In women in their mid-40s to early 50s, endometriosis--a condition in which tissue that normally lines the uterus grows outside the uterus--was linked with poor work ability and more sick days, but not with unemployment or early retirement. The findings, which are published in END ...

Physical relaxation through yoga or other practices can help reduce work-related stress, according to an analysis of studies conducted in healthcare staff. The analysis, which is published in the END ...

Students reported far higher rates of bullying at school before the COVID-19 pandemic than during the pandemic across all forms of bullying--general, physical, verbal, and social--except for cyber bullying, where differences in rates were less pronounced. The findings come from a study published in END ...

A new analysis called an evidence and gap map has mapped what we know about improving the functional ability of older adults living at home or in nursing homes, retirement homes, or other long-term care facilities. A total of 548 studies were included in the map, which is published in END ...

We're currently living in what many scientists are calling the Anthropocene, the period during which human activity has been the dominant influence on climate and the environment. An article published in the END ...

Experiencing a variety of positive emotions--or emodiversity--may benefit high school students, according to a study published in the END ...

Integrated Assessment Models (IAMs) connect trends in future socio-economic and technological development with impacts on the environment, such as global climate change. Critics have taken issue with the transparency of IAM methods and assumptions as well as the transparency of assessments of IAMs by the Intergovernmental Panel on Climate Change (IPCC), the United Nations body for assessing the science related to climate change. An article published in END ...

ANN ARBOR, Mich. - The number of adolescents admitted to the hospital for severe illness from eating disorders has increased significantly during the COVID-19 pandemic, new research suggests. At one center, the number of hospital admissions among adolescents with eating disorders more than doubled during the first 12 months of the pandemic, according to the study that appears in a pre-publication of Pediatrics. The 125 hospitalizations among patients ages 10-23 at Michigan Medicine in those 12 months reflect a significant increase over previous years, as admissions related to eating disorders ...

Using single cell technology, a new study sheds light on the significance of genetic risk factors for, and the diversity of cells involved in, the development of coronary artery disease. The researchers analysed human atherosclerotic lesions to map the chromatin accessibility of more than 7,000 cells. The chromatin accessibility is known to reflect active regions and genes in the genome. The findings were published in Circulation Research. Genome-wide association studies of the human genome have identified over 200 loci associated with coronary artery disease. More than 90% of them ...

If you've watched Netflix, shopped online, or run your robot vacuum cleaner, you've interacted with artificial intelligence, AI. AI is what allows computers to comb through an enormous amount of data to detect patterns or solve problems. The European Union says AI is set to be a "defining future technology." And yet, as much as AI is already interwoven into our everyday lives, there's one area of the globe where AI and its applications are in their infancy, says Ekaterina Kim, an associate professor at the Norwegian University of Science and Technology's (NTNU) Department of Marine Technology. That area is the Arctic, an area where she has specialized in studying sea ice, among other topics. "It's used a lot in marketing, in medicine, but ...

BINGHAMTON, N.Y. -- A million years ago, dry seasons became more frequent and forests retreated before the encroaching savanna. Meanwhile, clustered around a nearby lake, our ancient ancestors fashioned stone tools. During the long press of years, mud and sediment in that East African lake turned to stone, trapping pollen and microscopic organisms in its lattice. Today, researchers like Kennie Leet analyze samples of these ancient sediments, known as sediment cores, to create a picture of the environment early humans called home. A doctoral student in geological sciences, Leet is the first author ...

Researchers from University of Mannheim published a new paper in the Journal of Marketing that examines the effect of wage inequality on customer satisfaction and firm performance. The study, forthcoming in the Journal of Marketing, is titled "Wage Inequality: Its Impact on Customer Satisfaction and Firm Performance" and is authored by Boas Bamberger, Christian Homburg, and Dominik M. Wielgos. Irrespective of wage cuts and employee layoffs, the wages of top managers rose to record levels during the pandemic and wage inequality continues to grow worldwide. However, according to a 2015 OECD report, "wage inequality is harmful to long-term economic growth and undermines ...

The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease. To identify new biomarkers that can be used in the newborn screening protocol, also known as the neonatal heel prick, researchers at the Radboud University Medical Center joined forces with scientists at the Radboud University's FELIX laser laboratory. They published their findings in The Journal of Clinical Investigation. The discovery and identification ...

PULLMAN, Wash. - Even before the pandemic made Zoom ubiquitous, Washington State University researchers were using the video conferencing app to research a type of cannabis that is understudied: the kind people actually use. For the study, published in Scientific Reports, researchers observed cannabis users over Zoom as they smoked high-potency cannabis flower or vaped concentrates they purchased themselves from cannabis dispensaries in Washington state, where recreational cannabis use is legal. They then gave the subjects a series of cognitive tests. The researchers found no impact on the users' performance on decision-making tests in comparison to a sober control group but did find some memory impairments related to free ...

INDIANAPOLIS -- The vast majority of electronic health record (EHR) alerts attempting to reduce the prescribing of high-risk medications linked to dementia in older adults went unread in a study led by research scientists from Regenstrief Institute, Purdue University and Indiana University School of Medicine. The goal of the intervention was to facilitate the deprescribing of anticholinergics through both provider and patient-based alerts, however, engagement with the alerts was so low, the study team was unable to conclude if this approach could be ...

When blood flow to the brain is somehow reduced or restricted, a person can suffer what we know as a stroke (from "ischemic stroke" in medical jargon). Stroke is one of those conditions that seems fairly common. This isn't a misperception: just in Europe, there are over 1.5 million new cases each year. Some strokes can be lethal, and when they're not they often result in serious damage to the victim's ability to move. In fact, stroke is one of the major causes of long-term disability today. Recovery can be a long and arduous road. Again, in Europe, under 15% of the patients ...

Software to help towns and cities use street-planting to reduce citizens' exposure to air pollution has been developed by researchers at the University of Birmingham. Street planting, or 'green infrastructure', is an essential part of the urban realm, but there is a misconception that plants remove or 'soak up' a lot of pollution. Instead, planting at this scale primarily serves to redistribute pollution by changing air currents within streets and beside open roads. Because of this, not only the position and amount of planting within a street, but also ...

Astronomers have designed and trained a computer program which can classify tens of thousands of galaxies in just a few seconds, a task that usually takes months to accomplish. In research published today, astrophysicists from Australia have used machine learning to speed up a process that is often done manually by astronomers and citizen scientists around the world. "Galaxies come in different shapes and sizes" said lead author Mitchell Cavanagh, a PhD candidate based at The University of Western Australia node of the International Centre for Radio Astronomy Research (ICRAR). "Classifying the shapes of galaxies is an important step in understanding their formation and evolution, and can even shed light on the nature of the Universe itself." Mr Cavanagh said that ...

Most common bone and joint (orthopaedic) procedures, such hip replacements and shoulder repair surgery, are not backed up by high quality evidence, mainly because of a lack of definitive trials, suggests an analysis of data published by The BMJ today. Yet despite the lack of strong supporting evidence, some of these procedures are still recommended by national guidelines in certain situations, the findings show. Musculoskeletal conditions affect around 1 in 4 UK adults and account for over 25% of all NHS surgical interventions at a cost of £4.76 billion each year. National ...

Muscle relaxant drugs are largely ineffective for low back pain, despite being widely prescribed for this condition, suggests an analysis of the latest evidence published by The BMJ today. The findings show that muscle relaxants might reduce pain in the short term, but the effect is too small to be considered clinically meaningful, and there is an increased risk of side effects. But the researchers stress that the certainty of evidence is low and say large trials are urgently needed to resolve uncertainties around the use of these drugs for back pain. Low back pain is a global public health problem and muscle relaxants (a broad class of drugs that include ...

Mandatory covid-19 vaccination for care home workers is unnecessary, disproportionate and misguided, warn experts And is based on unreliable data In The BMJ today, experts argue that mandatory vaccination is "unnecessary, disproportionate, and misguided." The government decision to remove the right of care home staff in England to choose whether or not to be vaccinated against covid-19 is a profound departure from public health norms. The intended next step is a rapid and massive expansion of compulsory vaccination to legally require covid-19 and flu vaccination of all frontline health and social care workers, subject to consultation. But Lydia Hayes, Professor of Law at Kent ...

An estimated 8.4 billion people could be at risk from malaria and dengue by the end of the century if emissions keep rising at current levels, according to a new study published in The Lancet Planetary Health. The research team estimates that this worst-case scenario would mean the population at risk of the diseases might increase by up to 4.7 additional billion people (relative to the period 1970-1999), particularly in lowlands and urban areas, if temperatures rise by about 3.7°C 1 by 2100 compared to pre-industrial levels. The study was led by the London School of Hygiene & Tropical Medicine (LSHTM) with partners from Umeå University, Sweden; Abdus Salam ...

LOS ANGELES - A new prognostic tool developed by researchers from the UCLA Jonsson Comprehensive Cancer Center and five other institutions helps predict which men with advanced metastatic prostate cancer will respond favorably to a novel targeted therapy. The tool, described in a study published today in Lancet Oncology, analyzes a wide spectrum of imaging and clinical data and is intended to assist physicians considering treating patients with Lutetium-177 prostate-specific membrane antigen, or LuPSMA. LuPSMA, which binds to PSMA proteins and delivers targeted radiation to prostate cancer tissue, offers a new option to men with PSMA-positive metastatic cancer that is castration-resistant, meaning it has stopped ...

The protein actin is ubiquitous and essential for life. In mammals, every cell expresses two of its forms, beta-actin and gamma-nonmuscle-actin. Despite having distinct roles, the two forms are nearly identical, sharing 99% of their amino acid sequence. Research by Anna Kashina of Penn's School of Veterinary Medicine and colleagues has shown that, contrary to scientific dogma, it's not the slight differences in amino acid sequence that govern these proteins' discrete functions in the cell. Rather, their nucleotide sequences--the "letters" that make up their DNA coding sequence, which differ by roughly 13% between the two forms--are responsible for their individual roles in organisms' ...

Researchers have produced vaccine-like immune responses to a dangerous bacterium by colonizing 26 healthy volunteers with a related, but harmless, commensal bacterial species. The first-in-human, controlled infection study showed the strategy was safe, as no side effects were reported and the volunteers didn't transmit the commensal bacteria to bedroom-sharers over the 90-day study. Neisseria lactamica is a member of the microbiome that usually resides in the upper airways of children but can also safely colonize the airways of adults. Some researchers theorize that these bacteria ...