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Not all dietary proteins are created equal

New study published in the Journal of Nutrition concluded that 'ounce equivalents' of animal- and plant-based protein-rich foods may not be metabolically equivalent after all

2021-06-22
(Press-News.org) Dietary protein is needed to supply essential amino acids for the synthesis of the structural and functional components of living cells. Thus, food protein quantity and quality are both essential for good health. The 2020-2025 Dietary Guidelines for Americans (DGAs) published an "ounce equivalents" recommendation to help consumers meet protein requirements with a variety of protein food sources. For example, the DGAs present a variety of "ounce equivalents" in the protein food groups stating that 1 ounce of meat is equivalent to 1 cooked egg, ¼ cup of red kidney beans, 1 tablespoon of peanut butter, 2 ounces of tofu, and ½ ounce of mixed nuts. However, the DGAs do not currently address the issue of differences in protein quality associated with varied food sources. In general, animal proteins have higher protein digestibility and a better essential amino acid profile relative to dietary requirements. These measures of protein quality indicate that animal proteins can more readily provide the daily requirement of essential amino acids than plant protein.

A new manuscript recently published in The Journal of Nutrition investigated the physiological response to various ounce equivalents of protein food sources and found that the consumption of ounce equivalents of animal-based protein food sources resulted in greater gain in whole-body net protein balance above baseline than the ounce equivalents of plant-based protein food sources. (1) Robert Wolfe (University of Arkansas for Medical Sciences) and colleagues randomly assigned 56 young healthy adult participants to one of seven food intervention groups: 2 ounces of cooked beef sirloin, 2 ounces of cooked pork loin, 2 cooked eggs, ½ cup of red kidney beans, 2 tablespoons of peanut butter, 4 ounces of tofu, or 1 ounce of mixed nuts. Prior to the onset of the study, participants followed a 3-day dietary weight maintenance. Participants' net whole-body protein balance was assessed using a stable isotope tracer infusion protocol. The changes from baseline following consumption of the different protein food sources were compared with the baseline value for that individual.

Overall, investigators found that animal-based protein food sources elicited greater anabolic responses than plant-based protein food sources. Whole body protein balance increased more in the beef, pork, and eggs groups than all of the groups consuming plant-based protein food sources. Protein synthesis increased more in the beef group than in the groups consuming plant protein foods, kidney beans, peanut butter, or mixed nuts, while the egg and pork groups suppressed protein breakdown more compared with mixed nuts. The magnitude of the whole-body net balance response was correlated with the essential amino acid content of the protein food source. The researchers concluded that "ounce equivalents" of protein food sources as expressed in the DGAs are not metabolically equivalent in terms of either the anabolic response or caloric value and this should be considered as the DGAs develop approaches to establish healthy eating patterns.

"Our research illustrates that animal-based protein foods, such as beef, eggs and pork, and plant-based protein foods, such as kidney beans, peanut butter, tofu and mixed nuts, cannot be considered to be equivalent, or a substitute for each other, when developing healthy dietary patterns, given their unique physiological effects," said lead researcher Robert Wolfe, PhD, Director, Center for Translational Research in Aging and Longevity, and Professor of Geriatrics, University of Arkansas for Medical Sciences. "While it's well-established that animal proteins can more readily provide essential amino acids than plant protein foods, our study also indicates that eating animal protein foods such as beef, pork and eggs may lead to increased protein synthesis, which has been shown to have benefits such as improved satiety and lean muscle mass maintenance."

A corresponding editorial by Glenda Courtney-Martin (University of Toronto) stresses the importance and timely contribution of this study, which could guide future decisions regarding how protein foods can be better categorized by the DGAs. (2)

INFORMATION:

This research was supported by the Beef Checkoff, National Pork Board and American Egg Board's Egg Nutrition Center.

References 1. Park S, Church DD, Schutzler WE, Azhar G, Il-Young K, Ferrando AA, Wolfe RR. Metabolic Evaluation of the Dietary Guidelines' Ounce Equivalents of Protein Food Sources in Young Adults: A Randomized Controlled Trial. The Journal of Nutrition, Volume 151, Issue 5, May 2021, Pages 1190-1196, https://doi.org/10.1093/jn/nxaa401. 2. Courtney-Martin G. False equivalence or fake news: is a peanut really an egg? The Journal of Nutrition, Volume 151, Issue 5, May 2021, Pages 1055-1056, https://doi.org/10.1093/jn/nxab051.



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[Press-News.org] Not all dietary proteins are created equal
New study published in the Journal of Nutrition concluded that 'ounce equivalents' of animal- and plant-based protein-rich foods may not be metabolically equivalent after all