The University of Chicago Medicine Comer Children’s Hospital will be among the first in the country to offer gene therapy for sickle cell disease in patients 12 years and older, after federal regulators approved two new treatments on December 8, 2023. Thousands of patients with sickle cell disease experience vaso-occlusive crises (VOCs), which are often painful and frequently require hospitalization. The two new potentially curative treatments show promise for eliminating VOCs and offer an alternative to bone marrow transplants, which can be arduous and carry risk of rejection even if a matching donor is found. People ...

Northwestern University researchers have developed the first physics-based metric to predict whether or not a person might someday suffer an aortic aneurysm, a deadly condition that often causes no symptoms until it ruptures.   In the new study, the researchers forecasted abnormal aortic growth by measuring subtle “fluttering” in a patient’s blood vessel. As blood flows through the aorta, it can cause the vessel wall to flutter, similar to how a banner ripples in the breeze. While stable flow predicts normal, natural growth, unstable flutter is highly predictive of future abnormal growth and potential rupture, the researchers found.   Called ...

In a new study, researchers at the University of Chicago were able to predict postoperative infections in liver transplant patients by analyzing molecules in their poop. Their analysis represents a key leap forward in exploring the connection between the gut microbiome — the bacteria that inhabit the human body — and overall health. “Antibiotic resistance is growing every year and getting worse. Without antibiotics that work, we can't do things like perform surgeries, protect premature infants or treat cancer,” said Christopher Lehmann, MD, ...

SAN FRANCISCO – Wildfire management systems outfitted with remote sensing technology could improve first responders’ ability to predict and respond to the spread of deadly forest fires. To do this, researchers at The Ohio State University are testing the use of Synthetic Aperture Radar, or SAR, to help with wildfire detection. For many ecosystems, fires are vital tools that help to clear away plant waste, provide safer habitats for smaller species and burn off disease. Yet as Earth continues to experience warmer, drier conditions, the likelihood and severity of large, uncontrolled fire incidents that result in widespread ...

Because of warming waters and melting glaciers, the sea level at Virginia’s Eastern Shore has risen almost 3 inches since 2016, and the projected trajectory looks ominous. The region, sandwiched between the Chesapeake Bay and the Atlantic Ocean, has one of the highest rates of relative sea-level rise on the Atlantic coast. The Virginia Institute of Marine Science’s Center for Coastal Resource Management projects a relative sea-level rise between 4.5 to 7 feet by 2100, which is three to four times the global average. Hampton, Virginia — its neighbor across the bay — ranks second only to New Orleans as the largest population center ...

SAN FRANCISCO – As efforts to transition away from fossil fuels strengthen the hunt for new sources of low-carbon energy, scientists have developed a deep learning model to scan the Earth for surface expressions of subsurface reservoirs of naturally occurring free hydrogen.  Researchers used the algorithm to help narrow down the potential whereabouts of ovoids or semicircular depressions (SCDs) in the ground that form near areas associated with natural or “gold hydrogen” deposits. Though these circular ...

To what extent methodological limitations and incomplete data impact the revenue estimations of cybercriminal groups using the Bitcoin blockchain was largely unknown. A new study, conducted by IMDEA Software Institute researchers Gibran Gomez, Kevin van Liebergen, and Juan Caballero challenges existing figures regarding cybercriminals' Bitcoin earnings to date. The study, entitled "Cybercrime Bitcoin Revenue Estimations: Quantifying the Impact of Methodology and Coverage", recently presented at the ...

Under the Defense University Research Instrumentation Program, Dr. Patrick Shamberger and a research team from the Department of Materials Science and Engineering received a grant from the U.S. Department of Defense (DOD) to acquire instrumentation for thermal energy storage research. The grant, administered through the Office of Naval Research, will support the acquisition of a high-sensitivity multi-modal calorimeter for advanced research and education on tunable energy storage materials. This equipment will allow cutting-edge research to study the capability of pressure and humidity to control how well these materials can store ...

Arabidopsis thaliana is a species grown worldwide for genetic research and was the first plant to have its complete set of chromosomes (its genome) sequenced. The initial genome sequence, released in the year 2000, had numerous gaps, but technological improvements in the years since closed the gaps, one by one, until only two remained: large undefined regions on chromosomes 2 and 4 where genes encoding ribosomal RNAs are repeated in hundreds of copies. These ribosomal RNA gene clusters, known as nucleolus organizer regions (NORs), are not just difficult to define in Arabidopsis; gaps remain at ...

Many ocular diseases involve changes in the structure and function of different regions of the back of the eye, also known as the “eye fundus.” For example, fluorescent pigments and tiny yellowish deposits called drusen accumulate under the retina in age-related macular degeneration, and the degeneration of neurons called ganglion cells is a defining characteristic of glaucoma. Interestingly, changes in the eye fundus are not restricted to vision-related diseases only. Certain neurological diseases like Parkinson’s and Alzheimer’s can cause changes in retinal nerves and ...

Sepideh Dolatshahi, an assistant professor of biomedical engineering at the University of Virginia, is spearheading an exploration of systems immunology in its crucial development phase — during pregnancy. Systems immunology is about unraveling concealed patterns within the human immune system, said Dolatshahi, whose approaches to her research span computational modeling, systems serology and cutting-edge spatial analysis techniques to investigate immune interactions between mother and fetus during pregnancy that could later support early childhood immunity.   Designing Tailored and Effective Vaccine Plans Babies are immunocompromised ...

A new study finds that radiation therapy (RT) suppresses a key protein called bone morphogenetic protein and activin membrane-bound inhibitor (BAMBI) and activates immune suppressive cells. These effects dampen the capacity of cancer-fighting immune cells and decrease the effectiveness of radiation, inducing therapy resistance in cancer patients, according to a paper published December 15, 2023 in the Journal of Clinical Investigation. Radiation therapy is a common cancer treatment that kills cancer cells and activates immune cells to fight cancer. Yet this process also ...

The word “drought” typically conjures images of parched soil, dust-swept prairies, depleted reservoirs, and dry creek beds, all the result of weeks or seasons of persistently dry atmospheric conditions. In the sun-soaked islands in the Caribbean, however, drought conditions can occur much more rapidly, with warning signs appearing too late for mediation strategies to limit agriculture losses or prevent stresses on infrastructure systems that provide clean water to communities. Such occurrences – known as flash droughts – are the focus of a new paper authored by Assistant Professor Craig Ramseyer of the College of Natural Resources ...

It has long been known that exposure to pesticide sprays is harmful to honey bees. In a new study, researchers have uncovered the effect of such sprays on the sense of smell in bees, which could disrupt their social signals. Honey bees live in dynamic communities and constantly communicate with each other using chemicals that serve as social cues. For example, nurse bees—that are responsible for taking care of larvae that ultimately become queens and worker bees—constantly monitor the ...

Immune cells play an active and intimate role in directing the growth of human lung tissue during development, researchers find, revolutionising our understanding of early lung development and the role of immune cells outside of immunity. The research offers new insights for understanding and treating respiratory conditions, such as chronic obstructive pulmonary disease (COPD). Respiratory conditions account for almost 20 per cent of all deaths in children under five years worldwide1. The work reveals a surprising coordination between the immune and respiratory systems, much earlier in development than previously thought. This discovery raises questions about the ...

New research has revealed that Rembrandt impregnated the canvas for his famous 1642 militia painting ‘The Night Watch’ with a lead-containing substance even before applying the first ground layer. Such lead-based impregnation has never before been observed with Rembrandt or his contemporaries. The discovery, published today in Science Advances, underlines Rembrandt's inventive way of working,  in which he did not shy away from using new techniques. The surprising observation is yet another result from Operation Night Watch, the largest and most wide-ranging research and conservation project in the history ...

Salmon researchers from British Columbia are embarking on a three-year study to understand and help mitigate the cumulative threats affecting the vulnerable species in the province’s watersheds. The Watershed Futures Initiative, which includes researchers from Simon Fraser University, University of British Columbia and University of Montana, has received $1.25 million from the federal and provincial governments – through the joint British Columbia Salmon Restoration and Innovation Fund – to tackle the combined impacts of logging, mining, urban development, agriculture, climate change and other factors on salmon.   While ...

The average menstruator will use over 11,000 tampons or sanitary pads in their lifetime. Vaginal and vulvar tissue that touch pads and tampons is highly permeable. Through this permeable tissue chemicals are absorbed without being metabolized, which makes endocrine-disrupting chemicals potentially dangerous when found in menstrual products. Endocrine-disrupting chemicals can interfere with human hormones and cause medical issues, including gynecological conditions such as endometriosis and uterine fibroids.  Joanna Marroquin, a Mason PhD in Public Health student, and Associate ...

The U.S. Department of Energy’s (DOE) Argonne National Laboratory has named five highly accomplished scientists as Argonne Distinguished Fellows in 2023. They are Glenn Decker, Paul Fenter, Robert Fischetti, Sven Leyffer and Valentine Novosad. The honor recognizes scientists who have not only achieved international esteem but who have also demonstrated exceptional achievements in science or engineering relevant to Argonne’s core missions. They are leaders of major, complex, high-priority projects or programs that have an impact on the future of the Laboratory. Only a small ...

Exposure to phthalates, a group of plasticizing and solvent chemicals found in many household products, was linked to a lower probability of getting pregnant, but not to pregnancy loss, according to research by a University of Massachusetts Amherst environmental and reproductive epidemiologist. The study, published this week in the journal Environmental Health Perspectives, also noted an association between preconception exposure to phthalates and changes in women’s reproductive hormones, as well as increased inflammation and oxidative stress.   “Phthalates ...

WASHINGTON  –  Debra Rolison, Ph.D., of the U.S. Naval Research Laboratory (NRL) has been named Fellow of the National Academy of Inventors (NAI), for having demonstrated a highly prolific spirit of innovation in creating and facilitating outstanding inventions that have made a tangible impact on the quality of life, economic development, and welfare of society.   Rolison has been at the lab for over 43 years and heads the Advanced Electrochemical Materials section. The recognition by the NAI is attributed to the efforts made by her team’s inventions related to a new form factor for zinc anodes in rechargeable ...

SAN FRANCISCO — One of the hottest debates in archeology is how and when humans first arrived in North America. Archaeologists have traditionally argued that people walked through an ice-free corridor that briefly opened between ice sheets an estimated 13,000 years ago.   But a growing number of archeological and genetic finds — including human footprints in New Mexico dated to around 23,000 years old — suggests that people made their way onto the continent much earlier. These early Americans likely traveled along the Pacific coastline from Beringia, the land bridge between Asia and North America ...

We are pleased to announce that the American Institute of Aeronautics and Astronautics (AIAA), a preeminent aerospace professional society, has selected professor Xinfeng Gao to be a member of the class of 2024 AIAA associate fellows. Only one member of the Institute for every 150 members is selected as an associate fellow each year by the review committee. “This recognition illustrates the impact of our outstanding faculty. Aerospace engineering at UVA continues on a great trajectory and professor Gao is a big part of that,” said Richard W. Kent, professor and chair of the Department of Mechanical and Aerospace Engineering. Pioneering ...

Addiction is one of society’s most misunderstood and rebuked health conditions. That stigma discourages many people from seeking treatment for substance dependence, according to a new report published in Psychological Science in the Public Interest, a journal of the Association for Psychological Science.  Research on stigma toward people with substance use disorder (SUD) is relatively sparse, the report adds. “Characterizing the nature and etiology of SUD stigma is critical for developing tailored and effective interventions ...

LAWRENCE — Research appearing in ACS Nano, a premier journal on nanoscience and nanotechnology, reveals the ballistic movement of electrons in graphene in real time. The observations, made at the University of Kansas’ Ultrafast Laser Lab, could lead to breakthroughs in governing electrons in semiconductors, fundamental components in most information and energy technology. “Generally, electron movement is interrupted by collisions with other particles in solids,” said lead author Ryan Scott, ...