HOUSTON - The recently identified TRIM24 protein plays an active role in pushing normal breast cells into rapid cell proliferation and, potentially, into breast cancer. Reporting in the journal Nature, a team led by researchers at The University of Texas MD Anderson Cancer Center found that TRIM24 (tripartite motif-containing 24) pushes estrogen-responsive genes toward active expression. This expression, in turn, sets the stage for malignant transformation of breast cells. TRIM24 functions by reading a specific code, or signature, present at estrogen-regulated genes and ...

Rising concentrations of zinc in a waterway on Colorado's Western Slope may be the result of climate change that is affecting the timing of annual snowmelt, says a new study led by the University of Colorado at Boulder. The study focused on the Snake River watershed just west of the Continental Divide near Keystone, Colo., where CU-Boulder researchers have observed a four-fold increase in dissolved zinc over the last 30 years during the lowest water flow months, said Caitlin Crouch. Crouch, a master's degree student who led the study, said the high levels of zinc affect ...

A new study from researchers at North Carolina State University sheds light on how a technique that is commonly used for making single-metal nanoparticles can be extended to create nanoparticles consisting of two metals – and that have tunable properties. The study also provides insight into the optical properties of some of these nanoparticles. Tuning the optical properties of nanoparticles is of interest for applications such as security technology, and for use in making chemical reactions more efficient – which has multiple industrial and environmental applications. ...

WASHINGTON, Dec. 15, 2010 — The quest to cure a terrible form of food poisoning caused by population explosions of algae that stain the water red and produce a potent toxin is the topic of a new episode in the American Chemical Society (ACS) Prized Science video series. Entitled "Taming the Red Tides," the high-definition video, released today, focuses on Michael Crimmins, Ph.D., winner of the 2010 Ernest Guenther Award in the Chemistry of Natural Products. Crimmins, a chemist at the University of North Carolina in Chapel Hill, studies brevetoxin A, a poison produced ...

Findings from a new study of 141 adults add to an ongoing medical debate over which patients with symptoms of celiac disease should go on a gluten-free diet. Published in ACS' Journal of Proteome Research, the study concludes that people currently diagnosed as "potential" celiac disease patients and not advised to follow a gluten-free diet may not be "potential" patients at all. Rather, the scientists found that these patients have the same distinctive metabolic fingerprint as patients with full-blown disease who do benefit from gluten-free diets. In the study, Ivano ...

In a study that the authors describe as lending credence to the idiom, "by the skin of your teeth," scientists are reporting that the protective shield fluoride forms on teeth is up to 100 times thinner than previously believed. It raises questions about how this renowned cavity-fighter really works and could lead to better ways of protecting teeth from decay, the scientists suggest. Their study appears in ACS' journal Langmuir. Frank Müller and colleagues point out that tooth decay is a major public health problem worldwide. In the United States alone, consumers spend ...

Manufacturer recalls of toys, promotional drinking glasses, and other children's products constitute an ongoing "toxic toys crisis" that requires banning potentially harmful ingredients in these products and other changes in policy and practices. That's the conclusion of a new analysis in ACS' journal Environmental Science & Technology. Monica Becker, Sally Edwards and Rachel Massey note that in June the United States government recalled 12 million promotional drinking glasses sold at a fast-food restaurant chain because the painted coating contained cadmium, a toxic ...

Montreal, December 15, 2010 – Conduct disorders in preteens are predictive of eventual teenage serious violent and delinquent behavior, according to a new study from the Université de Montréal. The findings, published in this month's issue of Journal of Child Psychology and Psychiatry, have implications for concerned parents. Preteens who steal, destroy property, fight and bully are six times as likely to sell illicit drugs, nine times as likely to join a gang, 11 times as likely to carry a weapon and eight times as likely to be arrested as a future teenager, according ...

With chitlins about to make their annual appearance on Christmas and New Year's Day menus, scientists have good news for millions of people who love that delicacy of down-home southern cooking, but hate the smell. They are reporting the first identification of an ingredient in cilantro that quashes the notoriously foul odor of chitlins — a smell known to drive people from the house when chitlins are cooking. Their report appears in ACS' Journal of Agricultural and Food Chemistry. Yasuyoshi Hayata and colleagues note that chitlins — hog large intestines — are infamous ...

A mounting tide of scientific evidence suggests that the old adage from Aesop's fables — "You are known by the company you keep" — also applies to the trillions of microscopic bacteria and viruses that live on the human body. Humanity's invisible but constant companions — more bacteria hang out on the palms of your hands than there are people on Earth — is the topic of an article in the current edition of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine. C&EN Associate Editor Sarah Everts notes in the article that the astonishing diversity of microbes inhabiting ...

The virus that causes AIDS is chameleon-like in its replication. As HIV copies itself in humans, it constantly mutates into forms that can evade even the best cocktail of current therapies. Understanding exactly how HIV cells change as they reproduce is key to developing better tests and treatments for patients. In the Journal of Biological Chemistry and Nature Structural & Molecular Biology, MU microbiologist and biochemist Stefan Sarafianos, PhD, reveals new findings that shed light on how HIV eludes treatment by mutating. His discoveries provide clues into HIV's mechanisms ...

For the first time in history, a change will be made to the atomic weights of some elements listed on the Periodic table of the chemical elements posted on walls of chemistry classrooms and on the inside covers of chemistry textbooks worldwide. The new table, outlined in a report released this month, will express atomic weights of 10 elements - hydrogen, lithium, boron, carbon, nitrogen, oxygen, silicon, sulfur, chlorine and thallium - in a new manner that will reflect more accurately how these elements are found in nature. "For more than a century and a half, many ...

CHAMPAIGN, Ill. — University of Illinois researchers have found a key to keeping stem cells in their neutral state: It takes a soft touch. In a paper published in the journal PLoS One, the researchers demonstrated that culturing mouse embryonic stem cells (mESCs) on a soft gel rather than on a hard plate or dish keeps them in their pluripotent state, a ground state with the ability to become any type of tissue. The soft substrate maintains homogeneous pluripotent colonies over long periods of time – without the need for expensive growth chemicals. "This has huge applications ...

Red tides and similar blooms can render some seafood unsafe to eat, though it can be difficult to tell whether a particular batch harbors toxins that cause food poisoning. A new kind of marker developed by chemists at the University of California, San Diego, and reported in the journal ChemComm makes it easier to see if shellfish are filled with toxin-producing organisms. Mussels and oysters accumulate single-celled marine creatures called dinoflagellates in their digestive systems as they filter seawater for food. Usually dinoflagellates are harmless, but sometimes ...

CHAMPAIGN, Ill. — Fortified with iron: It's not just for breakfast cereal anymore. University of Illinois researchers have demonstrated a simpler method of adding iron to tiny carbon spheres to create catalytic materials that have the potential to remove contaminants from gas or liquid. Civil and environmental engineering professor Mark Rood, graduate student John Atkinson and their team described their technique in the journal Carbon. Carbon structures can be a support base for catalysts, such as iron and other metals. Iron is a readily available, low-cost catalyst ...

Using an automated screening technique developed by pharmaceutical companies to find new drugs, a team of researchers from UC San Diego and three other research institutions has discovered a molecule with the most potent effects ever seen on the biological clock. Dubbed by the scientists "longdaysin," for its ability to dramatically slow down the biological clock, the new compound and the application of their screening method to the discovery of other clock-shifting chemicals could pave the way for a host of new drugs to treat severe sleep disorders or quickly reset the ...

Los Angeles, CA (December 15, 2010) Being a part of many different social groups can improve mental health and help a person cope with stressful events. It also leads to better physical health, making you more able to withstand—and recover faster from—physical challenges, according to a study in the current Social Psychological and Personality Science (published by SAGE). Belonging to groups, such as networks of friends, family, clubs and sport teams, improves mental health because groups provide support, help you to feel good about yourself and keep you active. But ...

Los Angeles, CA (December 15, 2010) When computerized neuropsychological testing is used, high school athletes suffering from a sports-related concussion are less likely to be returned to play within one week of their injury, according to a study in The American Journal of Sports Medicine (published by SAGE). Unfortunately, concussed football players are less likely to have computerized neuropsychological testing than those participating in other sports. A total of 544 concussions were recorded by the High School Reporting Information Online surveillance system during ...

ANCHORAGE, Alaska – Sea-ice habitats essential to polar bears would likely respond positively should more curbs be placed on global greenhouse gas emissions, according to a new modeling study published today in the journal, Nature. The study, led by the U.S. Geological Survey, included university and other federal agency scientists. The research broke new ground in the "tipping point" debate in the scientific community by providing evidence that during this century there does not seem to be a tipping point at which sea-ice loss would become irreversible. The report ...

Washington, D.C.—Scientists from all over the world are taking a second, more expansive, look at the car-sized asteroid that exploded over Sudan's Nubian Desert in 2008. Initial research was focused on classifying the meteorite fragments that were collected two to five months after they were strewn across the desert and tracked by NASA's Near Earth Object astronomical network. Now in a series of 20 papers for a special double issue of the journal Meteoritics and Planetary Science, published on December 15, researchers have expanded their work to demonstrate the diversity ...

A small area deep in the brain called the perirhinal cortex is critical for forming unconscious conceptual memories, researchers at the UC Davis Center for Mind and Brain have found. The perirhinal cortex was thought to be involved, like the neighboring hippocampus, in "declarative" or conscious memories, but the new results show that the picture is more complex, said lead author Wei-chun Wang, a graduate student at UC Davis. The results were published Dec. 9 in the journal Neuron. We're all familiar with memories that rise from the unconscious mind. Imagine looking ...

Dolphins along coast of Argentina could experience a significant loss of genetic diversity because some of the animals that accidently die when tangled in fishing nets are related. According to a new genetic analysis published this week in the journal PLoS One, Franciscana dolphins that die as by-catch are more than a collection of random individuals: many are most likely mother-offspring pairs. This result, which suggests reduced genetic diversity and reproductive potential, could have significant implications for the conservation of small marine mammals. "It has always ...

Polar bears were added to the threatened species list nearly three years ago when their icy habitat showed steady, precipitous decline because of a warming climate. But it appears the Arctic icons aren't necessarily doomed after all, according to results of a study published in this week's issue of the journal Nature. The findings indicate that there is no "tipping point" that would result in unstoppable loss of summer sea ice when greenhouse gas-driven warming rises above a certain threshold. Scientists from several institutions, including the U.S. Geological Survey ...

New York, NY, December 15, 2010 – There is burgeoning public interest in possible wide-ranging health benefits from vitamin D, including cardiovascular health. In a study published in the December 2010 issue of The American Journal of Medicine, investigators found that there was no independent association between serum levels of vitamin D or parathyroid hormone and cardiovascular mortality in this prospective study, the first in a population of older community-dwelling adults with a low prevalence of vitamin D deficiency and a broad range of kidney function. Researchers ...

Madison, WI DECEMBER 15, 2010 -- The manufacturing of nanomaterials has been steadily on the rise in the medical, industrial, and scientific fields. Nanomaterials are materials that are engineered to have dimensions less than 100 nanometers and have very unique properties as a result of their small size. In a study funded by the U.S. Environmental Protection Agency, a team of scientists from the University of Kentucky determined that earthworms could absorb copper nanoparticles present in soil. One crucial step in determining the uptake of nanomaterials was discerning ...