The virus that gives rise to COVID-19 is the third coronavirus to threaten humanity in the past two decades. It also happens to move more efficiently from person to person than either SARS or MERS did. The first African case of COVID-19 was diagnosed in Egypt in mid-February of 2020. Four weeks later, the first lockdowns began across Africa. Steven Schiff, Brush Chair Professor of Engineering at Penn State, who already had established research partnerships in Uganda, saw an opportunity for his team to apply what they were learning from their ongoing efforts to track and control infectious disease and ...

Ten estuaries on the West Coast of North America have been identified as priority locations for expanding the use of conservation aquaculture in a study led by the Native Olympia Oyster Collaborative and funded by the Science for Nature and People Partnership (SNAPP). SNAPP is a research collaboration supported by the National Center for Ecological Analysis & Synthesis (NCEAS) at UC Santa Barbara. The study, published in Plos One, recommends locations and methods for the strategic expansion of conservation aquaculture to bring back Olympia oyster populations -- both to local estuaries where they have most declined, and into more local restaurants for oyster lovers to dine on. The authors propose using aquaculture in these estuaries -- ...

Even the mundane act of swallowing requires a well-coordinated dance of more than 30 muscles of the mouth. The loss of function of even one of these, due to disease or injury, can be extremely debilitating. For these people, nerve stimulation offers a ray of hope to regain some of their lost oral function. In a new study, researchers at Texas A&M University have delineated the minimum size of electrical currents needed to provide sensation in different parts of the mouth. The researchers said their study is a first but vital step toward building electrical stimulation implants that can restore essential intraoral functions that are lost due to nerve or brain damage. The results of the study are published in the journal ...

Magnetic resonance imaging (MRI) is widely used in medicine to detect, diagnose and treat diseases such as cancer, while relying on experts' interpretation of images. Quantitative MRI, which obtains numerical measurements during the scans, can now potentially offer greater accuracy, repeatability and speed -- but rigorous quality control is needed for it to reach its full potential, according to a new study. Researchers at the National Institute of Standards and Technology (NIST) led the study by 11 institutions comparing measurements by 27 MRI scanners from three vendors at nine clinical sites around the country. To obtain reference values and disentangle sources of bias and variation, the study used a tissue stand-in, or "phantom," originally ...

A city's street names can provide a glimpse into its cultural value system and a way to quantify cultural indicators, according to a study published June 30, 2021 in the open-access journal PLOS ONE by Melanie Bancilhon from Washington University in Saint Louis, U.S., and colleagues. Ever since named streets have existed, they have been used as a form of social engineering, mirroring a town or city's social, cultural, political, and religious values. Building off this concept in what they term "streetonomics," Bancilhon and colleagues used street names as an alternative route to quantify cultural indicators in four influential Western cities: Paris, Vienna, London, and New York. The authors used multiple open data sources ...

The deep sea Pacific Salas y Gómez and Nazca ridges are highly biodiverse and host unique fish and invertebrate taxa, according to video surveys. INFORMATION: Article Title: Deep-sea biodiversity at the extremes of the Salas y Gómez and Nazca ridges with implications for conservation Funding: The expeditions were funded by the National Geographic Society and Pristine Seas donors with support to AMF. Conservation International, the Paul M. Angell Family Foundation, Tom and Currie Barron, and Alan Eustace provided additional support to DW, WG and JG. The Chilean Millennium Science Initiative Program grant #NC120030 ...

In the German population, a surprisingly high 6% of under-18s are at risk of cognitive decline, falls and more from the cumulative effect of anticholinergic medications such as antihistamines and antidepressants. INFORMATION: Article Title: Anticholinergic burden: First comprehensive analysis using claims data shows large variation by age and sex Funding: The authors received no external funding for this work. Competing Interests: UH, OR, MB and JR are working at an independent, non-profit research institute, the Leibniz Institute for Prevention Research and Epidemiology - BIPS. Unrelated to this study, BIPS occasionally conducts studies financed by the pharmaceutical industry. Almost exclusively, these are post-authorization ...

Researchers have developed and successfully demonstrated a novel method for studying how cells repair damaged DNA in space. Sarah Stahl-Rommel of Genes in Space and colleagues present the new technique in the open-access journal PLOS ONE on June 30, 2021. Damage to an organism's DNA can occur during normal biological processes or as a result of environmental causes, such as UV light. In humans and other animals, damaged DNA can lead to cancer. Fortunately, cells have several different natural strategies by which damaged DNA can be repaired. Astronauts traveling outside of Earth's protective atmosphere face increased risk of DNA damage due to the ionizing radiation ...

An important function of our vision is to segregate relevant figures from the irrelevant background. When we look at a visual stimulus, it drives a cascade of neural activity from low-level to higher level visual brain areas. The higher areas also provide feedback to the lower areas, where figures elicit more activity than the background, as if figures in the brain are highlighted with extra activity. Researchers from the Netherlands Institute of Neuroscience (NIN) now showed that feedback causes the extra neuronal activity in low-level areas and that the extra activity is essential for figure-ground ...

MIT engineers and researchers in South Korea have developed a sweat-proof "electronic skin" -- a conformable, sensor-embedded sticky patch that monitors a person's health without malfunctioning or peeling away, even when a wearer is perspiring. The patch is patterned with artificial sweat ducts, similar to pores in human skin, that the researchers etched through the material's ultrathin layers. The pores perforate the patch in a kirigami-like pattern, similar to that of the Japanese paper-cutting art. The design ensures that sweat can escape through the patch, preventing skin irritation and damage to embedded sensors. The kirigami design also helps the patch conform to human skin as it stretches and bends. This flexibility, paired with ...

New Brunswick, N.J. (June 30, 2021) - A Rutgers-led team of researchers has developed a microchip that can measure stress hormones in real time from a drop of blood. The study appears in the journal Science Advances. Cortisol and other stress hormones regulate many aspects of our physical and mental health, including sleep quality. High levels of cortisol can result in poor sleep, which increases stress that can contribute to panic attacks, heart attacks and other ailments. Currently, measuring cortisol takes costly and cumbersome laboratory setups, so the Rutgers-led team looked for a way to monitor its natural fluctuations in daily life and provide patients with feedback that allows them to receive the right treatment at the right ...

A new study based on computational analyses of how SARS-CoV-2 interacts with host cell proteins has identified 200 previously approved drugs that could be repurposed to treat COVID-19, 40 of which have already entered clinical trials. Furthermore, Namshik Han and colleagues identified 30 proteins induced by the SARS-CoV-2 virus that are targeted by 8 or more existing drugs, finding that nitric oxide production, which is important for viral synthesis, may be targeted by these drugs to fight infection. The researchers also identified 2 of these drugs with good safety profiles that successfully reduced viral replication in cellular assays, suggesting they could potentially prevent or treat COVID-19. Scientists now have sufficient ...

The Bronze Age in the eastern Mediterranean has long been considered by researchers to have been the 'first international age,' especially the period from 1600-1200 BC, when powerful empires from Anatolia, Mesopotamia, and Egypt set up large networks of subordinate client kingdoms in the Near East. These empires fought, traded, and corresponded with one another, and ancient texts from the period reveal rich economic and social networks that enabled the movement of people and goods. A new study conducted by an interdisciplinary team of archaeologists, geneticists, and isotope experts, and published in PLOS ONE, investigated the movement of people in this period at a single regional center, a Bronze Age city-state called Alalakh in present-day southeastern Turkey. Their results indicate ...

University of Leeds news Embargo: Wednesday 30 June, 7pm GMT Bereavement care lacking for ethnic minorities Grieving friends and relatives from ethnic minority backgrounds are suffering from a lack of appropriate help to cope with the loss of a loved one, especially during the COVID-19 pandemic, researchers say. And the scarcity of data on the services that are available means providers do not know how support should be delivered to ensure they are suitable for different groups of people. The researchers, led by the University of Leeds and the University of Sheffield, reviewed evidence on UK bereavement care for ethnic minority ...

Research at Baylor College of Medicine, the Texas Heart Institute and collaborating institutions is moving a novel promising gene therapy to treat heart failure closer to the clinic. Published in Science Translational Medicine, the study showed that knocking down the Hippo signaling pathway in cardiomyocytes in the hearts of pigs after they had a heart attack, resulted in heart tissue renewal and improved function when compared with pig hearts in which the Hippo signaling pathway was not modified. Given that the pig's heart is considered a valuable model to study the human heart, the findings suggest that this gene therapy may be useful in treating human heart failure. Heart failure remains the leading cause of mortality in the western ...

A study published in Science Advances reports on the unexpected observation of thermal waves in germanium, a semiconductor material, for the first time. This phenomenon may allow a significant improvement in the performance of our electronic devices in a near future. The study is led by researchers from the Institute of Materials Science of Barcelona (ICMAB, CSIC) in collaboration with researchers from the Universitat Autònoma de Barcelona, and the University of Cagliari. Heat, as we know it, originates from the vibration of atoms, and transfers by diffusion at ambient temperatures. Unfortunately, ...

Cambridge scientists have identified 200 approved drugs predicted to work against COVID-19 - of which only 40 are currently being tested in COVID-19 clinical trials. In a study published today in Science Advances, a team led by researchers at the University of Cambridge's Milner Therapeutics Institute and Gurdon Institute used a combination of computational biology and machine learning to create a comprehensive map of proteins that are involved in SARS-CoV-2 infection - from proteins that help the virus break into the host cell to those generated as a consequence of infection. By examining this network using artificial intelligence (AI) approaches, ...

Language distinguishes us humans; we learn it through experience and social interactions. Especially in the first year of life, human vocalizations change dramatically, becoming more and more language-like. In our closest relatives, non-human primates, language development was previously thought to be largely predetermined and completed within the first few weeks after birth. In a behavioral study now published, researchers from the German Primate Center, the University of Tübingen and the Rockefeller University New York were able to show that the infantile development of vocalizations in common marmosets also includes an extended flexible phase, without ...

Researchers from Baidu Research Robotics and Auto-Driving Lab (RAL) and the University of Maryland, College Park, have introduced an autonomous excavator system (AES) that can perform material loading tasks for a long duration without any human intervention while offering performance closely equivalent to that of an experienced human operator. AES is among the world's first uncrewed excavation systems to have been deployed in real-world scenarios and continuously operating for over 24 hours, bringing about industry-leading benefits in terms of enhanced safety and productivity. The researchers described their methodology in a research paper published ...

Researchers studying the intersection of politics and psychology have long documented a link between threat sensitivity and social conservatism: People who are more socially conservative tend to react more strongly to threats. Conversely, those who are more socially liberal tend to be less sensitive to threats, viewing the world as a generally safe place and embracing change to explore new possibilities. These findings have held across a variety of events, but during the pandemic, U.S. polls show that Democrats, who tend to be more liberal, have generally been more concerned about the COVID-19 threat than ...

URBANA, Ill. - Proteins have been quietly taking over our lives since the COVID-19 pandemic began. We've been living at the whim of the virus's so-called "spike" protein, which has mutated dozens of times to create increasingly deadly variants. But the truth is, we have always been ruled by proteins. At the cellular level, they're responsible for pretty much everything. Proteins are so fundamental that DNA - the genetic material that makes each of us unique - is essentially just a long sequence of protein blueprints. That's true for animals, plants, ...

In cases of breast cancer, bone metastasis - when cancer cells spread to new sites in the bone - causes the most breast cancer-related harm and is often incurable in advanced disease. A new study by University of Arizona Health Sciences researchers found that cancer cells become more aggressive when exposed to tissue stiffening and that these changes persist over time. Tumor stiffening, which develops as diseased breast tissue becomes fibrotic, plays a major role in how breast cancer cells spread throughout the body. The paper, "Breast tumor stiffness instructs bone metastasis via maintenance of mechanical conditioning," published today in the journal Cell Reports, ...

A pair of College of Business professors and their doctoral student at The University of Texas at Arlington are exploring how ransomware attacks sometimes pit organizations against the law enforcement agencies trying to protect them. Kay-Yut Chen, Jingguo Wang and Yan Lang are authors of a new study in the journal Management Science titled "Coping with Digital Extortion: An Experimental Study on Benefit Appeals and Normative Appeals." Chen and Wang are professors of information systems and operations management at UTA. Lang is a doctoral student in the department. A ransomware attack is like a cyber hijacking, with criminals infiltrating and seizing an organization's data or computer systems and ...

In hospitals, we know that the nurses are the first to deal with patients in pain. For any ailment, including patients needing hemodialysis, the knowledge of pain management, the nurses have, allow them to provide optimal pain management. This qualitative study aims to explore the experiences, perceptions, and beliefs of nurses serving in the hemodialysis unit in terms of pain management practices. The study helped identify the educational needs of the nurses to improve pain management in practice. A subjective sample of 16 nurses working in four out-patient hemodialysis units in Amman, Jordan, was hired for this research. Using semi-structured interviews, the data was collected. The study found five themes and fifteen subcategories ...

Oak Brook, IL - The July edition of SLAS Discovery is a Special Edition featuring the cover article, "Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7-Methyltransferase Using RapidFire Mass Spectrometry" by Lesley-Anne Pearson, Charlotte J. Green, Ph.D., De Lin, Ph.D., Alain-Pierre Petit, Ph.D., David W. Gray, Ph.D., Victoria H. Cowling, Ph.D., and Euan A. F. Fordyce, Ph.D., (Drug Discovery Unit, School of Life Sciences, University of Dundee, Dundee, UK). In January 2021, a survey of immunologists, infectious-disease researchers and virologists found that 90% of respondents believe SARS-CoV-2 will become endemic, continuing to circulate in pockets of the global population for years to come. Even as vaccines are ...