Northwestern University researchers have developed a new technique for rapidly prototyping nanoscale devices and structures that is so inexpensive the "print head" can be thrown away when done. Hard-tip, soft-spring lithography (HSL) rolls into one method the best of scanning-probe lithography -- high resolution -- and the best of polymer pen lithography -- low cost and easy implementation. HSL could be used in the areas of electronics (electronic circuits), medical diagnostics (gene chips and arrays of biomolecules) and pharmaceuticals (arrays for screening drug candidates), ...

Researchers from Mount Sinai School of Medicine have identified a therapy that may enhance memory and prevent the loss of long-term memory. The research is published in the January 27th issue of Nature. Led by Cristina Alberini, PhD, Professor of Neuroscience at Mount Sinai, the research team evaluated how a protein called insulin-like growth factor II (IGF-II), a gene expressed during brain development that declines with aging, impacts memory formation and retention. IGF-II is enriched in the adult brain in several areas, including the hippocampus and cortex, which ...

Researchers have discovered that a drug used to treat dialysis catheter malfunction in kidney dialysis patients may now also help prevent both malfunction as well as infections. Dr. Brenda Hemmelgarn from the University of Calgary Faculty of Medicine and her colleague Dr. Nairne Scott-Douglas, both members of the Libin Cardiovascular Institute of Alberta, undertook a randomized trial at 11 sites across Canada. 115 hemodialysis patients were administered the usual catheter locking solution of heparin after every dialysis session, while 110 patients received rt-PA once ...

Cancer researchers at Princess Margaret Hospital (PMH) have discovered that targeting an enzyme called Uroporphyrinogen Decarboxylase (UROD) can sensitize diseased tissue to radiation and chemotherapy, which could mean fewer side effects for individuals with head and neck cancer. The findings, published online today in Science Translational Medicine (http://stm.sciencemag.org/lookup/doi/10.1126/scitranslmed.3001922) are significant because they suggest that targeting UROD – identified for the first time as a key player in human cancers – can selectively boost the effects ...

January 26, 2011 – In a study published online today in Genome Research (www.genome.org), in coordination with the publication of the orangutan genome sequence, scientists have presented the surprising finding that although orangutans and humans are more distantly related, some regions of our genomes are more alike than those of our closest living relative, the chimpanzee. The fossil record helped to establish evolutionary relationships and estimate divergence times of the primate branch leading to humans, but not until the advent of genome sequencing technology has it ...

WASHINGTON – Hands-on safety training for workers in highly hazardous jobs is most effective at improving safe work behavior, according to psychologists who analyzed close to 40 years of research. However, less engaging training can be just as effective in preparing workers to avoid accidents when jobs are less dangerous. More interactive types of safety training may help employees become more aware of the threats they face on the job and avoid making deadly mistakes, according to the findings in the January issue of the Journal of Applied Psychology, which is published ...

To combat last year's Deepwater Horizon oil spill, nearly 800,000 gallons of chemical dispersant were injected directly into the oil and gas flow coming out of the wellhead nearly one mile deep in the Gulf of Mexico. Now, as scientists begin to assess how well the strategy worked at breaking up oil droplets, Woods Hole Oceanographic Institution (WHOI) chemist Elizabeth B. Kujawinski and her colleagues report that a major component of the dispersant itself was contained within an oil-gas-laden plume in the deep ocean and had still not degraded some three months after it ...

Misaligned research, medical challenges and harsh economics are thwarting efforts to slow the destructive course of Alzheimer's disease in the United States, according to a trio of nationally regarded Alzheimer's researchers writing a "Perspective" in Thursday's (Jan. 27) issue of the journal Neuron. The foremost obstacle is that the most promising preventive strategies are being tested in patients firmly in the grip of Alzheimer's disease — the ones least likely to be helped. The approach would be similar to testing statins — drugs widely used to prevent heart disease ...

Boulder, CO, USA - LITHOSPHERE articles published in the February issue cover present-day movements and past deformation in El Salvador, Honduras, and Nicaragua; the tectonics of the northern Owens Valley in California, USA; the paleoseismology of the eastern North Anatolian fault at Yaylabeli, Turkey; exhumation in the southeastern Canadian Cordillera; and the diverse tectonic history of Tunisia. Keywords: Gulf of Fonseca, Central America; Owens Valley, California; North Anatolian fault, Yaylabeli, Turkey, Canadian Cordillera, Canadian Shield, Tunisia. Highlights ...

A new study into Staphylococcus aureus, the bacterium which is responsible for severe chronic infections worldwide, reveals how bacteria have developed a strategy of hiding within host cells to escape the immune system as well as many antibacterial treatments. The research, published by EMBO Molecular Medicine, demonstrates how 'phenotype switching' enables bacteria to adapt to their environmental conditions, lie dormant inside host cells and become a reservoir for relapsing infections. Staphylococcus aureus is a major human pathogen which can be carried by up to 70% ...

Some animals produce more offspring than others do. Hormones like prolactin and corticosterone can exercise a crucial influence on the behaviour of birds in the breeding season and therefore on their reproductive success. Scientists from the Max Planck Institute for Ornithology in Radolfzell and their colleagues at the universities of Princeton and Edinburgh have now demonstrated that hormone levels not only play a key role during the breeding season, but already dictate, long in advance, how many eggs a breeding pair will lay, when they will lay them and how often. An ...

Plants producing flower pollen must not leave anything to chance. The model plant thale cress (Arabidopsis), for instance, uses three signalling pathways in concert with partially overlapping functions. The yield becomes the greatest when all three processes are active; however, two are sufficient to form an acceptable quantity of flower pollen. In a new study, Peter Huijser and his colleagues at the Max Planck Institute for Plant Breeding Research in Cologne offer fascinating insights into the rich range of proteins that are used by seed plants to develop stamens and form ...

As many as ten to 20 per cent of nurses and nursing students may have substance abuse and addiction problems, but the key to tackling this difficult issue - and protecting public safety - is support and treatment, not punishment. That is the key message in a paper in the February issue of the Journal of Clinical Nursing. Researchers have recommended six key points that could be built into alternative-to-dismissal (ATD) strategies after reviewing the latest research and professional guidance from countries such as the USA, Canada, New Zealand, Australia and the UK. They ...

The temperature of water situated in the subtropical Atlantic experienced a drop of 0.15ºC between 1998 and 2006. This has been revealed by a study led by the IEO (Spanish Oceanography Institute) which suggests that circulation caused by wind could be responsible for this "unusual" behaviour. Whilst the water temperature in this area, situated along the 24.5º north parallel, from the African coast to the Caribbean, rose by 0.27ºC between 1957 and 1998, researchers have recorded a drop of 0.15ºC in the same area between 1998 and 2006. "In the ocean there are very ...

'Difficult' patient-clinician encounters have a negative impact on patients' health outcomes in the short-term, according to a new study by Sheri Hinchey from the Tripler Army Medical Centre in Honolulu and Jeffrey Jackson from the Zablocki VA Medical Centre in Milwaukee. Their findings1 show that nearly 18 percent of patients are perceived as difficult by their physicians and are less likely to trust or be satisfied with their doctor. Importantly, these patients are also more likely to report worse symptoms two weeks after the consultation. Hinchey and Jackson's work has ...

For 60 years, scientists have puzzled over the possibility of a hepatic osmoreceptor that influences blood pressure regulation. Now, researchers of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, the Experimental and Clinical Research Center (ECRC) of the MDC and Charité and the Hannover Medical School (MHH) appear to have made a breakthrough discovery. Dr. Stefan Lechner and Professor Gary R. Lewin (both of MDC), Professor Friedrich C. Luft (ECRC) and Professor Jens Jordan (ECRC; now MHH) have discovered a new group of sensory neurons in the mouse liver ...

Tel Aviv — The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth. At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing ...

The operating system (OS) is the backbone of your computer. If the OS is compromised, attackers can take over your computer – or crash it. Now researchers at North Carolina State University have developed an efficient system that utilizes hardware and software to restore an OS if it is attacked. At issue are security attacks in which an outside party successfully compromises one computer application (such as a Web browser) and then uses that application to gain access to the OS. For example, the compromised application could submit a "system call" to the OS, effectively ...

Massachusetts General Hospital (MGH) investigators have developed a novel system for delivery of growth factors to chronic wounds such as pressure sores and diabetic foot ulcers. In their work published in the Jan. 18 Proceedings of the National Academy of Sciences, the team from the MGH Center for Engineering in Medicine (CEM) reports fabricating nanospheres containing keratinocyte growth factor (KGF), a protein known to play an important role in wound healing, fused with elastin-like peptides. When suspended in a fibrin gel, these nanoparticles improved the healing of ...

This press release is available in French. Montreal, January 26, 2011 – Not all trout are created equal. Those swimming up the streams of British Columbia might resemble their cousins from Quebec, yet their genetic makeup is regionally affected and has an impact on how they reproduce, grow and react to environmental stressors. Such regional variance makes transplanting fish species – to bolster dwindling populations – tricky business. These are some of the findings of a compelling review published in Heredity, a journal from the Nature Publishing Group, which examined ...

DURHAM, N.H. – New research from the University of New Hampshire suggests that China should establish a unified supervisory agency, similar to what is used in Singapore, to oversee its complex financial sector. The new research by Honggeng Zhou, associate professor of decision sciences, and Wenjuan Xie, assistant professor of finance, both at UNH, is presented in the working paper "Challenges for the Unified Financial Supervision in the Post-crisis Era: Singaporean Experience and Chinese Practice." The paper is co-authored by Jing Geng of Harvard University and GuiBin ...

KNOXVILLE -- Four letter words may offend you more depending on which television channel you watch, according to a recent study out of Florida State University and the University of Tennessee, Knoxville. This study, published in the January issue of Mass Communication and Society, found that some TV viewers believe swearing on premium channels and cable is less offensive than vulgarity on broadcast channels. Similarly, viewers are more tolerant of swearing on the premium channels than they are on the advertiser supported cable channels. This differs from previous research, ...

St. John's, CANADA —January 26, 2011— According to a new study, dominant CEOS, who are powerful figures in the organization as compared to other members of the top management team, drive companies to extremes of performance. Unfortunately for shareholders, the performance of a company with an all powerful CEO can be either much worse than other companies, or much better. But there is one solution to an all powerful CEO: a strong board of directors. Companies with strong boards counteract powerful CEOS, and swing the tide of performance to the plus side. This study on dominating ...

CHICAGO (January 26, 2011) – A first of its kind surgical quality improvement program for children has the potential to identify outcomes of children's surgical care that can be targeted for quality improvement efforts to prevent complications and save lives. The results of a study of the American College of Surgeons National Surgical Quality Improvement Program-Pediatric (ACS NSQIP Peds) phase 1 pilot were published in the January issue of the Journal of the American College of Surgeons. A partnership of the American College of Surgeons (ACS) and the American Pediatric ...

New Rochelle, NY, January 26, 2011—An innovative genetic strategy for rendering T-cells resistant to HIV infection without affecting their normal growth and activity is described in a paper published in Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The paper is available free online at www.liebertpub.com/hum A team of researchers from Japan, Korea, and the U.S. developed an anti-HIV gene therapy method in which a bacterial gene called mazF is transferred into CD4+ T-cells. The MazF protein is an enzyme (an mRNA interferase) ...