SAN FRANCISCO—December 8, 2023—It only takes holding your breath for slightly too long to understand that too little oxygen is bad for you. But can you also have too much? Indeed, breathing air with a higher oxygen level than your body needs can cause health problems or even death.   But with scant research on the topic, scientists have known little about how the body senses too much oxygen. Now, a new study from Gladstone Institutes has greatly expanded the scientific body of knowledge about the mechanisms at play, and why it matters for health. Their findings, reported in the journal Science Advances, explain how breathing air with different levels of ...

TORONTO –  A team of researchers based at the University of Toronto’s (U of T) Leslie Dan Faculty of Pharmacy has discovered a novel ionizable lipid nanoparticle that enables muscle-focused mRNA delivery while minimizing off-target delivery to other tissues. The team also showed that mRNA delivered by the lipid nanoparticles investigated in their study triggered potent cellular-level immune responses as a proof-of-concept melanoma cancer vaccine. The study, led by Bowen Li, assistant professor, Leslie Dan Faculty of Pharmacy, U ...

“In the United States, 288,300 new cases of prostate cancer are estimated for 2023 [...]” BUFFALO, NY- December 8, 2023 – A new research perspective was published in Oncoscience (Volume 10) on November 30, 2023, entitled, “Evolving insights in blood-based liquid biopsies for prostate cancer interrogation.” During the last decade, blood sampling of cancer patients aimed at analyzing the presence of cells, membrane-bound vesicles, or molecules released by primary tumors or metastatic growths emerged as an alternative to traditional tissue biopsies. The advent of this minimally invasive approach, known as blood-based liquid biopsy, ...

The most durable, heat-resistant materials ever made could be hiding in plain sight. The U.S. Department of Defense wants to know if minerals and rocks found on Earth and in space hold the secrets of next-generation high-temperature materials. To find out, the DOD awarded $6.25 million through its Multidisciplinary University Research Initiative, or MURI, to a team from the University of Virginia and Arizona State University. The group is led by UVA’s Elizabeth J. Opila, the Rolls-Royce Commonwealth Professor and chair of the Department of Materials Science and Engineering. The ...

Magnesium oxide is a promising material for capturing carbon dioxide directly from the atmosphere and injecting it deep underground to limit the effects of climate change. But making the method economical will require discovering the speed at which carbon dioxide is absorbed and how environmental conditions affect the chemical reactions involved. Scientists at the Department of Energy’s Oak Ridge National Laboratory analyzed a set of magnesium oxide crystal samples exposed to the atmosphere for decades, and another for days to months, to gauge the reaction rates. They found that carbon ...

A study looking at 15 years of HIV transmission and suppression in Uganda reveals how closing gender gaps in treatment could slash infection rates. Providing more heterosexual men with easy access to HIV treatment and care could help to suppress the virus and rapidly cut transmission to their female partners, shows a new study published in Nature Microbiology. The research, led by scientists from Imperial College London and the Rakai Health Sciences Program in Uganda, analysed 15 years of data from 2003-2018, during which the US President’s Emergency Plan For AIDS ...

When Senior Scientist Jonathan Grimm came to Janelia 13 years ago, he didn’t know much about fluorescence or fluorescent dyes. But as an organic chemist who had been working in drug discovery at Merck, he certainly knew a thing or two about medicinal chemistry. On a whim, Grimm and Janelia Senior Group Leader Luke Lavis decided to try using a mainstay medicinal chemistry reaction Grimm had picked up in the pharmaceutical industry to improve centuries-old dye chemistry. They thought this approach could allow access to completely new, previously inaccessible rhodamines – molecules Lavis had been working to make brighter and longer-lasting so they could be ...

The Gerontological Society of America (GSA) — the country’s largest interdisciplinary organization devoted to the field of aging — is proud to acknowledge the work of 34 outstanding individuals through its prestigious awards program.   GSA salutes outstanding research, recognizes distinguished leadership in teaching and service, and fosters new ideas through a host of awards. Nominated by their peers, the recipients’ achievements serve as milestones in the history and development of ...

Nuclear fusion, the process that powers the sun, is the ultimate source of energy for all life on Earth. On the sun, deuterium and tritium nuclei combine to produce an alpha particle (the nucleus of a helium atom) and a neutron. The dream is to do the same down here, on Earth, in a controlled manner. It’s for good reason that harnessing fusion energy is one of the greatest scientific and technological challenges of the 21st century. Fusion requires the fuel to be heated to more than 100 million degrees (10 times hotter than the core of the sun). Practical fusion energy also requires that the burning fuel is kept at these hot temperatures long enough so that energy ...

More than 1.2 million people have died in the United States during the COVID-19 pandemic to date, more documented deaths than any other nation on Earth. While many have attributed the high death toll on widespread personal hesitancy to wear masks, avoid crowded places or receive vaccines once they were developed, there were several “system hesitancies” that contributed to the tragic outcomes that need addressing, according to an analysis published Dec. 6, 2023, in Health Affairs Forefront. The analysis ...

LOS ANGELES – December 8, 2023 – Stand Up To Cancer® (SU2C) today announced the appointment of Julian Adams, Ph.D., as president and chief executive officer, which will be effective on January 1, 2024. Adams had previously served on SU2C’s Scientific Advisory Committee since 2008, and officially joined SU2C in July 2023 in the newly created position of chief science officer. He succeeds Russell Chew, who joins SU2C’s Board of Directors. Adams is a longtime oncology researcher and pharmaceutical industry senior executive specializing in drug discovery and development in cancer. With this appointment, Adams assumes management responsibility for SU2C’s overall ...

Northwestern University researchers have developed new virtual reality (VR) goggles for mice. Besides just being cute, these miniature goggles provide more immersive experiences for mice living in laboratory settings. By more faithfully simulating natural environments, the researchers can more accurately and precisely study the neural circuitry that underlies behavior. Compared to current state-of-the-art systems, which simply surround mice with computer or projection screens, the new goggles provide a leap in advancement. In current systems, mice can still see the lab environment peeking out from behind the screens, and the screens’ ...

About The Study: In this study, in both Medicaid only and dual-eligible populations, Hispanic and non-Hispanic Black individuals had the lowest odds of receiving hospice, and Hispanic individuals had the highest odds of a short hospice stay. Knowledge about, access to, and acceptance of hospice may be lacking for these low-income individuals. Further research is needed to understand barriers to and facilitators of hospice use for people with nursing facility stays.  Authors: Julie ...

About The Study: In this analysis of U.S. county-level preterm and early preterm birth rates, substantial geographic disparities were observed, which were associated with place-based social disadvantage. Stability in aggregated rates of preterm birth at the national level masked increases in nearly 1 in 6 counties between 2007 and 2019.  Authors: Sadiya S. Khan, M.D.,M.S., of the Northwestern University Feinberg School of Medicine in Chicago, is the corresponding author.  To access the embargoed study: Visit our For The Media website at ...

LA JOLLA, CA—In August, researchers detected a new SARS-CoV-2 "variant of concern" in patients in Israel and Denmark. Since then, this variant, dubbed BA.2.86 or "Pirola," has made its way around the globe. The Pirola variant has raised alarms because it is highly mutated. In fact, Pirola is as mutated as the Omicron variant was, compared with the early SARS-CoV-2 variant included in the original vaccinations.  As Pirola spreads, researchers at La Jolla Institute for Immunology (LJI) are investigating whether COVID-19 vaccines (or previous ...

MIT engineers have developed a robotic replica of the heart’s right ventricle, which mimics the beating and blood-pumping action of live hearts.  The robo-ventricle combines real heart tissue with synthetic, balloon-like artificial muscles that enable scientists to control the ventricle’s contractions while observing how its natural valves and other intricate structures function.  The artificial ventricle can be tuned to mimic healthy and diseased states. The team manipulated the model to simulate conditions of right ventricular dysfunction, ...

 Dec. 8, 2023 Contact: Bill Lubinger 216.368.4443 william.lubinger@case.edu Ansley Kelm 678-313-6525 Ansley.Kelm@UHhospitals.org     CLEVELAND—Researchers at Case Western Reserve University and University Hospitals have identified an enzyme that blocks insulin produced in the body—a discovery that could provide a new target to treat diabetes. Their study, published Dec. 5 in the journal Cell, focuses on nitric oxide, a compound that dilates blood vessels, improves memory, fights infection and stimulates the release of hormones, among ...

HOUSTON and SOUTH SAN FRANCISCO, Calif. ― The University of Texas MD Anderson Cancer Center and Rigel Pharmaceuticals, Inc. today announced a multi-year strategic development collaboration to expand the evaluation of olutasidenib in acute myeloid leukemia (AML) and other hematologic cancers. The alliance brings together MD Anderson’s clinical research expertise with Rigel’s differentiated targeted molecule. Under the strategic collaboration, Rigel and MD Anderson will evaluate the potential of olutasidenib to treat newly diagnosed and relapsed ...

A recent study from researchers in Canada and Germany has revealed that an unlikely event, occurring over 12 million years ago played an important role in shaping one of Canada’s most damaging invasive species. Zebra and quagga mussels, belonging to the Dreissenid family, are widespread freshwater invasive species throughout North America that present a significant danger to native ecosystems by competing for resources. Using a fibrous anchor called a byssus, Dreissenid mussels contribute to biofouling on surfaces and obstruct intake structures in power stations and water treatment plants. “This new study, which looks into the way these mussels stick to surfaces, may help improve ...

EPFL researchers have developed a hybrid device that significantly improves existing, ubiquitous laser technology. The team at EPFL’s Photonic Systems Laboratory (PHOSL) has developed a chip-scale laser source that enhances the performance of semiconductor lasers while enabling the generation of shorter wavelengths. This pioneering work, led by Professor Camille Brès and postdoctoral researcher Marco Clementi from EPFL’s School of Engineering represents a significant advance in the field of photonics, with implications for telecommunications, metrology, and other high-precision applications. The ...

SAN ANTONIO – Patients with low-risk ductal carcinoma in situ (DCIS) who skipped adjuvant radiotherapy after breast-conserving surgery had comparable five-year outcomes to those with high-risk DCIS who received adjuvant radiotherapy, according to results from the E4112 clinical trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023. “Nearly all women with DCIS—a noninvasive form of breast cancer—will have their cancer successfully removed, but some women will have a high risk of the disease returning or progressing to invasive breast cancer,” said Seema A. Khan, MD, a professor of surgery and the Bluhm Family ...

Women 50 or older who de-escalated to less-frequent mammography three years after curative surgery for early-stage breast cancer had similar outcomes to women who received annual mammography, according to results from the Mammo-50 trial presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023. Both U.S. and U.K. guidelines recommend annual breast cancer screening following surgery to remove early-stage breast cancer; in the U.S., annual mammography is recommended indefinitely, and in the U.K., it is recommended for five years, followed by screening every three years for patients 50 years and older. However, the optimal screening schedule has yet to ...

SAN ANTONIO – Comprehensive profiling of fusion RNAs present in a large cohort of metastatic breast tumors revealed unique fusion mutations that may be therapeutically targetable, according to results presented at the San Antonio Breast Cancer Symposium, held December 5-9, 2023. Fusion mutations occur when a portion of one gene becomes fused to a portion of another, which can create gene products with new functions. They are common in cancer types that are characterized by genomic rearrangements and structural damage to the DNA, including breast cancer. “Fusion RNAs may serve as ...

Data from Australian researchers could partly explain why a trial of a new drug for diabetes, was recently halted because it was found to be so effective. Importantly, the data also reveals how anti-obesity drugs like Ozempic, actually work, which to date have been a mystery. In early November the FLOW trial of the drug semaglutide on the progression of renal impairment in people with type 2 diabetes and chronic kidney disease was halted ahead of schedule because of the drug’s efficacy. Part of the rationale for the cessation of the trial could be explained by ...

With the increase in the production of batteries for electric vehicles, demand is also rising for the necessary raw materials. In view of risks to the supply chain, environmental problems and precarious working conditions which are all associated with the mining and transportation of these materials, the recycling of battery materials has become an important issue in research, politics and industry. Prof. Stephan von Delft from the University of Münster (Germany) heads a team of researchers from the fields of science ...