JCI online early table of contents: Nov. 14, 2011
EDITOR'S PICK: Glioblastoma multiforme in the Dock
Glioblastoma multiforme (GBM) is the most common malignant brain cancer in humans. Patients with GBM have a poor prognosis because it is a highly aggressive form of cancer that is commonly resistant to current therapies. A team of researchers — led by Bo Hu and Shi-Yuan Cheng, at the University of Pittsburgh Cancer Institute, Pittsburgh — has now identified a molecular pathway that drives the aggressive cancerous nature of a substantial proportion of glioblastomas; specifically, those that overexpress the protein PDGFR-alpha. ...

