Although there has been a steady increase in medical research from low- and middle- income countries in recent decades, there are still many countries that lack anything resembling a health research strategy, according to international experts writing in this week's PLoS Medicine. In anticipation of the upcoming World Health Report on the need for health research, Martin McKee from the London School of Hygiene & Tropical Medicine, UK and colleagues make the case for the importance of establishing national health research strategies so that public health systems can function ...

"Journals, professional associations, clinical guideline developers, and others need to worry not just that disclosure provides a band-aid to the real problem of the [conflict of interest] itself, but that any attempt to stem the trouble through disclosure policies may actually be worsening the problem," say the editors of PLoS Medicine writing in an editorial that discusses the response to a paper published in the Journal last month, which examined the financial conflicts of interest of members of the American Psychiatric Association (APA) responsible for updating the ...

JACKSONVILLE, Fla. — A single gene that promotes initial development of the most common form of lung cancer and its lethal metastases has been identified by researchers at Mayo Clinic in Florida. Their study suggests other forms of cancer may also be driven by this gene, matrix metalloproteinase-10 (MMP-10). The study, published in the journal PLoS ONE on April 24, shows that MMP-10 is a growth factor secreted and then used by cancer stem-like cells to keep themselves vital. These cells then drive lung cancer and its spread, and are notoriously immune to conventional ...

New research confirms that the controversial decision by Warren Buffet – the 81-year-old CEO of Berkshire Hathaway – to undergo a blood test screening for prostate cancer despite his age is hardly unusual. Despite recommendations in 2008 from the United States Preventive Services Task Force against testing for prostate cancer in men aged 75 years or older, almost half of men in that age group continue to get screening tests. In 2005, before the recommendations were released, 43 percent of men age 75 and above elected to take the prostate-specific antigen (PSA) test. In ...

Primary cilia are hair-like structures which protrude from almost all mammalian cells. They are thought to be sensory and involved in sampling the cell's environment. New research, published in BioMed Central's open access journal Cilia, launched today, shows that cilia on cells in the retina and liver are able to make stable connections with each other - indicating that cilia not only are able to sense their environment but are also involved in cell communication. Primary cilia are structurally and functionally very similar to eukaryotic flagella (motile tails used to ...

Discerning males remain faithful ...if you are a spider. Sex for male orb web spiders (Argiope bruennichi) is a two shot affair since the act of mating destroys their genitalia. If they survive being eaten during their first encounter with a female, they have two choices – to mate again with the same female (monogynous) or try to find a new partner (bigynous). New research published in BioMed Central's open access journal Frontiers in Zoology shows that choice of mating behavior for A. bruennichi depends on the size and age of the first female they mate with. Monogamous ...

Scientists funded by the Biotechnology and Biological Sciences Research Council (BBSRC) have discovered that maize crops emit chemical signals which attract growth-promoting microbes to live amongst their roots. This is the first chemical signal that has been shown to attract beneficial bacteria to the maize root environment. The study was led by Dr Andy Neal of Rothamsted Research in Hertfordshire and Dr Jurriaan Ton of the University of Sheffield's Department of Animal and Plant Sciences. By deepening our understanding of how cereals interact with microorganisms in ...

Women who go through the menopause early are nearly twice as likely to suffer from osteoporosis in later life, suggests new research published today (25 April) in BJOG: An International Journal of Obstetrics and Gynaecology. The Swedish study looked at the long-term effects of early menopause on mortality, risk of fragility fracture and osteoporosis. In 1977, 390 white north European women aged 48 were recruited in the Malmo Perimenopausal Study, an observational study where women were followed from age 48 onwards. The women were divided into two categories; women ...

As childhood and adolescent deaths from infectious diseases have declined worldwide, policymakers are shifting attention to preventing deaths from noncommunicable causes, such as drug and alcohol use, mental health problems, obesity, traffic crashes, violence and unsafe sex practices. "We now need to think of how to prevent these behavior problems and conditions early in life because they don't only cause problems in adolescence, they can launch health issues across life," said Richard Catalano, director of the University of Washington's Social Developmental Research ...

Community health plans are improving how patients transition from hospital to home by breaking down silos of care, coordinating among providers, and directly engaging with patients, according to a new report entitled Transitions of Care from Hospital to Home. In the report, prepared by Avalere Health for the Alliance of Community Health Plans (ACHP), Avalere researchers examined ACHP community health plans and found five practices that the plans identified as facilitating the success of their care transitions programs: Using data to tailor care transition programs ...

Research: Diagnostic value of single complete compression ultrasonography in pregnant and postpartum women with suspected deep vein thrombosis: prospective study A single ultrasound scan (known as compression ultrasonography) may safely rule out a diagnosis of deep vein thrombosis (DVT) in women during pregnancy or in the first few weeks after giving birth (post-partum period), finds a study published on bmj.com today. During pregnancy the risk of DVT increases, but accurately diagnosing it is a challenge for doctors. Tests that are safe and reliable in non-pregnant ...

Many athletes with asthma may not be using the best treatment for their condition and could be putting their long term health at risk, according to a roundup by journalist Sophie Arie published by the BMJ today. The article will feature on the BMJ's new Olympics portal, an online resource to keep doctors up to date with sports medicine content from across the BMJ Group. The portal will be open until the end of the Olympic and Para-Olympic games at www.bmj.com/olympics. Asthma is strikingly common in elite athletes and has gradually risen at almost every Olympics since ...

VIDEO: This is a video of a nano-structure. Click here for more information. DURHAM, N.C. -- Microscopic particles are being coaxed by Duke University engineers to assemble themselves into larger crystalline structures by the use of varying concentrations of microscopic particles and magnetic fields. These nano-scale crystal structures, which until now have been difficult and time-consuming to produce using current technologies, could be used as basic components for advanced ...

A method for the analysis of flavanols in cocoa has been developed by a team of researchers from Mars Botanical, a scientific division of Mars, Incorporated, and recently published in the Journal of AOAC International. Drawing on the research team's expertise in flavanol chemistry and analytics, the method identifies and quantifies the distinct stereochemical forms of flavanols found in cocoa and chocolate products. Foods rich in flavanols are increasingly recognized for their ability to exert positive effects on the cardiovascular system, but investigations have shown ...

Park Ridge, IL (April 24, 2012) – This week at Experimental Biology (EB) 2012 in San Diego, experts are convening to discuss the latest science in a variety of health and disease-related areas, including nutrition. Research on whole egg consumption in individuals with metabolic syndrome as well as the positive effects of a higher-protein breakfast is further revealing the potential benefits of including eggs in the diet. Whole Egg Consumption May Improve Markers of Metabolic Syndrome A University of Connecticut study presented this week suggests that eating eggs may ...

Washington, DC — Older animals show cellular changes in the brain "clock" that sets sleep and wakeful periods, according to new research in the April 25 issue of The Journal of Neuroscience. The findings may help explain why elderly people often experience trouble sleeping at night and are drowsy during the day. Like humans, mice experience shifts in daily activities and sleep patterns as they age. To find out why, researchers directed by Johanna Meijer, PhD, at the Leiden University Medical Center in the Netherlands studied the electrical activity of cells in the suprachiasmatic ...

(WASHINGTON, April 24, 2012) – The American Society of Hematology (ASH), the world's largest professional society committed to the study and treatment of blood disorders, today issued a report urging federal agencies to coordinate hematology research funding around seven specific high-need areas that would produce the greatest impact and translate into improvements in patient care in the United States. Developed by the Society's Committee on Scientific Affairs, a team of world-class experts in hematology, the ASH Agenda for Hematology Research is a strategic plan identifying ...

LA JOLLA, CA – April 24, 2012 – Scientists at The Scripps Research Institute have found clinical evidence that the drug gabapentin, currently on the market to treat neuropathic pain and epilepsy, helps people to quit smoking marijuana (cannabis). Unlike traditional addiction treatments, gabapentin targets stress systems in the brain that are activated by drug withdrawal. In a 12-week trial of 50 treatment-seeking cannabis users, those who took gabapentin used less cannabis, experienced fewer withdrawal symptoms such as sleeplessness, and scored higher on tests of attention, ...

Although people generally talk about "cancer", it is clear that the disease occurs in a bewildering variety of forms. Even single groups of cancers, such as those of the white blood cells, may show widely differing properties. How do the various cancers arise and what factors determine their progression? Clues to these two issues, at least for leukaemias, have now been provided by Boris Kovacic and colleagues at the University of Veterinary Medicine, Vienna (Vetmeduni Vienna). The results are published in the current issue of the journal EMBO Molecular Medicine and ...

Eating disorders can be triggered by lack of support following traumatic events such as bereavement, relationship problems, abuse and sexual assault, according to research published in the May issue of the Journal of Clinical Nursing. Even changing school or moving home can prove too much for some young people and lead to conditions such as anorexia or bulimia. Researchers from the University of Minnesota, USA, spoke to 26 women and one man aged from 17 to 64 receiving treatment from a specialist outpatient clinic. They had suffered from eating disorders for an average ...

April 24, 2012, Cambridge, Mass. and Shenzhen, China – BGI, the world's largest genomics organization, introduced today its latest-generation cloud-based Software as a Service (SaaS) solution, EasyGenomics, at the 10th Bio-IT World Conference & Expo being held April 24 to 26 in Boston, Mass. EasyGenomics allows scientists to easily access data-heavy omics-related research with rapid turnaround time, reliable results, real-time data monitoring, and a user-friendly interface. EasyGenomics integrates various popular next generation sequencing (NGS) analysis workflows including ...

Researchers from the Bellvitge Biomedical Research Institute (IDIBELL) have shown that overactivation of the RANK signalling pathway promotes the initiation, progression and metastasis of tumours in human breast epithelial cells by dedifferentiation of breast cells to stem cells. The results of this study have been advanced in the electronic edition of the journal Cancer Research. RANK signalling pathway The study was coordinated by Eva Gonzalez-Suarez, head of the IDIBELL research group on Transformation and Metastasis. A year ago, the team published a paper which ...

Queen Mary scientists working with images from NASA's Cassini spacecraft have discovered strange half-mile-sized objects punching through parts of Saturn's F ring, leaving glittering trails behind them. These trails in the rings, which scientists are calling 'mini-jets', fill in a missing link in our understanding of the curious behaviour of the F ring. The results will be presented today (24 April) at the European Geosciences Union meeting in Vienna, Austria. Scientists have known that relatively large objects like the moon Prometheus (as long as 92 miles across) ...

Toxic prions in the brain can be detected with self-illuminating polymers. The originators, at Linköping University in Sweden, has now shown that the same molecules can also render the prions harmless, and potentially cure fatal nerve-destroying illnesses. Linköping researchers and their colleagues at the University Hospital in Zürich tested the luminescent conjugated polymers, or LCPs, on tissue sections from the brains of mice that had been infected with prions. The results show that the number of prions, as well as their toxicity and infectibility, decreased drastically. ...

Where do viruses dangerous to humans come from, and how have they evolved? Scientists working with Prof. Dr. Christian Drosten, Head of the In¬stitute for Virology at the Universitätsklinikum Bonn, have made significant progress in answering this question. "We already knew from prior studies that bats and rodents play a role as carriers of paramyxoviruses," said Prof. Drosten. The many varied members of this large virus family cause, e.g., measles, mumps, pneumonias and colds. The highly dangerous Hendra and Nipah viruses cause types of encephalitis that result in death ...