Tirzepatide for weight reduction in Chinese adults with obesity

JAMA

2024-05-31

(Press-News.org) About The Study: In Chinese adults with obesity or overweight, once-weekly injection with tirzepatide 10 mg or 15 mg resulted in statistically significant and clinically meaningful weight reduction with an acceptable safety profile.

Corresponding Author: To contact the corresponding author, Xiaoying Li, M.D., email li.xiaoying@zshospital.sh.cn.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2024.9217)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.9217?guestAccessKey=83007825-a985-4c21-a783-852d03c8295c&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=053124

END

ELSE PRESS RELEASES FROM THIS DATE:

U of T researchers discover ‘trojan horse’ virus hiding in human parasite

2024-05-31

An international team led by researchers at the University of Toronto has found a new RNA virus that they believe is hitching a ride with a common human parasite. The virus, called Apocryptovirus odysseus, along with 18 others that are closely related to it, was discovered through a computational screen of human neuron data – an effort aimed at elucidating the connection between RNA viruses and neuroinflammatory disease. The virus is associated with severe inflammation in humans infected with the ...

Clues to mysterious disappearance of North America’s large mammals 50,000 years ago found within ancient bone collagen

2024-05-31

50,000 years ago, North America was ruled by megafauna. Lumbering mammoths roamed the tundra, while forests were home to towering mastodons, fierce saber-toothed tigers and enormous wolves. Bison and extraordinarily tall camels moved in herds across the continent, while giant beavers plied its lakes and ponds. Immense ground sloths weighing over 1,000 kg were found across many regions east of the Rocky Mountains. And then, sometime at the end of the Last Ice Age, most of North America’s megafauna disappeared. How and why remains hotly contested. Some researchers believe the arrival of humans was pivotal. Maybe the animals were hunted and eaten, or maybe humans just altered ...

Revolutionizing interaction recognition: The power of merge-and-split graph convolutional networks

2024-05-31

In a significant advancement for robotics and artificial intelligence, researchers at Chongqing University of Technology, along with their international collaborators, have developed a cutting-edge method for enhancing interaction recognition. The study, published in Cyborg and Bionic Systems, introduces the Merge-and-Split Graph Convolutional Network (MS-GCN), a novel approach specifically designed to address the complexities of skeleton-based interaction recognition. Human interaction recognition plays a crucial role in various applications, ranging from enhancing human-computer interfaces ...

Do shape-memory alloys remember past strains in their life?

2024-05-31

Endowed with the power of memory, certain alloys can magically return to their original shape when heated or deformed. However, the repeated back-and-forth between the original and new configuration may leave permanent imprints on the alloy’s microscopic features, which could then impact its ability to reversibly transform shape. Thus, unraveling the impact of the strain history on these alloys’ functionality is essential to improving predictive capabilities, but it has not received enough attention. To fill this knowledge gap, the National Science Foundation ...

A novel electromagnetic driving system for 5-DOF manipulation in intraocular microsurgery

2024-05-31

The electromagnetic driving systems are proposed for the flexible 5-DOF magnetic manipulation of a micro-robot within the posterior eye, enabling precise targeted drug delivery. A research team has presented a novel electromagnetic driving system that consists of eight optimized electromagnets arranged in an optimal configuration and employs a control framework based on an active disturbance rejection controller (ADRC) and virtual boundary. The team published their findings in Cyborg and Bionic Systems on Mar 23, 2024. Intraocular microsurgery has witnessed a transition from the utilization of conventional handheld surgical tools to the adoption of robot-assisted surgery, owing ...

Researchers identify a genetic cause of intellectual disability affecting tens of thousands

2024-05-31

New York, NY [May 31, 2024]—Researchers at the Icahn School of Medicine at Mount Sinai and others have identified a neurodevelopmental disorder, caused by mutations in a single gene, that affects tens of thousands of people worldwide. The work, published in the May 31 online issue of Nature Medicine [DOI: 10.1038/s41591-024-03085-5], was done in collaboration with colleagues at the University of Bristol, UK; KU Leuven, Belgium; and the NIHR BioResource, currently based at the University of Cambridge, UK. The findings will improve clinical diagnostic ...

EMBARGOED: Nearly one-third of US adults know someone who’s died of drug overdose

2024-05-31

Losing a loved one to drug overdose has been a common experience for many Americans in recent years, crossing political and socioeconomic divides and boosting the perceived importance of the overdose crisis as a policy issue, according to a new survey led by researchers at the Johns Hopkins Bloomberg School of Public Health. A nationally representative survey of more than 2,300 Americans, fielded in spring 2023, suggests that 32 percent of the U.S. adult population, or an estimated 82.7 million individuals, has lost someone they know to a fatal drug overdose. ...

Mediterranean diet adherence and risk of all-cause mortality in women

2024-05-31

About The Study: Higher adherence to the Mediterranean diet was associated with a 23% lower risk of all-cause mortality in this cohort study. This inverse association was partially explained by multiple cardiometabolic factors. Corresponding Author: To contact the corresponding author, Shafqat Ahmad, Ph.D., email shafqat.ahmad@medsci.uu.se. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.14322) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest ...

Traumatic brain injury strikes 1 in 8 older Americans

2024-05-31

Some 13% of older adults are diagnosed with traumatic brain injury (TBI), according to a study by UC San Francisco and the San Francisco VA Health Care System. These injuries are typically caused by falls from ground level. Researchers followed about 9,200 Medicare enrollees, whose average age was 75 at the start of the study, and found that contrary to other studies of younger people, being female, white, healthier and wealthier was associated with higher risk of TBI. The study publishes in JAMA Network Open on May 31, 2024. The researchers, ...

Stem cells shed new light on how the human embryo forms

2024-05-31

A new study using stem cell-based models has shed new light on how the human embryo begins to develop, which could one day benefit the development of fertility treatment. The study led by at the University of Exeter Living Systems Institute has revealed how early embryo cells decide between contributing to the foetus or to the supporting yolk sac. Understanding this decision is important because the yolk sac is essential for later development in the womb. Producing the right number of yolk sac forming cells may be critical for infertility treatment using in vitro fertilised (IVF) embryos. Only limited research ...

Children’s Hospital of Philadelphia and Children’s Hospital Colorado researchers conduct first prospective study of pediatric EoE patients and disease progression

Tirzepatide for weight reduction in Chinese adults with obesity

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: