Tirzepatide Enhances Weight Loss with Sustained Treatment but Discontinuation Leads to Weight Regain The current class of anti-obesity drugs is proving remarkably effective at removing excess pounds. However, a phase 3 randomized clinical trial led by researchers at Weill Cornell Medicine and NewYork-Presbyterian found that people who stopped taking the medication regained much of that weight within a year. At the same time, the study shows that remaining on the drug not only promotes additional weight loss but preserves improvements in metabolic and cardiovascular health. The results from the SURMOUNT-4 study, which appeared Dec. ...

DALLAS, Dec. 11, 2023 — The American Heart Association — the world’s leading voluntary organization dedicated to a world of longer, healthier lives for all — continues its commitment to address the lack of diversity, equity and inclusion in clinical trials for medical research with the selection of two early-career scientists for the inaugural Robert A. Winn Clinical Investigator Leadership Award in Cardiovascular Research (Winn CILA-CV). The award is sponsored by the Bristol Myers ...

The phase 2 trial PrE0405 met its primary endpoint, achieving a complete response (CR) rate of 85% in 33 patients over the age of 60 with mantle cell lymphoma (MCL) who received bendamustine and rituximab, a standard chemo-immunotherapy treatment, along with venetoclax, which is investigational in this setting. The combination was generally well-tolerated, a notable finding according to Craig A. Portell, MD, who presented the data for PrECOG, LLC, at the 65th American Society of Hematology (ASH) Meeting and Exposition in San Diego, California, ...

FOR IMMEDIATE RELEASE December 11, 2023 ILSI Global press contact: Katherine Broendel +1 (202) 659-0074 Ext. 175 kbroendel@ilsi.org WASHINGTON—The International Life Sciences Institute (ILSI) has announced that its Annual Meeting, Technologies and Climate Change: Shaking up 21st Century Food Systems – Promises and Pitfalls, will take place in Clearwater, Florida, 21-24 January 2024. ILSI's Annual Meeting will feature scientific presentations, professional development and networking opportunities for researchers, academics, industry leaders, nongovernmental organizations, as well as public sector and ...

Amanda Madden, Assistant Professor, History and Art History; Director, Geospatial History, received funding for the project: "La sfera (The Globe): A Late Medieval World of Merchants, Maps, & Manuscripts." In collaboration with the project team, Co-PI Madden, Senior Developer Jason Heppler, and the Roy Rosenzweig Center for History and New Media (RRCHNM) propose to design and develop a digital edition of the text, including the user interface and data pipeline.  The NEH grant will fund the development of a dynamic, interactive ...

Scientists are developing an experiment to test whether gravity is quantum In quantum mechanics, which describes the behaviour of atoms and molecules –objects behave differently to everything we know: they can be in a quantum superposition of being in two places at the same time Now, scientists are investigating a way to determine whether gravity operates in this way, by levitating micro diamonds in a vacuum If gravity is quantum, it will ‘entangle’ the diamonds – an intriguing phenomenon which strongly links two objects in ways impossible in everyday life This research will help ...

BUFFALO, N.Y. – University at Buffalo research has identified how a misstep in the genesis of a key component of the kidney causes infantile cystinosis, a rare disease that significantly shortens the lifespan of patients. Published Nov. 30 in the International Journal of Molecular Sciences, the work reveals that the mechanisms that cause the disease could be addressed and potentially cured through the genome-editing technique CRISPR. That could make kidney transplants, the most effective treatment currently available for these patients, unnecessary. Infantile ...

Raz Developing Advanced Model-Based Tools For Portfolio Management Ali Raz, Professor, Systems Engineering and Operations Research (SEOR), received funding for the project: "Advanced Model-Based Tools for Portfolio Management and Analytic: System Architecture and Multi-Attribute Decision Making for Integrating Autonomy Phase 2 (AIRC RT-1081.07.5)." Raz is supporting Purdue University and Georgia Tech Research Institute (GTRI) in the enhancement of the IAPR System-of-systems (SoS) tool suite. Raz received $20,500 from Stevens Institute of Technology on a subaward from the U.S. Department of Defense for ...

December 11, 2023, Mountain View, CA -- The SETI Institute announced today the establishment of a new postdoctoral research fellowship program funded by its transformative bequest from Qualcomm Co-founder, Franklin Antonio.  The first two fellowships are being announced in conjunction with the American Geophysical Union Conference (AGU) being held this week in San Francisco.  The Baruch S. Blumberg Postdoctoral Fellowship for Astrobiology and the William J. Welch Postdoctoral Fellowship for SETI and Technosignatures ...

URBANA, Ill. — Natural resource management decisions in protected areas impact more than the wildlife and landscapes they’re charged to conserve. They also affect neighbors, who could otherwise hunt, build, or recreate as they choose on their own land. For decades, community members primarily voiced their opinions through brief and impersonal public comment periods. But an initiative led by environmental social scientists at the University of Illinois Urbana-Champaign is putting a new spin on neighborly communication.  “Historically, public land management ...

Philadelphia, December 11, 2023 – Advancements in the care of premature babies are leading to improved survival rates. However, the incidence of neonatal diseases with life-long consequences such as bronchopulmonary dysplasia (BPD) and retinopathy of prematurity (ROP) is increasing. A novel study has implicated granulocyte colony-stimulating factor (G-CSF) in both BPD and ROP, making it a promising therapeutic candidate. The results appear in The American Journal of Pathology, published by Elsevier. BPD, also called chronic lung disease of immaturity, afflicts approximately one third of all extremely ...

Statt at public bodies can be “overwhelmed” by having to implement human rights laws into the working of their organisation when staff are in “awe” of legislation, a new study warns. When laws are viewed as sacrosanct control over interpretation and implementation can be seen as the responsibility of a privileged few, according to the research. This leads to staff placing greater weight on implementation through processes. Laws are seen as so specialist staff feel they do not have the perceived required knowledge and expertise and cannot be trusted to implement them. Those who see equality and human rights law as malleable believe they should ...

Cola. A drink forever associated with the Christmas season. And also, for many, a liquid that can help clear a blocked oesophagus. Something that may be a bit more likely at this time of year.  However, research from Amsterdam UMC, published today in the BMJ Christmas Issue, shows that this is not worth wasting the sugary stuff.   "Emergency physician Elise Tiebie, the driving force behind this project, saw online that this was really a rumour, from tip websites to Wikipedia as well as an anecdote in a British newspaper about paramedics saving a life by using cola. I've even heard doctors recommending it,” says Arjan Bredenoord, Professor of Gastroenterology at ...

Jacques Morcos, MD, a renowned neurosurgeon from University of Miami Health System, will join UTHealth Houston as the new chair of the Vivian L. Smith Department of Neurosurgery with McGovern Medical School at UTHealth Houston, effective today. Morcos will also serve as co-director of UTHealth Houston Neurosciences alongside Louise McCullough, MD, PhD, chair of the Department of Neurology, and will be appointed as the Nancy, Clive and Pierce Runnells Distinguished Chair in Neuroscience. Nitin Tandon, MD, former chair ad interim of the neurosurgery department, ...

In March of 2020, India’s government announced a strict lockdown with just four hours notice, including a ban on the informal and traditional food outlets that 80 to 90 percent of Indians rely on for their main source of food. In a new paper, “Applying the six-dimensional food security framework to examine a fresh fruit and vegetable program implemented by self-help groups during the COVID-19 lockdown in India,” published in the journal World Development, researchers from the Alliance of Bioversity International and CIAT looked at the effects of a government-backed women’s self-help group program in the state of Odisha, India and how it impacted the six ...

Materials with enhanced structure derived from crustaceans and seaweed could be part of a next-generation answer to the challenge of replacing petroleum-based plastic films, according to new research from North Carolina State University. Combining chitosan, a biopolymer that makes crab shells hard, with agarose, a biopolymer extracted from seaweed that is used to make gels, creates unique biopolymer composite films with enhanced strength. The films are also biodegradable, have antibacterial properties, repel water and are transparent. The findings could eventually lead to sustainable packaging films for food ...

MIT researchers have used 3D printing to produce self-heating microfluidic devices, demonstrating a technique which could someday be used to rapidly create cheap, yet accurate, tools to detect a host of diseases.  Microfluidics, miniaturized machines that manipulate fluids and facilitate chemical reactions, can be used to detect disease in tiny samples of blood or fluids. At-home test kits for Covid-19, for example, incorporate a simple type of microfluidic.  But many microfluidic applications require chemical reactions that must be performed at specific temperatures. These more complex microfluidic devices, which are typically manufactured in a clean ...

Milan, December 11, 2023 - Taking a significant step forward in superconductivity research, the discovery could pave the way for sustainable technologies and contribute to a more environmentally friendly future. The study just published in Nature Communications by researchers from Politecnico di Milano, Chalmers University of Technology in Göteborg and Sapienza University of Rome sheds light on one of the many mysteries of high-critical-temperature copper-based superconductors: even at temperatures above the critical temperature, they are special, behaving like "strange" metals. This means that their electrical resistance ...

ARLINGTON, VA and DALLAS, December 11, 2023 — The American Diabetes Association® and the American Heart Association® have awarded grants to 10 community organizations to help people living with Type 2 diabetes lower their risk for cardiovascular diseases like heart attack, heart failure and stroke.  The community grants are part of the leading health non-profits’ joint Know Diabetes by Heart™ initiative which seeks to reduce cardiovascular events and deaths among people living with Type 2 diabetes. The grants will help organizations in California, Florida, Georgia, ...

A Stanford Medicine-led, international study of hundreds of samples from patients with Hodgkin lymphoma has shown that levels of tumor DNA circulating in their blood can identify who is responding well to treatment and others who are likely to experience a disease recurrence — potentially letting some patients who are predicted to have favorable outcomes forgo lengthy treatment.  Surprisingly, the study also revealed that Hodgkin lymphoma, a cancer of the lymph nodes, can be divided into two groups, each with distinct genetic changes and slightly different prognoses. These changes hint ...

The current emoji library doesn’t accurately represent the “tree of life” and the breadth of biodiversity seen in nature according to an analysis presented December 11 in the journal iScience. A team of conservation biologists categorized emojis related to nature and animals and mapped them onto the phylogenetic tree of life. They found that animals are well represented by the current emoji catalog, whereas plants, fungi, and microorganisms are poorly represented. Within the animal kingdom, vertebrates were overrepresented while arthropods were underrepresented with respect to their actual biodiversity. The researchers argue that creating a more diverse and representative ...

About The Study: High body mass index (BMI) in late adolescence was associated with early chronic kidney disease in young adulthood in this study that included 593,000 adolescents. The risk was also present in seemingly healthy individuals with high-normal BMI and before 30 years of age, and a greater risk was seen among those with severe obesity. These findings underscore the importance of mitigating adolescent obesity rates and managing risk factors for kidney disease in adolescents with high BMI.  Authors: Gilad Twig, M.D., Ph.D., of the Israel Defense Forces, Medical Corps, Tel Hashomer, Ramat Gan, Israel, is the corresponding author. To ...

Embargoed for release: Monday, December 11, 11:00 AM ET Key points: In a study of 3.5 million pregnancies across four countries between 2009 and 2021, researchers observed no elevated risk of major congenital malformations, including major cardiac malformations, among infants born to pregnant women with pre-gestational type 2 diabetes who took second-line non-insulin antidiabetic medications compared with those who took insulin. The researchers observed an increase in use of second-line non-insulin antidiabetic ...

  The Organoid Group (Hubrecht Institute) and the Rare Cancers Genomics Team (IARC/WHO) found a way to grow samples of different types of neuroendocrine tumors (NETs) in the lab. While generating their new model, the researchers discovered that some pulmonary NETs need the protein EGF to be able to grow. These types of tumors may therefore be treatable using inhibitors of the EGF receptor. The results were published in Cancer Cell on 11 December 2023.   Neuroendocrine tumors Neuroendocrine tumors (NETs) are relatively ...

BOSTON – Physician-investigators at Beth Israel Deaconess Medical Center (BIDMC) compared a chatbot’s probabilistic reasoning to that of human clinicians. The findings, published in JAMA Network Open, suggest that artificial intelligence could serve as useful clinical decision support tools for physicians. “Humans struggle with probabilistic reasoning, the practice of making decisions based on calculating odds,” said the study’s corresponding author Adam Rodman, MD, an internal medicine physician and investigator in ...