WORCESTER, Mass. – A research team at Worcester Polytechnic Institute (WPI) has demonstrated the feasibility of a novel technology that a surgeon could use to deliver stem cells to targeted areas of the body to repair diseased or damaged tissue, including cardiac muscle damaged by a heart attack. The technique involves bundling biopolymer microthreads into biological sutures and seeding the sutures with stem cells. The team has shown that the adult bone-marrow-derived stem cells will multiply while attached to the threads and retain their ability to differentiate and grow ...

Runners who continue running when they are exhausted unknowingly change their running form, which could be related to an increased risk for injury. A study by Tracy Dierks, assistant professor of physical therapy at Indiana University, found that toward the end of a normal running session, runners generally displayed an increase in motion in their hips, knees and ankles. "Our study showed that at the end of a normal run, when they were getting tired, their mechanics were beginning to change," Dierks said. "When you notice fatigue, you're most likely putting yourself ...

Rice University researchers have moved a step closer to creating robust, three-dimensional microbatteries that would charge faster and hold other advantages over conventional lithium-ion batteries. They could power new generations of remote sensors, display screens, smart cards, flexible electronics and biomedical devices. The batteries employ vertical arrays of nickel-tin nanowires perfectly encased in PMMA, a widely used polymer best known as Plexiglas. The Rice laboratory of Pulickel Ajayan found a way to reliably coat single nanowires with a smooth layer of a PMMA-based ...

Children exposed to Jalan Sesama, an Indonesian version of the children's television show Sesame Street, had improved educational skills and healthy development, according to a study by researchers at the Johns Hopkins Bloomberg School of Public Health. Over a 14-week period, the children who had the greatest exposure to Jalan Sesama improved significantly in literacy, mathematics, early cognitive skills, safety knowledge and social awareness, compared to those with no or low exposure to the program. The study is available online in advance of publication in the International ...

COLLEGE STATION, Dec. 9, 2010 – Changes in clouds will amplify the warming of the planet due to human activities, according to a breakthrough study by a Texas A&M University researcher. Andrew Dessler, a professor in the Department of Atmospheric Sciences, says that warming due to increases in greenhouse gases will cause clouds to trap more heat, which will lead to additional warming. This process is known as the "cloud feedback" and is predicted to be responsible for a significant portion of the warming over the next century. Dessler used measurements from the Clouds ...

WASHINGTON — A new National Research Council report finds no scientific basis that more stringent testing of meat purchased through the government's ground beef purchase program and distributed to various federal food and nutrition programs -- including the National School Lunch Program -- would lead to safer meat. The U.S. Department of Agriculture's Agricultural Marketing Service (AMS) buys ground beef from suppliers who must meet mandatory process, quality, traceback, and handling controls as well as comply with strict limitations on the amounts of bacteria in the ...

Columbus, Ohio – A University of Akron researcher is leveraging advanced modeling and simulation techniques to more precisely understand how organic materials bond to inorganic materials, a natural phenomenon that if harnessed, could lead to the design of composite materials and devices for such applications as bone replacement, sensing systems, efficient energy generation and treatment of diseases. Hendrik Heinz, Ph.D., an assistant professor of polymer engineering at UA, is accessing the systems of the Ohio Supercomputer Center (OSC) to study the process of biomineralization, ...

Menlo Park, Calif. – December 9, 2010 – Scientists from Pacific Biosciences of California, Inc. (NASDAQ: PACB) and Harvard Medical School have successfully employed single molecule, real-time (SMRT™) DNA sequencing technology to rapidly characterize the pathogen responsible for the recent deadly cholera epidemic in Haiti. Published Thursday in the New England Journal of Medicine, the results provide the first whole genome sequence analysis and most detailed genetic profile to date of the Haitian Vibrio cholerae outbreak strain. The multi-strain sequencing and bioinformatic ...

Fungi are a major cause of plant diseases and are responsible for large-scale harvest failure in crops like maize and other cereals all over the world. Together with scientists from the Helmholtz Zentrum in Munich, Regine Kahmann, from the Max Planck Institute for Terrestrial Microbiology in Marburg, and Jan Schirawski, who is now based at the University of Göttingen, analysed the genetic make-up of Sporisorium reilianum, an important maize parasite. Based on a comparison with the genome of a related fungal species, they succeeded in identifying new genes that play an important ...

COLUMBUS, Ohio – A preliminary look at an ice field atop the highest mountain in the eastern European Alps suggests that the glacier may hold records of ancient climate extending back as much as a thousand years. Researchers warn, however, that the record may soon be lost as global warming takes its toll on these high-altitude sites, according to a new study in the Journal of Glaciology. The glacier, Alto dell'Ortles, is the highest large ice body in the eastern Alps, reaching an altitude of 12,812 feet (3,905 meters) above sea level. It is small, though, measuring ...

ANN ARBOR, Mich. — The risk of esophageal cancer among patients who suffer from gastroesophageal reflux disease (GERD) is not as high as many may think, according to new research from University of Michigan gastroenterologists. GERD is considered a relative risk for developing esophageal adenocarcinoma, but the absolute risk is not known, says Joel Rubenstein, M.D., M.Sc., an investigator with the Department of Veterans Affairs Center for Clinical Management Research in Ann Arbor and Assistant Professor in the University of Michigan's Department of Internal Medicine. "Since ...

New clinical strains of cholera appear to have evolved a distinctly different mechanism to cause the same disease according to research published in the current issue of the online journal mBio®. Vibrio cholerae is the causative agent for the diarrheal disease cholera. While there are more than 200 different serogroups only the O1 and the O139 strains have been known to cause epidemic and pandemic outbreaks of disease, using a toxin-coregulated pilus (TCP) and cholera toxin (CT), which other strains lack. "While non-O1, non-O139 strains have caused sporadic disease ...

A light-weight bike that costs around £1000 may not get you to work any quicker than a similar, yet heavier and cheaper model, finds research in the Christmas issue published on bmj.com today. A keen cyclist since childhood, the author Dr Jeremy Groves, owns two bikes. One a second hand 13.5 kg steel framed bike bought for £50 and the other a brand new 9.5 kg carbon framed bike that cost £1000. When Dr Groves, a consultant in anaesthesia and intensive care at Chesterfield Royal Hospital, realised his new bike took 43 minutes to get him to work rather than the 44 minutes ...

A study in the BMJ's Christmas issue published on bmj.com today confirms that there is no need for doctors to fear red heads. The research concludes that, contrary to popular belief, people with red hair do not bleed any more than other patients. The authors, led by surgeon Jonathan Barry from Morriston Hospital in Swansea, say that "red haired patients are traditionally regarded with a degree of trepidation by surgeons and anaesthetists alike due to a reputation for excessive bleeding, reduced pain threshold and a propensity to develop hernias". Globally around 1-2% ...

The size of a genome tells us nothing about the comprehensiveness of the genetic information it contains. The genome of powdery mildew, which can destroy entire harvests with its fine fungal threads, is a good example of this. Although the pathogen has almost 120 million base pairs, and therefore one of the largest genomes of the sac fungi, at barely 6,000, its gene count is far lower than that of comparable species. It has lost many of the genes required for separate metabolism found in other fungi. Thus, from a genetic perspective, powdery mildew is stuck in an evolutionary ...

COLUMBUS, Ohio – An intensive, five-week working memory training program shows promise in relieving some of the symptoms of attention deficit hyperactivity disorder in children, a new study suggests. Researchers found significant changes for students who completed the program in areas such as attention, ADHD symptoms, planning and organization, initiating tasks, and working memory. "This program really seemed to make a difference for many of the children with ADHD," said Steven Beck, co-author of the study an associate professor of psychology at Ohio State University. "It ...

ANN ARBOR, Mich.---Older people who live in racially segregated neighborhoods with high crime rates have a much higher chance of developing cancer than do older people with similar health histories and income levels who live in safer, less segregated neighborhoods. That is one of the key findings of a new study forthcoming in the January 2011 issue of the American Journal of Public Health. The study was conducted by Vicki Freedman, an epidemiologist at the University of Michigan Institute for Social Research and colleagues at the University of Medicine and Dentistry of ...

EUGENE, Ore. -- (Dec. 9, 2010) -- When their razor-sharp mandibles wear out, leaf-cutter ants change jobs, remaining productive while letting their more efficient sisters take over cutting, say researchers from two Oregon universities. Their study -- appearing online ahead of regular publication in the journal Behavioral Ecology and Sociobiology -- provides a glimpse of nature's way of providing for its displaced workers. "This study demonstrates an advantage of social living that we are familiar with -- humans that can no longer do certain tasks can still make very ...

Babies born into the world addicted to drugs because of their mother's dependence on pain medication, or opioids, may be weaned off the substance more comfortably, with a shorter hospital stay and at a reduced cost, if the mother receives a new treatment option during pregnancy. A New England Journal of Medicine study published Dec. 9, co-authored by Vanderbilt's Peter Martin, M.D., director of the Division of Addiction Psychiatry, found that the newer buprenorphine is at least as good for both mother and child as the standard care methadone, when both were combined with ...

ANN ARBOR, Mich.---New molecular tools developed at the University of Michigan show promise for "cleansing" the brain of amyloid plaques, implicated in Alzheimer's disease. A hallmark of Alzheimer's disease---a neurodegenerative disease with no cure---is the aggregation of protein-like bits known as amyloid-beta peptides into clumps in the brain called plaques. These plaques and their intermediate messes can cause cell death, leading to the disease's devastating symptoms of memory loss and other mental difficulties. The mechanisms responsible for the formation of these ...

Since 1987, when a surgeon at Children's Hospital of The King's Daughters developed a minimally-invasive surgery to correct sunken chest, the procedure has been adopted world-wide as a standard of care and continually refined to increase its effectiveness and safety, according to a paper published in the December issue of the Annals of Surgery. Coming more than two decades after the procedure was developed by surgeon Donald Nuss, the article summarizes the cases of 1,215 patients who had the Nuss Procedure at Children's Hospital of The King's Daughters and focuses on ...

Despite the common clinical practice among surgeons to discontinue their patients' anti-platelet therapy prior to surgery, a recent study of patients undergoing carotid endarterectomy (CEA) indicated that this practice may be unnecessary. The study will be published in the December issue of the Annals of Vascular Surgery. The use of clopidogrel (Plavix, Bristol-Myers Squibb/Sanofi-Aventis), an antiplatelet agent prescribed for patients with acute myocardial infarction (severe heart attack), recent stroke or peripheral arterial disease, continues to rise with U.S. sales ...

Whatever its final incarnation, the recently enacted landmark Patient Protection and Affordable Care Act will expand Medicaid eligibility and is expected by 2013 to provide coverage, including mental health care, to an estimated 4.1 million children currently uninsured. That's a good thing. But what will the quality of care be, especially for vulnerable children with special health care needs? Poor, according to a new report in the current online edition of the Journal of the American Academy of Child and Adolescent Psychiatry. In cooperation with LA Care, one of ...

SAN ANTONIO, TEX. (December 9, 2010)––Nearly one-fifth of all metastatic breast cancer patients develop brain metastases and have significantly shorter overall survival than patients who do not have brain involvement. One way to improve the affected patients' survival might be to prevent the brain metastases from arising in the first place. With that in mind, researchers have been working on a predictive model that accurately identifies these high risk patients. Now, Veeraiah Siripurapu, M.D., and colleagues from Fox Chase Cancer Center have verified several factors––including ...

Despite their initial focus on national economic competitiveness, the nanotechnology research initiatives now funded by more than 60 countries have become increasingly collaborative, with nearly a quarter of all papers co-authored by researchers across borders. Researchers from the two leading producers of nanotechnology papers – China and the United States – have become each nation's most frequent international co-authors. Though Chinese and U.S. researchers now publish roughly the same number of nanotechnology papers, the U.S. retains a lead in the quality of publications ...