Evidence reported in the October issue of Cell Metabolism, a Cell Press publication, offers a completely new explanation for why people with diabetes account for more than half of all patients requiring dialysis or kidney transplantation. It appears that insulin has a significant influence on the structure and proper function of a particular group of very specialized cells, known as podocytes, that are integral to the kidney's ability to do its job filtering blood. "We've found that when you lose insulin signaling in the podocytes, the filter is not maintained," said ...

When mice are given drinking water laced with a special concoction of amino acids, they live longer than your average mouse, according to a new report in the October issue of Cell Metabolism, a Cell Press publication. The key ingredients in the supplemental mixture are so-called branched-chain amino acids, which account for 3 of the 20 amino acids (specifically leucine, isoleucine, and valine) that are the building blocks of proteins. "This is the first demonstration that an amino acid mixture can increase survival in mice," said Enzo Nisoli of Milan University in Italy, ...

By reconstructing an ancient protein and tracing how it subtly changed over vast periods of time to produce scores of modern-day descendants, scientists have shown how evolution tinkers with early forms and leaves the impression that complexity evolved many times. Human and other animal cells contain thousands of proteins with functions so diverse and complex that it is often difficult to see how they could have evolved from a few ancestral proteins, said biologist Joseph W. Thornton of the University of Oregon and the Howard Hughes Medical Institute, who led the research. ...

In an unprecedented international project, researchers have found multiple genetic mutations that play a role in heart attack or coronary artery disease (CAD) risk. The Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) — published in Circulation: Cardiovascular Genetics, an American Heart Association journal — consists of data from every published whole-genome study on genetic mutations in heart attack or CAD risk. Researchers are also pooling data from several unpublished genome-wide association studies to see if any new mutations can be uncovered. The ...

In a comparison of outcomes in Arizona for out-of-hospital cardiopulmonary resuscitation (CPR) for cardiac arrest performed by bystanders, patients who received compression-only CPR were more likely to survive to hospital discharge than patients who received conventional CPR or no CPR, according to a study in the October 6 issue of JAMA. Out-of-hospital cardiac arrest is a major public health problem, affecting approximately 300,000 individuals in the United States annually. Although survival rates vary considerably, outcomes can be improved with bystander CPR. In 2005, ...

Placing speed cameras on roads reduces the number of road traffic injuries and deaths, concludes a team of researchers from The University of Queensland, in Brisbane, Australia. Their findings are published this month in The Cochrane Library. Preventing road traffic injuries is of global public health importance. The World Health Organization predicts that by 2020 road traffic crashes will have moved from ninth to third in the rank of causes of poor health. Speed cameras are one of the measures that authorities can use to reduce traffic speed in the hope of preventing ...

From 1998 to 2007, the use of CT or MRI scans in emergency departments for injury-related conditions increased about 3-fold without a similar increase in the prevalence of the diagnosis of certain life-threatening trauma-related conditions, according to a study in the October 6 issue of JAMA. Injury-related conditions are among the most common reasons for visits to emergency departments in the United States. "The widespread availability of advanced radiology (computed tomography [CT] and magnetic resonance imaging [MRI]) and the associated diagnostic superiority in identifying ...

Patients with a severe traumatic brain injury (and not in shock because of blood loss) who received out-of-hospital administration of hypertonic fluids (a solution with increased concentration of certain electrolytes and thought to help reduce intracranial pressure) as initial resuscitation did not experience better 6-month neurologic outcomes or survival compared to patients who received a normal saline solution, according to a study in the October 6 issue of JAMA. Traumatic brain injury (TBI) is the leading cause of death following blunt trauma, and survivors often ...

Giving vitamin D supplements to healthy children with normal vitamin D levels does not improve bone density at the hip, lumbar spine, forearm or in the body as a whole, according to a new Cochrane Systematic Review. Building bone density in children helps protect against osteoporosis in later life. Osteoporosis is a condition where bones are weak, brittle and break easily. Vitamin D helps the body absorb calcium from food, reduces losses of calcium from the body and encourages calcium deposition into bone. Bone density is a major measure of bone strength and measures ...

When compared with placebo and other drugs, long-term use of finasteride improves urinary tract symptoms associated with benign prostatic hyperplasia, and reduces disease progression. This conclusion comes from combining the findings of 23 randomized clinical trials that evaluated almost 21,000 men, and is published this month in The Cochrane Library. Finasteride is frequently given to men who have lower urinary tract symptoms (LUTS) such as frequent voiding at night (nocturia), incomplete emptying, hesitancy, weak stream, and frequent and urgent urination. The symptoms ...

There is no evidence that increasing the dose of inhaled corticosteroids at the onset of an asthma exacerbation, as part of a patient-initiated action plan, reduces the need for rescue oral corticosteroids. This is the conclusion of work published in The Cochrane Library this month. There are two mechanisms acting in the lungs of people with asthma. The first is called bronchoconstriction, which is when people's airways constrict during an asthma attack, making it much harder for them to move air in and out of their lungs. The first line treatment for this sort of acute ...

Diabetes is the leading reason for kidney failure in the world, resulting in patients requiring dialysis or kidney transplantation. New research has found a cell in the kidney called the podocyte could be the key to understanding why this happens. The study led by Dr Richard Coward, in the School of Clinical Sciences at the University of Bristol, is published in Cell Metabolism and funded by the Medical Research Council (MRC). Diabetes related kidney disease has previously been thought to be mainly due to the high levels of sugar in the blood damaging the small blood ...

Kyoto, Japan -- Knowing how to build nanosized assemblies of polymers (long molecular chains) holds the key to improving a broad range of industrial processes, from the production of nanofibers, filters, and new materials to the manufacture of low-energy, nanoscale circuits and devices. A recent paper in Nature Communications sheds light on key behaviors of polymers in specially engineered confined spaces, opening the door to a level of control that has previously been impossible. Scientists in Japan at Kyoto University and Nagoya University have succeeded in manufacturing ...

Members of the European Parliament are calling on the Presidency of the EU and Member States to tackle urgently the problem of chronic non-communicable diseases that are responsible for 86% of all deaths in the WHO European Region. Their call is supported by an alliance of European health professionals, including ECCO – the European CanCer Organisation – and ESMO – the European Society for Medical Oncology. After a meeting later today (Tuesday) between MEPs and the Chronic Disease Alliance of ten not-for-profit European organisations that represent over 100,000 health ...

The Government's ability to intervene directly to protect people's health and well-being has reached its limits in modern society because the health issues of today are closely tied in with individual lifestyle choice and freedoms, a leading academic will say today (October 5). Public health issues have previously been more amenable to government intervention and included improving sanitation or air quality, or controlling infectious disease. But public health issues today, like smoking, drink and diet, have meant that legislation is a blunt instrument in tackling these ...

Washington, D.C. (October 5, 2010) -- A prototype device developed in Hong Kong will allow laboratory researchers to non-invasively test drugs for their ability to kill tumors by subjecting cancerous cells with different concentration gradients. The new device is built upon microfluidics -- a set of technologies that allows the control and manipulation of fluids at the sub-millimeter scale -- and is described in the American Institute of Physics' journal Biomicrofluidics. Microfluidic valves within the device, said Hongkai Wu of Hong Kong University of Science and Technology, ...

Washington, D.C. (October 5, 2010) -- The explosion of portable communication devices that we enjoy today -- such as cell and smart phones, Bluetooth hands-free units, and wireless Internet networks -- has resulted in part from the development of a wide variety of integrated circuits that create, process and receive the microwave frequencies on which the communication is based. Continuing demand for higher performance over a wider range of frequencies has shrunk the physical size of circuits and fueled the development of new materials in thin-film forms, tested in detail ...

Washington, D.C. (October 5, 2010) -- Protein molecules inside cells are constantly reorganizing themselves, driven by very tiny forces exerted by all the other molecules in their crowded environment. Most experimental techniques and theoretical/computational models are necessarily built around much greater driving forces. A new theoretical model reported in the Journal of Chemical Physics investigates the unfolding of fibronectin under gentler conditions. "Typical models study very fast processes and consume a lot of CPU time," says author Alessandro Pelizzola of the ...

Washington, D.C. (October 5, 2010) -- Carbon nanotubes -- long, hollow cylinders of carbon billionths of a meter in diameter -- have many potential uses in nanotechnology, optics, electronics, and many other fields. The exact properties of nanotubes depend on their structure, and scientists as yet have little control over that structure, which is determined during the initial formation -- or growth -- of the nanotubes. In fact, says chemical engineer and materials scientist Eray Aydil of the University of Minnesota, "we do not know precisely how the nanotubes grow." In ...

For Immediate Release - (October 5, 2010) –Toronto's Centre for Addiction and Mental Health (CAMH) has been selected as one of seven adult field trial sites in North America and the only site in Canada to test proposed diagnostic criteria for the American Psychiatric Association's (APA) fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM). Used by health professionals around the world, DSM is the manual that provides descriptions, symptoms and other criteria for diagnosing mental disorders. CAMH is participating in field trials to help assess ...

A research team from the University of British Columbia and the Child & Family Research Institute (CFRI) at BC Children's Hospital has identified the role of a type of T cell in type 1 diabetes that may lead to new treatment options for young patients. Also known as juvenile diabetes, type 1 diabetes is an autoimmune disease primarily affecting children and young adults. In patients with type 1 diabetes, the body attacks itself by destroying insulin-producing cells in the pancreas that regulate glucose, or blood sugar. Led by Rusung Tan, a Pathology professor in the ...

### For the complete business office feature with individual company rankings, go to dx.doi.org/10.1126/science.opms.r1000097. The article will be posted at this URL address the evening of 7 October 2010. The American Association for the Advancement of Science (AAAS) is the world’s largest general scientific society, and publisher of the journal, Science (www.sciencemag.org) as well as Science Translational Medicine (www.sciencetranslationalmedicine.org) and Science Signaling (www.sciencesignaling.org). AAAS was founded in 1848, and includes some 262 affiliated ...

Spanish and Scottish researchers have added wool fibres to the clay material used to make bricks and combined these with an alginate, a natural polymer extracted from seaweed. The result is bricks that are stronger and more environmentally-friendly, according to the study published recently in the journal Construction and Building Materials. "The objective was to produce bricks reinforced with wool and to obtain a composite that was more sustainable, non-toxic, using abundant local materials, and that would mechanically improve the bricks' strength", Carmen Galán and ...

Pioneering new research by archaeologists at the University of York suggests that Neanderthals belied their primitive reputation and had a deep seated sense of compassion. A team from the University's Department of Archaeology took on the 'unique challenge' of charting the development of compassion in early humans. The researchers examined archaeological evidence for the way emotions began to emerge in our ancestors six million years ago and then developed from earliest times to more recent humans such as Neanderthals and modern people like ourselves. The research by ...

Allergies occur when the defence mechanisms of the immune system malfunction and misread normal substances entering the body as invading pathogens. Antibodies are part of our biochemical arsenal for combating viruses, bacteria, parasites and other alien substances, but during an allergic reaction the antibody, known as IgE, is directed against usually harmless substances such as grass pollen, nuts, pets or eggs. Asthma and allergies are chronic diseases that reduce quality of life and pose an economic burden on society. New parents have therefore previously been asked if ...