‘One and done’: A single shot at birth may shield children from HIV for years, study finds
2025-07-30
A new study in Nature shows that delivering a single injection of gene therapy at birth may offer years-long protection against HIV, tapping into a critical window in early life that could reshape the fight against pediatric infections in high-risk regions.
This study is among the first to show that the first weeks of life, when the immune system is naturally more tolerant, may be the optimal window for delivering gene therapies that would otherwise be rejected at older ages.
“Nearly ...
New method for detecting neutrinos
2025-07-30
Neutrinos are extremely elusive elementary particles. Day and night, 60 billion of them stream from the Sun through every square centimeter of the Earth every second, which is transparent to them. After the first theoretical prediction of their existence, decades passed before they were actually detected. These experiments are usually extremely large to account for the very weak interaction of neutrinos with matter. Scientists at the Max Planck Institute for Nuclear Physics (MPIK) in Heidelberg have now succeeded in detecting antineutrinos from the reactor of a nuclear power plant using the CONUS+ experiment, with a detector mass of just ...
Respiratory viruses can wake up breast cancer cells in lungs
2025-07-30
JULY 30, 2025—Researchers at the University of Colorado Anschutz Medical Campus, Montefiore Einstein Comprehensive Cancer Center (MECCC), and Utrecht University have found the first direct evidence that common respiratory infections, including COVID-19 and influenza, can awaken dormant breast cancer cells that have spread to the lungs, setting the stage for new metastatic tumors. The findings published today in Nature, obtained in mice, were supported by research showing increases in death and in metastatic lung disease among cancer survivors infected with SARS-CoV-2, the virus that causes COVID-19.
“Our findings indicate that individuals with a history of ...
Stroke center certification and within-hospital racial disparities in treatment
2025-07-30
About The Study: In this cohort study, the likelihood of receiving stroke treatments increased for white but not Black patients within the same facility after the center was stroke certified as a primary stroke center or a thrombectomy-capable or comprehensive stroke center. These within-hospital racial differences serve as sobering evidence that racial disparities in stroke care persist despite increased access to care.
Corresponding Author: To contact the corresponding author, Renee Y. Hsia, MD, MSc, email renee.hsia@ucsf.edu.
To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/
(doi:10.1001/jamanetworkopen.2025.24027)
Editor’s ...
Mortality among surgeons in the United States
2025-07-30
About The Study: Although nonsurgeon physicians have lower mortality rates than other highly educated professionals, this mortality benefit does not extend to surgeons. Because surgeons and nonsurgeon physicians have similar levels of health care knowledge and resources, higher mortality rates among surgeons might reflect differences related to work environment, professional demands, and lifestyle. The results of this study indicate that several causes of death (e.g., motor vehicle collisions), disproportionately affect surgeons, aligning ...
Carbon 'offsets' aren't working. Here's a way to improve nature-based climate solutions
2025-07-30
A lot of the climate-altering carbon pollution we humans release into the atmosphere by burning fossil fuels gets drawn into Earth’s oceans and landscapes through natural processes, mostly through photosynthesis as plants turn atmospheric carbon dioxide into biomass.
Efforts to slow the climate crisis have long sought to harness nature, often through carbon “offsets,” aimed at bolstering forests, wetlands, and agriculture, but have generally had only marginal success so far.
A new approach: contributions ...
Preserving and promoting clinical trial representativeness
2025-07-30
About The Study: This review synthesizes the latest policies and initiatives concerning representation in clinical research and provides a strategic framework to ensure scientific validity of clinical trials by operationalizing broad representation at all levels. A coordinated approach among stakeholders is needed to address the scientific value of trial representation of the intended use population.
Corresponding Author: To contact the corresponding author, Roxana Mehran, MD, email roxana.mehran@mountsinai.org.
To access ...
Study reveals mixed impact of state e-cigarette flavor bans on tobacco use
2025-07-30
A new study by investigators from Mass General Brigham examined the effects of policies banning flavored e-cigarettes on adults and young people. Investigators found that e-cigarette use significantly declined among young adults and adults in states that had enacted flavor bans relative to states that did not. However, declines in cigarette smoking also slowed in those states with flavor bans relative to other states—a potential unintended consequence of the bans. Results are published in JAMA Network Open.
“Both ...
McMaster research offers promising new treatment for liver cancer
2025-07-30
Liver cancer cells thrive on fat, posing a serious risk of cancer diagnosis for millions of people living with fatty liver disease. But researchers at McMaster University in collaboration with Espervita Therapeutics have developed a promising new treatment that helps the immune system attack and destroy these tumours.
The discovery, detailed in a study published in Nature on July 30, 2025, opens new possibilities for slowing tumour growth and empowering the body’s natural defences. This is particularly important, as current treatments for ...
Most US adults have hearts older than their actual age. How old is yours?
2025-07-30
CHICAGO --- Most U.S. adults have a “heart age” several years older than their chronological age — sometimes by more than a decade. And that gap is wider among men and among those with lower incomes or education or who identify as Black or Hispanic, according to a new study led by Northwestern Medicine.
As part of the study, the Northwestern scientists created a free online tool that calculates a person’s “heart age” based on their risk for cardiovascular disease, using routine health data such as blood pressure, cholesterol levels and whether ...
JMIR Biomedical engineering invites submissions on voice phenotyping and vocal biomarkers
2025-07-30
(Toronto, July 30, 2025) JMIR Publications invites submissions to a new theme issue titled “Voice Phenotyping and Vocal Biomarkers” in its open access journal JMIR Biomedical Engineering. The premier, peer-reviewed journal is indexed in PubMed, PubMed Central, Scopus, DOAJ, Sherpa/Romeo, and EBSCO/EBSCO Essentials.
This Call for Papers is seeking high-quality submissions for a new e-collection on a leading-edge field that uses voice and speech analysis to advance the detection, monitoring, and treatment of health conditions.
This e-collection focuses on acoustic and ...
The metabolic dialogue between intratumoral microbes and cancer: implications for immunotherapy
2025-07-30
The tumor microenvironment (TME) represents a highly complex system that encompasses cellular components (such as cancer cells, stromal cells, and immune cells) and non-cellular components (such as blood vessels and signaling molecules)[1-3]. These diverse components engage in complex interactions with tumor cells and undergo dynamic changes during tumor progression. Specifically, intratumoral microbial metabolites play an important role on the TME. The metabolic products of these microorganisms encompass a range of bioactive molecules, including lactate, amino acids, short-chain fatty acids (SCFAs), bile acids, trimethylamine N-oxide, and inosine. These metabolites, ...
Demographic data supporting FDA authorization of AI devices for Alzheimer disease and related dementias
2025-07-30
About The Study: Transparency of evidence supporting Food and Drug Administration (FDA) authorization of artificial intelligence (AI)- and machine learning -based devices for Alzheimer disease and related dementias was limited, precluding effective evaluation of training and validation dataset representativeness. Disease status (i.e., dementia type and distribution), age, and sex were reported for fewer than half of devices, while race and ethnicity data were rarely disclosed, raising uncertainty about real-world generalizability and clinical accuracy in intended populations.
Corresponding Author: To contact the corresponding ...
How the common fungus Candida albicans colonizes the gut
2025-07-30
About 80% of people have the fungus Candida albicans in their gut. Although most of the time it persists unnoticed for years causing no health problems, C. albicans can turn into a dangerous microbe that causes serious diseases in many organs, including the urinary tract, lungs and brain. Understanding how this fungus colonizes the gut is key to preventing it from becoming harmful.
Working with a mouse model, researchers at Baylor College of Medicine and international collaborators have discovered unexpected factors that help C. albicans ...
How are coastal New Jersey communities communicating hazards of climate change?
2025-07-30
Recent climate-related crises — from severe storms and flooding to extreme heat — have raised new questions about how local governments communicate the risk of these crises and what they are doing to keep their citizens safe. To better understand what this communication looks like at local level, and the factors that may be shaping it, researchers from Drexel University analyzed climate resilience planning information available on the public-facing websites of 24 coastal communities in New Jersey that are contending with the effects of sea level rise. Their report, recently published in the Journal of Extreme Events, ...
AI-based breast cancer risk technology receives FDA Breakthrough Device designation
2025-07-30
A new technology that harnesses AI to analyze mammograms and improve the accuracy of predicting a woman’s personalized five-year risk of developing breast cancer has received Breakthrough Device designation from the Food and Drug Administration (FDA). Developed by researchers at Washington University School of Medicine in St. Louis, the software has been licensed to Prognosia Inc., a WashU startup company.
The system analyzes mammograms to produce a risk score estimating the likelihood that a woman will develop breast cancer over the next five years. The technology is ...
Young men with passive approach to news tend to believe medical misinformation
2025-07-30
True or false?
“It is safe to take an over-the-counter medicine to help you sleep, even if you are drunk on alcohol.”
“Driving while high on THC (cannabis) is safe.”
“Using psychedelics is safe for everyone.”
None of those statements is true. But young men who take a passive approach to news and information—consuming whatever flows over their social media transoms—were likely to believe them in a national survey conducted by Washington State ...
Announcing Zuber Lawler as a Sponsor of ARDD 2025
2025-07-30
The University of Copenhagen is excited to announce Zuber Lawler as a Sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online.
“Zuber Lawler demonstrates meticulous attention to detail with a client-first mentality… They offer personalized care from highly intelligent and creative counsel… ...
Is this what 2,500-year-old honey looks like?
2025-07-30
Decades ago, archaeologists discovered a sticky substance in a copper jar in an ancient Greek shrine. And until recently, the identity of the residue was still murky — is it a mixture of fats, oils and beeswax or something else? Researchers publishing in the Journal of the American Chemical Society have reanalyzed samples of the residue using modern analytical techniques and determined that it’s likely the remains of ancient honey — a conclusion previous analyses rejected.
Honey was an important substance in the ancient world, sometimes left in shrines as offerings ...
Economic evaluation of wastewater surveillance for COVID-19 testing in long-term care settings
2025-07-30
The COVID-19 pandemic has placed enormous pressure on healthcare systems and economies around the world, with particularly severe impacts on vulnerable groups like residents of long-term care facilities (LTCFs). One key lesson from the pandemic is that early detection and treatment can lower hospitalization and death rates while also cutting medical costs. Wastewater surveillance at treatment plants (WSTPs) has emerged as a low-cost and innovative method to detect outbreaks early. Many developed countries have adopted this approach, ...
Announcing Deep Origin as a sponsor of ARDD 2025
2025-07-30
The University of Copenhagen is excited to announce Deep Origin as the latest tier 3 sponsor of the 12th Aging Research & Drug Discovery Meeting, the world's largest conference on aging research in the biopharmaceutical industry that will transpire on August 25 - August 29, 2025 on-site at the Ceremonial Hall, University of Copenhagen, and online.
Deep Origin is building hybrid mechanistic, physics and AI-based models that help researchers design, test, and filter therapeutics in silico – particularly for challenging disease areas such as aging. ...
Cancer cells ‘power up’ when literally pressed to the limit
2025-07-30
Cancer cells mount an instant, energy‑rich response to being physically squeezed, according to a study published in the journal Nature Communications. The surge of energy is the first reported instance of a defensive mechanism which helps the cells repair DNA damage and survive the crowded environments of the human body.
The findings help explain how cancer cells survive complex mechanical gauntlets like crawling through a tumour microenvironment, sliding into porous blood vessels or enduring the battering of the bloodstream. The discovery of the ...
Huge hidden flood bursts through the Greenland ice sheet surface
2025-07-30
A huge flood triggered by the rapid draining of a lake beneath the Greenland ice sheet occurred with such force that it fractured the ice above and burst out across its surface.
This phenomenon, observed for the first time in Greenland and detailed in research published today in the journal Nature Geoscience, sheds new light on the destructive potential of meltwater stored beneath the ice sheet.
It reveals how, under extreme conditions, water flooding underneath the ice can force its way upwards through the ice and escape at the ice sheet surface.
This phenomenon is not considered by numerical models ...
The brain shapes what we feel in real time
2025-07-30
The cerebral cortex processes sensory information via a complex network of neural connections. How are these signals modulated to refine perception? A team from the University of Geneva (UNIGE) has identified a mechanism by which certain thalamic projections target neurons and modify their excitability. This work, published in Nature Communications, reveals a previously unknown form of communication between two regions of the brain, the thalamus and the somatosensory cortex. It could explain why the same sensory stimulus does not always elicit the same sensation ...
New study confirms post-pandemic surge in gut-brain disorders
2025-07-30
Bethesda, MD (July 29, 2025) — A new international study confirmed a significant post-pandemic rise in disorders of gut-brain interaction, including irritable bowel syndrome (IBS) and functional dyspepsia, according to the paper published in Clinical Gastroenterology and Hepatology.
Building on prior research, investigators used Rome Foundation diagnostic tools to analyze nationally representative samples from both 2017 and 2023 — offering the first direct, population-level comparison of disorders of gut-brain interaction prevalence before and after the COVID-19 pandemic.
Key findings:
Overall disorders of gut-brain ...
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