Key points: A system which replicates the womb lining (endometrium) with high biological fidelity has been developed by researchers at the Babraham Institute and used to listen in to the communication that happens between the embryo and endometrium at the crucial stage of development when the embryo implants. Using donated endometrial tissue to seed the model, the approach provides the most advanced culture system for understanding how early-stage human embryos implant into the endometrium to establish ...

For many of us, the holiday season can mean delightful overeating, followed by recriminatory New Year’s resolutions. But eating enough and no more should be on the menu for all of us, according to a recent UBC study. It found that 44 per cent of us would need to change our diets for the world to warm no more than 2 C. Dr. Juan Diego Martinez, who led the research as a doctoral student at UBC’s Institute for Resources, Environment and Sustainability, discusses the study’s findings and the simple dietary changes we can all make. What did you find? Half of us globally and at least 90 per cent of Canadians need to ...

To answer this question: How to make AI truly scalable and reliable for real-time traffic assignment? A research team from KTH Royal Institute of Technology, Monash University, Technical University of Munich, Southeast University, and the University of Electro-Communications has developed a new framework—MARL-OD-DA—that offers a promising answer. The approach redesigns learning agents at the origin–destination (OD) level and utilizes Dirichlet-based continuous actions to achieve stable and high-quality solutions under dynamic travel demand.   The team published their ...

Ride-pooling is widely recognized as a sustainable way to ease congestion, reduce costs and cut emissions, yet adoption remains limited.  When operators act independently, efficiency is low because requests cannot be matched across platforms.  Aggregation platforms seek to improve this by forcing all operators into a permanent coalition, but differences in size, cost and market position make such arrangements unstable.  To address this, researchers from Beihang University and Delft University of Technology developed a multi-level coalition formation game framework that enables coalitions to form dynamically in response to trip requests, allowing flexible cooperation ...

Researchers at Tsinghua University developed PriorFusion, a unified framework that integrates semantic, geometric, and generative shape priors to significantly improve the accuracy and stability of road element perception in autonomous driving systems. The research addresses a long-standing challenge: existing end-to-end perception models often generate irregular shapes, fragmented boundaries, and incomplete road elements in complex urban scenarios.   The team published their study in Communications in Transportation Research on November 18, 2025.   “We design PriorFusion to introduce shape priors into every ...

“This study outlines shifting priorities and translational gaps in aging research and offers a scalable, data-driven alternative to conventional reviews.” BUFFALO, NY — December 23, 2025 — A new research paper was published in Volume 17, Issue 11 of Aging-US on November 25, 2025, titled “A natural language processing–driven map of the aging research landscape.” In this study, Jose Perez-Maletzki from Universidad Europea de Valencia and Universitat de València, together with Jorge Sanz-Ros from Stanford University ...

Researchers at the ArQuS Laboratory of the University of Trieste (Italy) and the National Institute of Optics of the Italian National Research Council (CNR-INO) have achieved the first imaging of individual trapped cold atoms in Italy, introducing techniques that push single-atom detection into new performance regimes. By combining intense, microsecond-scale fluorescence pulses with fast re-cooling, the team demonstrated record-speed, low-loss imaging of individual ytterbium atoms—capturing clear single-atom signals in just a ...

A “standard reference thermoelectric module (SRTEM)*” for objectively measuring thermoelectric module performance has been developed in Korea for the first time. A research team led by Dr. Sang Hyun Park at the Korea Institute of Energy Research (KIER; President Yi, Chang-Keun) developed the world’s second standard reference thermoelectric module, following Japan, and improved its performance by more than 20% compared with existing modules, demonstrating the excellence of Korea’s homegrown technology. * SRTEM (Standard Reference Thermoelectric Module): A reference standard used to check the status ...

Researchers find that diversifying crops and integrating livestock improves farm efficiencies and ecosystem services in the US Midwest. Mathieu Delandmeter, Bruno Basso, and colleagues used a validated crop simulation model to assess 18 management scenarios across 46 million hectares over three decades at high spatial resolution. The authors compared corn monoculture to diverse rotations with cover crops and integrated pasture-cattle systems, looking at each system's productivity, profitability, yield stability, ...

A study conducted during the 2024 French elections finds that information about immigrants’ efforts to overcome poverty and learn French reduces negative beliefs about immigration and modestly decreases opposition to immigration among voters. Amine Sijilmassi and colleagues conducted three studies in France examining whether emphasizing “deservingness” cues—such as immigrants’ motivation to work, efforts to learn French, job-seeking behavior, and children’s upward mobility—could reduce anti-immigration attitudes. In one study, 480 participants rated fictional immigrant profiles more favorably when the profiles exhibited deservingness traits. ...

The distribution of Japanese eels (Anguilla japonica) at the northern edge of the species’ range appears to be shaped by river water temperature, which is influenced by watershed geology and land use. Osamu Kishida and colleagues conducted electrofishing surveys in 105 rivers across southern Hokkaido, Japan, capturing 222 Japanese eels from 52 rivers. The authors used structural equation modeling that incorporated catch per unit effort, environmental variables, and estimates of glass eel recruitment—the number of juvenile eels that enter rivers from the sea, where ...

Electropulsing treatment (EPT) is a state-of-the-art technology for rapidly heating metallic materials. The highly energy-efficient and eco-sufficient process utilizes a pulsed current or ‘electropulse,’ achieving unique effects such as electroplasticity and electropulsing anisotropy. It facilitates fast microstructural evolution in alloys—compared to the conventional furnace heat treatment (FHT) technique—possibly via athermal contributions that go beyond the effects of Joule heating. Recent efforts by scientists to determine these athermal contributions have focused on ...

China has achieved significant advancements in gastroenterology and digestive endoscopy, according to the 2024 national report published in the Chinese Medical Journal. Drawing data from the National Clinical Improvement System (NCIS) and Hospital Quality Monitoring System (HQMS), the study provides a comprehensive overview of care quality and accessibility across 4,620 NCIS and 7,074 HQMS-participating hospitals. In 2023, hospitals nationwide averaged 37.3 gastroenterology beds, 9.6 gastroenterologists, and 6.7 endoscopists per facility. Tertiary hospitals led ...

Over the past decade, colloidal quantum dots (QDs) have emerged as promising materials for next-generation displays due to their tunable emission, high brightness, and compatibility with low-cost solution processing. However, a major challenge is, achieving ultrahigh- resolution patterning without damaging their fragile surface chemistry. Existing methods such as inkjet printing and photolithography-based processes either fall short in resolution or compromise QD performance. To address this, a research team led by Associate Professor Jeongkyun Roh from the Department of Electrical Engineering, Pusan National University, Republic of Korea, has introduced a universal, photoresist-free, and ...

Researchers have used a cutting-edge robotic system capable of synthesising hundreds of metal complexes to develop a possible antibiotic candidate -  offering fresh hope in the global fight against drug-resistant infections. In a study published in Nature Communications, the researchers synthesised over 700 complex metal compounds in just one week. This rapid screening process identified a promising new iridium-based antibiotic candidate that kills bacteria while remaining non-toxic to human cells. As bacteria become increasingly resistant to existing treatments, the world faces a silent pandemic. Over one million people die ...

Patients experience significant changes in gut bacteria at the onset of inflammatory bowel disease (IBD), a new international study has found - offering new hope for earlier diagnosis and future treatments. Published today in Gastroenterology, the study was led by academics from the University of Birmingham and is the first to combine raw microbiome data from multiple studies. The team analysed data from more than 1,700 children and adults across 11 countries who have been recently diagnosed and before starting any treatment. The ...

SEATTLE, WASH. — DECEMBER 23, 2025 — Scientists have engineered a protein able to record the incoming chemical signals of brain cells (as opposed to just their outgoing signals). These whisper-quiet incoming messages are the release of the neurotransmitter glutamate, which plays a critical role in how brain cells communicate with one another but until now has been extremely difficult to capture. Why it matters Understanding the brain’s code: Scientists can now study how neurons compute—how they take thousands of input signals and—based off those—produce an output signal that ...

Memories and learning processes are based on changes in the brain’s neuronal connections and, as a result, in signal transmission between neurons. For the first time, DZNE researchers have observed an associated phenomenon in living brains – specifically in mice. This mechanism concerns the cellular pulse generator for neuronal signals (the “axon initial segment”) and had previously only been documented in cell cultures and in brain samples. A team led by neuroscientist Jan Gründemann reports on this in the ...

NEW YORK, NY -- Dec. 23, 2025 -- Using marijuana just once or twice a month was associated with worse school performance and emotional distress for teens, according to a large national study of adolescents led by Ryan Sultán, an assistant professor of clinical psychiatry at Columbia University Vagelos College of Physicians and Surgeons. The more frequently teens used cannabis, the more likely they were to report emotional distress and other social and academic problems.  “While previous studies have focused on the effects of frequent ...

Healthy, sustainable school meals could cut undernourishment, reduce diet-related deaths and significantly lower environmental impacts, according to a new modelling study led by a UCL (University College London) researcher. The study is part of a new collection of papers published in Lancet Planetary Health by members of the Research Consortium for School Health and Nutrition – the independent research initiative of the School Meals Coalition. The papers find that well-designed school meal programmes could be a strategic investment in a healthier, more sustainable future. Drawing together modelling, case studies and evidence from multiple disciplines, ...

A major review of prior research has found no evidence that menopause hormone therapy either increases or decreases dementia risk in post-menopausal women, in a new study led by University College London (UCL) researchers. The findings, commissioned by the World Health Organisation (WHO) and published in The Lancet Healthy Longevity, add much-needed clarity to a hotly-debated topic, and reinforce current clinical guidance that menopause hormone therapy, also called hormone replacement therapy or HRT, should be guided by perceived benefits and risks and not for dementia prevention. The new systematic review and meta-analysis is the most comprehensive and rigorous ...

After traumatic brain injury (TBI), some patients may recover completely, while others retain severe disabilities. Accurately evaluating prognosis is challenging in patients on life-sustaining thery. Though resting-state functional MRI (rs-fMRI) can assess neurological activity shortly after brain injury, it is unknown whether communication across brain regions at this early juncture predicts long-term recovery. Investigators from Mass General Brigham and collaborators in the U.S. and Europe analyzed data from three prospective cohorts comprising 97 patients who underwent rs-fMRI after injury, finding that early communication between three pairs ...

The researchers have succeeded in tracing two classic hallmarks of cancer – the evasion of apoptosis (a form of programmed cell death) and the dysregulation of energy metabolism – back to a common molecular mechanism. The study focuses on the protein MCL1, which is strongly overexpressed in many tumor types and has previously been considered primarily an anti-apoptotic factor of the Bcl-2 protein family. The Dresden researchers now show that MCL1 directly influences the central metabolic regulator mTOR and thus controls the bioenergetics of cancer ...

About 300 years ago, Swedish naturalist Carl Linnaeus set out on a bold quest: to identify and name every living organism on Earth. Now celebrated as the father of modern taxonomy, he developed the binomial naming system and described more than 10,000 species of plants and animals. Since his time, scientists have continued to describe new species in the quest to uncover Earth's biodiversity. According to a new University of Arizona-led study published in Science Advances, scientists are discovering species quicker than ever before, with more than 16,000 new species discovered each year. ...

Embargoed for release until 5:00 p.m. ET on Monday 22 December 2025    Follow @Annalsofim on X, Facebook, Instagram, Bluesky, and Linkedin              Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization ...