Direct oral anticoagulants (DOACs) are a common treatment for patients with a wide variety of cardiovascular conditions. DOACs are the preferred treatment over vitamin K antagonists (VKAs) for many patients with atrial fibrillation or venous thromboembolism, since the latter would have a higher risk of intracranial bleeding and more complex dosing routine. However, new research suggests that DOACs should not be the first line of treatment for every patient who need to treat or prevent blood clots. A systematic overview from researchers at Brigham and Women’s Hospital, a founding member of Mass General Brigham, discusses the efficacy ...

UPTON, NY—A new analysis by the STAR collaboration at the Relativistic Heavy Ion Collider (RHIC), a particle collider at the U.S. Department of Energy’s (DOE) Brookhaven National Laboratory, provides the first direct evidence of the imprint left by what may be the universe’s most powerful magnetic fields on “deconfined” nuclear matter. The evidence comes from measuring the way differently charged particles separate when emerging from collisions of atomic nuclei at this DOE Office of Science user ...

A recent study conducted in the lab of Dr. Hugo J. Bellen, distinguished service professor at Baylor College of Medicine and principal investigator at the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital, has discovered a biological role of a specific transmembrane protein called TMEM208.  The study, published in the Proceedings of the National Academy of Sciences, showed that a majority of fruit flies lacking this gene do not survive, and the few that do survive have many developmental defects. Similarly, a child with variants ...

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism. The results also revealed that 2MBC is accumulated in individuals with COVID-19, potentially explaining why these patients are at increased risk of thrombosis. “Our study provides mechanistic insight by implicating 2MBC as a metabolite that links gut microbiota dysbiosis to elevated thrombotic ...

About The Study: In this urban population-based cohort study of 2,180 participants, no modifiable risk factors of mortality at the level of the individual (e.g., depression or anxiety and substance use) or the family (e.g., household education level) were identified. However, the degree of neighborhood poverty in early childhood was significantly associated with death by unnatural causes (death due to unintentional injury, suicide, and homicide) in early adulthood, suggesting that economic policies are needed to advance health equity in relation to premature mortality.  Authors: Holly C. Wilcox, Ph.D., of the Johns Hopkins Bloomberg ...

About The Study: In this case-control study including 6,122 patients with hematologic cancers and SARS-CoV-2 infection, odds of severe COVID-19 remained high through mid-2022 despite vaccination, especially in patients requiring treatment.  Authors: Paul A. Monach, M.D., Ph.D., of the VA Boston Cooperative Studies Program in Boston, is the corresponding author.  To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamanetworkopen.2024.0288) Editor’s Note: Please see the article for additional information, including other authors, author contributions ...

About The Study: In this study, recreational marijuana laws that allow recreational marijuana sales were associated with a 10% increase in workplace injuries among individuals ages 20 to 34. The findings are consistent with the hypothesis that recreational marijuana impedes cognitive function and care among younger workers.  Authors: Joseph J. Sabia, Ph.D., of San Diego State University, is the corresponding author. To access the embargoed study: Visit our For The Media website at this ...

BOSTON - Amid continued debate over how to advance diversity and equity in higher education following the Supreme Court’s decision striking down affirmative action, researchers from Massachusetts General Hospital and Northeastern University today issued a “roadmap” of strategies to help academic health institutions maintain their commitments to racial and ethnic diversity among their students, staff, and faculty in academic health sciences. Their recommendations, published in JAMA Health Forum, outline 13 evidence-based strategies for increasing racial and ethnic equity in graduate-level health programs. “This ...

COLUMBUS, Ohio – Violence against teachers is likely to be higher in schools that focus on grades and test scores than in schools that emphasize student learning, a new study has found. Researchers surveyed over 9,000 U.S. teachers shortly before and during the height of the COVID-19 pandemic about their perception of the instructional emphasis in their schools. Participants also reported whether they had been subjected to physical, verbal or property violence – by students, parents, colleagues and/or administrators. Results ...

A new study identified a set of 140 genes that may help predict enhanced disease-free survival in patients with non-small cell lung cancer (NSCLC) treated with a combination of immunotherapy and low-dose radiation. The results, published in Cell Reports Medicine on Feb. 23, suggested that this “gene signature” could be used to identify a subclass of lung tumors that is more likely to be eradicated by immunotherapies. Immunotherapy has saved countless lives but only 20 to 25 percent of patients respond to this treatment that activates a person’s ...

Psychology and Economics come together in a recent line of research, led by Ismael Rodríguez-Lara, Professor at the University of Malaga, who studies how lies affect economic decisions. It is a study developed together with the Professor at the University of California (Santa Barbara, USA) Gary Charness, considered one of the most influential economists in the world within the experimental area, that has analyzed the way in which morality influences the degree of lying in certain economic situations. The results of this research have been published in the scientific journal Economics ...

New exploration  in underwater navigation, a team from the Naval University of Engineering in Wuhan, China, has created novel algorithms that rectify inertial errors using sparse acoustic signals. This exploration offers novel method for the  issue of underwater navigation , where traditional satellite systems are ineffective due to their signals' inability to penetrate water effectively. The increasing demand for precise underwater Positioning, Navigation, and Timing (PNT) due to expanding marine exploration and activities highlights the limitations of traditional Global Satellite Navigation Systems (GNSS) ...

Thanks to the rapid progress in tiny tech, we've been mainly using microfluidics to sort tiny particles by size. But now, there's a new way to sort them by shape, which could be a big deal for medical tests and chemistry. This study shows off a new method using sound waves to separate oddly shaped particles from round ones, without needing any labels. This breakthrough could lead to better ways to deliver drugs or diagnose diseases by offering a smarter approach to sort these tiny particles.  In the realm of microfluidics, separating micro-particles based solely on size has been the norm. However, distinguishing these particles ...

Downscaling of electronic devices, such as transistors, has reached a plateau, posing challenges for semiconductor fabrication. However, a research team led by materials scientists from City University of Hong Kong (CityUHK) recently discovered a new strategy for developing highly versatile electronics with outstanding performance, using transistors made of mixed-dimensional nanowires and nanoflakes. This innovation paves the way for simplified chip circuit design, offering versatility and low power dissipation in future electronics. In recent decades, as ...

Iron is a micronutrient for plants. Biologists from the Institute of Botany at Heinrich Heine University Düsseldorf (HHU) describe in a study, which has now been published in the Journal of Cell Biology, that regulatory proteins for iron uptake behave particularly dynamically in the cell nucleus when the cells are exposed to blue light – an important signal for plant growth. They found that the initially homogeneously distributed proteins relocated together into “biomolecular condensates” in the cell nucleus shortly after this exposure. Both iron deficiencies and excesses are problematic for plants. They ...

Microbially induced corrosion (MIC) is a prevalent issue in marine environments, leading to structural damages such as cracking in concrete infrastructure. This corrosion poses a persistent challenge, significantly reducing the lifespan of marine structures and resulting in substantial economic losses. In response to the need for an effective solution to combat the marine corrosion on concrete, researchers of the Hong Kong Polytechnic University have developed a biomineralization approach to protect marine concrete from MIC.   Prof. ...

Certain genes associated with hypertension affect blood pressure from early in life, and they increase the risk of cardiovascular disease as you get older.  However, you can do something about it. “We are talking about really small differences, so small that they may fall within what is considered normal blood pressure. The problem is that they tend to last your whole life,” says PhD Candidate Karsten Øvretveit at the Norwegian University of Science and Technology's (NTNU) Department of ...

Washington, D.C. — Feb. 23, 2024 —Streams with ample connections to shallow groundwater flowpaths have greater microbial diversity and are more effective at preventing toxic forms of metals—often products of upstream mining—from entering and being transported downstream. These streams are also better at detoxifying those metals already present. The research is published this week in Applied and Environmental Microbiology, a journal of the American Society for Microbiology. Under favorable conditions, the zone lining a stream channel stores nutrients and oxygen that meet nutritional and respiratory needs of local invertebrates and fish. That ...

Across the globe, more than 39 million people are living with the Human Immunodeficiency Virus (HIV), the virus that causes AIDS, including more than 1.3 million new HIV diagnoses last year. The majority of those afflicted — approximately 76% — have access to antiviral therapy that allows them to live with HIV as a chronic disease. Sharilyn Almodóvar, Ph.D., from the Department of Immunology and Molecular Microbiology at the Texas Tech University Health Sciences Center (TTUHSC) School of Medicine and the TTUHSC Graduate School of Biomedical Sciences, said that even with the widespread ...

WHO PQ paves the way for public procurement of SKYTyphoid™ by UN organizations Addition of new vaccine will diversify, expand TCV supply amid expected growing demand   February 23, 2024, SEOUL, Korea – SK bioscience and the International Vaccine Institute (IVI) announced today that the typhoid conjugate vaccine developed by SK bioscience with technology transfer from IVI has achieved the World Health Organization prequalification (PQ), which paves the way for public procurement of the vaccine by UN organizations and gives a boost to the global TCV supply.   WHO PQ certifies the safety, efficacy, and GMP of a vaccine by evaluating its manufacturing ...

Should we be using polygenic risk score assessment for embryo selection? Providing in-depth analysis, the Social, Ethical and Legal Issues Committee of the American College of Medical Genetics and Genomics (ACMG) has released a new Points to Consider statement to assist healthcare professionals and patients in understanding the safety and utility of preimplantation genetic testing for polygenic disorders (PGT-P) as a clinical service. “Clinical Utility of Polygenic Risk Scores for Embryo Selection: A Points to Consider Statement of the American College of Medical Genetics and Genomics (ACMG)” was published in the College’s flagship journal, Genetics ...

Microbially induced corrosion (MIC) is a prevalent issue in marine environments, leading to structural damages such as cracking in concrete infrastructure. This corrosion poses a persistent challenge, significantly reducing the lifespan of marine structures and resulting in substantial economic losses. In response to the need for an effective solution to combat the marine corrosion on concrete, researchers of the Hong Kong Polytechnic University have developed a biomineralization approach to protect marine concrete from MIC.   Prof. ...

Researchers at UBC Okanagan are revisiting old building practices—the use of by-products and cast-offs—as a way to improve building materials and sustainability of the trade. A technique known as rammed earth construction uses materials that are alternatives to cement and are often more readily available in the environment. One such alternative is wood fly ash, a by-product of pulp mills and coal-fired power plants, explains Dr. Sumi Siddiqua, with UBC Okanagan’s School of Engineering. Industry has been trying to find a use for materials like fly ash ...

Whiteflies, particularly the African cassava whitefly (Bemisia tabaci, SSA1-SG1), pose a significant threat to agricultural productivity in Sub-Saharan Africa by transmitting viruses that cause cassava brown streak disease and cassava mosaic virus disease. In a new study published in PeerJ Life & Environment, Dr. Tadeo Kaweesi and his team at the National Agricultural Research Organization identify potential gene targets that could revolutionize the management of this devastating pest and prove vital for food security in the region.   In the article ("In silico prediction of candidate gene targets ...

Milan (Italy), 23 February 2024 – TWIN is the name of the new robotic exoskeleton for lower limbs, designed and developed by Rehab Technologies IIT – INAIL, the joint laboratory between the Istituto Italiano di Tecnologia (IIT-Italian Institute of Technology) and the Prosthetic Center of INAIL (the prosthetic unit of the National Institute for Insurance against Accidents at Work), which will allow patients to wear it more easily. Presented today in Milan during a press conference held at the Museum of Science and Technology, TWIN was demonstrated ...