“The results provide novel preclinical data that demonstrate synergism between HDACi- and PARPi-mediated inhibition of DNA repair and decitabine in pancreatic cancer [...]” BUFFALO, NY- June 5, 2024 – A new research paper was published in Oncotarget's Volume 15 on June 3, 2024, entitled, “Synergistic cytotoxicity of histone deacetylase and poly-ADP ribose polymerase inhibitors and decitabine in pancreatic cancer cells: Implications for novel therapy.” Histone deacetylase inhibitors (HDACi) can modulate the acetylation status of proteins, influencing the genomic instability exhibited by cancer cells. Poly (ADP ribose) ...

Diabetes rates continue to rise, with 11.7 million Canadians living with diabetes or pre-diabetes. At UBC, scientists have created a pain-free drug delivery method to help people with diabetes manage the disease and maintain their health more easily. Researchers at the Li Lab have developed oral insulin drops that when placed under the tongue are quickly and efficiently absorbed by the body, potentially replacing the need for insulin injections. The drops contain a mixture of insulin and a unique cell-penetrating peptide (CPP) developed ...

EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, JUNE 5, 2024 MINNEAPOLIS – A new study suggests that people who take a few common drugs may have a decreased risk of having a bleeding stroke due to a ruptured brain aneurysm. The study is published in the June 5, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology. The results do not prove that these drugs reduce the risk of this type of aneurysm; they only show an association. “We urgently need new ways to prevent this type of stroke, which occurs at younger ages and with a higher death rate than other types of stroke,” said study author Jos Peter Kanning, ...

The Gerontological Society of America (GSA) has received renewed grant support to welcome a 15th class of reporters for the Journalists in Aging Fellows Program. The 2024 funders to date include Silver Century Foundation, The John A. Hartford Foundation, and National Institute for Health Care Management Foundation (NIHCM). Since its founding in 2010, this program has been responsible for more than 800 news stories produced by 231 alumni. It has two goals: to educate journalists about issues in aging, better allowing them to spread a new awareness to general-audience, ethnic, and other minority populations; and to disseminate information about new scientific findings, ...

Cyberattacks driven by Artificial Intelligence (AI) pose unprecedented risks to global economies, supply chains, and trade. A forthcoming study from the journal Risk Analysis explores the cascading impacts of AI-driven cyberattacks. Unlike traditional cyberattacks, which are typically manual or scripted, AI-driven cyberattacks utilize AI and machine learning algorithms to enhance their effectiveness, stealthiness and adaptability. AI-driven cyberattacks can autonomously learn and evolve their tactics, techniques and procedures based on real-time feedback and environmental changes. Through simulation scenarios, the researchers discovered the potential ...

HOUSTON ― The James P. Allison Institute at The University of Texas MD Anderson Cancer Center today announced the appointment of its newest members, Susan Bullman, Ph.D., and Xi Chen, Ph.D., to further the institute’s ongoing work of impactful immunobiology research. These accomplished researchers, joining as associate members, bring valuable expertise in studying how the intratumoral microbiome and the immune microenvironment influence patient responses to immunotherapy. As Allison Institute members, Bullman and Chen will lead impactful research programs aligned with the institute’s ...

The Focused Ultrasound Foundation has designated Virginia Tech as a Focused Ultrasound (FUS) Center of Excellence, making it the sixth such center in the United States and one of only 12 in the world. “Virginia Tech possesses significant strengths in the FUS field, and it is an honor to recognize them as a Center of Excellence,” said Neal F. Kassell, founder and chairman of the Focused Ultrasound Foundation. “With distinguished experts across the colleges of engineering, science, veterinary medicine, and medicine, ...

Images The U.S. public displays more positive than negative sentiment toward nuclear energy but concerns remain about waste, cost and safety, according to an analysis of 300,000 posts on X (formerly Twitter) by University of Michigan researchers.    The study was recently published in Renewable and Sustainable Energy Reviews.   Identifying public concerns and misconceptions about nuclear energy can target efforts to bridge these gaps as nuclear energy will play a large role in goals to decarbonize ...

A single universal equation can closely approximate the frequency of wingbeats and fin strokes made by birds, insects, bats and whales, despite their different body sizes and wing shapes, Jens Højgaard Jensen and colleagues from Roskilde University in Denmark report in a new study in the open-access journal PLOS ONE, publishing June 5. The ability to fly has evolved independently in many different animal groups. To minimize the energy required to fly, biologists expect that the frequency that animals flap their wings should be determined by the natural resonance frequency of the wing. However, finding a universal mathematical description of flapping flight has proved ...

Pro-inflammatory diets are associated with higher levels of the heart failure biomarker NT-proBNP, with potential implications for cardiovascular risk, per study of more than 10,000 US adults ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304289 Article Title: Association between dietary inflammatory index and NT-proBNP levels in US adults: A cross-sectional analysis Author Countries: China Funding: The study was funded by the Yan'an Science and Technology Plan Project (Grant No. 2022SLSFGG-025).The funders ...

Normal ageing might be associated with increased blood-brain barrier permeability in regions also vulnerable in Alzheimer's Disease, in small study comparing healthy brains of the young and old ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0299764 Article Title: Associations between regional blood-brain barrier permeability, aging, and Alzheimer’s disease biomarkers in cognitively normal older adults Author Countries: USA Funding: Research reported in this publication was supported ...

In an online study, virtual hospital rooms designed according to the principles of evidence-based design or the principles of Feng Shui were associated with greater potential benefit for viewers than virtual representations of standard hospital rooms. Emma Zijlstra of Hanze University of Applied Sciences in the Netherlands and colleagues present these findings in the open-access journal PLOS ONE on June 5. Hospital designers might consider employing specific design principles in an effort to improve patients’ experiences. Growing evidence suggests ...

The formation of relationships within violent US Islamist extremist groups is highly driven by mutual contacts and the tendency for people to bond with others similar to themselves, according to new research. Anina Schwarzenbach, formally of Harvard University and the University of Maryland (currently affiliated with the University of Bern) and Michael Jensen of the University of Maryland present these findings in the open-access journal PLOS ONE on June 5, 2024. Prior research on social structures within extremist networks have primarily ...

COLUMBUS, Ohio – Online news consumers tend to click on simpler headlines that use more common words and more readable writing, a new study finds.   Researchers evaluated more than 30,000 real-world field experiments from the Washington Post and the online news site Upworthy to see how readers reacted to headlines of varying complexity.   In addition, a follow-up experiment showed that average readers paid more attention to simpler headlines and processed them more deeply – unlike journalists, who paid just as much attention to complex headlines.   The results show ...

June 5, 2024 (Cambridge, MA) - Cirrus Therapeutics, the University of Bristol, and London’s Global University Institute of Ophthalmology have discovered a revolutionary treatment for age-related macular degeneration (AMD), the leading cause of vision loss among older adults. Featured on the cover of the journal Science Translational Medicine, this breakthrough research reveals that boosting a specific protein, IRAK-M, in retinal cells could offer a new and highly effective therapy for AMD. AMD ...

EAST LANSING, Mich. – The competition for online attention in today’s news environment is fierce. High-quality news from credible sources must compete for attention with misinformation and a rapidly increasing amount of partisan content. How can a news organization stand out as a reputable and trustworthy outlet while driving readers to its site? The answer is simple: literally. According to research from Michigan State University, news readers engage more with simple writing, suggesting journalists ...

UCLA scientists have identified a protein that plays a critical role in regulating human blood stem cell self-renewal by helping them sense and interpret signals from their environment. The study, published in Nature, brings researchers one step closer to developing methods to expand blood stem cells in a lab dish, which could make life-saving transplants of these cells more available and increase the safety of blood stem cell-based treatments, such as gene therapies. Blood stem cells, also known as hematopoietic stem cells, have the ability to make copies of themselves via a process called ...

Dr. Raffaele Teperino, head of the "Environmental Epigenetics" research group at Helmholtz Munich, along with his research team, has examined the impact of paternal diet on children's health – specifically, the influence of diet before conception. The researchers focused on special small RNA molecules in sperm, known as mitochondrial tRNA fragments (mt-tsRNAs, see background). These RNAs play a key role in the inheritance of health traits by regulating gene expression. For their study, the researchers used data from the LIFE Child cohort, which includes information from over 3,000 families. The analyses showed ...

A new study uncovers the intricate molecular mechanisms that regulate leaf senescence in apple plants, focusing on the crucial role of the E3 ligase enzyme, MdPUB23, and its interaction with the ABI5 protein. This research provides valuable insights into how plants manage stress responses and maintain growth, offering potential applications in improving crop yield and stress resistance. Leaf senescence is a vital phase in the life cycle of plants, impacting overall plant health and yield. Abscisic acid (ABA) ...

Researchers in Italy have unveiled the first successful application of commercial drones combined with artificial intelligence (AI) to monitor the invasive agricultural pest, Halyomorpha halys, commonly known as the brown marmorated stink bug. This research, published in the SCI journal Pest Management Science, marks a significant advancement in the use of unmanned aerial vehicles (UAVs) for automated monitoring of invasive species. Halyomorpha halys is notorious for its extensive damage to orchard crops across North America and southern Europe. In Italy, this invasive pest caused an ...

Recent research has uncovered the genetic mechanisms behind sea lavender's (Limonium bicolor) salt tolerance by studying basic helix–loop–helix (bHLH) transcription factors. Identifying 187 bHLH  genes, the study highlights their roles in salt gland development and stress responses. CRISPR-Cas9 validation demonstrated specific bHLH genes' critical role in enhancing salt tolerance, paving the way for future applications in crop improvement and saline soil management. Basic helix–loop–helix (bHLH) transcription factors are essential for various plant processes, including ...

Six faculty members from The University of Texas at Arlington received more than $3.23 million in awards as part of the National Science Foundation’s (NSF) Faculty Early Career Development Program. Called CAREER, these awards are considered the NSF’s most prestigious for early-career faculty and are given to those who have the potential to serve as academic role models in research and education. Between 2017 and 2022, UTA received nine CAREER awards; in 2023, it received six. Vice President of research and innovation Kate C. Miller called this “a true testament to the world-class research teams we’re assembling here in Arlington.” “CAREER ...

Some children with autism experience profound, lifelong difficulties like developmental delay, social struggles and even the inability to speak. Others experience more mild symptoms that improve with time. The disparity in outcomes has been a mystery to scientists, until now. A new study, published in Molecular Autism by researchers at University of California San Diego, is the first to shed light on the matter. Among its findings: The biological basis for these two subtypes of autism develops in utero. Researchers ...

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson offer insights into a lower-intensity therapy combination for older patients with acute myeloid leukemia (AML), a novel T cell therapy for patients with bone marrow failure syndromes, a proof-of-concept study using MRI to detect metabolic changes inside tumors, a molecular target to overcome treatment resistance ...

-With images- A new study has revealed alarming gaps in the implementation of conservation interventions for thousands of the world's most threatened species. The research, published in the journal Nature, shows that most terrestrial plant and animal species at risk of extinction from threats like habitat loss, over-exploitation for trade, and invasive species are not receiving the appropriate types of conservation efforts needed to protect them. The study findings suggest that there is a serious mismatch between the ...