Heart disease kills 18 million people each year, but the development of new therapies faces a bottleneck: no physiological model of the entire human heart exists – so far. A new multi-chamber organoid that mirrors the heart’s intricate structure enables scientists to advance screening platforms for drug development, toxicology studies, and understanding heart development. The new findings, using heart organoid models developed by Sasha Mendjan’s group at the Institute of Molecular ...

About The Study: The findings of this study of 33.1 million visits to 989 U.S. hospitals suggest that Black and Hispanic patients are more likely to receive care in hospitals with higher overall discharge against medical advice (DAMA) rates, suggesting interventions should address medical segregation. Structural racism may contribute to emergency department DAMA disparities via unequal allocation of health care resources in hospitals that disproportionately treat racial and ethnic minoritized groups. Monitoring variation in DAMA by race and ethnicity and hospital suggests ...

About The Study: Direct-mail human papillomavirus (HPV) self-sampling increased cervical cancer screening by more than 14% in individuals who were due or overdue for cervical cancer screening in this randomized clinical trial of 31,000 individuals. The opt-in approach minimally increased screening. To increase screening adherence, systems implementing HPV self-sampling should prioritize direct-mail outreach for individuals who are due or overdue for screening. For individuals with unknown screening history, ...

Scientists are warning that apparently stable glaciers in the Antarctic can “switch very rapidly” and lose large quantities of ice as a result of warmer oceans.    Their finding comes after a research team led by Benjamin Wallis, a glaciologist at the University of Leeds, used satellites to track the Cadman Glacier, which drains into Beascochea Bay, on the west Antarctic peninsula.   Between November 2018 and May 2021, the glacier retreated eight kilometres as the ice shelf at the end ...

CAMBRIDGE, MA -- Living cells are bombarded with many kinds of incoming molecular signal that influence their behavior. Being able to measure those signals and how cells respond to them through downstream molecular signaling networks could help scientists learn much more about how cells work, including what happens as they age or become diseased. Right now, this kind of comprehensive study is not possible because current techniques for imaging cells are limited to just a handful of different molecule types within a cell at one time. However, MIT researchers have developed ...

Key takeaways · A paradigm shift in trauma care: The circulation-airway-breathing (CAB) sequence has gained acceptance over the past decade over the airway-breathing-circulation (ABC) model for patients with severe bleeding injuries. · Better outcomes: A literature review found significantly lower mortality rates with CAB vs. ABC for patients with severe bleeding injuries. CHICAGO (November 28, 2023): For trauma patients suffering from massive blood loss, a care approach that emphasizes halting bleeding and restoring ...

Based on results from the CheckMate743 trial, the dual regimen of ipilimumab and nivolumab is the standard of care for the treatment of unresectable pleural mesothelioma. But research published today in the Journal of Thoracic Oncology (JTO) showed that a group of Australian patients treated with that immunotherapy combination experienced higher levels of toxicity than were reported in the clinical trial results.  The study is available here: https://www.jto.org/article/S1556-0864(23)02370-5/fulltext. JTO is the official journal of the International Association for the Study of Lung Cancer. Australia ...

Boston, MA – A new study led by researchers at the Harvard Pilgrim Health Care Institute has found that a federal policy implemented during the COVID-19 pandemic requiring continuous enrollment in Medicaid led to a significant reduction in the rates of becoming uninsured for adult Medicaid enrollees. The study, “Continuous Medicaid coverage during the COVID-19 public health emergency reduced churning, but did not eliminate it,” was published in the October 21 edition of Health Affairs Scholar. Many people who have Medicaid coverage frequently gain and lose it, sometimes over short periods of time. This phenomenon ...

To what extent does the digitalisation of industrial and manufacturing processes (Industry 4.0) improve energy efficiency and thus reduce energy intensity? A team from the Research Institute for Sustainability (RIFS) analysed developments across ten industrial manufacturing sectors in China between 2006 and 2019. Their findings show that contrary to the claims of many policymakers and industry associations, digitalisation may not automatically lead to anticipated energy savings in manufacturing and industry in China. China accounts for 30% of global manufacturing value added and the largest share of global manufacturing ...

Weill Cornell Medicine is dramatically expanding its campus and research footprint in New York City by securing five floors of 1334 York Ave., the current home of Sotheby's auction house, the institution announced today. Located one block from Weill Cornell Medicine’s main campus on Manhattan’s Upper East Side, the site will add approximately 200,000 square feet of dedicated research space—an average of 40,000 square feet per floor—making it the institution’s largest expansion since the Belfer Research Building opened in 2014. Laboratories in the new medical ...

UNIVERSITY PARK, Pa. — One voice does not fit all when it comes to virtual assistants like Siri and Alexa, according to a team led by Penn State researchers that examined how customization and perceived similarity between user and voice assistant (VA) personalities affect user experience. They found a strong preference for extroverted VAs — those that speak louder, faster and in a lower pitch. They also found that increasing personality similarity by automatically matching user and VA voice profiles encouraged users to resist persuasive information, such as misinformation about COVID-19 vaccines. In the study, 38% of unvaccinated individuals changed their minds about vaccination ...

WASHINGTON  –  The U.S. Naval Research Laboratory (NRL), in conjunction with the international Fermi Large Area Telescope Collaboration, announce the discovery of nearly 300 gamma ray pulsars in the publication of their Third Catalog of Gamma Ray Pulsars. This milestone comes 15 years since the launch of Fermi in 2008, when there were fewer than ten known gamma-ray pulsars.     “Work on this important catalog has been going on in our group for years,” said Paul Ray, Ph.D., head of the High Energy Astrophysics and Applications Section ...

DALLAS, Nov. 28, 2023 — More than 4,000 abstracts were presented during the American Heart Association’s Scientific Sessions 2023 and Resuscitation Science Symposium 2023, held earlier this month in Philadelphia. Here are some of the important scientific findings that could impact your heart and stroke health. Next wave of AI prediction models aims to predict risk of heart attack and stroke, as well as heart valve disease Artificial intelligence (AI) and deep learning models may help to predict the risk of cardiovascular disease events and detect heart ...

November 28, 2023—(BRONX, NY)—Acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS)—two related blood diseases that disproportionally strike older adults—are notoriously difficult to treat and associated with high relapse rates. Although new therapies have improved survival, treatment options remain limited, and the prognosis for the 50% of people who experience disease relapse remains poor. Researchers at the National Cancer Institute-designated Montefiore Einstein Comprehensive ...

Digital Science, a technology company serving stakeholders across the research ecosystem, is pleased to announce that Louisiana State University Health Shreveport (LSUHS) has chosen Dimensions Analytics and Dimensions Research Security from Digital Science’s flagship products to advance its world-class research programs. LSUHS is one of the first customers to subscribe to the new Dimensions Research Security app. The institution – one of the leading health science research programs in the U.S. – has signed a three-year deal to utilize the two products ...

INDIANAPOLIS – It is common for individuals seeking medical care for symptoms of concern to go to the nearest hospital. Physicians there may determine the facility cannot provide the care they believe the patient needs and recommend transfer to another hospital offering a higher level of care or specialized services. In a recent study, researchers from Regenstrief Institute and Indiana University School of Medicine reviewed electronic health records to compare older adults with dementia transferred to another hospital with older adults who did not have dementia. The researchers found significant differences in treatment following transfer. Patients with dementia more ...

Scientists have revealed how lattice vibrations and spins talk to each other in a hybrid excitation known as an electromagnon. To achieve this, they used a unique combination of experiments at the X-ray free electron laser SwissFEL. Understanding this fundamental process at the atomic level opens the door to ultrafast control of magnetism with light. Within the atomic lattice of a solid, particles and their various properties cooperate in wave like motions known as collective excitations. When atoms in a lattice jiggle together, the collective excitation is known as a phonon. Similarly, when the atomic spins - the magnetisation of the atoms -move together, it’s ...

Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant. Curing bacterial diseases is becoming more difficult than before, because antibiotics are perhaps our foremost weapons in the fight against them. An important step towards using fewer antibiotics is to find better methods for identifying pathogens, and here is the good news. “We have developed a simple tool that can identify all of the genetic material in bacteria. This allows us to find out more quickly what kind of bacteria a sick person or animal is affected ...

As Americans gear up for winter, many will face one of their toughest foes: ice. From delaying flights to making roads slippery, ice accumulation on surfaces wreaks havoc in many ways.  But not all ice is created equal. In new research from the University of Illinois Chicago, scientists studied the stickiness of ice containing everyday contaminants such as salt, soap and alcohol. Most laboratory studies typically test ice made from pure water, but in nature, ice is seldom pure. “Be it dirty sidewalks or the hull of ...

Philadelphia, November 28, 2023 – Researchers from Children’s Hospital of Philadelphia (CHOP) found that seizure patterns and response to treatment strategies were able to help clinical teams determine epilepsy and developmental trajectories for patients with STXBP1-related disorders, one of the most common genetic epilepsy disorders. The findings were published online by the journal Brain. Disease-causing variants in the gene STXBP1 are implicated in one of the most common genetic epilepsies and neurodevelopmental disorders, which are sometimes accompanied by autism spectrum disorder, increased or decreased muscle tone, or movement disorders. ...

An international study group led by researchers of Children’s Hospital of Philadelphia (CHOP) have identified how three novel genes cause neurodevelopmental disorders. Researchers now have a better sense of the genes’ roles in human brain development and function and their ability to serve as potential therapeutic targets in the future. The findings were recently published online by the Journal of Clinical Investigation. Over the last couple of decades, researchers have identified more than 1500 genes in different signaling pathways associated ...

DALLAS, November 28, 2023 — Cardiovascular disease (CVD) claims more lives than all forms of cancer, yet many women, particularly younger women, remain unaware.[1] Through its Go Red for Women® movement, the American Heart Association, which is devoted to a world of healthier lives for all, is being supported by Miss America’s Scholarship Foundation to empower the next generation of women to take charge of their health and make a lasting impact on the health and well-being of communities nationwide. The ...

Nanodiamonds are 2-8 nm carbon nanoparticles, which can be easily functionalized with various chemical groups like carboxylic groups or drugs. Previous research has shown that actively dividing cells are more likely to absorb nanodiamonds and that epithelial cells treated with carboxylic nanodiamonds lose the ability to migrate across cell permeable cellulose membranes. Rajiv K. Saxena and colleagues explored whether nanodiamonds might block tumor metastasis, a process that requires cell migration to new areas. The authors treated B16F10 melanoma cells with carboxylic nanodiamonds in culture and tested their ability to migrate and ...

Decarbonization of the global economy will require the production of a large number of batteries for electric vehicles (EVs). However, these batteries require energy and an array of minerals to produce and are not without their own environmental impacts. Fanran Meng and colleagues trace the energy consumption and greenhouse gas emissions in the global productions and supply chains of two common battery technologies as well as their future variants: nickel-manganese-cobalt (NMC) and lithium-iron-phosphate (LFP). Today, two-thirds of battery-related emissions occur in China (45%), Indonesia (13%), and Australia (9%), in part due to emissions-intensive electricity for ...

The Icahn School of Medicine at Mount Sinai announced today the launch of a new center for “Research on Emerging Substances, Poisoning, and Overdose, for New Discoveries,” to be known as the RESPOND Center. Its research findings could lead to major advances in this area of medicine, including better treatments for patients with drug overdoses in emergency departments across the United States. “Each day, clinicians on the front lines bear witness to devastating impacts from the current epidemic ...