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Medicine12 Dec 2023

Third-generation anti-CD19 CAR T-cells demonstrate efficacy without neurotoxicity in B-cell lymphoma phase 1 clinical trial

The Malaghan Institute of Medical Research in collaboration with Wellington Zhaotai Therapies Limited today announced results of its phase 1 dose escalation trial of a new third generation anti-CD19 chimeric antigen receptor (CAR) T-cell therapy to be presented at the American Society of Hematology (ASH) Annual Meeting in San Diego on 11 December, 3pm. Anti-CD19 CAR T-cells with a CD28 co-stimulatory domain, such as axicabtagene ciloleucel and brexucabtagene autoleucel, are among the most effective CAR T-cell therapies for B-cell non-Hodgkin lymphomas but are associated with neurotoxicity (immune effector cell-associated neurotoxicity syndrome, ICANS) in around half of recipients, ...

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Medicine11 Dec 2023

ASA endorses new legislation to fully avert Medicare payment cuts

The American Society of Anesthesiologists (ASA) strongly endorses H.R. 6683, legislation that would block a more than 3% Medicare payment cut scheduled to take effect on January 1, 2024. ASA supports the immediate passage of this legislation this year or early 2024, prior to full implementation of these destructive cuts. “We commend these lawmakers for their leadership on preventing this Medicare payment cut and their efforts to ensure the viability of the nation’s physician practices,” said ASA President Ronald ...

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Technology11 Dec 2023

Applications open for School of Advanced Science on Quantum Materials

Registrations are open to apply for the São Paulo School of Advanced Science on Quantum Materials, to be held on July 6-16, 2024, at the University of São Paulo’s Physics Institute in São Paulo City, Brazil. The School expects to select and fully support 100 graduate students and young researchers (50 from Brazil and 50 from abroad) to take part in short courses and talks focusing on fundamental, theoretical, and experimental aspects of quantum materials – a fertile ...

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Space11 Dec 2023

NASA’s Webb stuns with new high-definition look at exploded star

Like a shiny, round ornament ready to be placed in the perfect spot on a holiday tree, supernova remnant Cassiopeia A (Cas A) gleams in a new image from NASA’s James Webb Space Telescope. As part of the 2023 Holidays at the White House, First Lady of the United States Dr. Jill Biden debuted the first-ever White House Advent Calendar. To showcase the “Magic, Wonder, and Joy” of the holiday season, Dr. Biden and NASA are celebrating with this new image from Webb. While all ...

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Environment11 Dec 2023

NASA’s MAVEN observes the disappearing solar wind

In December 2022, NASA’s MAVEN (Mars Atmosphere and Volatile EvolutioN) mission observed the dramatic and unexpected “disappearance” of a stream of charged particles constantly emanating off the Sun, known as the solar wind. This was caused by a special type of solar event that was so powerful, it created a void in its wake as it traveled through the solar system. Due to this event, MAVEN’s measurements at Mars showed that the number of particles making up the solar wind dropped significantly. Without the pressure of the solar wind, the Martian atmosphere and magnetosphere expanded by thousands of kilometers. MAVEN is the only asset currently at Mars able to ...

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Science11 Dec 2023

Don't say "vegan"

As presented at the Society for Risk Analysis 2023 Annual conference, Patrycja Sleboda from Baruch College – CUNY and her colleagues from the University of Southern California conducted a national food choice experiment to determine how people respond to labels such as “vegan” and “plant-based” compared to “healthy,” “sustainable,” or “healthy and sustainable.” Research has shown that limiting meat and dairy intake and eating more fruit and vegetables reduces the risk of cardiovascular diseases, Type 2 diabetes, and cancer. Diets with less meat and dairy are also more environmentally ...

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Medicine11 Dec 2023

Group summarizes guidance for the prevention, diagnosis, evaluation, and treatment of hepatitis C virus in chronic kidney disease

Embargoed for release until 5:00 p.m. ET on Monday 11 December 2023 Annals of Internal Medicine Tip Sheet @Annalsofim Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. ---------------------------- 1. Group summarizes guidance for the prevention, ...

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Energy11 Dec 2023

Conference indicates surging interest in superhot, superdeep geothermal energy

Conference indicates surging interest in superhot, superdeep geothermal energy --Renewable resource has potential to revolutionize our energy system For Immediate Release: December 11, 2023 By Elizabeth A. Thomson for Quaise Energy For more information, including technical papers and graphic, please contact Elizabeth Thomson, 22elizabeththomson@gmail.com. CAMBRIDGE, Mass.--In an indication of growing interest in the holy grail of geothermal energy—tapping ...

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Medicine11 Dec 2023

UM School of Medicine awarded nearly $30 Million to improve health outcomes of IV drug users

University of Maryland School of Medicine (UMSOM) Dean Mark T. Gladwin, MD, announced today that the school will receive a $29 million research award over four years from the National Institutes of Health to lead a multicenter trial that aims to improve health outcomes in people who inject opioid drugs and are hospitalized with infectious complications of their drug use. Faculty affiliated with the Institute of Human Virology and the Kahlert Institute for Addiction Medicine at UMSOM will be conducting the research. The research award, which has provided ...

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Medicine11 Dec 2023

Risk factors for long-term arm morbidities following breast cancer treatments: A systematic review

“This review revealed 29 primary risk factors associated with arm morbidity after breast cancer treatment.” BUFFALO, NY- December 11, 2023 – A new review paper was published in Oncotarget's Volume 14 on December 1, 2023, entitled, “Risk factors for long-term arm morbidities following breast cancer treatments: A systematic review.” In this review, researchers Ifat Klein, Michael Friger, Merav Ben David, and Danit Shahar from Assuta Medical Center and Ben-Gurion University of the Negev in Israel ...

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Medicine11 Dec 2023

Clues to preventing Alzheimer’s come from patient who, despite genetics, evaded disease

Alzheimer’s disease has plagued one large Colombian family for generations, striking down half of its members in the prime of life. But one member of that family evaded what had seemed would be fate: Despite inheriting the genetic defect that caused her relatives to develop dementia in their 40s, she stayed cognitively healthy into her 70s. Researchers at Washington University School of Medicine in St. Louis now think they know why. A previous study had reported that, unlike her relatives, the woman carried ...

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Science11 Dec 2023

Hungarian scientists prove that senescence can accelerate evolution

The mystery of aging has fascinated people for millennia, with many willing to do anything to halt or reverse this process, because aging is typically associated with gradual deterioration of most body functions. While senescence is a natural part of life, biologists understand surprisingly little about the emergence of this process during evolution. It is not clear whether aging is inevitable, because there are organisms that seemingly do not age at all, moreover, the phenomenon known as negative aging, or rejuvenation, does exist: some turtles’ vital functions improve ...

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Medicine11 Dec 2023

Real world data shows impact of immunotherapy in populations underrepresented in clinical trials, according to JNCCN study

PLYMOUTH MEETING, PA [December 11, 2023] — New research in the December 2023 issue of JNCCN—Journal of the National Comprehensive Cancer Network finds patients treated with first-line immunotherapy for advanced Non-Small Cell Lung Cancer (NSCLC) showed similar results in terms of survival, progression-free survival, and treatment duration, regardless of race or ethnicity, even with differences in income and insurance. The clinical investigators focused on patients in under-represented groups who were typically less likely to be included in the immunotherapy clinical trials that have been conducted ...

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Medicine11 Dec 2023

Research by Sylvester, collaborators leads to new treatment options for advanced myelofibrosis, other blood malignancies

DOWNLOADABLE VIDEO MIAMI, FLORIDA (EMBARGOED UNTIL MONDAY, DEC. 11, 2023, AT 2:45 P.M. ET) – Few standard treatments have been available for advanced myelofibrosis, a bone marrow disorder characterized by excessive scar tissue that disrupts the normal production of blood cells But new research conducted by investigators at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine and collaborating cancer centers indicates that a new type of targeted therapy may ...

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Medicine11 Dec 2023

A new mechanism by which rotavirus makes you sick

Rotavirus causes gastroenteritis, a condition that includes diarrhea, deficient nutrient absorption and weight loss. Severe cases result in approximately 128,000 deaths annually in infants and children worldwide. Despite intense research on how rotavirus causes diarrhea, there is still no complete answer, but in this new study researchers at Baylor College of Medicine report a new mechanism by which rotavirus induces diarrhea, interfering with the normal absorption of nutrients in the intestine. The study, published in Proceedings of the National Academy of Sciences, is the first to show that rotavirus-altered lipid metabolism in the intestine plays a ...

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Technology11 Dec 2023

Portable, non-invasive, mind-reading AI turns thoughts into text

In a world-first, researchers from the GrapheneX-UTS Human-centric Artificial Intelligence Centre at the University of Technology Sydney (UTS) have developed a portable, non-invasive system that can decode silent thoughts and turn them into text. The technology could aid communication for people who are unable to speak due to illness or injury, including stroke or paralysis. It could also enable seamless communication between humans and machines, such as the operation of a bionic arm or robot. The ...

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Medicine11 Dec 2023

Tirzepatide enhances weight loss with sustained treatment but discontinuation leads to weight regain

Tirzepatide Enhances Weight Loss with Sustained Treatment but Discontinuation Leads to Weight Regain The current class of anti-obesity drugs is proving remarkably effective at removing excess pounds. However, a phase 3 randomized clinical trial led by researchers at Weill Cornell Medicine and NewYork-Presbyterian found that people who stopped taking the medication regained much of that weight within a year. At the same time, the study shows that remaining on the drug not only promotes additional weight loss but preserves improvements in metabolic and cardiovascular health. The results from the SURMOUNT-4 study, which appeared Dec. ...

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Medicine11 Dec 2023

Scholars named for research leadership program to increase diversity in clinical trials

DALLAS, Dec. 11, 2023 — The American Heart Association — the world’s leading voluntary organization dedicated to a world of longer, healthier lives for all — continues its commitment to address the lack of diversity, equity and inclusion in clinical trials for medical research with the selection of two early-career scientists for the inaugural Robert A. Winn Clinical Investigator Leadership Award in Cardiovascular Research (Winn CILA-CV). The award is sponsored by the Bristol Myers ...

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Medicine11 Dec 2023

Venetoclax with standard chemo-immunotherapy induced a high response rate as first-line treatment for mantle cell lymphoma and was generally well tolerated, a PrECOG early-phase trial shows

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting. The combination was generally well-tolerated, a notable finding according to Craig A. Portell, MD, who presented the data for PrECOG, LLC, at the 65th American Society of Hematology (ASH) Meeting and Exposition in San Diego, California, ...

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Science11 Dec 2023

Schedule of sessions and press registration information now available for the ILSI 2024 Annual Meeting and Science Symposium

FOR IMMEDIATE RELEASE December 11, 2023 ILSI Global press contact: Katherine Broendel +1 (202) 659-0074 Ext. 175 kbroendel@ilsi.org WASHINGTON—The International Life Sciences Institute (ILSI) has announced that its Annual Meeting, Technologies and Climate Change: Shaking up 21st Century Food Systems – Promises and Pitfalls, will take place in Clearwater, Florida, 21-24 January 2024. ILSI's Annual Meeting will feature scientific presentations, professional development and networking opportunities for researchers, academics, industry leaders, nongovernmental organizations, as well as public sector and ...

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Science11 Dec 2023

Madden studying merchants, maps & manuscripts of late medieval world

Amanda Madden, Assistant Professor, History and Art History; Director, Geospatial History, received funding for the project: "La sfera (The Globe): A Late Medieval World of Merchants, Maps, & Manuscripts." In collaboration with the project team, Co-PI Madden, Senior Developer Jason Heppler, and the Roy Rosenzweig Center for History and New Media (RRCHNM) propose to design and develop a digital edition of the text, including the user interface and data pipeline. The NEH grant will fund the development of a dynamic, interactive ...

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Technology11 Dec 2023

New project will take a step towards answering whether gravity is quantum

Scientists are developing an experiment to test whether gravity is quantum In quantum mechanics, which describes the behaviour of atoms and molecules –objects behave differently to everything we know: they can be in a quantum superposition of being in two places at the same time Now, scientists are investigating a way to determine whether gravity operates in this way, by levitating micro diamonds in a vacuum If gravity is quantum, it will ‘entangle’ the diamonds – an intriguing phenomenon which strongly links two objects in ways impossible in everyday life This research will help ...

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Medicine11 Dec 2023

Stem cell study reveals how infantile cystinosis causes kidney failure – and how to cure it

BUFFALO, N.Y. – University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients. Published Nov. 30 in the International Journal of Molecular Sciences, the work reveals that the mechanisms that cause the disease could be addressed and potentially cured through the genome-editing technique CRISPR. That could make kidney transplants, the most effective treatment currently available for these patients, unnecessary. Infantile ...

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Science11 Dec 2023

Raz developing advanced model-based tools for portfolio management

Raz Developing Advanced Model-Based Tools For Portfolio Management Ali Raz, Professor, Systems Engineering and Operations Research (SEOR), received funding for the project: "Advanced Model-Based Tools for Portfolio Management and Analytic: System Architecture and Multi-Attribute Decision Making for Integrating Autonomy Phase 2 (AIRC RT-1081.07.5)." Raz is supporting Purdue University and Georgia Tech Research Institute (GTRI) in the enhancement of the IAPR System-of-systems (SoS) tool suite. Raz received $20,500 from Stevens Institute of Technology on a subaward from the U.S. Department of Defense for ...

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Science11 Dec 2023

SETI Institute unveils two prestigious postdoctoral fellowships: the Baruch S. Blumberg Fellowship and the William J. Welch Fellowship

December 11, 2023, Mountain View, CA -- The SETI Institute announced today the establishment of a new postdoctoral research fellowship program funded by its transformative bequest from Qualcomm Co-founder, Franklin Antonio. The first two fellowships are being announced in conjunction with the American Geophysical Union Conference (AGU) being held this week in San Francisco. The Baruch S. Blumberg Postdoctoral Fellowship for Astrobiology and the William J. Welch Postdoctoral Fellowship for SETI and Technosignatures ...

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