Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal proliferation of cytotoxic lymphocytes. Among them, T-cell LGLL (T-LGLL) and NK-cell LGLL (NK-LGLL) are the most prominent. Due to overlapping morphological, clinical, and immunophenotypic characteristics, distinguishing these disorders from related entities such as T-prolymphocytic leukemia (T-PLL), adult T-cell leukemia/lymphoma (ATLL), Sézary syndrome (SS), and aggressive NK-cell leukemia (ANKL) presents a significant diagnostic challenge. This review integrates recent molecular insights and updates from the WHO 5th edition ...

Chemicals used as food preservatives, flavoring agents, dyes, pesticides, cosmetics, cleaners, and other industrial materials are being increasingly recognized as a health hazard. Their rampant use has led to an increase in the prevalence of various chemical toxicity-induced diseases, including hormonal disruption, cancer, neurological disorders, skin conditions, and occupational poisoning. Numerous chemicals are known to trigger “carcinogenesis” or cancer development by exerting genotoxic effects (direct or indirect interference with DNA replication and damage repair processes ...

Scientists writing a policy forum article in the CABI One Health journal say the “plant world” needs to come out and claim its place at the One Health table as part of a desire to break down barriers that currently limit true cross-domain integration. The researchers say that while plant health is increasingly recognized as a vital part of One Health, it lacks recognition and – historically focussed on health service provision, zoonotic diseases and antimicrobial resistance – One Health overlooks plant health in strategic plans. They add that cross-sectoral approaches, core to One Health, are already used ...

Traumatic brain injury (TBI) is a serious issue affecting thousands of people in the U.S. every year. For military service members, the impact is even more profound. Since 2000, over 492,000 cases of TBI have been reported, making it one of the defining injuries of modern warfare, according to the U.S. Department of Defense. Many veterans have experienced multiple TBIs, raising concerns about long-term effects on brain health. Given the subjective and nonspecific nature of symptom presentation, treatment and prognosis can be difficult. Researchers ...

The first few days of a human embryo’s development, known as pre-implantation, are important. It’s when the first cells are formed, and these decide if the embryo can survive, how it will implant in the womb and how the tissues of the fetus will develop. Today there are still logistical, ethical and legal limitations to using human embryos for research purposes, so scientists use alternative models including stem cell-based and animal models. In a new study published in Nature Cell Biology, Sophie Petropoulos, a researcher ...

Discussion of "alternative facts" has gained sad notoriety in US politics. Yet the question has been around much longer: How do people conduct political debates – is the focus more on facts or personal opinions? A team of international researchers led by the Cluster of Excellence "The Politics of Inequality" looked into the matter. The researchers examined political rhetoric in eight million speeches by members of the US Congress between 1879 and 2022 to see if the focus of their language was more on data and facts or personal convictions and subjective interpretations. The team noticed a significant decline in the use of evidence-based political ...

Nursing poses major metabolic demands on mothers, to which they respond by eating more and saving energy to sustain milk production. There are significant hormonal changes during lactation, but how they lead to metabolic adaptations in nursing mothers remained unclear. In this study, which appeared in Nature Metabolism, leading researchers at Baylor College of Medicine and Pennington Biomedical Research Center uncovered a mechanism that connects prolactin, estrogen, the brain and metabolic adaptations during lactation. “We worked with animal models to investigate ...

UNDER EMBARGO UNTIL THURSDAY 10 APRIL, 10AM LONDON TIME, 5AM EASTERN TIME. Urgent action is needed to protect endangered species, human health and industry from the impacts of the Caspian Sea shrinking, research led by the University of Leeds has found. Water levels in the Caspian Sea – the world’s largest landlocked water body – are getting lower, as hotter temperatures cause more water to evaporate than is flowing in. Even if global warming is limited to below 2°C, ...

New York, NY [April 10, 2025]—A seminal study from researchers at the Icahn School of Medicine at Mount Sinai and their collaborators in the United Kingdom, Belgium, Spain, the Netherlands, and Iceland has uncovered a new genetic cause of neurodevelopmental disorders (NDDs). The discovery offers both closure and hope to potentially thousands of families worldwide who have long been searching for answers. The study, published in the April 10 online issue of Nature Genetics [DOI: 10.1038/s41588-025-02159-5], reveals that mutations in a small, previously overlooked non-coding gene called RNU2-2 are responsible for relatively common NDD. Non-coding genes ...

Researchers have created a “metal detector” algorithm called PRRDetect to hunt down vulnerable tumours, in a development that could one day revolutionise the treatment of cancer. In a paper published today (Thursday 10th April) in Nature Genetics, scientists funded by Cancer Research UK and the National Institute for Health and Care Research (NIHR) analysed the full DNA sequence of 4,775 tumours from seven types of cancer. Based at the University of Cambridge and NIHR Cambridge Biomedical Research Centre, they used that data from Genomics England’s 100,000 Genomes ...

A new USC-led study using functional magnetic resonance imaging (fMRI) reveals the neural mechanisms that contribute to urinary incontinence, a common condition affecting stroke survivors that has a significant impact on their quality of life. The research, just published in Stroke, was conducted by a multidisciplinary team of urologists, neurosurgeons, and imaging experts from the Keck School of Medicine of USC, Keck Medicine of USC, the Rancho Los Amigos National Rehabilitation Center, and the Shirley Ryan Ability Lab. The team discovered significant differences in brain activity during voluntary versus involuntary bladder contractions, presenting potential pathways for targeted therapies. Urinary ...

Using eye-tracking — a technique for recording and analysing eye movements — a team from the University of Geneva (UNIGE) has shown that individuals with multiple disabilities can improve their social and emotional skills. Although these patients are often considered ‘‘untestable’’, nine young people have undergone personalised training over a period of one year, with promising results in terms of their ability to socialise. This work opens the way to new methods of assessment and support. It is published in Acta Psychologica. Multiple disabilities involve a combination of severe intellectual and motor impairments, resulting in profound dependence. ...

Since the pandemic, we are very aware of the power of social distancing to protect against infectious disease. But can social distancing be effective if the infectious agent isn’t a virus or bacterium, but an insect powered by a brain and wings, and with the instinct to seek out new hosts? Now, a study published to Frontiers in Bee Science has shown that physical distance does play a leading role in protecting bumblebees against a flying insect parasite, the bumblebee wax moth Aphomia sociella. The source of the potentially lethal infection was another species, namely nearby hives of domestic honeybees. “Here we show that infestation with bumblebee wax moths is much greater ...

Lacquers, paint, concrete—and even ketchup or orange juice: Suspensions are widespread in industry and everyday life. By a suspension, materials scientists mean a liquid in which tiny, insoluble solid particles are evenly distributed. If the concentration of particles in such a mixture is very high, phenomena can be observed that contradict our everyday understanding of a liquid. For example, these so-called non-Newtonian fluids suddenly become more viscous when a strong force acts upon them. For a brief moment, the liquid behaves like a solid. This sudden thickening is caused by the particles present ...

Genome wide association studies (GWAS) have identified hundreds of genome regions containing thousands of genetic variants associated with asthma, but it’s still not clear which variants have an actual causal link to the disease. This “variant-to-function” gap is one of the biggest challenges to the usefulness of these genomic studies and has motivated researchers to develop new tools to make sense of GWAS results. A new study by researchers from the University of Chicago combines genetic data and improved computational tools to look more closely ...

People should learn to meditate and hone their critical thinking skills as AI becomes more integrated into daily lives, an expert suggests. Digital strategy expert Giulio Toscani has spoken with 150 AI experts across 50 countries to understand the challenges and opportunities around human interactions with artificial intelligence. He argues in his new book, Augmented: prAIority to Enhance Human Judgment through Data and AI, that as humans operate largely unconsciously by design, they are inclined toward immediacy and instant rewards, often overlooking potential ...

The development of new antibiotics to treat superbugs and other bacterial infections is a global priority, with the rate of infections that cannot be treated with current antibiotics rising and presenting one of the biggest threats to human health. In line with that, new research has shown a daily dose of epidermicin NI01 – an antibiotic compound developed by University of Plymouth spinout company Amprologix – is as effective at removing Methicillin-resistant Staphylococcus aureus (MRSA) as the current standard of care. The results were achieved through a robust skin MRSA infection model, and those behind the research say it justifies ...

WASHINGTON (April 9, 2025) — A new study from researchers at the George Washington University has found that certain bacteria living in the nose may influence how likely someone is to get a COVID-19 infection. Published in EBioMedicine, the research reveals that certain types of nasal bacteria can affect the levels of key proteins the virus needs to enter human cells, offering new insight into why some people are more vulnerable to COVID-19 than others. “We’ve known that the virus SARS-CoV-2 enters the body through the respiratory tract, with the nose being a key entry point. What’s new—and surprising—is that bacteria in our noses ...

A study led by the Barcelona Institute for Global Health (ISGlobal), a centre supported by the "la Caixa" Foundation, has shown that Europe has adapted better to low temperatures than to high temperatures over the last two decades. The research, carried out in collaboration with the Barcelona Supercomputing Centre (BSC) and published in The Lancet Planetary Health, shows that there has been a significant decrease in cold-related mortality risk in recent years compared to the first decade of the 2000s. There has also been a reduction in the risk of heat-related ...

In a cave overlooking the ocean on the southern coast of South Africa, archaeologists discovered thousands of stone tools, created by ancient humans roughly 20,000 years ago. By examining tiny details in the chipped edges of the blades and stones, archaeologists are able to tell how the tools were made. In a new study published in the Journal of Paleolithic Archaeology, researchers analyzed these stone tools and discussed how the different techniques used to make them hint at the ways that prehistoric people traveled, interacted, and shared their craft. “This is an important insight into how people who lived in this region ...

10 April 2025: The world’s first baby has been born following conception with a fully automated, digitally controlled intracytoplasmic sperm injection (ICSI) system. ICSI, developed and adopted into widespread use in the 1990s and now a routine method of assisted conception, achieves fertilisation by injecting a single sperm cell into the centre of a mature egg. The details are reported today in the peer-review medical journal Reproductive Biomedicine Online.(1) The automated system was described and developed by a multidisciplinary team of specialists from Conceivable ...

Education projects supporting marginalised girls in lower-income countries are more likely to achieve lasting transformations when they mobilise young women and their communities as “agents of change”, a new report indicates. The recommendation comes from the latest evaluation of the Girls’ Education Challenge: a UK Government-supported initiative which has funded projects reaching more than 1.6 million girls. The University of Cambridge-led study finds that these projects initiated “virtuous cycles” of change – particularly by rooting themselves in communities and empowering young women to lead the way. In ...

New research suggests conservation efforts could more effectively identify and protect bird species at greatest risk from climate change by better understanding the range of specific conditions they need to thrive. The study, led by the University of East Anglia (UEA), examined the relationship between the extent of the climatic conditions that species tolerate and in which populations can survive - known as climatic niche breadth - and their likelihood of declining in response to climate change. For species inhabiting a similar area of geographic space, those able to tolerate ...

Astronomers have peered back in time to find what looks like a population of 'hidden' galaxies that could hold the key to unlocking some of the universe's secrets. If their existence is confirmed it would "effectively break current models of galaxy numbers and evolution". The possible galaxies may also provide the missing piece of the puzzle for the energy generation in the universe in infrared light. That's because their combined light would be enough to top-up the energy budget of the universe to the maximum we observe, effectively ...

UNDER EMBARGO UNTIL 00:01 BST THURSDAY 10 APRIL / 19:01 ET WEDNESDAY 9 APRIL 2025 For the first time, a study led by University of Oxford researchers has ‘listened in’ to the fascinating courtship displays of Fiddler crabs using geophones. The findings, published today in the Journal of Experimental Biology, provide new insights into how the animals communicate effectively on the noisy seashore. For male fiddler crabs, vibrational signals are a crucial part of their courtship routines – produced by drumming the ground using their oversized claw, ...