene were responsible for severe neurodegenerative disorders, in two infants, ultimately leading to their early death. Although the teams' investigations dealt with an infant, their discovery also has implications for understanding the causes of ...

Tampa, FL (Oct. 8, 2012) -- The chaperone protein Grp94 can interfere with the clearance of another protein known to cause the glaucoma when mutated, a new study led by researchers at the University of South Florida has found. Using a cell model, the researchers also demonstrated that a new specific inhibitor of Grp94 facilitates clearance of the genetically-defective protein, called myocilin, from cells. Reported online this month in JBC (The Journal of Biological Chemistry), the discoveries could lead to a new treatment for some hereditary cases of glaucoma, an eye ...

If quantum computers are ever going to perform all those expected feats of code-breaking and number crunching, then their component qubits---tiny ephemeral quantum cells held in a superposition of internal states---will have to be protected from intervention by the outside world. In other words, decoherence, the loss of the qubits' quantum integrity, has to be postponed. Now theoretical physicists at the Joint Quantum Institute (JQI) and the University of Maryland have done an important step forward to understand qubits in a real-world setup. In a new study they show, ...

Biofuels are going to save us from climate threats and the oil crisis, while at the same time providing an opportunity to the smallholder farmers of the world. Hopes are high, but completely unrealistic. It is like trying to push a square peg into a round hole, according to a current thesis at Linköping University. Bioenergy could replace fossil fuels and solve the looming energy crisis. Into the bargain, we will benefit from reduced greenhouse gas emissions. A further bonus could be that demand for biofuels gives a lift to smallholder farmers in poor countries, who would ...

A newly discovered function of PARP-1 could be the key to more effective therapeutics to treat advanced prostate cancer patients, a recent preclinical study published in Cancer Discovery by Jefferson's Kimmel Cancer Center researchers suggests. The team, led by Karen E. Knudsen, Ph.D., Professor in the Departments of Cancer Biology, Urology, & Radiation Oncology at Thomas Jefferson University, found that functions of PARP-1 not only include DNA damage repair but also androgen receptor (AR) regulation in advanced prostate cancer growth and progression. PARP inhibition ...