Neutrophil-to-lymphocyte ratio may aid risk stratification in depressive disorder
January 6, 2026 — An elevated neutrophil-to-lymphocyte ratio (NLR) is significantly associated with increased risk of depressive disorder (DD) and may also correlate with suicide risk among individuals with DD, according to a systematic review and meta-analysis published in the November issue of Harvard Review of Psychiatry, part of the Lippincott portfolio from Wolters Kluwer.
“Studies demonstrate altered immune responses in DD, including diminished lymphocyte reactivity and dysregulated neutrophil activity,” explain Yongjun Chen, MD, of Shandong University of Traditional ...