Lasofoxifene statistically reduced the overall risk of breast cancer, as well as ER positive invasive breast cancer in postmenopausal women with low bone density, according to a study published online in The Journal of the National Cancer Institute. Lasofoxifene is a SERM, or selective estrogen receptor modulator, that, like tamoxifen, blocks the effects of estrogen in breast tissue. Another SERM, raloxifene, has been shown to reduce breast cancer risk. In the Postmenopausal Evaluation and Risk-Reduction with Lasofoxifene (PEARL) trial, a double-blind, placebo-controlled, ...

CAMBRIDGE, Mass. -- Researchers at Harvard University say America's obesity epidemic won't plateau until at least 42 percent of adults are obese, an estimate derived by applying mathematical modeling to 40 years of Framingham Heart Study data. Their work, published this week in the journal PLoS Computational Biology, runs counter to recent assertions by some experts that the obesity rate, which has been at 34 percent for the past five years, may have peaked. An additional 34 percent of American adults are overweight but not obese, according to the federal government's ...

Chevy Chase, MD—The beneficial effects of six months of testosterone treatment on muscle mass, strength and quality of life in frail elderly men are not maintained at six months post-treatment, according to a study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Frailty is an age-related state of physical limitation caused by the loss of muscle mass and function and can lead to adverse clinical outcomes such as dependency, institutionalization and death. Testosterone levels naturally decline with aging and testosterone ...

Chevy Chase, MD—Researchers may have identified a promising novel diagnostic biomarker for ectopic pregnancy, according to a study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). In the western world, deaths from ectopic pregnancy are not common but in the developing world one in ten women who are admitted with an ectopic pregnancy die. An ectopic pregnancy is an abnormal pregnancy that occurs outside the uterine cavity. Most ectopic pregnancies take place in the Fallopian tube but implantation can also occur ...

LA JOLLA, CA – November 2, 2010 – Embargoed by the journal Cell Stem Cell until November 4, noon, Eastern time – Scripps Research Institute scientists have taken a step closer to understanding the cause of Friedreich's ataxia, a debilitating neurological condition that affects tens of thousands of people worldwide, and so far has no cure. Researchers already know that the disease arises from the silencing of the gene FXN, due to an abnormally expanded stretch of DNA within the gene. The length of this "triplet repeat expansion" determines the degree of gene silencing, ...

Researchers have identified the deletion of a genomic region on chromosome 17 as a significant risk factor for autism spectrum disorders (ASD) and schizophrenia. A mutation of one of the genes in the deleted interval already is a known cause of renal cysts and diabetes syndrome (RCAD). The research, by an international collaboration of scientists led by Emory University, will be published in the American Journal of Human Genetics. Lead author of the study is Daniel Moreno-De-Luca, MD, MSc, Emory postdoctoral fellow in the Department of Human Genetics. Senior authors ...

LA JOLLA, CA—A study by researchers at the Salk Institute for Biological Studies revealed that stem cells can sense a decrease in available nutrients and respond by retaining only a small pool of active stem cells for tissue maintenance. When, or if, favorable conditions return, stem cell numbers multiply to accommodate increased demands on the tissue. Elucidating the mechanisms by which hormonal signaling influences stem cell behavior under normal conditions and in response to stress provides important insights into the activities of stem cells in regenerative medicine, ...

Researchers at the University of Cambridge hope to revolutionise cancer therapy after discovering one of the reasons why many previous attempts to harness the immune system to treat cancerous tumours have failed. New research, published today in the journal Science, reveals that a type of stromal cell found in many cancers which expresses fibroblast activation protein alpha (FAP), plays a major role in suppressing the immune response in cancerous tumours – thereby restricting the use of vaccines and other therapies which rely on the body's immune system to work. They ...

Scientists at the Wellcome Trust Centre for Human Genetics, University of Oxford, have identified a genetic variant which influences whether a person with dyslexia is more skilled with either the left or right hand. The finding identifies a novel gene for handedness and provides the first genetic evidence to support a much speculated link between handedness and a language-related disorder. The majority of people worldwide are right-handed. Since the left side of the brain controls the right side of the body, and vice versa, this implies that for most people the left hemisphere ...

WASHINGTON, DC: A new report from the Project on Emerging Nanotechnologies (PEN) at the Woodrow Wilson International Center for Scholars explores a variety of voluntary options available for the oversight of nanotechnology products and processes. The report, Voluntary Initiatives, Regulation, and Nanotechnology Oversight: Charting a Path, by Dr. Daniel Fiorino, Director of the Center for Environmental Policy at American University, provides a historical overview of voluntary approaches to environmental protection and assesses their applicability to the emerging field of ...

Laparoscopic or 'keyhole' surgery is a safe, effective way of removing bowel tumours and should be offered to all patients undergoing surgery for colorectal cancer, according to researchers from the University of Leeds. Patients who have laparoscopic surgery spend less time in hospital and recover more quickly from the operation. Now long-term follow-up data has confirmed that this way of doing surgery does not make patients with colorectal cancer more vulnerable to the disease returning, as some had feared. And overall survival rates for keyhole surgery are just the ...

Synopsis: A patient with a long head biceps (LHB) tendinopathy, which is a pain and/or tearing of the tendon, may also have a shoulder problem and/or a rotator cuff tear. LHB tendinopahy can be caused by injury, trauma, overuse, inflammation or degeneration. Because of the variety of the causes and the range of possible severity, a patient needs a thorough examination, including radiographic imaging to determine the diagnosis and treatment. Traditional treatments include both surgical and nonsurgical approaches. "The surgeon's goal in treating any long head biceps tendinopathy ...

Was it the evolution of the hand, or of the brain, that enabled prehistoric toolmakers to make the leap from striking off simple flakes of rock to fashioning a sophisticated hand axe? A new study finds that the ability to plan complex tasks was key. The research, published Nov. 3 in the Public Library of Science journal PLoS ONE, is the first to use a cyber data glove to precisely measure the hand movements of stone tool making, and compare the results to brain activation. (Video: http://tinyurl.com/2w9cd4d) "Making a hand axe appears to require higher-order cognition ...

Shopping was the next most popular answer in the survey, carried out last month by researchers from Nottingham University Business School. On a scale of zero to 10, Robin scored an average of 8.2 for visitors and 8.6 for locals in terms of the importance of his links to the city — and most agreed he was a "hero". Yet tourism experts say neither Nottinghamshire nor Yorkshire, which stakes a rival claim to the legend, has made the most of Robin — despite fighting over his origins. In fact, five years ago Nottingham infamously ditched him from its branding in favour ...

According to a new study from the Journal of Bone and Joint Surgery (JBJS), patients with acute plantar fasciitis who perform manual plantar fasciitis stretching exercises, as opposed to shockwave therapy, had superior results and higher patient satisfaction. Study details and findings: A total of 102 patients who had acute plantar fasciitis pain, were randomly assigned to two groups. Acute is defined as any patient that experiences pain for less than six weeks. 54 people performed an eight-week stretching program, while 48 people received repetitive low-energy radial ...

Vomiting is unpleasant. Nearly 30% of all patients suffer from nausea and vomiting after surgery. The financial repercussions of this are longer patient stays in the recovery room, with increased need for personnel. Appropriate prophylaxis and treatment can prevent postoperative nausea and vomiting. In a systematic review of the literature, Dirk Rüsch and co-authors investigate how treatment recommendations for nausea after general anesthesia can be improved (Dtsch Arztebl Int 2010; 107[42]: 733 741). The pathogenesis of postoperative nausea remains unclear, but it has ...

New York University researchers have developed a method to shape solid materials using a corn starch solution. The process, devised by researchers in NYU's Courant Institute of Mathematical Sciences and Department of Physics, offers a potential technique for material cutting and manufacturing processes. Their work is described in the journal Physical Review Letters. Manufacturers use a variety of methods for shaping solid materials, ranging from laser cutting to high-speed jets of water. While altering the shape of such materials, such as glass, metal, or stone, is ...

BATON ROUGE – Genetic diseases impact millions around the world each and every day. Complex medical conditions with genetic predispositions, such as hypertension, can also weigh heavily on our lives. Susceptibility to hypertension has many genetic components and often goes undiagnosed until a person has signs of advanced disease. Many imagine a day when science will give us the tools to discover how to work with these genetic issues and discover ways to not only diagnose, but to use them to our advantage as individuals. LSU Boyd Professor Mark Batzer and an international ...

NASA's infrared satellite imagery has confirmed that Tomas is intensifying as convection is strengthening and cloud tops within the system are getting colder. Infrared imagery helps scientists detect cold top temperatures within a tropical cyclone, and Tomas' cloud tops have grown colder over the last 24 hours. Tomas showed strong convective activity in his center as indicated by high thunderstorms that were as cold as -63 degrees Fahrenheit. The colder the cloud tops, the higher and stronger the thunderstorms are that power the tropical cyclone. The infrared imagery ...

When it comes to public issues pertaining to science and technology, "talking it out" doesn't seem to work. A new study from North Carolina State University shows that the more people discuss the risks and benefits associated with scientific endeavors, the more entrenched they become in their viewpoint – and the less likely they are to see the merit of other viewpoints. "This research highlights the difficulty facing state and federal policy leaders when it comes to high-profile science and technology issues, such as stem cell research or global warming," says Dr. Andrew ...

A common roadside plant could have the right stuff to become a new source of biofuel, according to U.S. Department of Agriculture (USDA) studies. Scientists with the Agricultural Research Service (ARS), USDA's principal intramural scientific research agency, have found that field pennycress yields impressive quantities of seeds whose oil could be used in biodiesel production. Field pennycress belongs to the Brassicaceae family, along with canola, camelina and mustard—other prolific producers of oil-rich seeds. The ARS studies help support USDA's efforts to develop ...

AMES, Iowa – Patricia Thiel of Iowa State University and the Ames Laboratory put a box of tissues to the right, a stack of coasters to the middle and a trinket box to the left. "Nature," she said of her table-top illustration, "doesn't want lots of little things." So Thiel grabbed the smaller things and slid them into a single pile next to the bigger tissue box. "Nature wants one big thing all together, like this." Thiel, an Iowa State Distinguished Professor of Chemistry and a faculty scientist for the U.S. Department of Energy's Ames Laboratory, and James Evans, an ...

Washington, DC – November 2, 2010 – Food safety problems can arise at any of multiple stages of food production, and illnesses that result from them are frequently not detected or reported, according to a new report from the American Academy of Microbiology. The report, "Global Food Safety: Keeping Food Safe from Farm to Table," is based on a colloquium convened by the Academy in 2009. Colloquium participants with expertise in microbiology, public health, food science, and economics reviewed the current state of affairs in microbiological food safety around the world. The ...

AUDIO: Researchers at Washington University School of Medicine in St. Louis have identified a gene linked to the spread of melanoma of the eye. Although more research is needed, the researchers... Click here for more information. Researchers at Washington University School of Medicine in St. Louis have identified a gene linked to the spread of eye melanoma. Although more research is needed, the researchers say the discovery is an important step in understanding why some ...

(ST. LOUIS): Botanists at the Missouri Botanical Garden have described eight new plant species collected in the Madidi National Park and surrounding areas located on the eastern slopes of the Andes in northern Bolivia. The new species are from several different genera and families and are published in a recent edition of the Missouri Botanical Garden journal Novon. Missouri Botanical Garden scientists and colleagues from the National Herbarium in La Paz, Bolivia describe Prestonia leco, Passiflora madidiana, Siphoneugena minima, Siphoneugena glabrata, Hydrocotyle apolobambensis, ...