INFORMATION:
The research was supported in part by funding from the Pennsylvania Department of Health and the Geisinger Health Plan and Clinic.
About Geisinger
Geisinger is committed to making better health easier for the more than 1 million people it serves. Founded more than 100 years ago by Abigail Geisinger, the system now includes nine hospital campuses, a 550,000-member health plan, two research centers and the Geisinger Commonwealth School of Medicine. With nearly 24,000 employees and more than 1,600 employed physicians, Geisinger boosts its hometown economies in Pennsylvania by billions of dollars annually. Learn more at geisinger.org or connect with us on Facebook, Instagram, LinkedIn and Twitter.
Geisinger researchers find AI can predict death risk
Algorithm using echocardiogram videos of the heart outperforms other predictors of mortality
2021-02-08
(Press-News.org) DANVILLE, Pa. - Researchers at Geisinger have found that a computer algorithm developed using echocardiogram videos of the heart can predict mortality within a year.
The algorithm--an example of what is known as machine learning, or artificial intelligence (AI)--outperformed other clinically used predictors, including pooled cohort equations and the Seattle Heart Failure score. The results of the study were published in Nature Biomedical Engineering.
"We were excited to find that machine learning can leverage unstructured datasets such as medical images and videos to improve on a wide range of clinical prediction models," said Chris Haggerty, Ph.D., co-senior author and assistant professor in the Department of Translational Data Science and Informatics at Geisinger.
Imaging is critical to treatment decisions in most medical specialties and has become one of the most data-rich components of the electronic health record (EHR). For example, a single ultrasound of the heart yields approximately 3,000 images, and cardiologists have limited time to interpret these images within the context of numerous other diagnostic data. This creates a substantial opportunity to leverage technology, such as machine learning, to manage and analyze this data and ultimately provide intelligent computer assistance to physicians.
For their study, the research team used specialized computational hardware to train the machine learning model on 812,278 echocardiogram videos collected from 34,362 Geisinger patients over the last ten years. The study compared the results of the model to cardiologists' predictions based on multiple surveys. A subsequent survey showed that when assisted by the model, cardiologists' prediction accuracy improved by 13 percent. Leveraging nearly 50 million images, this study represents one of the largest medical image datasets ever published.
"Our goal is to develop computer algorithms to improve patient care," said Alvaro Ulloa Cerna, Ph.D., author and senior data scientist in the Department of Translational Data Science and Informatics at Geisinger. "In this case, we're excited that our algorithm was able to help cardiologists improve their predictions about patients, since decisions about treatment and interventions are based on these types of clinical predictions."
ELSE PRESS RELEASES FROM THIS DATE:
Molecular sleuthing identifies and corrects major flaws in blood-brain barrier model
2021-02-08
A type of cell derived from human stem cells that has been widely used for brain research and drug development may have been leading researchers astray for years, according to a study from scientists at Weill Cornell Medicine and Columbia University Irving Medical Center.
The cell, known as an induced Brain Microvascular Endothelial Cell (iBMEC), was first described by other researchers in 2012, and has been used to model the special lining of capillaries in the brain that is called the "blood-brain barrier." Many brain diseases, including brain cancers as well as degenerative ...
"Prediabetes" diagnosis less useful in older patients
2021-02-08
Older adults who are classified as having "prediabetes" due to moderately elevated measures of blood sugar usually don't go on to develop full-blown diabetes, according to a study led by researchers at Johns Hopkins Bloomberg School of Public Health.
Doctors still consider prediabetes a useful indicator of future diabetes risk in young and middle-aged adults. However, the study, which followed nearly 3,500 older adults, of median age 76, for about six and a half years, suggests that prediabetes is not a useful marker of diabetes risk in people of more advanced age.
The results were published February 8 in JAMA ...
As you look around, mental images bounce between right and left brain
2021-02-08
Ask anyone from an NFL quarterback scanning the field for open receivers, to an air traffic controller monitoring the positions of planes, to a mom watching her kids run around at the park: We depend on our brain to hold what we see in mind, even as we shift our gaze around and even temporarily look away. This capability of "visual working memory" feels effortless, but a new MIT study shows that the brain works hard to keep up. Whenever a key object shifts across our field of view--either because it moved or our eyes did--the brain immediately transfers a memory of it by re-encoding it among neurons in the opposite brain hemisphere.
The finding, published in Neuron by neuroscientists at The Picower Institute for Learning and Memory, explains via experiments in animals how we can keep ...
These shrimplike crustaceans are the fastest snappers in the sea
2021-02-08
The snapping claws of male amphipods--tiny, shrimplike crustaceans--are among the fastest and most energetic of any life on Earth. Researchers reporting in the journal Current Biology on February 8 find that the crustaceans can repeatedly close their claws in less than 0.01% of a second, generating high-energy water jets and audible pops. The snapping claws are so fast, they almost defy the laws of physics.
"What's really amazing about these amphipods is that they're sitting right on the boundary of what we think is possible in terms of how small something can be and how fast it can move without self-destructing," says senior author Sheila Patek, a Professor of Biology at Duke University. "If they accelerated any faster, their bodies would break."
While amphipods are ...
Comparison of demand for drugs for COVID-19 treatment, other drugs early in pandemic in Italy
2021-02-08
What The Study Did: The National Health Service in Italy provides universal coverage to citizens but because no approved drug was available for COVID-19, patients received potentially effective drugs, participated in clinical trials, accessed compassionate drug use programs or self-medicated. This study evaluated changes in drug demand during the early phase of the COVID-19 outbreak in Italy compared with the period before the outbreak.
Authors: Adriana Ammassari, M.D., of the Italian Medicines Agency in Rome, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2020.37060)
Editor's ...
Fetal surgery for spina bifida leads to better mobility in school-age children
2021-02-08
Philadelphia, February 8, 2021--Adding to a growing body of research affirming the benefits of fetal surgery for spina bifida, new findings show prenatal repair of the spinal column confers physical gains that extend into childhood. The researchers found that children who had undergone fetal surgery for myelomeningocele, the most severe form of spina bifida, were more likely than those who received postnatal repair to walk independently, go up and down stairs, and perform self-care tasks like using a fork, washing hands and brushing teeth. They also had stronger leg muscles and walked faster than children who had their spina bifida surgery ...
Risk of progression to diabetes among older adults with prediabetes
2021-02-08
What The Study Did: This observational study compared different measures of prediabetes and the risk of progression to diabetes among adults age 71 to 90.
Authors: Mary R. Rooney, Ph.D., M.P.H., of the Johns Hopkins Bloomberg School of Public Health in Baltimore, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamainternmed.2020.8774)
Editor's Note: The article includes conflicts of interest and funding/support disclosures. Please see the article for additional information, including other authors, author contributions and ...
Assessment of SARS-CoV-2 and risk factors associated with COVID-19 among outpatients in Virginia
2021-02-08
What The Study Did: Researchers assessed what percentage of the Virginia population had been exposed to SARS-CoV-2 after the first wave of COVID-19 infections in the U.S.
Authors: Eric R. Houpt, M.D., of the University of Virginia in Charlottesville, is the corresponding author.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2020.35234)
Editor's Note: The article includes conflict of interest and funding/support disclosures. Please see the article for ...
Climate change: Erratic weather slows down the economy
2021-02-08
If temperature varies strongly from day to day, the economy grows less. Through these seemingly small variations climate change may have strong effects on economic growth. This shows data analyzed by researchers from the Potsdam Institute for Climate Impact Research (PIK), Columbia University and the Mercator Research Institute on Global Commons and Climate Change (MCC). In a new study in Nature Climate Change, they juxtapose observed daily temperature changes with economic data from more than 1,500 regions worldwide over 40 years - with startling results.
"We ...
Understanding catalytic couplings: not all synergies are simple
2021-02-08
Negishi cross-coupling reactions have been widely used to form C-C bonds since the 1970s and are often perceived as the result of two metals (i.e zinc and palladium/nickel) working in synergy. But like all relationships, there is more under the surface than what we first expected. PhD student Craig Day and Dr. Rosie Somerville from the Martin group at ICIQ have delved into the Negishi cross-coupling of aryl esters using nickel catalysis to understand how this reaction works at the molecular level and how to improve it. The results have been published in Nature Catalysis.
Compared to palladium, nickel has the advantage of being readily available transition metal, ...
LAST 30 PRESS RELEASES:
Fentanyl detection through packaging
Prof. Eran Meshorer elected to EMBO for pioneering work in epigenetics
New 3D glacier visualizations provide insights into a hotter Earth
Creativity across disciplines
Consequences of low Antarctic sea ice
Hear here: How loudness and acoustic cues help us judge where a speaker is facing
A unique method of rare-earth recycling can strengthen the raw material independence of Europe and America
Epilepsy self-management program shows promise to control seizures, improve mood and quality of life
Fat may play an important role in brain metabolism
New study finds no lasting impact of pandemic pet ownership on human well-being
New insights on genetic damage of some chemotherapies could guide future treatments with less harmful side effects
Gut microbes could protect us from toxic ‘forever chemicals’
Novel modelling links sea ice loss to Antarctic ice shelf calving events
Scientists can tell how fast you're aging from a single brain scan
U.S. uterine cancer incidence and mortality rates expected to significantly increase by 2050
Public take the lead in discovery of new exploding star
What are they vaping? Study reveals alarming surge in adolescent vaping of THC, CBD, and synthetic cannabinoids
ECMWF - delivering forecasts over 10 times faster and cutting energy usage by 1000
Brazilian neuroscientist reveals how viral infections transform the brain through microscopic detective work
Turning social fragmentation into action through discovering relatedness
Cheese may really be giving you nightmares, scientists find
Study reveals most common medical emergencies in schools
Breathable yet protective: Next-gen medical textiles with micro/nano networks
Frequency-engineered MXene supercapacitors enable efficient pulse charging in TENG–SC hybrid systems
Developed an AI-based classification system for facial pigmented lesions
Achieving 20% efficiency in halogen-free organic solar cells via isomeric additive-mediated sequential processing
New book Terraglossia reclaims language, Country and culture
The most effective diabetes drugs don't reach enough patients yet
Breast cancer risk in younger women may be influenced by hormone therapy
Strategies for staying smoke-free after rehab
[Press-News.org] Geisinger researchers find AI can predict death riskAlgorithm using echocardiogram videos of the heart outperforms other predictors of mortality