Treating mild strokes with the clot-busting drug approved for severe stroke could reduce the number of patients left disabled and save $200 million a year in disability costs, according to a study presented at the American Stroke Association's International Stroke Conference 2011. Researchers analyzed hospital records from 437 patients diagnosed with mild ischemic stroke at 16 sites in the Greater Cincinnati/Northern Kentucky region in 2005. The patients arrived at the hospital within the 3.5 hours, well within the 4.5 hour window for treatment with intravenous tissue ...

Strokes will increase dramatically over the coming decades, with increases being considerably steeper in Mexican-Americans compared with non-Hispanic whites, according to research presented at the American Stroke Association's International Stroke Conference 2011. "The tremendous number of strokes projected has large personal, social and economic consequences for the United States," said Shawnita Sealy-Jefferson, M.P.H., an investigator at the School of Public Health at the University of Michigan in Ann Arbor. According to the American Stroke Association, stroke accounts ...

New research examines the anxious brain during a fear conditioning task and provides insight into why some individuals may be more or less prone to anxiety disorders. The study, published by Cell Press in the February 10 issue of the journal Neuron, reveals neural mechanisms that may contribute to resilience against pathological fear and anxiety. The findings may help to direct therapeutic strategies for individuals who suffer from chronic anxiety as well as strategies that could help "at risk" individuals avoid developing anxiety disorders. Previous studies have implicated ...

New research using a mouse model of the motor neuron disease spinal muscular atrophy (SMA) reveals an abnormality in the way that sensory information is relayed to motor neurons in the spinal cord. Importantly, this disruption in communication occurs very early in disease progression and precedes the neuronal death and muscle weakness that are the hallmark of the disease. The study, published by Cell Press in the February 10 issue of the journal Neuron, suggests that therapeutic strategies designed to improve communication at these spinal synapses might help to slow or ...

CINCINNATI—Treating mild strokes with the clot-busting drug approved for severe stroke could reduce the number of patients left disabled and save $200 million a year in disability costs, according to new research from the University of Cincinnati (UC). The study led by Pooja Khatri, MD, an associate professor in the department of neurology, examined the public health impact of treating mild strokes with the clot-busting drug intravenous tissue plasminogen activator (tPA). It is being presented Wednesday, Feb. 9, in Los Angeles at International Stroke Conference 2011, the ...

CINCINNATI—While smoking and alcohol use remained relatively stable over a 13-year study period, street drug use among stroke patients rose more than nine-fold, according to new research from the University of Cincinnati (UC). The findings are being presented Wednesday, Feb. 9, in Los Angeles at International Stroke Conference (ISC) 2011, the annual meeting of the American Stroke Association, by Felipe De los Rios, MD, of the UC Department of Neurology and the UC Neuroscience Institute. De los Rios is a fourth-year resident in the neurology department. The research is ...

CINCINNATI—Poorer patients have more severe ischemic strokes, or strokes resulting from blockages in blood vessels in the brain, according to new research from the University of Cincinnati (UC). A study led by Dawn Kleindorfer, MD, an associate professor in the department of neurology, found that increasing poverty in the neighborhood where the stroke patient lived was associated with worse stroke severity at presentation, independent of other known factors associated with stroke outcomes. The study is being presented Wednesday, Feb. 9, in Los Angeles at International ...

Omega-3 fatty acids –fats commonly found in fish oil – were shown several years ago to prevent retinopathy, a major form of blindness, in a mouse model of the disease. A follow-up study, from the same research team at Children's Hospital Boston, now reveals exactly how omega-3's provide protection, and provides reassurance that widely used COX-inhibiting drugs like aspirin and NSAIDs don't negate their benefit. The findings, published in the February 9th issue of Science Translational Medicine, also suggest that omega-3's may be beneficial in diabetes. Retinopathy – an ...

Cambridge, Mass. – February 9, 2011 – Engineers and scientists collaborating at Harvard University and the MITRE Corporation have developed and demonstrated the world's first programmable nanoprocessor. The groundbreaking prototype computer system, described in a paper appearing today in the journal Nature, represents a significant step forward in the complexity of computer circuits that can be assembled from synthesized nanometer-scale components. It also represents an advance because these ultra-tiny nanocircuits can be programmed electronically to perform a number ...

VIDEO: Kelly Frazer, PhD, describes genome-wide association studies and the new CAD risk findings. Click here for more information. The discovery that a "gene desert" on chromosome 9 was a hotspot for coronary artery disease (CAD) risk was among the highlights of findings produced recently by genome-wide association studies, which compare the genomes of many people for genetic variations and have been broadly used in the past few years to study hundreds of diseases and complex ...

STANFORD, Calif. — Using skin cells from young patients who have a severe genetic heart defect, Stanford University School of Medicine scientists have generated beating heart cells that carry the same genetic mutation. The newly created human heart cells — cardiomyocytes — allowed the researchers for the first time to examine and characterize the disorder at the cellular level. In a study to be published online Feb. 9 in Nature, the investigators also report their identification of a promising drug to reverse the heart malfunction — for which there are currently no decent ...

Blocking a factor that can activate the human immune response against intestinal bacteria or certain foods could prevent the development of celiac disease in those most at risk, researchers report in the journal Nature. The study, to be published early online Feb. 9, points to two chemical signals—interleukin 15 and retinoic acid, a derivative of vitamin A—as triggers for the inflammatory response to gluten, a protein found in many grains that causes celiac disease. "We found that having elevated levels of IL-15 in the gut could initiate all the early stages of celiac ...

(Boston) - Researchers from Boston University School's of Medicine (BUSM), Management (SMG) and Law (LAW), along with collaborators from the National Institutes of Health, believe that public-sector research has had a more immediate effect on improving public health than was previously realized. The findings, which appear as a Special Article in the February 10th issue of The New England Journal of Medicine, have economic and policy implications. Historically, public sector research institutions (PSRI) have not participated in any major way in the downstream, applied ...

Scientists have discovered a new way genes are regulated that is unique to primates, including humans and monkeys. Though the human genome – all the genes that an individual possesses – was sequenced 10 years ago, greater understanding of how genes function and are regulated is needed to make advances in medicine, including changing the way we diagnose, treat and prevent a wide range of diseases. "It's extremely valuable that we've sequenced a large bulk of the human genome, but sequence without function doesn't get us very far, which is why our finding is so important," ...

LA JOLLA, CA – Embargoed by the journal Neuron until February 9, 2011, noon, Eastern time – A study from The Scripps Research Institute has unveiled a surprising mechanism that controls brain formation. The findings have implications for understanding a host of diseases, including some forms of mental retardation, epilepsy, schizophrenia, and autism. The research, led by Scripps Research Professor Ulrich Mueller, was published in the journal Neuron on February 10, 2011. In the new study, Mueller and colleagues focused on a protein called reelin. They found reelin is ...

Thirty years ago, the first human fetal surgery was performed at the University of California, San Francisco. Now, a randomized controlled trial has proven definitively that fetal surgery can help certain patients before birth. Babies who undergo an operation to repair the birth defect spina bifida while still in the womb develop better and experience fewer neurologic complications than babies who have corrective surgery after birth, according to findings from a major multicenter trial led by UCSF researchers. The study is the first to systematically evaluate the best ...

LOS ANGELES (EMBARGOED UNTIL FEB. 9, 2011 AT 9:15 PM EST) – Whether or not you're fond of Indian, Southeast Asian and Middle Eastern food, stroke researchers at Cedars-Sinai Medical Center think you may become a fan of one of their key spices. The scientists created a new molecule from curcumin, a chemical component of the golden-colored spice turmeric, and found in laboratory experiments that it affects mechanisms that protect and help regenerate brain cells after stroke. Research scientist Paul A. Lapchak, Ph.D., director of Translational Research in the Department ...

Two groups of lowly marine worms are related to complex species including vertebrates (such as humans) and starfish, according to new research. Previously thought to be an evolutionary link between simple animals such as jellyfish and the rest of animal life - the worms' surprising promotion implies that they have not always been as simple as they now appear. Although the marine worms Xenoturbella and Acoelomorpha are very simple animals – they lack a developed nervous system or gut – they have been a source of much debate among zoologists. Acoelomorphs were reclassified ...

ST. PAUL, Minn. – People who have memory problems or other declines in their mental abilities may be at higher risk for stroke, according to a study released today that will be presented at the American Academy of Neurology's 63rd Annual Meeting in Honolulu April 9 to April 16, 2011. "Finding ways to prevent stroke and identify people at risk for stroke are important public health problems," said study author Abraham J. Letter of the University of Alabama at Birmingham. "This study shows we might get a better idea of who is at high risk of stroke by including a couple ...

A new strategic plan from an arm of the National Institutes of Health envisions scientists being able to identify genetic bases of most single-gene disorders and gaining new insights into multi-gene disorders in the next decade. This should lead to more accurate diagnoses, new drug targets and the development of practical treatments for many who today lack therapeutic options, according to the plan from the National Human Genome Research Institute (NHGRI). Molecular pathways that are implicated in single-gene disorders may hold important clues for the diagnosis and treatment ...

Fears that most UK companies would slash investment in skills training as a result of the recession have proved to be largely unfounded, researchers at Cardiff University and the University of London have concluded. Although some employers have cut spending to the bone, total expenditure on training has reduced only slightly. Many employers are also "training smarter", according to a new study from researchers at Cardiff University and the Centre for Learning and Life Chances in Knowledge Economies and Societies (LLAKES), at the Institute of Education, University of ...

Performing delicate surgery in the womb, months before birth, can substantially improve outcomes for children with a common, disabling birth defect of the spine. Experts at The Children's Hospital of Philadelphia (CHOP) co-led a new landmark study showing that fetal surgery for spina bifida greatly reduces the need to divert fluid from the brain, improves mobility and improves the chances that a child will be able to walk independently. Spina bifida is the most common birth defect of the central nervous system, affecting about 1,500 babies born each year in the United ...

Stem Cell scientists in Australia have found that patients suffering from hearing problems which began during infancy and childhood could benefit from a transplant of stem cells from their nose. The research, published today in STEM CELLS, reveals that mucosa-derived stem cells can help preserve hearing function during the early-onset of sensorineural hearing loss. Sensorineural hearing loss is caused by the loss of sensory cells or neurons in the cochlea, the sensory organ of the inner ear responsible for hearing. The condition can have genetic causes, often arising ...

It is time to reopen private finance initiative (PFI) contracts say leading public health physician, Professor Allyson Pollock, and colleagues on bmj.com today. Professor Pollock, who is based at the Centre for International Public Health Policy at the University of Edinburgh, argues that "NHS PFI contracts are not good value and are endangering patient care". Since 1997 most large-scale public capital investment in the UK has been through PFI purchasing schemes where investment banks and building companies raise the finance for public infrastructure projects. In ...

COLUMBUS, Ohio – Many school officials react in exactly the wrong ways when one of their students completes suicide, according to the authors of a new book. While they may be well-intentioned, administrators who don't send the right messages may make copycat suicides more likely, and are not providing the help needed by others hurting from the tragedy. "Without the proper knowledge and resources, many school administrators may implement strategies that could actually increase the risk of suicide among students," said Darcy Haag Granello, professor of counselor education ...