OAKLAND, Calif. – Compared to women never on hormone therapy, those taking hormone therapy only at midlife had a 26 percent decreased risk of dementia; while women taking HT only in late life had a 48 percent increased risk of dementia, according to Kaiser Permanente researchers. Women taking HT at both midlife (mean age 48.7 years) and late life had a similar risk of dementia as women not on HT, according to the study which appears in the Annals of Neurology. The study was funded in part by the National Institutes of Health. Although previous research has shown that ...

A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine. The researchers also found that inhibitors of this protein currently used to control asthma could possibly be used to prevent or treat Alzheimer's disease. The researchers published their findings, "5-Lipoxygenase as Endogenous Modulator of Amyloid ...

Retinitis pigmentosa is an inherited eye disorder characterized by progressive loss of vision that in many instances leads to legal blindness at the end stage. In a ChIP-Seq based approach, the researchers identified a key regulatory role of the transcription factor Crx (Cone-rod homeobox) in the expression of retina-specific genes and thus described an important genetic basis for visual perception. In-depth analysis of Crx mediated regulation in photoreceptors with latest technology provided by Genomatix lead then to the identification of nonsense mutations in the human ...

New stars are born in the Universe around the clock – on the Milky Way, currently about ten per year. From the birth rate in the past, we can generally calculate how populated space should actually be. But the problem is that the results of such calculations do not match our actual observations. "There should actually be a lot more stars that we can see," says Dr. Jan Pflamm-Altenburg, astrophysicist at the Argelander-Institut für Astronomie of the University of Bonn. So, where are those stars? For years, astronomers worldwide have been looking for a plausible explanation ...

The casting sessions aren't just for movie stars, but what is involved in casting decisions that can launch fashion models to fame – or at the very least – to land a job? Stephanie Sadre-Orafai, a University of Cincinnati assistant professor and socio-cultural anthropologist, spent 11 months of fieldwork at a premiere casting agency in New York to uncover the decisions that happen behind the scenes of the glossy photos and slick commercials. Her research, "Polaroids and Go-Sees: Casting Encounters, Casting Epistemologies," was presented Nov. 17 at the 109th annual meeting ...

HOUSTON – (Nov. 18, 2010) – Discovery of a fifth gene defect and the identification of 47 DNA regions linked to thoracic aortic disease are the subject of studies released this month involving researchers at The University of Texas Health Science Center at Houston (UTHealth). In both studies, the investigators have identified alterations in the genetic material or DNA that affect the ability of smooth muscle cells, which line the aorta and other blood vessels, to contract. This can lead to a weakening of the wall of the aorta, the main blood vessel leading out of the ...

Technical progress in the automobile industry is unbroken. But, the sector has still some hard nuts to crack: "Lead-free materials" is one of the challenges – hidden behind this challenge is a EU environmental directive which, based on a step-by-step plan, gradually bans all lead-containing materials and components from automotive vehicles – such as piezoelectric components. These elements are important for diesel engine injectors, for example, which control the supply of fuel to the combustion chamber. The problem: Up to now lead-zirconate-titanate (PZT) is the material ...

A short push on the light switch – and the whole ceiling lights up in a uniform and pleasant color. This "illuminated sky" is not available as yet, but researchers from all over the world are working on it flat out. The technology behind this marvel is based on organic light-emitting diodes, or OLEDs for short. These diodes use special molecules to emit light as soon as current passes through them. Although the first OLEDs have only recently become available, they are small and expensive. A flat disk with a diameter of eight centimeters costs around Euro 250. Experts of ...

Scientists at Johns Hopkins have identified a compound that could be used to starve cancers of their sugar-based building blocks. The compound, called a glutaminase inhibitor, has been tested on laboratory-cultured, sugar-hungry brain cancer cells and, the scientists say, may have the potential to be used for many types of primary brain tumors. The Johns Hopkins scientists, are inventors on patent applications related to the discovery, caution that glutaminase inhibitors have not been tested in animals or humans, but their findings may spark new interest in the glutaminase ...

PHILADELPHIA – Cells have their own version of the cut-and-paste editing function called splicing. Researchers at the University of Pennsylvania School of Medicine have documented a novel form of splicing in the cytoplasm of a nerve cell, which dictates a special form of a potassium channel protein in the outer membrane. The channel protein is found in the dendrites of hippocampus cells -- the seat of memory, learning, and spatial navigation -- and is involved in coordinating the electrical firing of nerve cells. Dendrites, which branch from the cell body of the neuron, ...

Montreal, November 18, 2010 – Schizophrenia is a mental disorder that differs between the sexes in terms of age at onset, symptomatology, response to medication, and structural brain abnormalities. Now, a new study from the Université de Montréal shows that there is gender difference between men and women's mental ability – with women performing better than men. These findings, published recently in, Schizophrenia Research, have implications for the more than 300 000 affected Canadians. "We are the first to report sex differences in brain function of schizophrenics," ...

The Soufriere Hills Volcano on Montserrat erupted in 1995, and an international team of researchers has studied this volcano from land and sea since then to understand the workings of andesite volcanos more completely. "To the extent that the Soufriere Hills Volcano is typical of andesitic dome building volcanoes, results from this research can be expected to apply more generally," said Barry Voight, professor emeritus of geosciences, Penn State. Voight and R. S. J. Sparks, the Channing Wills professor of geology, Bristol University, guest edited and introduced a special ...

People who contract gastroenteritis from drinking water contaminated with E. coli are at an increased risk of developing high blood pressure, kidney problems and heart disease in later life, finds a study published on bmj.com today. The findings underline the importance of ensuring a safe food and water supply and the need for regular monitoring for those affected. It is estimated that E. coli O157:H7 infections cause up to 120,000 gastro-enteric illnesses annually in the US alone, resulting in over 2,000 hospitalisations and 60 deaths. However, the long term health ...

Vitamin D is somewhat of an unusual "vitamin," because it can be made in the body from sunlight and most foods do not contain vitamin D unless added by fortification. Synthesis of vitamin D in the body requires exposure to ultraviolet light and can be influenced by genetics, skin color, and sun exposure. Reports of greater than expected vitamin D insufficiency coupled with emerging evidence that higher circulating concentrations of this nutrient may protect against cardiovascular disease have prompted a renewed interest in teasing out how environment, genetics, and behavior ...

DURHAM, NC – Researchers have been stymied for years over the fact that people infected with the AIDS virus do indeed produce antibodies in response to the pathogen – antibodies that turn out to be ineffective in blocking infection. Now, scientists at Duke University Medical Center can explain why: Some of the earliest and most abundant antibodies available to fight HIV can't actually "see" the virus until after it's already invaded a healthy cell. The scientists based their conclusion on the results of a series of crystallography and biochemical experiments that revealed ...

Boston, MA – A new poll from researchers at the Harvard School of Public Health (HSPH) and Knowledge Networks (KN) shows that many people with heart disease, diabetes or cancer believe the economic downturn is hurting their health and will have further negative impacts in the future. Many Americans with these illnesses face financial problems paying for medical bills in this economy. Most of these people do not believe the new national health care reform law (Patient Protection and Affordable Care Act 2010) will help them. This national poll is the first in a collaborative ...

Alcoholic drinks served in pubs should be taxed at a lower level than drinks bought from shops, says an expert in this week's BMJ. This action would deliver the health benefits associated with introducing a minimum price on alcohol, increase tax revenue for the Treasury and save pubs says Dr Nick Sheron. The author is head of clinical hepatology at the University of Southampton, a member of the Alcohol Health Alliance and an advisor for the 2010 House of Commons Select Committee Report on Alcohol. Sheron says lowering VAT for alcohol sold in pubs would solve the plight ...

New Orleans, LA – Dr. Rohan Walvekar, Assistant Professor of Otolaryngology Head and Neck Surgery, Director of Clinical Research and the Salivary Endoscopy Service at LSU Health Sciences Center New Orleans, has reported the first use of a surgical robot guided by a miniature salivary endoscope to remove a 20mm salivary stone and repair the salivary duct of a 31-year-old patient. Giant stones have traditionally required complete removal of the salivary gland. Building upon their success with the combination of salivary endoscopic guidance with surgery, Dr. Walvekar and his ...

Living in a deprived area increases the risk of violence more sharply for girls than boys, according to a Cardiff University study of former industrial areas. The new results suggest violence prevention strategies need to focus more on local inequalities, especially to protect vulnerable adolescent girls. The survey was conducted by the Violence and Society Research Group at Cardiff University. The team studied nearly 700 young people, aged 11 to 17, who attended casualty departments in South Wales with injuries from violence. The researchers matched the patients against ...

INDIANAPOLIS – A potent anti-tumor gene introduced into mice with metastatic melanoma has resulted in permanent immune reconfiguration and produced a complete remission of their cancer, according to an article to be published in the December 2010 issue of the Journal of Clinical Investigation. The online version is now available. Indiana University School of Medicine researchers used a modified lentivirus to introduce a potent anti-melanoma T cell receptor gene into the hematopoietic stem cells of mice. Hematopoietic stem cells are the bone marrow cells that produce all ...

Many studies support the assertion that moderate drinking is beneficial when it comes to cardiovascular health, and for the first time scientists have discovered that a well-known molecule, called Notch, may be behind alcohol's protective effects. Down the road, this finding could help scientists create a new treatment for heart disease that mimics the beneficial influence of modest alcohol consumption. "Any understanding of a socially acceptable, modifiable activity that many people engage in, like drinking, is useful as we continue to search for new ways to improve ...

Scientists have simulated, for the first time, the merger of two black holes of vastly different sizes, with one mass 100 times larger than the other. This extreme mass ratio of 100:1 breaks a barrier in the fields of numerical relativity and gravitational wave astronomy. Until now, the problem of simulating the merger of binary black holes with extreme size differences had remained an unexplored region of black-hole physics. "Nature doesn't collide black holes of equal masses," says Carlos Lousto, associate professor of mathematical sciences at Rochester Institute ...

YAOUNDÉ, Cameroon (19 November 2010) – A new study finds a lack of transparency and corruption are reducing the impact of an initiative in Cameroon that channels a portion of national timber levies to rural forest communities. The study highlights the challenges of using a climate change pact to do something similar in forested regions around the world. In an article published in the peer-reviewed journal International Forestry Review, scientists at the Center for International Forestry Research (CIFOR) examined how revenues from a tax paid by logging companies in Cameroon, ...

Researchers from the Department of Cell Biology, Physiology and Immunology at Universitat Autònoma de Barcelona (UAB), in collaboration with researchers from the Institute of Microelectronics of Barcelona (IMB-CNM) of the Spanish National Research Council (CSIC), have developed an identification system for oocytes and embryos in which each can be individually tagged using silicon barcodes. Researchers are now working to perfect the system and soon will test it with human oocytes and embryos. The research, published online in Human Reproduction, represents a first step ...

Successfully treating and reversing the effects of multiple sclerosis, or MS, may one day be possible using a drug originally developed to treat chronic pain, according to Distinguished Professor Linda Watkins of the University of Colorado at Boulder. Watkins and her colleagues in CU-Boulder's department of psychology and neuroscience discovered that a single injection of a compound called ATL313 -- an anti-inflammatory drug being developed to treat chronic pain -- stopped the progression of MS-caused paralysis in rats for weeks at a time. Lisa Loram, a senior research ...