A team of melanoma researchers with the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) is honored with the 2023 Paper of the Year distinction by the Journal of Clinical Oncology. The recognition is for the results of the DREAMseq randomized phase 3 clinical trial. DREAMseq (EA6134) showed an optimal treatment sequence for combination therapy in patients with advanced melanoma with a BRAFV600 tumor gene mutation. The treatment sequence beginning with immunotherapy (nivolumab and ipilimumab), followed by targeted therapy (dabrafenib and trametinib) if there was disease progression, resulted ...

Rockville, MD (January 16, 2024) – To educate physicians and other health care professionals on the fundamentals of nutrition, The American Journal of Clinical Nutrition has launched a new article series titled Nutrition for the Clinician. The effort supports the White House National Strategy on Hunger, Nutrition, and Health and its directives to expand nutrition knowledge of health care providers, an effort long supported by the American Society for Nutrition. Nancy Krebs, MD, MS, Professor of Pediatrics, University of Colorado ...

Columbia researchers analyzing images from NASA’s James Webb Space Telescope have found that galaxies in the early universe are often flat and elongated, like breadsticks—and are rarely round, like balls of pizza dough. “Roughly 50 to 80% of the galaxies we studied appear to be flattened in two dimensions,” explained Viraj Pandya, a NASA Hubble Fellow at Columbia University, and the lead author of a new paper slated to appear in The Astrophysical Journal that outlines the findings. “Galaxies that look like long, thin breadsticks seem to be very common in the early universe, which is surprising, since they are uncommon among galaxies ...

Consider a group of new sociology students who are about to dive into a completely new subject. Half of them are fresh out of upper secondary school. They need to settle into student life and get to know other students. They are about to embark on studies in a new field and must learn new ways of acquiring knowledge, regardless of their discipline. They also need to come to grips with concepts such as legitimation, linguistic objectification, internalization and externalization. What on Earth do ...

A new test invented by University of Illinois Chicago researchers allows dentists to screen for the most common form of oral cancer with a simple and familiar tool: the brush.  The diagnostic kit, created and patented by Guy Adami and Dr. Joel Schwartz of the UIC College of Dentistry, uses a small brush to collect cells from potentially cancerous lesions inside the mouth. The sample is then analyzed for genetic signals of oral squamous cell carcinoma, the ninth most prevalent cancer globally.  This new screening method, which is currently seeking commercialization ...

Women who consume higher amounts of protein, especially protein from plant-based sources, develop fewer chronic diseases and are more likely to be healthier overall as they age, according to a study led by researchers at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University and published Jan. 17 in The American Journal of Clinical Nutrition. Analyzing self-reported data from more than 48,000 women, the researchers saw notably less heart disease, cancer, and diabetes, and cognitive and mental health decline, in those who included more protein in their diets from sources such as fruits, ...

Like Indiana Jones, thresher sharks (Alopias spp.) have mastered the art of the whip using their tails. With incredible speed, their long, machete-like tails can slap and stun their prey, allowing them to swallow multiple fish in one fell swoop. Their exceptionally elongated tail, which can often be as long as their entire body, not only makes this particular shark unique, but also a formidable hunter. Thresher shark “tail-whipping” consists of four phases: preparation, strike, wind-down recovery, and prey collection. Overhead tail slaps begin in the preparation phase by lunging ...

Cold, flu and COVID-19 season brings that now-familiar ritual: swab, wait, look at the result. But what if, instead of taking 15 minutes or more, a test could quickly determine whether you have COVID-19 with a glowing chemical? Now, in ACS Central Science, researchers describe a potential COVID-19 test inspired by bioluminescence. Using a molecule found in crustaceans, they have developed a rapid approach that detects SARS-CoV-2 protein comparably to one used in vaccine research. From fireflies ...

Though natural fertilizers made from treated sewage sludge are used to reintroduce nutrients onto agricultural fields, they bring along microplastic pollutants too. And according to a small-scale study published in ACS’ Environmental Science & Technology Letters, more plastic particles get picked up by the wind than once thought. Researchers have discovered that the microplastics are released from fields more easily than similarly sized dust particles, becoming airborne from even a slight breeze. Microplastics, or small bits of plastic less than 5 millimeters long, have appeared everywhere from clouds to heart tissues. And with these plastics’ increasing prevalence in ...

LOS ALAMOS, N.M., Jan. 17, 2024 — New insights from artificial intelligence about permafrost coverage in the Arctic may soon give policy makers and land managers the high-resolution view they need to predict climate-change-driven threats to infrastructure such as oil pipelines, roads and national security facilities. “The Arctic is warming four times faster than the rest of the globe, and permafrost is a component of the Arctic that’s changing really rapidly,” said Evan Thaler, a Chick Keller Postdoctoral Fellow at Los Alamos National Laboratory. Thaler is corresponding ...

Emotions exert a profound influence on human behavior, prompting extensive explorations in the realms of psychology and linguistics. Understanding central emotions also has practical utility since it can help organizations create messages that resonate better with people. For instance, businesses can enhance their connection with their customers, and non-profits can prompt quicker action by skillfully leveraging the salient emotions in humans. Colexification is a phenomenon in which the occurrence of a single word is associated with multiple concepts that share semantic relationships. The analysis of colexification is an innovative linguistic method for ...

Research Highlights: Consistently high scores of perceived stress during adolescence through adulthood may contribute to worse cardiometabolic health including obesity in young adults.. Researchers suggest the adoption of healthy coping strategies for stress management early in life may help prevent cardiometabolic diseases, from heart disease to Type 2 diabetes. Embargoed until 4 a.m. CT/5 a.m. ET Wednesday, January 17, 2024 DALLAS, January 17, 2024 — Young adults who reported higher stress during their teenage years to adulthood were more likely to ...

Over the last decades, air pollution emissions have decreased substantially; however, the magnitude of the change varies by demographics, according to a new study by Columbia University Mailman School of Public Health. The results indicate there are racial/ethnic and socioeconomic disparities in air pollution emissions reductions, particularly in the industry and energy generation sectors. The findings are published in the journal Nature Communications. The research provides a national investigation of air pollution emission ...

New York, January 17, 2024 — In all species, brain function relies on an intricate network of connections that allows neurons to send information back and forth between one another, commanding thought and physical activity. But within those networks a small number of neurons share much stronger connections to one another than all the others. These abnormally strong connections—known as “heavy tailed” based on the shape of their distribution—are thought to play an outsized role in brain function.   Researchers ...

A new study by physicists and neuroscientists from the University of Chicago, Harvard and Yale describes how connectivity among neurons comes about through general principles of networking and self-organization, rather than the biological features of an individual organism. The research, published on January 17, 2024 in Nature Physics, accurately describes neuronal connectivity in a variety of model organisms and could apply to non-biological networks like social interactions as well. “When you’re building simple models to ...

Sensors built with a new manufacturing approach are capable of recording activity deep within the brain from large populations of individual neurons–with a resolution of as few as one or two neurons–in humans as well as a range of animal models, according to a study published in the Jan. 17, 2024 issue of the journal Nature Communications. The research team is led by the Integrated Electronics and Biointerfaces Laboratory (IEBL) at the University of California San Diego.  The approach is unique in several ways. It relies on ultra-thin, flexible and customizable probes, made of clinical-grade materials, and equipped with sensors that can record extremely localized ...

Large-scale genetic analysis has helped researchers uncover the interplay between cancer-driving genetic mutations and inherited genetic variants in a rare type of blood cancer. Researchers from the Wellcome Sanger Institute, the University of Cambridge, and collaborators, combined various comprehensive data sets to understand the impact of both cancer-driving spontaneous mutations and inherited genetic variation on the risk of developing myeloproliferative neoplasms (MPN). The study, published today (17 January) in Nature Genetics, describes how inherited genetic variants can influence whether a spontaneous mutation in a particular ...

When a person has one or more blocked arteries, providers may choose to conduct a minimally invasive procedure known as percutaneous coronary intervention, or PCI.  By inflating a balloon and potentially placing a stent, blood can flow more freely from the heart.  Despite carrying less risk than open surgery, stenting and balloon angioplasty can result in complications like bleeding and kidney injury.  Researchers at Michigan Medicine developed an AI-driven algorithm that accurately predicts death and complications after PCI — which could emerge as a tool ...

A new analysis of trial data on pregnant smokers, led by researchers at Queen Mary University of London, finds that the regular use of nicotine replacement products during pregnancy is not associated with adverse pregnancy events or poor pregnancy outcomes.   The PREP 2 study used data collected from over 1100 pregnant smokers attending 23 hospitals in England and 1 stop-smoking service in Scotland to compare pregnancy outcomes in women who did or did not use nicotine in the form of e-cigarettes (EC) or nicotine patches ...

The pioneering research of Dr Yiliang Ding investigating the structure and function of RNA in living cells has been recognised with a major award.  Yiliang a group leader at the John Innes Centre, is among nine recipients of the 2024 Blavatnik Awards for Young Scientists in the UK, announced today by the Blavatnik Family Foundation and The New York Academy of Sciences.   The awards recognise research that is transforming medicine, technology, and our understanding of the world across three categories: Chemical Sciences, Physical Sciences & Engineering, and ...

Researchers at the University of Basel have built a quantum memory element based on atoms in a tiny glass cell. In the future, such quantum memories could be mass-produced on a wafer. It is hard to imagine our lives without networks such as the internet or mobile phone networks. In the future, similar networks are planned for quantum technologies that will enable the tap-proof transmission of messages using quantum cryptography and make it possible to connect quantum computers to each other. Like their conventional counterparts, such quantum networks require memory elements in which information can be temporarily stored ...

Osaka, Japan – Cytokines are chemical messengers that help the body get rid of invading bacteria and viruses, and control inflammation. The body carefully balances cytokines because they help keep the immune system healthy. However, this balance is upset if the immune system overreacts. A serious infection or a severe burn can unleash a cytokine storm in the body. During the storm—also called cytokine release syndrome (CRS)—the body produces too many cytokines, leading to life-threatening inflammation. Interleukin-6 (IL-6) is a key cytokine in the storm because it helps to drive the inflammation that damages ...

Osaka, Japan – Have you ever wondered what wildlife animals do all day? Documentaries offer a glimpse into their lives, but animals under the watchful eye do not do anything interesting. The true essence of their behaviors remains elusive. Now, researchers from Japan have developed a camera that allows us to capture these behaviors. In a study recently published in PNAS Nexus, researchers from Osaka University have created a small sensor-based data logger (called a bio-logger) that automatically detects and records video of infrequent behaviors in wild seabirds without supervision by researchers. Infrequent behaviors, such as diving into the water for food, can ...

Canada's biggest companies often speak of their plans to be more sustainable, but a new study found corporations aren't fully backing up those commitments.   A team of University of Waterloo researchers concluded that corporate investing in communities fell despite an increase in companies committing to the United Nation's Sustainable Development Goals (SDGs) over the last decade. Researchers investigated the community investment of Canada's 58 leading private-sector companies as a percentage of their net profit after tax to determine whether introducing SDGs created ...

Polyimide (PI) has emerged as a promising organic photocatalyst owing to its distinct advantages of high visible-light response, facile synthesis, molecularly tunable donor-acceptor structure, and excellent physicochemical stability. However, the synthesis of high-quality PI photoelectrode remains a challenge, and photoelectrochemical (PEC) water splitting for PI has been less studied.   A research group of Huiyan Zhang and Sheng Chu from Southeast University prepared PI films by a ...