LA JOLLA, CA—When you take a drug, where in your body does it actually go? For most medications, scientists can make only educated guesses about the answer to this question. Traditional methods can measure the concentration of a drug in an organ like the liver, but they can’t pinpoint exactly which cells the drug binds to—or reveal unexpected places where the drug takes action. “Usually we have almost no idea, after a drug enters the body, how it actually interacts with its target,” says Professor Li Ye, the N. Paul Whittier Endowed Chair at Scripps Research and a Howard Hughes Medical Institute investigator. “It’s been a ...

EMBARGOED until Monday, December 22, 2025, at 12:00 P.M. PST SANTA CRUZ, Calif. – Researchers at the University of California, Santa Cruz, have already leveraged the vast troves of geolocation data from vessel-tracking systems to pinpoint where whales and other large marine species are endangered by ship traffic and industrial fishing. Now, in a new study led by Heather Welch at UC Santa Cruz's Institute of Marine Sciences, researchers show how the geolocation data generated by satellites for the global ...

Embargoed Until: December 22, 2025 at 3:00 PM U.S. Eastern time. Study provided upon request EMBARGOED: New Evidence Points to Potential Treatment for Vascular Dementia A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides novel insights into the mechanisms that regulate brain blood flow and highlight a potential therapeutic strategy to correct vascular dysfunction. Their preclinical findings, published December 22 in Proceedings of the National Academy of Sciences, suggest that adding a missing phospholipid back into a person’s ...

LA JOLLA, CA—A new study by Scripps Research reveals that alcohol dependence disrupts two signaling pathways in a stress-related part of the brain—and offers insights on developing drugs to treat this condition. The research, conducted in animal models and published in Frontiers in Pharmacology on November 26, 2025, helps explain why people with alcohol use disorder (AUD) struggle to stay sober, especially under stress. "We think that alcohol dependence changes these systems, and that's why individuals are prone to seek out alcohol even if they've gone without it for some ...

Over half of Americans believe tech companies should take action to restrict extremely violent content on their platforms, according to Pew data, yet even trained content moderators consistently disagree in their decisions for how to classify hate speech and offensive images. A new study by Annenberg School for Communication Professor Damon Centola and Stanford University Assistant Professor Douglas Guilbeault (Ph.D. ‘20) has identified a key mechanism to aid content moderators, even those across the political aisle, in reaching consensus on classifying controversial material online: working in teams. In an experiment involving over 600 participants ...

(MEMPHIS, Tenn. – December 22, 2025) G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to transmit signals inside the cell. These signals are transmitted primarily through the activation of G proteins, which produce various physiological effects. Due to their important role in growth, metabolism and neurotransmitter signaling, GPCRs represent outstanding drug targets, including one-third of Food and Drug Administration (FDA) approved drugs. However, a lack of understanding about how different ligands that bind the same GPCR can cause varying ...

In the past year, two separate experiments in two different materials captured the same confounding scenario: the coexistence of superconductivity and magnetism. Scientists had assumed that these two quantum states are mutually exclusive; the presence of one should inherently destroy the other.  Now, theoretical physicists at MIT have an explanation for how this Jekyll-and-Hyde duality could emerge. In a paper appearing today in the Proceedings of the National Academy of Sciences, the team proposes that under certain conditions, a magnetic material’s electrons could splinter into fractions of themselves to form quasiparticles known as “anyons.” ...

Despite the fact that the U.S. is home to over 15 million military veterans that make up more than 6% of the total workforce, little research is available about their quantitative impact on the economy.  “I noticed after publishing a couple papers and a book chapter that no one has done a review in this area,” explained the University of Cincinnati’s Daniel Peat, PhD, who specializes in military-affected individuals in business management. “That’s usually a sign that there’s a bit of an immaturity in the field itself.” That’s why he and his team published a new research ...

Vortex phenomena are widespread in nature, from typhoons to ocean currents. In the field of optics, vortex beams, which carry orbital angular momentum, have spiral wavefronts and ring-shaped intensity distributions, showing great potential in quantum information processing, particle manipulation, and other applications. However, the ring-shaped intensity and orbital angular momentum of traditional vortex beams are influenced by the topological charge, limiting their use in scenarios involving multiple beam superposition. The advent of perfect vortex beams has addressed this issue their ring-shaped ...

In the context of the continuous development of high-speed optical communication, on-chip optical information processing is regarded as the core of next-generation computing architectures. Integrated photonics, as the cornerstone of this transformation, will strongly drive the advent of the all-optical computing era. Among various photonic integration platforms, lithium niobate (LiNbO₃, LN) is hailed as the "optical silicon" due to its unique nonlinear optical properties. However, traditional LN waveguides are limited by low refractive index contrast, weak optical field confinement, and large device size, making it difficult to achieve high integration and limiting further applications. ...

When people learn that surrounding visuals and sounds may signify specific choice outcomes, these cues can become guides for decision making. For people with compulsive disorders, addictions, or anxiety, the associations between cues and choice outcomes can eventually promote poor decisions as they come to favor or avoid cues in a more biased manner. Giuseppe di Pellegrino, from the University of Bologna, led a study to explore associative ...

Every cell depends on proteins to function and stay healthy. These proteins are made inside the cell from amino acids but cannot simply accumulate inside the cell forever. Once they have done their job or become damaged, the cell needs to clear them out. Cells do this by breaking proteins down and recycling them, a process summarily referred to as “protein removal”. But this ongoing and vital "dance" of protein making and protein removal takes energy and coordination, and the cell must constantly strike the ...

About The Study: Compared with maternal vaccination with the respiratory syncytial virus (RSV) prefusion F protein (RSVpreF) vaccine, passive infant immunization with nirsevimab was associated with lower risks of RSV-related hospitalization and severe outcomes. These findings reflect the first RSV season with use of these immunization strategies in mainland France; their use should be reevaluated in future studies. Corresponding Author: To contact the corresponding author, Marie-Joelle Jabagi, PharmD, PhD, email marie-joelle.jabagi@ansm.sante.fr. To access the embargoed study: Visit ...

About The Study: According to the results of this population-based surveillance study, during 2024-2025, both maternal respiratory syncytial virus (RSV) vaccine and nirsevimab were estimated to be effective at protecting infants from RSV-associated hospitalizations in their first RSV season, and RSV-associated hospitalization rates in newborns and infants ages 0 to 11 months were reduced by up to half compared to seasons before these products were introduced.  Corresponding Author: To contact the corresponding author, Heidi L. Moline, MD, MPH, email ick6@cdc.gov. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2025.5778) Editor’s ...

ITHACA, N.Y. -- After ChatGPT became available to the public in late 2022, scientists began talking among themselves about how much more productive they were using these new artificial intelligence tools, while scientific journal editors complained of an influx of well-written papers with little scientific value. These anecdotal conversations represent a real shift in how scientists are writing up their work, according to a new study by Cornell researchers. They showed that using large language models (LLMs) like ChatGPT boosts paper production, especially for non-native English speakers. But the overall increase in AI-written papers is making it harder for many people – from ...

Forests and plantations play a vital role in carbon sequestration, yet accurately monitoring their growth remains costly and labor-intensive. Researchers have developed an advanced artificial intelligence (AI) model that produces high-resolution canopy height maps using only standard RGB imagery. By integrating a large vision foundation model with self-supervised enhancement, this method achieves near-lidar accuracy, enabling precise, low-cost monitoring of forest biomass and carbon storage over large areas. Monitoring forest canopy structure is essential for understanding global carbon cycles, assessing tree growth, and managing plantation resources. Traditional lidar ...

Key Takeaways: Inherited retinal degenerations (IRDs) were found by Mass Eye and Ear researchers to occur in only 28% of people who carry IRD genetic variants. Findings challenge conventional models of rare disease genetics, with implications for genetic testing and treatment.   A new study challenges what’s long been assumed about genetic variants thought to always cause inherited blindness. Investigators from Mass General Brigham used large public biobanks to determine that genes thought to cause inherited retinal degenerations (IRDs) with 100% certainty only led to disease in fewer than 30% of cases.  ...

CAMBRIDGE, MA - One of the biggest risk factors for developing liver cancer is a high-fat diet. A new study from MIT reveals how a fatty diet rewires liver cells and makes them more prone to becoming cancerous. The researchers found that in response to a high-fat diet, mature hepatocytes in the liver revert to an immature, stem-cell-like state. This helps them to survive the stressful conditions created by the high-fat diet, but in the long term, it makes them more likely to become cancerous. “If ...

About The Study: In this cohort study of the U.S. Medicare population, specific fine particulate matter (PM2.5) components (sulfate, elemental carbon, and soil dust) were associated with increased depression risk in older adults, particularly those with preexisting comorbidities. These findings underscore the importance of targeted regulation of harmful PM2.5 components to protect vulnerable populations. Corresponding Author: To contact the corresponding author, Yang Liu, PhD, email yang.liu@emory.edu. To access the embargoed study: Visit our For ...

About The Study: This cohort study found that the U.S. health care system imposes cost burdens on a larger share of the population than suggested by cross-sectional analyses, and most individuals in the U.S. will experience such burdens during their lifetimes. Policies that reduce out-of-pocket costs might improve the well-being of individuals in the U.S.  Corresponding Author: To contact the corresponding author, Adam Gaffney, MD, MPH, email agaffney@challiance.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamainternmed.2025.6948) Editor’s Note: Please see the article for additional ...

About The Study: In this meta-analysis, nirsevimab was associated with reduced lower respiratory tract infection-related hospitalizations and emergency department visits in infants and young children. These findings support nirsevimab’s potential to reduce respiratory-related morbidity in young children and health care utilization.  Corresponding Author: To contact the corresponding author, Seyed M. Moghadas, PhD, email moghadas@yorku.ca. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamapediatrics.2025.5280) Editor’s ...

Abstract: A research group led by Professor Hiroaki SUZUKI and Takeshi HAYAKAWA from the Faculty of Science and Engineering at Chuo University, graduate student Zhitai HUANG, graduate students Kanji KANEKO (at the time) and Ryotaro YONEYAMA (at the time), together with Specially Appointed Assistant Professor Tomoya MARUYAMA from the Research Center for Autonomous Systems Materialogy (ASMat), Institute of Integrated Research (IIR), Institute of Science Tokyo, and Professor Masahiro TAKINOUE from ...

A research team at the Nano Life Science Institute (WPI-NanoLSI) and the Faculty of Medicine at Kanazawa University has developed a new class of engineered extracellular vesicles (EVs) capable of inducing antigen-specific regulatory T cells (Tregs), the immune cells that play a central role in suppressing excessive immune responses. The findings, now published in Drug Delivery, may pave the way for next-generation therapies for autoimmune and allergic diseases, where unwanted immune activation must ...

(Toronto, December 22, 2025) A new study published by JMIR Serious Games reports that popular video games, such as the Super Mario Bros. and Yoshi games, may offer meaningful emotional benefits for young adults. The research, titled “Super Mario Bros. and Yoshi Games’ Affordance of Childlike Wonder and Reduced Burnout Risk in Young Adults: In-Depth Mixed Methods Cross-Sectional Study,” found that these lighthearted, familiar games can spark a sense of childlike wonder that boosts overall happiness, which in turn reduces burnout risk. The research team conducted in-depth interviews with university ...

Deepest Gas Hydrate Cold Seep ever discovered in the Arctic: international research team unveils Freya Hydrate Mounds at 3,640 m Depth.   A multinational scientific team led by UiT has uncovered the deepest known gas hydrate cold seep on the planet.  The discovery was made during the Ocean Census Arctic Deep – EXTREME24 expedition and reveals a previously unknown ecosystem thriving at 3,640 metres on the Molloy Ridge in the Greenland Sea. The groundbreaking findings regarding the Freya Hydrate Mounds, which hold scientific significance and implications for Arctic ...