About The Study: In this study of children tested for SARS-CoV-2 infection in Canadian pediatric emergency departments, although children infected with SARS-CoV-2 reported increased chronic symptoms, few of these children developed post–COVID-19 condition, and overall quality of life did not differ from children with negative SARS-CoV-2 tests.  Authors: Stephen Freedman, M.D.C.M., M.Sc., of the University of Calgary in Calgary, Alberta, Canada, is the corresponding author.   To access the embargoed study: ...

About The Study: In this study of 465,000 individuals, a higher self-reported frequency of adding salt to foods was associated with a higher risk of chronic kidney disease in the general population. These findings suggest that reducing the frequency of adding salt to foods at the table might be a valuable strategy to lower chronic kidney disease risk in the general population.  Authors: Lu Qi, M.D., Ph.D., of Tulane University in New Orleans, is the corresponding author.   To access the embargoed study: Visit our For The ...

A research team, led by Professor Yongwon Seo in the Graduate School of Carbon Neutrality at UNIST has unveiled a highly efficient method for desalinating seawater using hydrate-based desalination (HBD) technology. The breakthrough is expected to have far-reaching implications for the application of hydrate-based desalination techniques, with the ability to calculate optimal temperatures for enhanced efficiency. Hydrate desalination technology, known for its eco-friendly freshwater production capabilities, offers a low-energy solution that can be effectively used in treating high concentrations of brine or contaminated water. By ...

“[...] the results of this preclinical investigation program suggest that induction of apoptosis is a key component of GFH009’s anti-tumor mechanism of action [...]” BUFFALO, NY- December 28, 2023 – A new research paper was published in Oncotarget's Volume 14 on December 20, 2023, entitled, “The pharmacodynamic and mechanistic foundation for the antineoplastic effects of GFH009, a potent and highly selective CDK9 inhibitor for the treatment of hematologic malignancies.” To evade cell cycle controls, malignant cells rely upon rapid expression of select proteins to mitigate pro-apoptotic signals ...

“Angelica gigas Nakai (AG), a traditional medicinal herb, is garnering scientific attention for its potential in addressing a variety of health conditions.” BUFFALO, NY- December 27, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, “Angelica gigas extract inhibits acetylation of eNOS via IRE1α sulfonation/RIDD-SIRT1-mediated posttranslational modification ...

FOR IMMEDIATE RELEASE In a Viewpoint article published Dec. 27, 2023, in JAMA Surgery, three Johns Hopkins researchers urge the medical community to dismiss a widely held, but scientifically unsupported belief that many people who are transgender and gender diverse (TGD), and undergo gender affirming surgery (GAS), later regret their decision to undergo such procedures. The researchers are: Harry Barbee, Ph.D., assistant professor and interdisciplinary social scientist at the Johns Hopkins Bloomberg School of Public Health Bashar ...

Climate change is the biggest global health threat in the 21st century, and the rising temperatures have undermined the health and safety of the working population, as well as caused labor losses, which are closely tied to social-economic development. Although the future temperatures increase in China has been forecasted by state-of-the-art climate change projections, to what extent the influence on labor has not been well studied. In a paper published in Science Bulletin, a Chinese research team presents evidence of future labor losses due to heat stress in China under climate change scenarios. This study was led by Cunrui Huang, a professor at the Vanke School of Public ...

Supraglacial environments mainly consist of four main types of habitats for microbes and viruses, including snow, ice, meltwater, and cryoconites (the granular sediment on glacier surfaces). The paper revealed that there were more than 10,000 viral species in global supraglacial environments. This is a 15-fold expansion of DNA viral genomic inventory ever known. These viruses mainly belong to bacteriophages, viruses infecting bacteria. Liu et al., also found the viral communities showed a clear regional and habitat distribution pattern, with polar glacier samples separated from mountain ...

Scientists at MIT, the University of Birmingham, and elsewhere say that astronomers’ best chance of finding liquid water, and even life on other planets, is to look for the absence, rather than the presence, of a chemical feature in their atmospheres.  The researchers propose that if a terrestrial planet has substantially less carbon dioxide in its atmosphere compared to other planets in the same system, it could be a sign of liquid water — and possibly life — on that planet’s surface.  What’s more, this new signature is within the sights of NASA’s James Webb Space Telescope (JWST). While scientists have proposed ...

- The nomination of the new generation of FGFR2/3 inhibitor for the treatment of tissue-agnostic solid tumors, bringing the total number of PCCs nominated by Insilico in 2023 to six.  - ISM8001 is an oral, highly selective, covalent inhibitor that demonstrated superior potency in multiple FGFR2/3-driven efficacy models, and also in gatekeeper and molecular brake mutant resistant models.  - The program once again demonstrates Insilico's ability to efficiently generate novel molecules with high quality that are currently available for partnering.   Insilico Medicine ("Insilico"), a generative artificial intelligence (AI)-driven clinical-stage drug discovery ...

(WASHINGTON, Dec. 28, 2023) – Lisocabtagene maraleucel (liso-cel), a CAR T-cell therapy, is a cost effective second line treatment for relapsed and refractory (hard to treat) diffuse large B-cell lymphoma (r/r DLBCL), according to a study published today in Blood Advances. The study is the first of its kind to incorporate healthcare expenses, societal productivity losses, and patient quality of life in assessing the drug’s cost-effectiveness. "In our study, we incorporated the often-overlooked societal costs associated with cancer treatment, which are typically neglected in ...

This new method is based on the exsolution process activated by microwave radiation. Exsolution is a method of generating metallic nanoparticles on the surface of ceramic materials. "At elevated temperatures and in a reducing atmosphere (usually hydrogen), metal atoms migrate from the structure of the material to its surface, forming metal nanoparticles anchored to the surface. This anchoring significantly increases the strength and stability of these nanoparticles, which positively impacts the efficiency of these catalysts," explains Beatriz García Baños, a researcher in the Microwave Area of the ITACA Institute at the UPV. In the work now ...

Brigham researchers’ findings from next-generation sequencing suggest that revising current cancer care guidelines could allow approximately 6,000 more patients in the U.S. to benefit from immunotherapy treatment each year Immunotherapy is a highly effective treatment for patients whose cancers harbor mismatch repair deficiency, and a new study identifies more cancer patients who could benefit from this form of therapy. Investigators from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, found that nearly six percent of endometrial cancer patients and one percent of colorectal cancer patients with mismatch repair deficiency were ...

Health care systems in the United States have gradually embraced the concept that mental health should be treated on par with physical health, especially in light of increased rates of anxiety and depression during and after the COVID-19 pandemic. To improve access to mental health treatment, many Medicaid programs have required their managed care organizations to pay for behavioral health and physical health together. That’s in contrast to the traditional approach in which behavioral health, including treatment for substance use disorders, was “carved out” ...

Scientists have devised a new way to identify habitable planets and potentially inhabited planets, by comparing the amount of carbon dioxide in their atmosphere, to neighbouring planets. An international team of researchers from the University of Birmingham (UK), the Massachusetts Institute of Technology (MIT) (US) and elsewhere, have shown that if a planet has a reduced amount of CO2 in its atmosphere compared to neighbouring planets, it suggests there is liquid water on that planet’s surface. The drop in CO2 levels implies ...

Green hydrogen can be produced through water electrolysis technology, which uses renewable energy to split water into hydrogen and oxygen without emitting carbon dioxide. However, the production cost of green hydrogen is currently around $5 per kilogram, which is two to three times higher than gray hydrogen obtained from natural gas. For the practical use of green hydroten, the innovation in water electrolysis technology is required for the realization of hydrogen economy, especially for Korea where the utilization ...

A few years ago, the World Health Organization estimated that blood poisoning, or sepsis, is involved in one in five deaths in the world. 11 million people die from sepsis each year, of which nearly 3 million are children. This is also a problem in Norway, with thousands of people affected every year. “Sepsis is a severe immunological overreaction to an infection. It causes the body’s organs to fail,” says Nina Vibeche Skei. She is a doctoral research fellow at the Norwegian University of Science and Technology (NTNU) and a senior anaesthetist ...

For decades, a substantial number of proteins, vital for treating various diseases, have remained elusive to oral drug therapy. Traditional small molecules often struggle to bind to proteins with flat surfaces or require specificity for particular protein homologs. Typically, larger biologics that can target these proteins demand injection, limiting patient convenience and accessibility. In a new study published in Nature Chemical Biology, scientists from the laboratory of Professor Christian Heinis at EPFL have achieved a significant milestone in drug development. Their research ...

The Asian Fund for Cancer Research (AFCR) is pleased to announce that Degron Therapeutics was selected as the winner of the 2023 BRACE Award Venture Competition. AFCR’s BRACE (Bridging Research from Academia to Cancer Entrepreneurship) Award Venture Competition is designed to support and accelerate oncology innovations on their path toward commercialization, with the ultimate goal of improving outcomes for patients affected by cancer globally. AFCR aims to support the winners of the BRACE Award with funding resources, advisory experts, and access to our global network of key opinion leaders in cancer research. The winner of the BRACE ...

Embargoed for release: December 27, 2023, 2:00 PM ET Key points: Researchers estimated that Facebook, Instagram, Snapchat, TikTok, X (formerly Twitter), and YouTube collectively derived nearly $11 billion in advertising revenue during 2022 from U.S. youth, who are vulnerable to negative mental health outcomes. The study is the first to offer estimates of the number of youth users on these platforms and how much annual ad revenue is attributable to them. According to the researchers, the study’s ...

Toronto, ON, December 27, 2023 – Compared to patients who had a virtual visit with their own family doctor, those who received virtual care from a doctor outside of their family care team were 66 percent more likely to visit the emergency department within seven days, according to new research. The study, led by researchers at the University Health Network (UHN), Unity Health Toronto, and ICES, also showed that patients receiving virtual care outside of an existing family doctor-patient relationship were 25 percent more likely to have an in-person visit and 88 percent more likely to have another virtual visit within seven days. “This study sheds light on how different types ...

About The Study: The results of this study suggest that artificial intelligence (AI) can be a useful and convenient tool for people who want to know the energy and macronutrient information of their foods. Although AI chatbots cannot replace nutritionists, they may provide real-time analysis of foods, and the capacity to harness AI technology in a supportive role may fundamentally transform the way nutritionists communicate with patients.  Authors: Jung-Su Chang, Ph.D., of Taipei Medical University in Taipei, Taiwan, is the corresponding author.  To ...

About The Study: In this study using data from three large prospective cohort studies among 123,000 individuals, low-carbohydrate diets that emphasized high-quality proteins, fats and carbohydrates from whole grains and other healthy plant-based foods were significantly associated with slower weight gain in the long term. In contrast, low-carbohydrate diets emphasizing animal-sourced proteins and fats or refined carbohydrates were associated with faster weight gain. Authors: Qi Sun, M.D., Sc.D., of the Harvard T.H. Chan School of Public Health in Boston, is the corresponding author.  To access the ...

About The Study: This nationwide case-time-control study revealed an increased risk of miscarriage associated with benzodiazepine use during pregnancy after accounting for measurable confounders, and results were unlikely to be due to unmeasured confounding. These findings underscore the necessity for health care professionals to meticulously balance the risk-benefit ratio when considering the use of benzodiazepines to treat psychiatric and sleep disorders during pregnancy.  Authors: Fei-Yuan Hsiao, Ph.D., of National ...

About The Study: In this study of individuals diagnosed with cancer in the National Cancer Database (NCDB), Hispanic and American Indian or Alaska Native individuals diagnosed with breast, colorectal, lung, and prostate cancer were undercaptured in the NCDB, but their representation improved over time. Increased study is needed to determine where these populations predominantly seek cancer care.  Authors: Juan Javier-DesLoges, M.D., M.S., of the University of California, San Diego, is the corresponding author.  To ...