The 7th World Conference on Targeting Phage Therapy 2024, two-day event dedicated to advancing the field of phage research and therapy will be hosted at Corinthia Palace Malta on June 20-21. Robert T. Schooley, M.D., Professor of Medicine at the University of California, San Diego, Co-Director of the Center for Innovative Phage Applications and Therapeutics, and member of the Executive Committee for the University of California Disaster Resilience Network, will introduce the messages and strategies behind phages therapy 2024. His talk titled “Phage Therapeutics 2024: Essential Translational Research Components for ...

“The present studies were performed to extend our knowledge of GZ17-6.02 biology from that known in solid tumor cell types such as prostate cancer cells to liquid tumor cell types, for example, mycosis fungoides.” BUFFALO, NY- February 26, 2024 – A new research paper was published in Oncotarget's Volume 15 on February 8, 2024, entitled, “GZ17-6.02 interacts with bexarotene to kill mycosis fungoides cells.” In this new study, researchers Michael R. Booth, Laurence Booth, Jane L. Roberts, Cameron West, and Paul Dent from Virginia Commonwealth University and Genzada Pharmaceuticals investigated the therapeutic agent GZ17-6.02, composed of curcumin, ...

Memphis, Tenn. (February 26, 2024) – Shelley White-Means, PhD, a professor of Health Economics in the Department of Interprofessional Education and the director of the Consortium for Health Education, Economic Empowerment and Research (CHEER) at UT Health Science Center, recently received a $1.5 million, four-year grant from the National Institute on Minority Health and Health Disparities to explore the root causes of the disparity in breast cancer survival of Black women compared to white women.   Dr. White-Means and a team will look beyond the social determinants of health to explore what she terms “the intersectionality of race, ...

Stanford researchers are getting closer to building a tiny electron accelerator based on “accelerator-on-a-chip” technology with broad potential applications in studying physics as well as medical and industrial uses. The researchers have demonstrated that a silicon dielectric laser accelerator, or DLA, can now both speed up and confine electrons, creating a focused beam of high-energy electrons. “If the electrons were microscopic cars, it’s as if, for the first time, we’re steering and we have our foot on the gas,” said Payton Broaddus, PhD ’23 in electrical engineering and the lead author on a paper published on ...

FINDINGS Scientists at City of Hope, one of the largest cancer research and treatment organizations in the United States, have devised an innovative approach to target and destroy hard-to-kill leukemia stem cells. The journal Blood published the preclinical findings today. By overcoming challenges, such as drug resistance and treatment relapse common to patients with acute myeloid leukemia (AML), the therapy method could provide a less toxic and more effective approach for older and sicker patients who don’t quality for stem cell transplants — currently the only cure for AML available. Type II interferon (IFNy), a substance produced by immune cells, disrupts ...

NEWPORT NEWS, VA – Scientists are getting a more detailed look than ever before at the electrons they use in precision experiments. Nuclear physicists with the U.S. Department of Energy’s Thomas Jefferson National Accelerator Facility have shattered a nearly 30-year-old record for the measurement of parallel spin within an electron beam – or electron beam polarimetry, for short. The achievement sets the stage for high-profile experiments at Jefferson Lab that could open the door to new physics discoveries. In a peer-reviewed ...

FOR IMMEDIATE RELEASE, February 26, 2024 Contact: Gina DiGravio, 617-358-7838, ginad@bu.edu BU Researchers Identify Potential New Subtype of Chronic Traumatic Encephalopathy One in six cases have a distinct distribution of disease, clinical profile (Boston)—Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease defined by abnormal tau protein accumulating in a particular pattern in specific regions of the brain.   Studies to-date suggest CTE begins in the outermost layer of the frontal lobe, the neocortex, where it then spreads to connected brain regions. Later, in high-stage disease, ...

EMBARGOED by Cell until 11 am ET Feb. 26, 2024 Contact: Gina DiGravio, 617-358-7838, ginad@bu.edu   BU Researchers Describe New Technological Platform to   Accelerate Drug Development   (Boston)— Drug development is currently an extremely long, expensive and inefficient process. Findings generated in a lab are often very hard to replicate once translated into animal models or in humans.   A family of pharmacological targets, on which approximately 35% of FDA-approved drugs work, consists of receptors at the surface ...

One of the most striking examples of gut plasticity can be observed in animals that are exposed to prolonged periods of fasting, such as hibernating animals or phyton snakes that goes for months without eating, where the gut shrinks with as much as 50%, but recovers in size following a few days of re-feeding. Importantly, the capacity of the gut to undergo resizing is broadly conserved. Hence, in humans, an increase in gut size is observed during pregnancy, which facilitates the uptake of nutrients to support the growth of the fetus. The Colombani Andersen ...

What if it were possible to use a scientific model to predict hate crimes, protests, or conflict? Researchers at McGill University and University of Toronto have begun the groundwork to develop a formal predictive model of prejudice, similar to meteorological weather predictions. The model can be explained by the equation: Prejudice = Threat – Contact + Identification, “with some numbers involved,” says lead author Eric Hehman, Associate Professor in the Department of Psychology and lead author of a new study published in Psychological ...

Imagine a world where your smartphone can detect your mood just by the way you type a message or the tone of your voice. Picture a car that adjusts its music playlist based on your stress levels during rush hour traffic. These scenarios are not just futuristic fantasies. They are glimpses into the rapidly evolving field of affective computing. Affective computing is a multidisciplinary field integrating computer science, engineering, psychology, neuroscience and other related disciplines. A new and comprehensive review on affective computing was published Jan. 5 in Intelligent ...

AI decision-making is now common in self-driving cars, patient diagnosis and legal consultation, and it needs to be safe and trustworthy. Researchers have been trying to demystify complex AI models by developing interpretable and transparent models, collectively known as explainable AI methods or XAI methods. A research team offered their insight specifically into audio XAI models in a review article published Jan. 23 in Intelligent Computing, a Science Partner Journal. Although audio tasks are less researched than visual tasks, their expressive power is not less important. Audio signals are easy to understand and communicate, as they typically depend less on expert explanations ...

JMIR Publications is pleased to announce a new theme issue in JMIR Neurotechnology exploring brain-computer interfaces (BCIs) that represent the transformative convergence of neuroscience, engineering, and technology. The peer-reviewed journal aims to bridge the gap between clinical neuroscience and information technology by providing a platform for applied human research in the field of neurology.  JMIR Neurotechnology welcomes submissions from scientists, clinicians, and technologists. PhD students and early career researchers are ...

Your liver plays a vital role in your metabolism, the biological process which converts food into energy. We know that being overweight can negatively affect metabolic activity, but not exactly how. To better understand this, researchers compared the livers of mice which were a typical weight with mice which were obese. They were surprised to find that biological regulation of metabolic activity, after a period of feasting and fasting, was reversed between them. In typical mice, allosteric regulation (the process which controls metabolism) was inhibited during feeding and activated when fasting. However, ...

Striped marlin are some of the fastest animals on the planet and one of the ocean’s top predators. When hunting in groups, individual marlin will take turns attacking schools of prey fish one at a time. Now a new study reported in the journal Current Biology on February 5 helps to explain how they might coordinate this turn-taking style of attack on their prey to avoid injuring each other. The key, according to the new work, is rapid color changes. “We documented for the first time rapid color change in a group-hunting predator, the striped marlin, as groups of marlin hunted schools of sardines,” says Alicia Burns of Humboldt University ...

When a star like our Sun reaches the end of its life, it can ingest the surrounding planets and asteroids that were born with it. Now, using the European Southern Observatory’s Very Large Telescope (ESO’s VLT) in Chile, researchers have found a unique signature of this process for the first time — a scar imprinted on the surface of a white dwarf star. The results are published today in The Astrophysical Journal Letters. “It is well known that some white dwarfs — slowly cooling embers of stars like our Sun — are ...

About The Study: This survey study found that primary care pediatricians felt less prepared to manage adolescents’ opioid use disorder (OUD) than alcohol, cannabis, or e-cigarette use and were more likely to refer them to offsite care. These results reveal an opportunity for greater workforce training in line with a 2019 survey showing fewer than 1 in 3 pediatric residency programs included education on prescribing OUD medications.  Authors: Scott E. Hadland, M.D., M.P.H., M.S., of Mass General for Children in Boston, is the corresponding author. To access the embargoed study: Visit our For The ...

About The Study: The findings of this study of 8,988 preadolescent children suggest that the increased risk of suicide attempts, consistently reported for adolescents and adults who smoke cigarettes, extends to a range of emerging tobacco products and manifests among elementary school–aged children. Further investigations are imperative to clarify the underlying mechanisms and to implement effective preventive policies for children. Authors: Phil H. Lee, Ph.D., of Massachusetts General Hospital and Harvard Medical School in Boston, is the corresponding author.  To ...

In the face of increasing temperatures globally, a new Monash-led study of 1.2 million births in Sydney over two decades has shown a strong association between the risk of pre-term birth and exposure to extreme hot temperatures in the third trimester of pregnancy. The data suggested that this association with extreme temperature might be reduced by the level of greenery in a pregnant person’s residential surrounds. The findings suggest health services should consider preparing for an increase in preterm births as our climate warms. The study, published in JAMA Pediatrics, looked at the relationship ...

Sight loss in certain inherited eye diseases may be caused by gut bacteria, and is potentially treatable by antimicrobials, finds a new study in mice co-led by a UCL and Moorfields researcher. The international study observed that in eyes with sight loss caused by a particular genetic mutation, known to cause eye diseases that lead to blindness, gut bacteria were found within the damaged areas of the eye. The authors of the new paper, published in Cell and jointly led by researchers in China, say their findings suggest that the genetic mutation may relax the body’s defences, thus allowing harmful bacteria to reach the eye and cause blindness. The gut contains trillions ...

DCM is the leading cause of heart failure in patients with chronic diabetes. However, the underlying mechanisms of DCM are poorly understood, and treatment options are limited. Another mystery is the regulation of cytochrome P450 enzymes (CYPs) in the central nervous system. Moreover, the link between the gut microbiome, microbiota-derived metabolites, and the progression of AD remains unknown. In the December issue of JPA, three articles provide insights into the pathologies of DCM, hippocampal neurotoxicity, and AD, providing a comprehensive ...

Electrogenerated chemiluminescence (ECL) cells, characterized by their self-emissive nature, have gathered significant interest for prospective display applications due to their uncomplicated structure and straightforward fabrication process. These cells are created by sandwiching a solution-based emitting layer between two transparent electrodes. Nevertheless, when compared to other self-emissive devices like light-emitting diodes (LED) and organic LEDs, the luminescent performance of ECL cells ...

Human herpesviruses comprise the alpha, beta, and gamma subfamilies and are a widely prevalent group of DNA-enveloped viruses, capable of establishing lifelong latent infections in humans and causing various diseases. Among them, herpes simplex virus (HSV) belongs to the alpha herpesvirus group and infects a wide population, causing symptoms like oral or genital herpes. As an enveloped virus, HSV possesses a series of glycoproteins involved in virus recognition, adhesion, and infection processes. Among these, gB serves as the viral fusion protein, mediating the fusion between the virus and host cell membranes, and ...

As Canada’s flu season collides with record strep A cases and ongoing COVID-19 concerns, a new study is shedding light on our understanding of respiratory immune responses. Scholars from the Research Institute of the McGill University Health Centre (RI-MUHC) have discovered a surprising facet about a century-old vaccine for tuberculosis, Bacillus Calmette Guérin (BCG). The study, published in the journal Nature Immunology, uncovered a previously unknown mechanism that extends the vaccine’s shield to combat influenza A virus—the most prevalent flu strain. “The immune interactions ...

Fungi are frequently found both around and within plant tissues (especially in roots) and are involved in both plant nutrient acquisition and resistance to pathogens. Thus, characterizing the diversity and composition of plant-associated fungal communities has been a growing interest in recent years.   High-throughput sequencing (HTS), also called metabarcoding, has become a prominent tool to assess complex microbial communities from environmental samples. However, HTS applied to plant-associated ...