Invade and conquer: Nicotine's role in promoting heart and blood vessel disease
San Diego, Calif. – Cigarette smoke has long been considered the main risk factor for heart disease. But new research from Brown University in Providence, R.I., shows that nicotine itself, a component of cigarette smoke, can contribute to the disease process by changing cell structure in a way that promotes migration and invasion of the smooth muscle cells that line blood vessels. In particular, invading cells can remodel structures called podosomes, and this leads to further degradation of vessel integrity.
Ultimately, this cellular migration and invasion process gives ...








