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Drug-resistant malaria suggests a health policy change for pregnant women and infants

2010-09-09
September 9, 2010 – Malaria remains a serious global health problem, killing more than one million people per year. Treatment of the mosquito-borne illness relies on antibiotics, and the emergence of drug-resistant malaria is of growing concern. In a report published online today in Genome Research (www.genome.org), scientists analyzed the genomic features of a Peruvian parasite population, identifying the genetic basis for resistance to a common antibiotic and gaining new insights that could improve the efficacy of diagnosis and treatment strategies. The World Health ...

Researchers design more accurate method of determining premature infants' risk of illness

Researchers design more accurate method of determining premature infants risk of illness
2010-09-09
STANFORD, Calif. - Stanford University researchers have developed a revolutionary, non-invasive way of quickly predicting the future health of premature infants, an innovation that could better target specialized medical intervention and reduce health-care costs. "What the PhysiScore does is open a new frontier," said Anna Penn, MD, PhD, an assistant professor of pediatrics at the School of Medicine and a neonatologist at Lucile Packard Children's Hospital. "The national push toward electronic medical records helped us create a tool to detect patterns not readily ...

Researchers identify genes tied to deadliest ovarian cancers

2010-09-09
Scientists at the Johns Hopkins Kimmel Cancer Center have identified two genes whose mutations appear to be linked to ovarian clear cell carcinoma, one of the most aggressive forms of ovarian cancer. Clear cell carcinoma is generally resistant to standard therapy. In an article published online in the September 8 issue of Science Express, the researchers report that they found an average of 20 mutated genes per each ovarian clear cell cancer studied. Two of the genes were more commonly mutated among the samples: ARID1A, a gene whose product normally suppresses tumors; ...

Study identifies critical 'traffic engineer' of the nervous system

Study identifies critical traffic engineer of the nervous system
2010-09-09
Athens, GA—A new University of Georgia study published in the journal Nature has identified a critical enzyme that keeps traffic flowing in the right direction in the nervous system, and the finding could eventually lead to new treatments for conditions such as Alzheimer's and Parkinson's disease. "There was no medical or any other applied science drive for this project; it was purely curiosity about how transport inside cells works," said study co-author Jacek Gaertig, professor in the cellular biology department in the UGA Franklin College of Arts and Sciences. "But ...

Novel sensing mechanism discovered in dendritic cells to increase immune response to HIV

Novel sensing mechanism discovered in dendritic cells to increase immune response to HIV
2010-09-09
New York, NY (September 8, 2010) – Dendritic cells are the grand sentinels of the immune system, standing guard 24/7 to detect foreign invaders such as viruses and bacteria, and bring news of the invasion to other immune cells to marshal an attack. These sentinels, however, nearly always fail to respond adequately to HIV, the virus causing AIDS. Now a team of scientists at NYU Langone Medical Center has discovered a sensor in dendritic cells that recognizes HIV, spurring a more potent immune response by the sentinels to the virus. They report their findings in the September ...

House-sharing with microbes

2010-09-09
Household dust contains up to 1000 different species of microbes, with tens of millions of individual bacterial cells in each gram. And these are just the ones that can be grown in the lab! Dr Helena Rintala, speaking at the Society for General Microbiology's autumn meeting in Nottingham describes how we share our living and working spaces with millions of microbes, not all of whom are bad news. Microbes are a part of our normal environment and can be both beneficial and detrimental to our health. "Exposure to microbes in childhood can prevent the development of allergies. ...

Yeast holds clues to Parkinson's disease

2010-09-09
Yeast could be a powerful ally in the discovery of new therapeutic drugs to treat Parkinson's disease says a scientist presenting his work at the Society for General Microbiology's autumn meeting in Nottingham today. Dr Tiago Fleming Outeiro from the Instituto de Medicina Molecular in Lisbon, Portugal describes how his group is slowly uncovering the molecular basis of Parkinson's disease by studying the associated human protein in yeast cells. Parkinson's disease is a neurodegenerative disorder without any known cure that affects around 6 million people worldwide. The ...

Why chromosomes never tie their shoelaces

Why chromosomes never tie their shoelaces
2010-09-09
In the latest issue of the journal Nature, Miguel Godinho Ferreira, Principal Investigator at the Instituto Gulbenkian de Ciência (IGC) in Portugal, lead a team of researchers to shed light on a paradox that has puzzled biologists since the discovery of telomeres, the protective tips of chromosomes: while broken chromosome ends generated by DNA damage (such as radiation or cigarette smoke) are quickly joined together, telomeres are never tied to each other, thus allowing for the correct segregation of the genetic material into all cells in our body. Since telomeres erode ...

Anti-aphrodisiac protects young bedbugs

Anti-aphrodisiac protects young bedbugs
2010-09-09
Male bedbugs are known to be very unfussy when it comes to mating, mounting any well-fed bug they can see - regardless of age or gender. Researchers writing in the open access journal BMC Biology have discovered how immature bedbug nymphs, who would be harmed by the traumatic insemination technique practiced by the males, release alarm pheromones to deter this unwanted attention. Vincent Harraca, from Lund University, Sweden, worked with a team of researchers to stage encounters between males and females or nymphs. He said, "The chemical communication, as well as the ...

Scots Pine shows its continental roots

Scots Pine shows its continental roots
2010-09-09
By studying similarities in the genes of Scots Pine trees, scientists have shown that the iconic pine forests of Highland Scotland still carry the traces of the ancestors that colonised Britain after the end of the last Ice Age, harbouring genetic variation that could help regenerate future populations, according to new results published in the journal Heredity. The research was carried out by an international team from the Centre for Ecology & Hydrology, the Polish Academy of Sciences, the University of Edinburgh and the Macaulay Land Use Research Institute. Today's ...

Study adds new clue to how last ice age ended

Study adds new clue to how last ice age ended
2010-09-09
As the last ice age was ending, about 13,000 years ago, a final blast of cold hit Europe, and for a thousand years or more, it felt like the ice age had returned. But oddly, despite bitter cold winters in the north, Antarctica was heating up. For the two decades since ice core records revealed that Europe was cooling at the same time Antarctica was warming over this thousand-year period, scientists have looked for an explanation. A new study in Nature brings them a step closer by establishing that New Zealand was also warming, indicating that the deep freeze up north, ...

Investigating better endpoints for immunotherapy trials

2010-09-09
Cancer immunotherapy calls for revised clinical endpoints that differ from those used for chemotherapy, according to an article published online September 8 in The Journal of the National Cancer Institute. Unlike chemotherapy, which acts directly on tumors, cancer immunotherapies exert their effects on the immune system, which may delay or change response patterns, perhaps owing to the dynamics of the immune system itself. For example, initial tumor burden may increase due to lymphocytic infiltration, because of T-cell proliferation, which is followed by lymphocyte-induced ...

Researchers identify potential new drug for neurodegenerative disease

2010-09-09
BOSTON, Mass. (September 8, 2010)‹Scientists have discovered a small molecule that helps human cells get rid of the misfolded, disfigured proteins implicated in Alzheimer¹s disease and other neurodegenerative ailments. This potential drug could have applications for other conditions as well. Cells create and discard proteins continuously, a process that relies on a balance between the speed with which new proteins are created and damaged ones destroyed. Protein destruction occurs through a sophisticated system that marks proteins for disposal by tagging them with ...

New study suggests changes in diagnosis and treatment of malaria

2010-09-09
LA JOLLA, CA - September 7, 2010 –A team of scientists from The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation (GNF), and the U. S. Naval Research Detachment in Peru has completed a study that could improve the efficacy of diagnosis and treatment strategies for drug-resistant malaria. In the new study—published online on September 9, 2010 by the journal Genome Research—the scientists analyzed the genomic features of a population of malaria parasites in Peru, identifying the genetic basis for resistance to a common antibiotic. Malaria ...

NIST researchers hear puzzling new physics from graphene quartet's quantum harmonies

2010-09-09
GAITHERSBURG, Md. – Using a one-of-a-kind instrument designed and built at the National Institute of Standards and Technology (NIST), an international team of researchers have "unveiled" a quartet of graphene's electron states and discovered that electrons in graphene can split up into an unexpected and tantalizing set of energy levels when exposed to extremely low temperatures and extremely high magnetic fields. Published in this week's issue of Nature,* the new research raises several intriguing questions about the fundamental physics of this exciting material and reveals ...

New sickle cell screening program for college athletes comes with serious pitfalls, experts say

2010-09-09
The Johns Hopkins Children's Center top pediatrician is urging a "rethink" of a new sickle cell screening program, calling it an enlightened but somewhat rushed step toward improving the health of young people who carry the sickle cell mutation. Beginning this fall, all Division I college athletes will undergo mandatory screening for the sickle cell trait. The program, rolled out by the National Collegiate Athletic Association (NCAA), is an attempt to prevent rare but often-lethal complications triggered by intense exercise in those who carry the genetic mutation yet ...

Liver defect likely cause of DHA deficiency in Alzheimer's patients, UCI study finds

2010-09-09
Irvine, Calif. — UC Irvine researchers have discovered that markedly depleted amounts of an omega-3 fatty acid in brain tissue samples from Alzheimer's patients may be due to the liver's inability to produce the complex fat, also contained in fish-oil supplements. Low levels of docosahexaenoic acid, or DHA, have been associated with the chronic neurodegenerative disease affecting millions of Americans, but no cause had been identified. In postmortem liver tissue from Alzheimer's patients, the UCI team found a defect in the organ's ability to make DHA from shorter molecules ...

The Economics of Ecosystems and Biodiversity (TEEB) Local and Regional Policy Makers report launched at major biodiversity conference in Ghent

The Economics of Ecosystems and Biodiversity (TEEB) Local and Regional Policy Makers report launched at major biodiversity conference in Ghent
2010-09-09
Ghent, 9 September 2010 – Factoring the planet's multi-trillion dollar ecosystem services into policy-making can help save cities and regional authorities money while boosting the local economy, enhancing quality of life, securing livelihoods and generating employment. This is the finding from a major international study, launched in a report by TEEB for Local and Regional Policy Makers, being released in Belgium, Brazil, India, Japan and South Africa. In the Framework of the Belgian Presidency of the European Union, the Flemish Ministry of Environment, Nature and ...

Unauthorized population would soar if birthright citizenship repealed

2010-09-09
University Park, Pa. -- Repeal of birthright citizenship for the U.S.-born children of unauthorized immigrants would expand the nation's unauthorized population by at least 5 million over the next decade, according to a new report from the Migration Policy Institute. The report's principal author is Jennifer Van Hook, professor of sociology and demographics at Penn State and non-resident fellow at the Washington, D.C.-based institute. "While some are discussing an end to birthright citizenship as a means to reduce illegal immigration," Van Hook said, "repeal of birthright ...

Satellite data reveal seasonal pollution changes over India

Satellite data reveal seasonal pollution changes over India
2010-09-09
CHAMPAIGN, Ill. — Armed with a decade's worth of satellite data, University of Illinois atmospheric scientists have documented some surprising trends in aerosol pollution concentration, distribution and composition over the Indian subcontinent. In addition to environmental impact, aerosol pollution, or tiny particles suspended in the air, can be detrimental to human health by causing a range of respiratory problems. Aerosols can come from natural sources, such as dust and pollen carried on the wind, but the most hazardous aerosols are generated by human activity – soot ...

Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction

Why the biological clock? Penn study says aging reduces centromere cohesion, disrupts reproduction
2010-09-09
PHILADELPHIA –- University of Pennsylvania biologists studying human reproduction have identified what is likely the major contributing factor to the maternal age-associated increase in aneuploidy, the term for an abnormal number of chromosomes during reproductive cell division. Using naturally aging mouse models, researchers showed that this basic fact of reproductive life is most likely caused by weakened chromosome cohesion. Older oocytes, or egg cells, have dramatically reduced amounts of a protein, REC8, that is essential for chromosomes to segregate correctly ...

Cash hoarding nothing new for businesses, scholar says

2010-09-09
CHAMPAIGN, Ill. — The U.S. economy is experiencing anemic growth, yet businesses are sitting on a mountain of cash worth nearly $2 trillion, according to Federal Reserve estimates. But this trend is nothing new for firms, who have been steadily increasing their cash holdings over the past three decades, a University of Illinois business professor says. Finance professor Heitor Almeida says the fact that businesses are stuffing corporate piggy banks with spare cash for the proverbial "rainy day" is unrelated to the belt-tightening brought about by the continuing financial ...

Twins are intriguing research subjects for Notre Dame biometircs researchers

2010-09-09
Each year in August, the aptly named town of Twinsburg, Ohio, is the site of the largest official gathering of twins in the world. Open to all multiples — identical and fraternal twins, triplets and quads from newborns to octogenarians — the weekend's events include food, live entertainment, a golf tournament, and a twins' parade. The event also has become an important site for field research by Kevin Bowyer and Patrick Flynn of the University of Notre Dame's Department of Computer Science and Engineering. Flynn has a twin sister, making this research especially relevant ...

New model to measure disease burden of postmenopausal osteoporosis

2010-09-09
An article just published in the scientific journal 'Osteoporosis International' introduces a validated new model that can be used to describe the current and future burden of postmenopausal osteoporosis in different national settings. The model, published by researchers from the UK on behalf of the International Osteoporosis Foundation's Committee of Scientific Advisors, was developed and validated using Swedish data. It can be used to forecast the incidence and prevalence of fractures not only by age and calendar year, but also by BMD category. It provides a high degree ...

Report issued today examines improving long-term climate forecasts

2010-09-09
MIAMI — September 8, 2010 -- Operational forecasting centers produce climate predictions that provide input for important decisions regarding water management, agriculture, and energy. "Assessment of Intraseasonal to Interannual Climate Prediction and Predictability", a new report from the National Research Council/National Academy of Sciences, examines current capabilities for making climate predictions -- such as seasonal hurricane or longer-term drought forecasts -- and identifies opportunities for improvement. The report finds that operational forecast centers could ...
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