One out of 100 people will experience a psychotic episode in their lifetime, and these usually appear in late adolescence or early adulthood. A Canada-US team consisting of Sylvain Bouix, from École de technologie supérieure (ÉTS), Martha E. Shenton and Ofer Pasternak, from the Brigham and Women’s Hospital (Harvard University), and René Kahn, from Mount Sinai Hospital (New York) has just received US $33 million in funding—the equivalent of CAD 45 million—over five years from the National Institute of Mental Health ...

PULLMAN, Wash. – An epidemiological study found that 56% of a large breeding colony of Caspian terns died from a 2023 outbreak of highly pathogenic avian influenza at Rat Island in Washington state. Since then, no birds have successfully bred on the island, raising concerns that the outbreak may have had a significant impact on an already declining Pacific-coast population. As part of the study, a team including Washington Department of Fish and Wildlife (WDFW) as well as Washington State University researchers also documented that the avian flu virus H5N1was transmitted to harbor seals for the first time in the northeastern ...

Why do mice have tails? The answer to this is not as simple as you might think. New research from the Okinawa Institute of Science and Technology (OIST) has shown that there’s more to the humble mouse tail than previously assumed. Using a novel experimental setup involving a tilting platform, high-speed videography and mathematical modelling, scientists have demonstrated how mice swing their tails like a whip to maintain balance – and these findings can help us better understand balance issues in humans, paving the way for spotting and treating neurodegenerative diseases like multiple ...

CHAMPAIGN, Ill. — Materials scientists can now use insight from a very common mineral and well-established earthquake and avalanche statistics to quantify how hostile environmental interactions may impact the degradation and failure of materials used for advanced solar panels, geological carbon sequestration and infrastructure such as buildings, roads and bridges. The new study, led by the University of Illinois Urbana-Champaign in collaboration with Sandia National Laboratories and Bucknell University, shows that the amount ...

Vitamin D during pregnancy boosts children’s bone health even at age seven Children whose mothers took extra vitamin D during pregnancy continue to have stronger bones at age seven, according to new research led by the University of Southampton and University Hospital Southampton (UHS). Bone density scans revealed that children born to mothers who were given vitamin D supplements during pregnancy have greater bone mineral density in mid-childhood. Their bones contain more calcium and other minerals, making them stronger and less likely to break. Researchers say the findings, published in The American Journal of Clinical Nutrition,   reinforce the importance of ...

The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can be used to correct specific defective sections of the genome. Unfortunately, however, there is a catch: under certain conditions, the repair can lead to new genetic defects – as in the case of chronic granulomatous disease. This was reported by a team of basic researchers and physicians from the clinical research program ImmuGene at the University of Zurich (UZH). Chronic granulomatous disease is ...

In a large multi-ethnic group of adults in the United States without cardiovascular disease, those with work-related stress were more likely to have unfavorable measures of cardiovascular health. The findings are published in the Journal of the American Heart Association. For the analysis, investigators assessed data collected between 2000 and 2002 for 3,579 community-based men and women aged 45–84 years enrolled in the Multi-Ethnic Study of Atherosclerosis. Cardiovascular health was determined based on seven metrics—smoking, physical activity, body mass index, diet, total cholesterol, blood pressure, and blood glucose—with each metric contributing zero points, ...

Because nitrogen fertilizers contribute to global greenhouse gas emissions, scientists are looking for ways to modify agricultural plants so that they rely on less nitrogen. In research published in New Phytologist, investigators have found that blocking a particular protein may achieve this goal in potatoes. The protein, called Solanum tuberosum CYCLING DOF FACTOR 1 (StCDF1), binds to DNA and plays a key role in regulating tuberization in potatoes. In this latest research, investigators found that StCDF1 ...

An analysis published in the Journal of Accounting Research uncovers evidence that conflicts of interest arising from commercial ties lead to bias in environmental, social, and governance (ESG) ratings. Investigators focused on Moody’s and S&P’s acquisitions of ESG rating agencies Vigeo Eiris and RobecoSAM. Their analysis revealed that after these ESG rating agencies were acquired by Moody’s and S&P, they issued higher ratings to existing paying clients of Moody’s and S&P. Specifically, ...

In Islamic cultures, purdah, which literally means “curtain,” is a practice that involves the seclusion of women from public observation and the enforcement of high standards of female modesty. Research published in the Journal of Management Studies examines the significance of purdah (spatial modesty) in gender relations in financial institutions in Pakistan. The research was based on the lived experiences of women and men working in two banks based in Pakistan. One of the study’s co-authors, Shafaq Chaudhry, PhD, of the University of Central Lancashire, in the UK, sought internships for six weeks ...

Attempts to discover a breakthrough dementia drug might be drawing attention these days, but traditional medicinal products can offer hints for preventive medicine. A research group led by Specially Appointed Professor Takami Tomiyama of Osaka Metropolitan University’s Graduate School of Medicine has found that administering the dried seeds of a type of jujube called Ziziphus jujuba Miller var. spinosa, used as a medicinal herb in traditional Chinese medicine, holds promise in restoring cognitive and motor function in model mice. By administering hot water extracts of Zizyphi spinosi semen to model mice with ...

[Vienna, November 6, 2024] — “Tell me how you read and I’ll tell you who you are.” By analyzing online reading behavior across millions of firms worldwide, a new study out of the Complexity Science Hub (CSH) connects how much information companies consume and how the consumption relates to their size. "The way companies consume information is reminiscent of biological organisms. They take in, transmit, and transform information to make decisions. As with organisms, there are important size differences. Larger firms tend to consume information more efficiently ...

A tightly tied waist cord of the underskirt (petticoat) traditionally worn under a saree, particularly in rural parts of India, may lead to what has been dubbed ‘petticoat cancer,’ warn doctors in the journal BMJ Case Reports after treating two women with this type of malignancy.  The continued pressure and friction on the skin can cause chronic inflammation, leading to ulceration, and, in some cases, progression to skin cancer, say the authors. This phenomenon has previously been described as “saree cancer,” but it is the tightness of the waist cord that’s to blame, ...

EMBARGOED UNTIL 6:30 PM EST Tuesday, November 5, 2024 Contact: Jillian McKoy, jpmckoy@bu.edu Michael Saunders, msaunder@bu.edu ## 10% of Children in High-Burden Tuberculosis Settings May Develop the Disease by Age 10 New findings also indicate that children who live in settings with a high burden of TB have a consistently high annual risk of developing TB infection throughout childhood. An estimated 1.2 million children develop tuberculosis disease (TB) and 200,000 kids die from TB worldwide each year, but the risk of developing TB infection and disease throughout childhood remains under-studied. Furthermore, the majority of studies on the pediatric burden of TB are informed by data ...

The Biden administration’s recently announced plan to replace all lead pipes in the U.S. is a reminder that the toxic metal remains a threat, even in a country that has largely banned its use. The smallest levels of lead exposure can cause a range of health damages over time, especially to children’s brain development. Stanford researchers Stephen Luby and Jenna Forsyth have spent years examining the widespread presence of lead in low-income countries, including in some commonly consumed products. They led a perspective published Nov. 5 in The Lancet Public Health that tallies lead’s global ...

The University of Tennessee, Knoxville, and defense technology company Lockheed Martin announced the signing of a new five-year master research agreement Oct. 31, reinforcing a longstanding partnership that helps UT take its research capabilities from the lab to the field. “This partnership allows UT researchers to conduct true translational research,” said James Andes, director of national security research initiatives for UT. “Our research concepts are matured by working with technical champions at Lockheed Martin, and as a ...

UNIVERSITY PARK, Pa. — The “RNA world” hypothesis proposes that the earliest life on Earth may have been based on RNA — a single-stranded molecule similar in many ways to DNA — like some modern viruses. This is because, like DNA, RNA can carry genetic information, but, like a protein, it can also act as an enzyme, initiating or accelerating reactions. While the activity of a few RNA enzymes — called ribozymes — have been tested on a case-by-case basis, there are thousands more that have been computationally predicted to exist in organisms ranging from bacteria to plants and animals. Now, ...

At the end of the last global ice age, the deep-frozen Earth reached a built-in limit of climate change and thawed into a slushy planet. Results from a Virginia Tech-led study provide the first direct geochemical evidence of the slushy planet — otherwise known as the “plumeworld ocean” era — when sky-high carbon dioxide levels forced the frozen Earth into a massive, rapid melting period. “Our results have important implications for understanding how Earth's climate and ocean chemistry changed after the extreme conditions of the last global ...

International survey of more than 1600 biomedical researchers on the perceived causes of irreproducibility of research results   ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002870 Article Title: Biomedical researchers’ perspectives on the reproducibility of research Author Countries: Canada, Australia, United States Funding: The author(s) received no specific funding for this work. END ...

Integrating data from different experimental approaches into one model is challenging – this study presents a community-based, full-scale in silico model of the rat hippocampal CA1 region that integrates diverse experimental data from synapse to network ##### In your coverage, please use this URL to provide access to the freely available paper in PLOS Biology:   http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002861 Article Title: Community-based reconstruction ...

SAN ANTONIO — November 5, 2024 — Hydrologists at Southwest Research Institute (SwRI) will begin a 12-month targeted water-sampling campaign of the Las Moras Springs system near Brackettville, Texas. The project will analyze and characterize the system of springs and their relationship to the Pinto Creek watershed to improve water management and conservation efforts. “Las Moras, like many other Texas spring systems, are at-risk and prone to going dry. It is important to clear up uncertainties about their source and relationship with ...

Considered one of the fastest-growing agricultural frontiers in Brazil, and the area with the highest greenhouse gas emissions in the Cerrado, Brazil’s savanna-type biome, the region known as MATOPIBA risks facing water shortages in the years ahead. Water overuse may mean that between 30% and 40% of demand for crop irrigation cannot be met in the period 2025-40. MATOPIBA is a portmanteau of the names of four states – Maranhão, Tocantins, Piauí, and Bahia (all but Tocantins located in Brazil’s Northeast ...

Thanks to a 'natural experiment' involving 30,000 people, researchers at Radboud university medical center were able to determine very precisely what an extra year of education does to the brain in the long term. To their surprise, they found no effect on brain structure and no protective benefit of additional education against brain aging. It is well-known that education has many positive effects. People who spend more time in school are generally healthier, smarter, and have better jobs and higher incomes than those with less education. However, whether prolonged education actually causes changes in brain structure over the long term ...

Targeting and customizing blood vessels in tumors to increase T cell infiltration and maintain their function may represent the next breakthrough in cancer therapy. The European Research Council has recognized this by awarding a prestigious Synergy Grant to the project VASC-IMMUNE, where three researchers, each possessing complementary expertise in this research topic, will synergize to advance the field. Professors Anna Dimberg and Magnus Essand are both from the Department of Immunology, Genetics and Pathology, Uppsala University and Professor Thomas Tüting is from the Department of Dermatology, University Hospital Magdeburg. The successful implementation ...

Mosquitoes are much more blunt. Mating occurs for a few seconds in midair. And all it takes to woo a male is the sound of a female’s wingbeats. Imagine researchers’ surprise when a single change completely killed the mosquitoes’ libidos.   Now a study out of UC Santa Barbara reveals that this is really all there is to it. Researchers in Professor Craig Montell’s lab created deaf mosquitoes and found that the males had absolutely no interest in mating. “You could leave them together with the females ...