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Medicine 2026-03-20

Tobacco smoking and lung cancer risk after negative baseline low-dose computed tomography findings

JAMA Network Open
About The Study: In this cohort study, smokers with negative baseline low-dose computed tomography findings exhibited a substantially elevated long-term lung cancer risk, which became significant only after 2 years after screening. These findings suggest support for extending the initial screening interval and implementing personalized long-term monitoring based on smoking history.

Corresponding Author: To contact the corresponding author, Shaokai Zhang, PhD, email shaokaizhang@126.com.

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(doi:10.1001/jamanetworkopen.2026.1913)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication. 

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