The surprising results of a decade-long investigation by Alessandro Vezzosi and Agnese Sabato provide a strong basis for advancing a project researching Leonardo da Vinci's DNA. Their extensive study, published by the journal "Human Evolution" (Pontecorboli Editore, Florence), documents with new certainty the continuous male line, from father to son, of the Da Vinci family (later Vinci), from progenitor Michele (born 1331) to grandson Leonardo (6th generation, born 1452) through to today -- 21 generations in all, including five family branches -- and identifies 14 living descendants. The work fills gaps and corrects errors in previous genealogical research into Leonardo's family, while ...

A new study shows how urbanisation has influenced anthropogenic CO2 and air pollutant emissions across all world regions, by making use of the latest developments in the Emissions Database for Global Atmospheric Research (EDGAR, https://edgar.jrc.ec.europa.eu/) developed by the Joint Research Centre of the European Commission. The results show that by 2015 urban centres were the source of a third of global anthropogenic greenhouse gases, and the majority of air pollutant emissions. The authors, from institutions in France and Italy, used the EDGAR database to provide a country-to-global ...

Researchers at Karolinska Institutet in Sweden publish new findings in the journal Cancer Discovery showing how pharmacological activation of the protein p53 boosts the immune response against tumours. The results can be of significance to the development of new combination therapies that will give more cancer patients access to immunotherapy. Given its ability to react to damage to cellular DNA and the key part it is thought to play in preventing tumour growth, the protein p53 has been dubbed the "guardian of the genome". Half of all tumours have mutations in the gene that codes for the protein, and in many other tumours, p53 is disabled by another protein, MDM2. It has long been known ...

Scientists have taken the first steps in developing a new method of identifying the movements of criminals using chemical analysis of soil and dust found on equipment, clothing and cars. The locating system allows police or security services to match soil remnants found on personal items to regional soil samples, to either implicate or eliminate presence at a crime scene. The work is presented as a Keynote Lecture at the Goldschmidt Geochemistry Conference, after recent publication. Dr Patrice de Caritat, Principal Research Scientist at Geoscience Australia, Australia's public sector geoscience organisation, said: "We've ...

A unique study of ancient diamonds has shown that the basic chemical composition of the Earth's atmosphere which makes it suitable for life's explosion of diversity was laid down at least 2.7 billion years ago. Volatile gases conserved in diamonds found in ancient rocks were present in similar proportions to those found in today's mantle, which in turn indicates that there has been no fundamental change in the proportions of volatiles in the atmosphere over the last few billion years. This shows that one of the basic conditions necessary to support life, the presence of life-giving elements in sufficient quantity, appeared soon after Earth formed, and has remained fairly constant ever since. Presenting the work at the Goldschmidt ...

Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. 1. Infusion centers associated with substantially better outcomes than the ER for patients with acute pain events and sickle cell disease Abstract: https://www.acpjournals.org/doi/10.7326/M20-7171 Editorial: https://www.acpjournals.org/doi/10.7326/M21-2650 Summary: ...

LAWRENCE -- A new paper from a lead author based at the University of Kansas finds wetlands constructed along waterways are the most cost-effective way to reduce nitrate and sediment loads in large streams and rivers. Rather than focusing on individual farms, the research suggests conservation efforts using wetlands should be implemented at the watershed scale. The paper, just published in the Proceedings of the National Academy of Sciences, relied on computer modeling to examine the Le Sueur River Basin in southern Minnesota, a watershed subject to runoff from intense agricultural production of corn and soybeans -- crops characteristic of the entire ...

In the movie "A Fish Called Wanda", the villain Otto effortlessly gobbles up all the occupants of Ken`s fish tank. Reality, however, is more daunting. At least one unfortunate fan who re-enacted this scene was hospitalized with a fish stuck in the throat. At the same time this also was a painful lesson in ichthyology (the scientific study of fishes), namely that the defense of some fishes consists of needle-sharp fin spines. Two types of fin elements Indeed, many fish species possess two types of fin elements, "ordinary" soft fin rays, which are blunt and flexible and primarily serve locomotion, and fin spines, which are sharp and heavily ossified. As fin spines serve the ...

For 400 million years, shark-like fishes have prowled the oceans as predators, but now humans kill 100 million sharks per year, radically disrupting ocean food chains. Based on microscopic shark scales found on fossil- and modern coral reefs in Caribbean Panama, Smithsonian scientists reveal the changing roles of sharks during the last 7000 years, both before and after sharks in this region were hunted. They hope this new use for dermal denticles will provide context for innovative reef conservation strategies. Microscopic scales covering a shark's body--dermal ...

A study published the week of July 5 in the Proceedings of the National Academy of Sciences led by Michael Moore at Washington University in St. Louis finds that dragonfly males have consistently evolved less breeding coloration in regions with hotter climates. "Our study shows that the wing pigmentation of dragonfly males evolves so consistently in response to the climate that it's among the most predictable evolutionary responses ever observed for a mating-related trait," said Moore, who is a postdoctoral fellow with the Living Earth Collaborative at Washington University. "This work reveals that mating-related traits can be just as important to how organisms ...

Scientists recently made news by using fossil shark scales to reconstruct shark communities from millions of years ago. At the same time, an international team of researchers led by UC Santa Barbara ecologist Erin Dillon applied the technique to the more recent past. Human activities have caused shark populations to plummet worldwide since records began in the mid-20th century. However, the scientists were concerned that these baseline data may, themselves, reflect shark communities that had already experienced significant declines. Dillon compared the abundance and variety of shark scales from a Panamanian coral reef 7,000 years ago to those in reef sediments ...

A vast seabird colony on Ascension Island creates a "halo" in which fewer fish live, new research shows. Ascension, a UK Overseas Territory, is home to tens of thousands of seabirds - of various species - whose prey incudes flying fish. The new study, by the University of Exeter and the Ascension Island Government, finds reduced flying fish numbers up to 150km (more than 90 miles) from the island - which could only be explained by the foraging of seabirds. The findings - which provide rare evidence for a long-standing theory first proposed at Ascension - show how food-limited seabird populations naturally are, and why they are often so sensitive to competition with human fishers. ...

Nanomaterials found in consumer and health-care products can pass from the bloodstream to the brain side of a blood-brain barrier model with varying ease depending on their shape - creating potential neurological impacts that could be both positive and negative, a new study reveals. Scientists found that metal-based nanomaterials such as silver and zinc oxide can cross an in vitro model of the 'blood brain barrier' (BBB) as both particles and dissolved ions - adversely affecting the health of astrocyte cells, which control neurological responses. But the researchers also believe that their discovery will help to design safer nanomaterials and could open ...

Like female voles, connections between oxytocin neurons in the hypothalamus and dopamine neurons in reward areas drive parental behaviors in male voles, according to new research published in JNeurosci. Motherhood receives most of the attention in the research world, yet in 5% of mammals -- including humans -- fathers provide care, too. The "love hormone" oxytocin plays a role in paternal care, but the exact neural pathways underlying the behavior were not known. He et al. measured the neural activity of vole fathers while they interacted with their offspring. Oxytocin neurons connecting the hypothalamus to a reward area fired when the fathers cared for their offspring. ...

The psychedelic drug psilocybin, a naturally occurring compound found in some mushrooms, has been studied as a potential treatment for depression for years. But exactly how it works in the brain and how long beneficial results might last is still unclear. In a new study, Yale researchers show that a single dose of psilocybin given to mice prompted an immediate and long-lasting increase in connections between neurons. The findings are published July 5 in the journal Neuron. "We not only saw a 10% increase in the number of neuronal connections, but also they were on average about 10% larger, so the connections were stronger as well," said Yale's Alex Kwan, associate professor of psychiatry and of neuroscience and senior author of the paper. Previous ...

A new collaborative research led by researchers from the National Institute for Environmental Studies, Potsdam Institute for Climate Impact Research, Ritsumeikan University, and Kyoto University found that although unlimited irrigation could increase global BECCS potential (via the increase of bioenergy production) by 60-71% by the end of this century, sustainably constrained irrigation would increase it by only 5-6%. The study has been published in Nature Sustainability on July 5. Bioenergy with carbon capture and storage (BECCS) is a process of extracting bioenergy from biomass, ...

"The number of black holes is roughly three times larger than expected from the number of stars in the cluster, and it means that more than 20% of the total cluster mass is made up of black holes. They each have a mass of about 20 times the mass of the Sun, and they formed in supernova explosions at the end of the lives of massive stars, when the cluster was still very young" says Prof Mark Gieles, from the Institute of Cosmos Sciences of the University of Barcelona (ICCUB) and lead author of the paper. Tidal streams are streams of stars that were ejected from disrupting ...

Land plants - plants that live primarily in terrestrial habitats and form vegetation on earth - are anchored to the ground through their roots, and their performance depends on both the belowground soil conditions and the aboveground climate. Plants utilize sunlight to grow through the process of photosynthesis where light energy is converted to chemical energy in chloroplasts, the powerhouses of plant cells. Therefore, the amount and quality of light perceived by chloroplasts through light absorbing pigments, such as chlorophyll, is a defining factor in plant growth and health. ...

MADISON, Wis. -- About 100 additional wolves died over the winter in Wisconsin as a result of the delisting of grey wolves under the Endangered Species Act, alongside the 218 wolves killed by licensed hunters during Wisconsin's first public wolf hunt, according to new research. The combined loss of 313 to 323 wolves represents a decline in the state's wolf population of between 27% and 33% between April 2020 and April 2021. Researchers estimate that a majority of these additional, uncounted deaths are due to something called cryptic poaching, where poachers hide evidence of illegal killings. The findings are the first estimate of Wisconsin's wolf population since the public hunt in February, which ended early after hunters ...

The theory that modern society is too clean, leading to defective immune systems in children, should be swept under the carpet, according to a new study by researchers at UCL and the London School of Hygiene & Tropical Medicine. In medicine, the 'hygiene hypothesis' states that early childhood exposure to particular microorganisms protects against allergic diseases by contributing to the development of the immune system. However, there is a pervading view (public narrative) that Western 21st century society is too hygienic, which means toddlers and children are likely to be less exposed to germs in early life and so become less resistant to allergies. In this paper, published in the Journal of Allergy and Clinical Immunology, researchers point to four significant reasons which, ...

Research published today has demonstrated the viability of 3D-printed tissue scaffolds that harmlessly degrade while promoting tissue regeneration following implantation. The scaffolds showed highly promising tissue-healing performance, including the ability to support cell migration, the 'ingrowth' of tissues, and revascularisation (blood vessel growth). Professor Andrew Dove, from the University of Birmingham's School of Chemistry, led the research group and is the lead author on the paper published in Nature Communications, which characterises the physical properties of the scaffolds, and explains how their 'shape memory' is key to promoting tissue regeneration. ...

Flies have discriminating taste. Like a gourmet perusing a menu, they spend much of their time seeking sweet nutritious calories and avoiding bitter, potentially toxic food. But what happens in their brains when they make these food choices? Yale researchers discovered an interesting way to find out. They tricked them. In a study that could also help illuminate how people make food choices, the researchers gave hungry fruit flies the choice between sweet, nutritious food laced with bitter quinine and a less sweet, but not bitter, food containing fewer calories. Then, using neuroimaging, they tracked neural activity in their brains as they made these tough choices. So which won? Calories or better taste? "It depends on how hungry they are," said Michael Nitabach, professor of ...

Researchers at Uppsala University have discovered lymph node-like structures close to the tumour in brain cancer patients, where immune cells can be activated to attack the tumour. They also found that immunotherapy enhanced the formation of these structures in a mouse model. This discovery suggests new opportunities to regulate the anti-tumour response of the immune system. Glioma is a deadly brain tumour with a dismal prognosis. One reason why brain tumours are very hard to treat is that our immune system, which is designed to detect and destroy foreign ...

Although most Canadians die from predictable causes and have health needs that can be met at home, only 20% of people receive a physician home visit in their last year of life. To help understand the changing care needs of older adults as they age and when they might be nearing the end of their lives, a team of researchers developed the Risk Evaluation for Support: Predictions for Elder-Life in the Community Tool (RESPECT). The calculator, which predicts death within 6 months, is based on data from more than 491 000 community-dwelling older adults who used home care in the 6-year period between 2007 and 2013. "The RESPECT calculator allows families and their loved ...

Oncotarget published "Carcinoma cells that have undergone an epithelial-mesenchymal transition differentiate into endothelial cells and contribute to tumor growth" which reported that the authors investigated whether EMT can confer endothelial attributes upon carcinoma cells, augmenting tumor growth and vascularization. Hypoxic regions, demarcated by HIF-1α staining, exhibited focal areas of E-cadherin loss and elevated levels of vimentin and the EMT-mediator FOXC2. Implantation of MCF-7 cells, co-mixed with human mammary epithelial cells overexpressing the EMT-inducer Snail, markedly ...