Researchers from DZNE and Otto von Guericke University Magdeburg have identified individuals with increased risk for dementia using mobility data, recorded during a smartphone-based wayfinding task on the university campus. The findings, reported in the journal PLOS Digital Health, show the potential of smartphone data, collected in conditions close to everyday life, for the early detection and monitoring of Alzheimer’s disease. The study included 72 adults; about a third of them with subjective cognitive decline (SCD), a condition that is a known risk factor for dementia. Alzheimer’s disease usually develops unnoticed over years and eventually ...

Government subsidies for business practices and processes should be approached with caution, even when they seem to be environmentally friendly, writes a group of scientists and economists in this week’s Policy Forum in the journal Science. They argue that subsidies can alter market pressures, leading to unintended consequences that not only perpetuate harmful subsidies over time but also diminish the overall effectiveness of those intended to promote environmental sustainability. Therefore, when they must be used, subsidies should have clear end-dates, advise the authors. “We’ve got this odd juxtaposition of ...

Neuroscientists had a problem. For decades, researchers had a theory about how an animal’s brain keeps track of where it is relative to its surroundings without outside cues – like how we know where we are, even with our eyes closed. According to the theory, which was based on brain recordings from rodents, networks of neurons called ring attractor networks maintain an internal compass that keeps track of where you are in the world. An accurate internal compass was thought to require a large network with many neurons, while a small network with few neurons would cause the compass’s needle to drift, creating errors. Then researchers discovered an internal compass ...

University of Texas at Arlington UTeach Master Teacher Karen Jo Matsler will be awarded the 2025 Melba Newell Phillips Medal in January from the American Association of Physics Teachers (AAPT) in recognition of her extensive contributions to physics education and her tireless efforts to support educators nationwide. Founded in 1930, AAPT is a national organization dedicated to advancing the teaching and understanding of physics. For more than 20 years, Dr. Matsler has been a tireless advocate of physics education, working with state legislators and educational agencies ...

About The Study: The modified vaccinia Ankara–Bavarian Nordic (MVA-BN) vaccination generated mpox antibodies that waned by 6 to 12 months. In participants who received 2 doses of MVA-BN vaccine, mpox antibody responses at 12 months were comparable to or lower than peak antibody responses in people receiving 1 dose, which provided limited protection. Quote from corresponding author Dan H. Barouch, MD, PhD: “In this observational study, we show that mpox antibody responses decline 6-12 months following Jynneos (MVA-BN) vaccination. Our data suggest that protective immunity may ...

A new study led by researchers at Johns Hopkins Bloomberg School of Public Health estimates that thousands of lives could have been saved during the first year of the COVID-19 pandemic if convalescent plasma had been used more broadly, particularly in outpatients at high risk for severe disease and in hospitalized patients during their first few days of admission. Convalescent plasma from patients who had recovered from COVID was used starting in the early months of the pandemic at the urging of a group of physicians who cited the blood ...

Quantum communication and quantum computing operate based on quantum bits (qubits) as the smallest unit of information — related to bits in a classical computer. Of the many different approaches currently being investigated around the world, one promising option is to use Andreev pair qubits. These qubits are formed at interfaces between a metal and a superconductor in a process known as Andreev reflection. Here, an electron from the metal enters the superconductor, where it becomes part of an electron pair (a Cooper pair) — while a hole, ...

Jacksonville, Fla. – A University of North Florida biology professor has been awarded a prestigious four-year National Institutes of Health (NIH) grant totaling over $720K to study the functional role of an enzyme called dual-specificity phosphatase 4 (Dusp4) in skeletal muscle atrophy.    Dr. David Waddell’s NIH-funded research project will help contribute to knowledge about skeletal muscle atrophy associated with neuromuscular disorders, neurodegenerative diseases and aging. Skeletal muscle atrophy is a decrease in muscle mass that occurs when protein degradation exceeds protein ...

A study published on Eurosurveillance has demonstrated that Spain's influenza vaccination campaign for children aged 6-59 months during the 2023/24 season was effective in preventing acute respiratory infections (ARI) and hospitalisation, as vaccination was recommended for this age group at the national level for the first time. In the context of Child Health Day 2024, this research emphasises that continued efforts should be made to increase vaccination coverage among children for future seasons. Context and methods Influenza A was dominant in the 2023/2024 season, ...

Santa Barbara, CA and New York, NY -- The Glenn Foundation for Medical Research (GFMR) and the American Federation for Aging Research (AFAR) are pleased to announce the 2024 recipients of the Glenn Foundation Discovery Awards: Jeffrey Friedman, MD, PhD (Professor, The Rockefeller University and Investigator, Howard Hughes Medical Institute) and Myriam Heiman, PhD (Associate Professor of Neuroscience, Massachusetts Institute of Technology).  The Glenn Foundation Discovery Award supports research projects with strong potential to develop pioneering discoveries to understand ...

Human stem cell transplants successfully repaired macular holes in a monkey model, researchers report October 3rd in the journal Stem Cell Reports. After transplantation, the macular holes were closed by continuous filling of the space with retinal tissue. “We confirmed for the first time in a non-human primate model that embryonic stem-derived retinal organoid sheet transplantation facilitates the closure of macular holes,” says senior study author Michiko Mandai of the Kobe City Eye Hospital. “Our results suggest that this method could become a practical, safe, and effective ...

The moment a person steps off the street and into a restaurant—to take just one example—the brain mentally starts a new “chapter” of the day, a change that causes a big shift in brain activity. Shifts like this happen all day long, as people encounter new environments, like going out for lunch, attending their kid’s soccer game, or settling in for a night of watching TV. But what determines how the brain divides the day into individual events that we can understand and remember separately?  That’s what a new paper in the journal Current Biology aimed to find ...

About The Study: Decades following treatment, one-third of childhood cancer survivors in this study reported elevated fear their cancer will recur or a subsequent malignant neoplasm will develop. Findings suggest that fear of cancer recurrence should be routinely screened, and clinically significant symptoms intervened upon as a part of survivorship care.  Corresponding Author: To contact the corresponding author, Nicole M. Alberts, PhD, email nicole.alberts@concordia.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.36144) Editor’s ...

About The Study: In this retrospective cohort study of women undergoing screening mammography, mean absolute artificial intelligence (AI) scores were higher for breasts developing vs not developing cancer 4 to 6 years before their eventual detection. These findings suggest that commercial AI algorithms developed for breast cancer detection may identify women at high risk of a future breast cancer, offering a pathway for personalized screening approaches that can lead to earlier cancer diagnosis.  Corresponding Author: To contact the corresponding author, Solveig Hofvind, PhD, email sshh@kreftregisteret.no. To access the embargoed study: ...

Highlights: Mycobacterium tuberculosis, which causes tuberculosis (TB), is a threat to public health. A new study identified that a semi-synthetic compound can be derived from natural compounds and shows potent activity against M. tuberculosis, including multi-drug resistant strains. This is a promising step toward new potent treatment for TB. Washington, D.C.—A new study published in the American Society for Microbiology journal Microbiology Spectrum demonstrates that a novel semi-synthetic compound can be derived from ...

EL PASO, Texas (Oct. 3, 2024) – Scientists at The University of Texas at El Paso and Stanford University were recently surprised to find that the natural community of zooplankton — tiny, aquatic animals known to graze on bacteria — present in freshwater and saltwater do not clean water that is contaminated with fecal microorganisms.  The research, published today in the biology journal mSphere, reveals important insights about the limitations of zooplankton in treating bodies of water that have been contaminated with fecal organisms, the team said. A 2017 U.S. water quality inventory ...

The rising demand for tech jobs presents an outstanding opportunity for growth and inclusivity in the industry. Developing accessible training programs tailored for individuals with disabilities can foster a more diverse workforce. Florida Atlantic University’s College of Education and the College of Engineering and Computer Science have received a $9,961,460 grant from the United States Department of Education’s Office of Special Education and Rehabilitative Services to increase the capacity and participation of transition-age youths and working-age adults with disabilities in high demand technology jobs locally and nationally. ...

Tending a garden is hard work. Imagine it from the plants’ perspective. Each relies on fine-tuned genetic processes to pass down accurate copies of chromosomes to future generations. These processes sometimes involve billions of moving parts. Even the tiniest disruption can have a cascading effect. So, for plants like Arabidopsis thaliana, it’s good to have a backup plan. “Chromosomes have to be accurately partitioned every time a cell divides,” explains Cold Spring Harbor Laboratory (CSHL) Professor and HHMI Investigator Rob Martienssen. “For that to happen, each chromosome has ...

Increasingly complex applications such as artificial intelligence require ever more powerful and power-hungry computers to run. Optical computing is a proposed solution to increase speed and power efficiency but has yet to be realized due to constraints and drawbacks. A new design architecture, called diffraction casting, seeks to address these shortcomings. It introduces some concepts to the field of optical computing that might make it more appealing for implementation in next-generation computing devices. Whether ...

Researchers have long observed that a common family of environmental bacteria, Comamonadacae, grow on plastics littered throughout urban rivers and wastewater systems. But what, exactly, these Comamonas bacteria are doing has remained a mystery. Now, Northwestern University-led researchers have discovered how cells of a Comamonas bacterium are breaking down plastic for food. First, they chew the plastic into small pieces, called nanoplastics. Then, they secrete a specialized enzyme that breaks down the plastic even further. Finally, the bacteria use a ring of carbon atoms from the plastic as a ...

10-2-24   Contacts: Sougata Roy, Mechanical Engineering, 515-294-5001, sroy@iastate.edu Mike Krapfl, News Service, 515-294-4917, mkrapfl@iastate.edu   Researchers study 3D printing tungsten parts for extreme conditions in nuclear reactors   AMES, Iowa – Sougata Roy, who doesn’t study electrons or grids or wind turbines, has found a way to contribute to a clean-energy future.   “This work in advanced manufacturing, particularly in using additive manufacturing, is about making a difference,” ...

EMBARGOED: NOT FOR RELEASE UNTIL THURSDAY 3 OCTOBER AT 07:00 ET (12:00 UK TIME) An international team of researchers have made a promising breakthrough in the development of drugs to treat Alzheimer’s Disease. For the first time, scientists have developed a drug that works on both major aggregation-promoting ‘hotspots’ of the Tau protein - addressing a critical gap in current treatments. The drug, a peptide inhibitor called RI-AG03, was effective at preventing the build-up of Tau proteins - a key driver of neurodegeneration - in both lab and fruit fly studies. The ...

University of Copenhagen mathematicians have developed a recipe for upgrading quantum computers to simulate complex quantum systems, such as molecules. Their discovery brings us closer to being able to predict how new drugs will behave within our bodies and has the potential to revolutionize pharmaceutical development. Developing a new drug can take more than a decade and cost anywhere from hundreds of millions to billions of euro — with multiple failed attempts along the way. But what if we could predict how a drug worked ...

A new publication in Nature Reviews Methods Primers provides essential guidance for conducting rigorous systematic reviews on studies with animals and cells. It also highlights the benefits of these reviews, such as improving reproducibility and reducing animal use, and addresses potential pitfalls and recent advancements like review automation. Systematic reviews synthesize existing evidence in a scientific field to answer specific research questions in a structured and unbiased way. With over 100 million animals used in scientific ...

Oysters once formed extensive reefs along much of Europe's coastline – but these complex ecosystems were destroyed over a century ago, new research shows.   Based on documents from the 18th and 19th Centuries, the study reveals that European flat oysters formed large reefs of both living and dead shells, providing a habitat supporting rich biodiversity. Today these oysters are mostly found as scattered individuals – but the researchers found evidence of reefs almost everywhere, from Norway to the Mediterranean, covering at least 1.7 million hectares, an area larger than Northern Ireland. The research was ...