Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer’s disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation. While studies of other forms of cell death such as apoptosis focus largely on ...

JMIR Publications is pleased to announce a new section titled, “AI Language Models in Health Care” in JMIR Medical Informatics. This leading peer-reviewed journal is indexed in PubMed and has a unique focus on clinical informatics and the digitization of care processes. This section will have a broad focus and encompass topics about the successful implementation of artificial intelligence (AI) language models in diverse health care settings. The topics will include details about the process, use, outcomes, and ...

Researchers at the Centre for Genomic Regulation (CRG) in Barcelona and the Spanish National Cancer Research Centre (CNIO) in Madrid have captured the world’s first high-resolution images of the earliest moments of microtubule formation inside human cells. The findings, published today in the journal Science, lay the foundations for potential breakthroughs in treating many different types of diseases ranging from cancer to neurodevelopmental disorders. “Microtubules are critical components of cells, but all the images we see in textbooks describing the first moments of their creation are models or cartoons based ...

We often think of fish as carefree swimmers in the ocean, reacting to the world around them without much forethought. However, new research from the Okinawa Institute of Science and Technology (OIST) suggests that our marine cousins may be more cognizant than we credit them for.  By observing how a colony of clown anemonefish (Amphiprion ocellaris) – the species of the titular character in Finding Nemo – reacts to intruders in their sea anemone home, OIST researchers have found that ...

Bacteria are traditionally imagined as single-cell organisms, spread out sparsely over surfaces or suspended in liquids, but in many environments the true bacterial mode of growth is in sticky clusters called biofilms. Biofilm formation can be useful to humans—it is integral, for example, to the production of kombucha tea. But it is more often problematic, because it makes it more difficult to control bacterial growth: When bacterial cells produce a biofilm, it acts as a shield against outside invaders, making the bacteria more ...

· Researchers at the Centre for Genomic Regulation (CRG) , the Spanish National Cancer Research Center (CNIO) and the IBMB-CSIC solve a key problem in biology: how human cells build their microtubules · During cell division, microtubules function as nanometer-thick long ‘ropes' inside cells that pull chromosomes apart so that each daughter cell receives a copy of the genetic material · The work published in Science lays the groundwork for future breakthroughs in the treatment of diseases ranging from cancer to neurodevelopmental disorders   Cells in the human body are constantly dividing. With each division the genetic information contained in the ...

Single-cell projectome analysis has revealed previously unknown spatial organization principles of the brain-wide structure and connectivity of more than 10,000 individual hippocampal neurons in the mouse brain, according to a new study. Specialized projections called axons allow neurons to transmit signals to other neurons across the brain. The hippocampus (HIP) – one of the most extensively studied brain regions – plays a crucial role in many crucial brain functions, including learning, memory, ...

The effect of large herbivores on plant abundance and diversity depends more on their size and diet than whether they are native or introduced into their host ecosystems, according to a meta-analysis of more than 200 studies worldwide. The findings counter the widely held notion that the impacts of introduced megafauna are distinct and more harmful than those of native megafauna and suggest that trait-based ecology provides better insight into megaherbivore-plant interactions than concepts of species origin. Large mammal herbivores play a key role in shaping ecosystems and biodiversity by consuming vegetation, dispersing seeds and nutrients, and creating ...

A computational analysis has highlighted the poorly understood relationships and elusive histories of modern sign languages worldwide, revealing two major sign language families shaped by geopolitical forces and relevant signing communities. The findings show that the computational methods applied – which have been useful in understanding spoken languages – can be extended to the study of sign languages; as such, they offer promise for addressing the disparities in our understanding of other marginalized and diverse ...

A new machine learning model – trained on video and audio recorded from the first-person perspective of one young child for over a year – has provided new insights into early language acquisition. Not only do the findings offer a valuable framework to understand how children learn words and concepts, but they could be critical in developing artificial intelligence (AI) systems that can learn language in more human-like ways. Beginning around 6 to 9 months of age, children begin acquiring their ...

MIAMI, FLORIDA (EMBARGOED UNTIL FEB. 1, 2024, AT 2 P.M. ET) – New research from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating organizations has identified a next-generation BTK degrader that could help overcome treatment resistance in chronic lymphocytic leukemia (CLL) and related blood cancers. Their findings, published Feb. 2 in the journal Science, could offer a therapeutic option for CLL patients whose tumors become drug-resistant or are unresponsive to frontline treatment. “This new compound not only inhibits the cellular molecule BTK, but goes further by taking aim at the target ...

*Embargoed until 14:00 US Eastern / 19:00 UK GMT / 20:00 Europe CET – Thursday 1 February* Governments and businesses are relying on dangerous amounts of future removal of carbon dioxide (CO2) from the atmosphere, instead of more rapidly reducing emissions and phasing out fossil fuels. This problem is partly due to an incomplete picture1 of the damaging consequences of carbon dioxide removal for people, food security and natural ecosystems, according to new research published in Science. The paper finds that the carbon dioxide removal potential currently reported by the UN ...

A study published in Science on Feb. 1 reported a comprehensive database of single-neuron projectomes consisting of over 10,000 mouse hippocampal neurons, thus revealing the spatial connectivity patterns of mouse hippocampal neurons at the mesoscopic level.    The study was conducted by teams from the Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), the HUST-Suzhou Institute for Brainsmatics, Hainan University, the Kunming Institute of Zoology of CAS, Lingang Laboratory, and the Shanghai Center for ...

New research published today in the journal Science has concluded that eradicating animals on the basis that they are not native in order to protect plant species, can be a flawed practice costing millions of dollars, and resulting in the slaughter of millions of healthy wild animals. Introduced large herbivores, or megafauna, are claimed to have distinct and harmful ecological impacts, including damaging sensitive plants and habitats, reducing native plant diversity, and facilitating introduced plants. However, up to now these impacts have been studied without comparison to a proper ...

INDIANAPOLIS—An Indiana University School of Medicine surgeon-scientist is leading a multi-institutional grant investigating the role of the sinus microbiome in chronic rhinosinusitis, an inflammatory disease that causes the lining of the sinuses to swell. The research team will study biospecimens from human sinus surgery patients in the lab and examine how bacteria in the microbiome shape the disease process and might offer novel therapeutic strategies. Vijay Ramakrishnan, MD, professor of otolaryngology—head ...

LOS ANGELES – February 1, 2024 – Stand Up To Cancer® (SU2C) today announced changes to its Scientific Advisory Committee (SAC), which oversees SU2C’s scientific research.   Composed of cancer research leaders from academic, government, industry, and advocacy fields, SU2C’s SAC sets direction for research initiatives, reviews proposals for new grant awards, and conducts rigorous oversight of all active grants in the SU2C research portfolio in collaboration with SU2C’s president and CEO Julian Adams, Ph.D.   World renowned cancer researcher and Nobel laureate Phillip A. Sharp, Ph.D., who has chaired the SAC since SU2C launched in ...

Philadelphia, February 1, 2024 – New findings in The American Journal of Pathology, published by Elsevier, report that a class of small RNAs (microRNAs), microRNA-29, can restore normal skin structure rather than producing a wound closure by a connective tissue (scar). Any improvement of normal skin repair would benefit many patients affected by large-area or deep wounds prone to dysfunctional scarring. Because the burden of non-healing wounds is so significant, it is sometimes called a “silent pandemic.” Worldwide, costs associated with wound care are expected to ...

EDMONTON — New research shows an innovative education program is helping to address Alberta’s rural doctor shortage by making it more likely medical students will set up a rural family practice after graduation. The University of Alberta was one of the first medical schools in Canada to set up its Rural Integrated Community Clerkship program back in 2007. It sends up to 25 third-year students for 10-month intensive work experiences with a single or small number of teaching physicians.  Instead of rotating to a new specialty placement every four to six weeks as in an urban ...

All animals need to regulate their body temperature and cannot survive for long if it gets too high or too low. Warm-blooded organisms like humans have various ways to do this. They release heat by sweating or expanding the blood vessels in their skin, while shivering or burning fat in their brown adipose tissue has the opposite effect. Cold-blooded animals such as the zebrafish, by contrast, cannot do any of these, so they have a different strategy. They look for places nearby that are at their “comfortable temperature,” just like how we might go out into the sun when we feel chilly or seek out some shade once it gets too ...

While newly approved drugs for Alzheimer’s show some promise for slowing the memory-robbing disease, the current treatments fall far short of being effective at regaining memory. What is needed are more treatment options targeted to restore memory, said Buck Assistant Professor Tara Tracy, PhD, the senior author of a study that proposes an alternate strategy for reversing the memory problems that accompany Alzheimer’s disease and related dementias. Since most current research on potential treatments for Alzheimer’s focuses on reducing the toxic proteins, such as tau and amyloid beta, that accumulate in ...

(Boston)—One of the major challenges in cancer research and clinical care is understanding the molecular basis for therapeutic resistance as a major cause of long term treatment failures. In cases of melanoma, the main targeted therapeutic strategy is directed against the mitogen-activated protein kinase (MAPK) pathway. Unfortunately, in the vast majority of these patients, resistance to MAPK inhibitor therapies develops within one year of treatment.   In a new study from Boston University Chobanian & Avedisian School of Medicine, ...

During the COVID-19 pandemic, lower occupancy in buildings led to reduced water use, raising concerns about water quality due to stagnation. Government warnings highlighted increased risks of chemical and microbiological contamination in water systems. Studies showed that reduced usage and stagnation could elevate heavy metal levels and decrease disinfectant effectiveness, affecting microbial growth. To address this, regular fixture flushing was recommended, which temporarily improved water quality but also revealed the complexities of managing building water systems effectively. In a recent study (https://doi.org/10.1016/j.ese.2023.100314) ...

The study delves into hypersaline lakes in Xinjiang, China, exploring the genetic and metabolic diversity of microbial communities termed "microbial dark matters". Hypersaline lake ecosystems, characterized by extreme salinity, harbor unique microorganisms with largely unexplored biosynthesis and biodegradation capabilities. The research seeks to uncover novel biological compounds and pathways, potentially revolutionizing biotechnology, medicine, and environmental remediation by tapping into the untapped potential of these extremophiles. A recent study (https://doi.org/10.1016/j.ese.2023.100359) published ...

While surgery to remove rectal cancer can be necessary and lifesaving, it can sometimes come with significant drawbacks, like loss of bowel control. According to a study led by Wilmot Cancer Institute researchers, patients with rectal cancer who respond well to radiation and chemotherapy are increasingly foregoing surgery and opting for a watch-and-wait approach. The study, published in JAMA Oncology, shows that the number of patients opting out of surgery rose nearly 10 percent between 2006 and 2020. These data reflect a shift toward what ...

Somewhere between 24 and 50 million Americans have an autoimmune disease, a condition in which the immune system attacks our own tissues. As many as 4 out of 5 of those people are women. Rheumatoid arthritis, multiple sclerosis and scleroderma are examples of autoimmune disorders marked by lopsided female-to-male ratios. The ratio for lupus is 9 to 1; for Sjogren’s syndrome, it’s 19 to 1. Stanford Medicine scientists and their colleagues have traced this disparity to the most fundamental feature differentiating ...