Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a study led by Cedars-Sinai investigators. The Phase I clinical trial results are published in the peer-reviewed journal eBioMedicine, a Lancet journal. “Although several drugs are approved for pulmonary arterial hypertension, mortality remains high,” said Eduardo Marbán, MD, PhD, executive director of the Smidt Heart Institute at Cedars-Sinai, the Mark S. Siegel Family Foundation ...

Elika Bergelson, associate professor of psychology at Harvard University, studies how infants and toddlers learn language from the world around them. The developmental psychologist specifically strives to parse the various theories that account for the onset and eventual mastery of language comprehension and production. Bergelson’s latest paper, published this month in the Proceedings of the National Academy of Sciences, represents a more global approach to developing and testing such theories.  Written ...

DALLAS, Dec. 13, 2023 — The winter holidays can turn deadly as research shows that more people die from heart attacks during the last week of December than at any other time of the year. While being aware of the signs of a heart attack and taking steps to reduce your risk are important all year long, the American Heart Association, the world’s leading voluntary organization focused on heart and brain health for all, says that’s especially critical during the next few weeks. A number of scientific studies confirm ...

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include a novel blood-based test to predict lung cancer relapses, improved detection of genes associated with complex traits, insights into how B cell activity influences immunodeficiency, novel targets that drive treatment ...

The most comprehensive analysis of Indigenous Australians’ genomes collected to date has revealed an “abundance” of DNA variations – some of which have never been reported anywhere else in the world – paving the way for new, personalised treatments that address health inequities for Aboriginal and Torres Strait Islander peoples. A team of Australian researchers, led by scientists from The Australian National University (ANU), found DNA differences between Indigenous Australians living in the Tiwi Islands and Indigenous peoples living in the Australian ...

Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences have proposed a new “nano-micro composite” delivery concept for vaccines. Based on this idea, they have developed a single-dose, dry-powder, inhalable vaccine platform using nano-micro composite multilevel structures, which has been successfully prepared in the laboratory, and the vaccine has been shown to be effective in blocking respiratory viral infection and transmission in animal models. This platform holds great promise for combating future emerging and epidemic infectious diseases. This ...

Cannabis use for medicinal or recreational purposes is now permitted is most states in the U.S. Many of the products sold in dispensaries contain delta-9-tetrahydrocannabinol (better known as “THC”), and are thus classified as Schedule I drugs, making them illegal under federal law. However, there is a parallel market for products derived from hemp—defined as cannabis containing less that 0.3 percent THC—spurred in part by the passage of the 2018 Farm Bill, which removed hemp-derived cannabinoids from the federal Controlled Substances Act. A new U-M study published in JAMA Network Open examines past-year use of some of these hemp-derived ...

PHILADELPHIA— New research reveals that neurons in the preoptic hypothalamus—the region of the brain that regulates sleep and body temperature—are rhythmically activated during non-rapid eye movement sleep (NREM). Stress activates these brain cells out of turn, causing “microarousals,” that interrupt sleep cycles and decrease the duration of sleep episodes, according to research from Perelman School of Medicine at the University of Pennsylvania, published today in Current Biology. While our bodies are at rest when we are asleep, ...

By Jake Siegel Imagine you’re teaching a dog to play fetch. You throw a ball, and your dog sprints after it, picks it up, and runs back. You then reward your panting pup with a treat. But now comes the real trick for your dog: figuring out which part of that sequence earned the treat. Scientists call this the 'credit assignment problem' in the brain. It's a fundamental question about understanding which actions are responsible for the positive outcomes we experience.   Dopamine, a key chemical ...

LA JOLLA (December 14, 2023)—Salk Institute researchers, as part of a worldwide initiative to revolutionize scientists’ understanding of the brain, analyzed more than 2 million brain cells from mice to assemble the most complete atlas ever of the mouse brain. Their work, published December 14, 2023 in a special issue of Nature, not only details the thousands of cell types present in the brain but also how those cells connect and the genes and regulatory programs that are active in each cell. The efforts were coordinated by the National Institutes of Health’s Brain Research Through Advancing Innovative Neurotechnologies® Initiative, or the BRAIN Initiative®, ...

By Jake Siegel Six years and 32 million cells later, scientists have created the first full cellular map of a mammalian brain. In a set of 10 papers in Nature today, a network of researchers unveiled an atlas cataloging the location and type of every cell in the adult mouse brain. Using advanced technologies that profile individual cells, the teams identified over 5,300 cell types – far more than known before – and pinpointed their locations within the brain’s intricate geography. ...

SAN FRANCISCO—December 13, 2023—In a study of historic scale, scientists at Gladstone Institutes have created an intricate map of how the immune system functions, examining the detailed molecular structures governing human T cells using the next-generation CRISPR tool known as base editing. Their findings, published in Nature, uncover detailed information that could help overcome the limitations of today’s immunotherapies and identify new drug targets for a wide range of diseases, including autoimmune diseases and cancer. Led by Gladstone Senior Investigator Alex Marson, MD, PhD, the team dove deep into the DNA of T cells, pinpointing ...

Liquid crystal is a state of matter that exhibits properties of both liquid and solid. It can flow like a liquid, while its constituent molecules are aligned as in a solid. The liquid crystal is widely used nowadays, for example, as a core element of LCD devices. The magnetic analog of this kind of material is dubbed the “spin-nematic phase”, where spin moments play the role of the molecules. However, it has not yet been directly observed despite its prediction a half-century ago. The main challenge stems ...

COLUMBUS, Ohio – Scientists have revealed a never-before-seen phenomenon in a protein: Alone, the enzyme processes DNA and RNA but, when bound to another protein as part of a defense system, interacts with a completely different type of compound to help bacteria commit suicide. The finding came about as the researchers focused on detailing how this defense mechanism works in bacteria that are infected by phages, viruses that invade and make copies of themselves inside bacterial cells. In addition to detailing the proteins’ structures and binding sites, the experiments unearthed ...

Researchers from Tokyo Medical and Dental University (TMDU) develop models based on machine learning that predict long-term visual acuity in patients with high myopia, one of the top three causes of irreversible blindness in many regions of the world  Tokyo, Japan – Machine learning has been found to predict well the outcomes of many health conditions. Now, researchers from Japan have found a way to predict whether people with severe shortsightedness will have good or bad vision in the future. In a study recently published in ...

For the first time ever, an international team of researchers has created a complete cell atlas of a whole mammalian brain. This atlas serves as a map for the mouse brain, describing the type, location, and molecular information of more than 32 million cells and providing information on connectivity between these cells. The mouse is the most commonly used vertebrate experimental model in neuroscience research, and this cellular map paves the way for a greater understanding of the human brain—arguably the most powerful computer in the world. The cell atlas also lays the foundation for the development of a new generation of precision therapeutics for people ...

Hard-to-detect colorectal pre-cancerous lesions known as serrated polyps, and the aggressive tumors that develop from them, depend heavily on the ramped-up production of cholesterol, according to a preclinical study from researchers at Weill Cornell Medicine. The finding points to the possibility of using cholesterol-lowering drugs to prevent or treat such tumors. In the study, published Oct. 13 in Nature Communications, the researchers analyzed mice that develop serrated polyps and tumors, detailing the chain of molecular events in these tissues that leads to increased cholesterol production. They ...

WASHINGTON, DC, 2023 – Recent U.S. wildfire events -- including the 2023 Maui wildfire in Hawaii, the 2022 Hermit’s Peak/Calf Canyon fire in New Mexico, and the 2020 Cameron Peak Fire in Colorado -- are tragic examples of how disadvantaged communities can suffer most during and after a wildfire. While all three fires had a devastating impact on an entire community, they disproportionately affected low-income populations who were left without adequate insurance or the financial means to rebuild their homes.  To study inequities in U.S. wildfire management, ...

COLUMBUS, Ohio – Parents who drank alcohol while watching the Super Bowl were more likely than those who abstained to use aggressive discipline on their children during the game, a new study shows.   Most of the parents in the study – more than 90% - were mothers, which is significant, said Bridget Freisthler, lead author of the study and professor of social work at The Ohio State University.   “The links between alcohol use, aggression and watching violent sports have been studied almost exclusively among ...

The percentage of adolescents reporting they used any illicit substances in 2023 continued to hold steady below the pre-pandemic levels reported in 2020, with 10.9% of eighth graders, 19.8% of 10th graders, and 31.2% of 12th graders reporting any illicit drug use in the past year, according to the latest results from the Monitoring the Future survey. Reported use for almost all substances decreased dramatically between 2020 and 2021, after the onset of the COVID-19 pandemic and related changes like school closures and social distancing. In 2022, most reported substance use among adolescents ...

Washington, December 13, 2023—For years, research showed that print reading, whether for leisure or school, improved developing readers’ ability to comprehend text. However, the explosive use of digital reading devices, constant access to these devices, and new types of reading materials have introduced new reading habits. Now, a new comprehensive review of research on digital leisure reading habits finds a virtually nonexistent relationship between digital reading and improvement in reading comprehension among students. The study was published in Review of Educational Research, a peer-reviewed journal of the American Educational ...

Ishikawa, Japan -- Various molecular systems have been developed by researchers for photoinduced (i.e., light-driven) electron transfer, including supramolecules, hybrid materials, and organic polymeric systems. While these systems fulfill the distance criterion required by the electron donor and acceptor for efficient electron transfer, they frequently fall short in accommodating molecular motion, especially in fluid environments. Is there a viable approach to design a system that facilitates electron transfer without succumbing to these limitations? This issue has been specifically addressed in a recent study. ...

WASHINGTON, DC, Dec. 13, 2023 – Wildfires pose an increasing threat to communities at the wildland-urban interface (WUI) – where dry, flammable vegetation borders back yards, often in remote locations. Despite the well-known danger, many communities at highest risk do not have a strong wildfire evacuation plan in place. (One of these was the town of Lahaina on Maui, where wind-driven wildfires killed nearly 100 people in August 2023.)  Researchers from UCLA’s John Garrick Institute for the Risk Sciences have built a new web-based software platform that allows emergency planners to design custom-made evacuation plans for their communities ...

Patients with lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), often undergo progressive kidney damage, with approximately 20% of these patients advancing to end-stage renal disease. The current therapeutic landscape for LN, dominated by glucocorticoids and immunosuppressants, is limited by suboptimal response rates, the risk of disease flare-ups and adverse effects, accentuating the necessity for safer and more effective treatment modalities. In the latest issue of the Chinese Medical Journal (CMJ) published online on December 15, 2023, a review authored by Dr. Wei Chen from the Department of Nephrology of the First Affiliated ...

San Francisco and New York — Dec. 13, 2023 — The Parker Institute for Cancer Immunotherapy (PICI), the largest concentration of immuno-oncology (IO) expertise in the world, announced it has added Weill Cornell Medicine to its network of preeminent academic and medical research institutions at the forefront of the fight against cancer. Under the agreement, Weill Cornell Medicine, with new PICI Network researchers, will establish a PICI immuno-oncology research center in New York City.     Since its inception, PICI has distributed $260 million to member researchers to support ...