LA JOLLA, CA – December 6, 2012 – For scientists who study the genetics of hearing and deafness, finding the exact genetic machinery in the inner ear that responds to sound waves and converts them into electrical impulses, the language of the brain, has been something of a holy grail. Now this quest has come to fruition. Scientists at The Scripps Research Institute (TSRI) in La Jolla, CA, have identified a critical component of this ear-to-brain conversion—a protein called TMHS. This protein is a component of the so-called mechanotransduction channels in the ear, which ...

For the first time, a silicon-based optical fiber with solar-cell capabilities has been developed that has been shown to be scalable to many meters in length. The research opens the door to the possibility of weaving together solar-cell silicon wires to create flexible, curved, or twisted solar fabrics. The findings by an international team of chemists, physicists, and engineers, led by John Badding, a professor of chemistry at Penn State University, will be posted by the journal Advanced Materials in an early online edition on 6 December 2012 and will be published on a ...

In Hubble's image, NGC 922 clearly reveals itself not to be a normal spiral galaxy. The spiral arms are disrupted, a stream of stars extends out towards the top of the image, and a bright ring of nebulae encircles the core. Observing with NASA's Chandra X-ray Observatory reveals more chaos in the form of ultraluminous X-ray sources dotted around the galaxy. NGC 922's current unusual form is a result of a cosmic bullseye millions of years ago. A smaller galaxy, catalogued as 2MASXI J0224301-244443, plunged right through the heart of NGC 922 and shot out the other side. ...

AMHERST, Mass. – Molecular chaperones have emerged as exciting new potential drug targets, because scientists want to learn how to stop cancer cells, for example, from using chaperones to enable their uncontrolled growth. Now a team of biochemists at the University of Massachusetts Amherst led by Lila Gierasch have deciphered key steps in the mechanism of the Hsp70 molecular machine by "trapping" this chaperone in action, providing a dynamic snapshot of its mechanism. She and colleagues describe this work in the current issue of Cell. Gierasch's research on Hsp70 chaperones ...

The latest telescope at ESO's Paranal Observatory in Chile -- the VLT Survey Telescope (VST) -- was inaugurated today at the Italian National Institute for Astrophysics (INAF) Observatory of Capodimonte, in Naples, Italy. The ceremony was attended by the Mayor of Naples, Luigi De Magistris, the INAF President, Giovanni Bignami, the ESO representatives Bruno Leibundgut and Roberto Tamai, and the main promoter of the telescope, Massimo Capaccioli of the University of Naples Federico II and INAF. The VST is a state-of-the-art 2.6-metre telescope, with the huge 268-megapixel ...

Working with mice, Johns Hopkins researchers have shed light on the activity of a protein pair found in cells that form the walls of blood vessels in the brain and retina, experiments that could lead to therapeutic control of the blood-brain barrier and of blood vessel growth in the eye. Their work reveals a dual role for the protein pair, called Norrin/Frizzled-4, in managing the blood vessel network that serves the brain and retina. The first job of the protein pair's signaling is to form the network's proper 3-D architecture in the retina during fetal development. ...

Researchers have discovered an immune system 'kill switch' that destroys blood stem cells when the body is under severe stress, such as that induced by chemotherapy and systemic infections. The discovery could have implications for protecting the blood system during chemotherapy or in diseases associated with overwhelming infection, such as sepsis. The kill switch is triggered when internal immune cell signals that protect the body from infection go haywire. Dr Seth Masters, Dr Motti Gerlic, Dr Benjamin Kile and Dr Ben Croker from the Walter and Eliza Hall Institute ...

Researchers at Cambridge and Cardiff have found that, on average, a normal healthy person carries approximately 400 potentially damaging DNA variants and two variants known to be associated directly with disease traits. They showed that one in ten people studied is expected to develop a genetic disease as a consequence of carrying these variants. It has been known for decades that all people carry some damaging genetic variants that appear to cause little or no ill effect. But this is the first time that researchers have been able to quantify how many such variants each ...

This press release is available in Spanish and Portuguese. A collaborative study conducted in Mexico by researchers of the University of West Virginia-Charleston (USA), Universidad Popular Autónoma del Estado de Puebla (Mexico), Universidad de Chile and the Institute of Molecular Epidemiology of the Universidad Católica de la Santísima Concepción (Chile), revealed that IPAS-Mexico overestimated rates of maternal and abortion mortality up to 35% over the last two decades. The research, recently published in the International Journal of Women's Health highlights that Mexico ...

BOSTON - Scientists at Dana-Farber Cancer Institute have isolated a previously unknown protein in muscles that spurs their growth and increased power following resistance exercise. They suggest that artificially raising the protein's levels might someday help prevent muscle loss caused by cancer, prolonged inactivity in hospital patients, and aging. Mice given extra doses of the protein gained muscle mass and strength, and rodents with cancer were much less affected by cachexia, the loss of muscle that often occurs in cancer patients, according to the report in the Dec. ...

A team of researchers from the Spanish National Cancer Research Centre (CNIO), led by Manuel Serrano, from the Tumour Suppression Group, together with scientists from London and Santiago de Compostela, has discovered that the cellular reprogramming gene SOX2, which is involved in several types of cancers, such as lung cancer and pituitary cancer, is directly regulated by the tumor suppressor CDKN1B(p27) gene, which is also associated with these types of cancer. The same edition of the online version of the journal also includes a study led by Massimo Squatrito, who recently ...

Berkeley — A gene that helps the body convert that big plate of holiday cookies you just polished off into fat could provide a new target for potential treatments for fatty liver disease, diabetes and obesity. Researchers at the University of California, Berkeley, are unlocking the molecular mechanisms of how our body converts dietary carbohydrates into fat, and as part of that research, they found that a gene with the catchy name BAF60c contributes to fatty liver, or steatosis. In the study, to be published online Dec. 6 in the journal Molecular Cell, the researchers ...

HOLLYWOOD, FL and EVANSTON, IL, December 6, 2012 -- Naurex Inc., a clinical stage company developing innovative treatments to address unmet needs in psychiatry and neurology, today reported positive results from a Phase IIa clinical trial of its lead antidepressant compound, GLYX-13. GLYX-13 is a novel partial agonist of the NMDA receptor. The Phase Ila results are being presented this week at the 51st Annual Meeting of the American College of Neuropsychopharmacology (ACNP). The Phase IIa results show that a single administration of GLYX-13 produced statistically significant ...

Research by Indiana University paleobotanist David L. Dilcher and colleagues in Europe sheds new light on what Charles Darwin famously called "an abominable mystery": the apparently sudden appearance and rapid spread of flowering plants in the fossil record. Writing in the Proceedings of the National Academy of Sciences, the researchers present a scenario in which flowering plants, or angiosperms, evolved and colonized various types of aquatic environments over about 45 million years in the early to middle Cretaceous Period. Dilcher is professor emeritus at IU Bloomington ...

Bisphenol A, a substance found in many synthetic products, is considered to be harmful, particularly, for fetuses and babies. Researchers from the University of Bonn have now shown in experiments on cells from human and mouse tissue that this environmental chemical blocks calcium channels in cell membranes. Similar effects are elicited by drugs used to treat high blood pressure and cardiac arrhythmia. The results are now presented in the journal "Molecular Pharmacology." The industrial chemical bisphenol A (BPA) is worldwide extensively utilized for manufacturing polycarbonates ...

New research in human volunteers has shown that molecular changes to our genes, known as epigenetic marks, are driven mainly by ageing but are also affected by what we eat. The study showed that whilst age had the biggest effects on these molecular changes, selenium and vitamin D status reduced the accumulation of epigenetic changes, and high blood folate and obesity increased them. These findings support the idea that healthy ageing is affected by what we eat. Researchers from the Institute of Food Research led by Dr Nigel Belshaw, working with Prof John Mathers and ...

Jerusalem Dec. 6, 2012 – A new understanding of what takes place on the cellular level during the development of neurodegenerative diseases, such as Parkinson's, Alzheimer's, ALS and Huntington's diseases, offers promise towards possible new strategies for combating such diseases, say Hebrew University of Jerusalem researchers. Neurodegenerative conditions result from an impairment of motor function or cognitive function or both. This impairment results from degeneration in the particular area of the brain responsible for those functions. Although these neurodegenerative ...

People who recall being absolved of their sins, are more likely to donate money to the church, according to research published today in the journal Religion, Brain and Behavior. Researchers from Royal Holloway and the University of Oxford assigned participants two memory tasks. In the first, they were asked to privately recall a sin that they had committed in the past, while in the second, they recalled attending confession for this sin or imagined doing so, if they had not confessed in reality. Each participant was also given an opportunity to donate to a local Catholic ...

We all have E.coli bacteria in our gut but each of us carries a version that is genetically slightly different. The same can be said of most gut microbes: our own gut metagenome, that is the sum of all the genomes of all our gut microbes, appears to be really specific to each of us, and to remain stable over time. For the first time, researchers from the European Molecular Biology Laboratory (EMBL) have studied this metagenome at such a high resolution that individual mutations in the various strains could be analysed. Their findings, published today in Nature, could have ...

Scientists at the Babraham Institute have gained a new understanding of when and how the DNA in developing egg and sperm cells is 'reset', in preparation for making a new embryo. It is well known that small chemical groups can be added to DNA to alter gene activity, these modifications to the DNA are acquired during development in the womb and throughout adult life and can arise from changes in environment. Most of these modifications are removed in immature egg and sperm cells to 'reset' the DNA and to erase any 'environmental memory', but some remain. Decoding this reprogramming ...

Fighting cancer using the body's own defense system is a promising treatment approach. Immune therapies have even become clinical routine in treating a few cancers such as malignant melanoma and prostate cancer. Natural killer cells (or NK cells) are considered to be particularly suitable weapons against cancer. They are part of the innate immune system and respond to a wide range of cancer cells of diverse origin. Moreover, NK cells also kill tumor cells that have lost a specific target and go unnoticed by other immune cells. "The big problem in using NK cells for therapy ...

The ice sheet in West Antarctica is melting faster than expected. New observations published by oceanographers from the University of Gothenburg and the US may improve our ability to predict future changes in ice sheet mass. The study was recently published in the journal Nature Geoscience. A reduction of the ice sheets in Antarctica and Greenland will affect the water levels of the world's oceans. It is therefore problematic that we currently have insufficient knowledge about the ocean circulation near large glaciers in West Antarctica. This means that researchers ...

Disgust – it's an emotion we experience when we encounter things that are dirty, impure, or otherwise contaminated. From an evolutionary standpoint, experiencing the intense, visceral sense of revulsion that comes with disgust presumably helps us to avoid contaminants that can make us sick or even kill us. But new research suggests that disgust not only helps us to avoid impurities, it may also make us better able to see them. If something looks dirty and disgusting, we typically assume it's contaminated in some way; when something is white, however, we are more likely ...

Research led by the University of York has found that the impacts of climate change on rare plants in tropical mountains will vary considerably from site to site and from species to species. While some species will react to climate change by moving upslope, others will move downslope, driven by changes in seasonality and water availability. The researchers believe that this predicted variation, together with the long-term isolation and relative climatic stability of the mountains, may shed light on historical processes behind current patterns of biodiversity. The study, ...

How well are the most important climate models able to predict the weather conditions for the coming year or even the next decade? The Potsdam scientists Dr. Dörthe Handorf and Prof. Dr. Klaus Dethloff from the Alfred Wegener Institute for Polar and Marine Research in the Helmholtz Association (AWI) have evaluated 23 climate models and published their results in the current issue of the international scientific journal Tellus A. Their conclusion: there is still a long way to go before reliable regional predictions can be made on seasonal to decadal time scales. None of ...