July 12, 2021-- A new study sheds light on how the specter of dementia and chronic pain reduce people's desire to live into older ages. Among Norwegians 60 years of age and older the desire to live into advanced ages was significantly reduced by hypothetical adverse life scenarios with the strongest effect caused by dementia and chronic pain, according to research conducted at the Robert N. Butler Columbia Aging Center based at the Columbia Mailman School of Public Health. The paper is among the first to study Preferred Life Expectancy (PLE) based on hypothetical health and living conditions. The findings are published ...

A new University of Arizona Health Sciences study found women on hormone therapy were up to 58% less likely to develop neurodegenerative diseases including Alzheimer's disease, and reduction of risk varied by type and route of hormone therapy and duration of use. The findings could lead to the development of a precision medicine approach to preventing neurodegenerative diseases. The study, published in Alzheimer's & Dementia: Translational Research & Clinical Interventions, found that women who underwent menopausal hormone therapy for six years or greater were 79% less likely to ...

A team of researchers at the University of Cambridge has developed a new experimental and theoretical platform to study how viruses evolve while spreading within an organism. In the study, published in PHYSICAL REVIEW X, the researchers used experimental data and simulations of a phage-bacteria ecosystem to uncover that viral expansions can transition from 'pulled' - where the expansion is led by the pioneering viral particles at the very edge of the population, to 'pushed', where the expansion is driven by viruses arising behind the front and within the infected region. Crucially, pushed waves are known ...

Commonly-used household products should carry a warning that they increase the risk of asthma, according to a new evidence review. New research conducted by Smartline, a research project funded by the European Regional Development Fund, finds evidence that a group of chemicals found in a wide range of products in people's homes increases the risk of asthma. Authors conclude that labelling should reflect this risk, and warn people to ventilate their homes while using them. The research reviewed 12 studies into Volatile Organic Compounds (VOCs), which are emitted as gases from certain solids or liquids. VOCs are emitted by a wide array of products, including some that are widely used as ingredients in household products. ...

The city park may be an artificial ecosystem but it plays a key role in the environment and our health, the first global assessment of the microbiome in city parks has found. The study, published in END ...

The discovery of iron-based superconductors with a relatively high transition temperature Tc in 2008 opened a new chapter in the development of high-temperature superconductivity. The following decade saw a 'research boom' in superconductivity, with remarkable achievements in the theory, experiments and applications of iron-based superconductors, and in our understanding of the fundamental mechanism of superconductivity. A UOW paper published last month reviews progress on high-pressure studies on properties of iron-based superconductor (ISBC) families. FLEET PhD student Lina Sang (University of Wollongong) was first author on the Materials Today Physics review paper, investigating ...

Movies and television often show romance sparking when two strangers meet. Real-life couples, however, are far more likely to begin as friends. Two-thirds of romantic relationships start out platonically, a new study in Social Psychological and Personality Science finds. This friends-first initiation of romance is often overlooked by researchers. Examining a sample of previous studies on how relationships begin, the authors found that nearly 75 percent focused on the spark of romance between strangers. Only eight percent centered on romance that develops among friends over time. "There are a lot of people ...

Destroying tropical ecosystems and replacing them with soybeans and other crops has immediate and devastating consequences for soybeans, according to new peer-reviewed research in the journal World Development. With 35.8 million hectare currently under soy cultivation in Brazil, extreme heat--which adjacent tropical forests help keep in check--has reduced soybean income by an average of approximately US$100 per hectare per year. The study, Conserving the Cerrado and Amazon biomes of Brazil protects the soy economy from damaging warming, shows that protecting the Amazon and Cerrado can prevent the sort of high temperatures that damages the productivity of crops--estimated to cost the sector US$3.55 billion. Another recent study found annual agricultural losses associated ...

PULLMAN, Wash. - After cutbacks and layoffs, remaining employees were more likely to feel they were treated fairly if the companies invested in them - and morale was less likely to plunge, according to new research. Those investments can include training for workers, team-building exercises or improving company culture. Even keeping workloads manageable after layoffs can help employees' job attitudes, according to the Journal of Organizational Behavior study. "Whenever possible, cost-cutting is best combined with signals that people remain the firm's most prized asset," said Jeff Joireman, the study's co-author and a professor in Washington State University's Carson College of Business. Researchers reviewed 137 previous studies examining job attitudes before, during and after cost-cutting ...

If we pay closer attention to how birds, rabbits and termites transform their local living spaces in response to varying climate conditions, we could become much better at predicting what impact climate change will have on them in future. This is according to a group of researchers* from the Universities of Montana and Wyoming in the United States, the University of Tours in France and Stellenbosch University (SU) in South Africa. They examined how animals' ability to respond to climate change likely depends on how well they modify their habitats, such as the way they build nests and burrows. The findings of their study were published recently in the high-impact journal Trends in Ecology and Evolution. "It's crucial that we continuously improve our ability to predict and mitigate the ...

Human Usher syndrome (USH) is the most common form of hereditary deaf-blindness. Sufferers can be deaf from birth, suffer from balance disorders, and eventually lose their eyesight as the disease progresses. For some 25 years now, the research group led by Professor Uwe Wolfrum of the Institute of Molecular Physiology at Johannes Gutenberg University Mainz (JGU) has been conducting research into Usher syndrome. Working in cooperation with the group headed up by Professor Reinhard Lührmann at the Max Planck Institute for Biophysical Chemistry in Göttingen, his team has now identified a novel pathomechanism leading to Usher syndrome. They have discovered that the Usher syndrome type 1G protein SANS plays a crucial role in regulating ...

Turning away from fossil fuels is necessary if we are to avert an environmental crisis due to global warming. Both industry and academia have been focusing heavily on hydrogen as a feasible clean alternative. Hydrogen is practically inexhaustible and when used to generate energy, only produces water vapor. However, to realize a truly eco-friendly hydrogen society, we need to be able to mass-produce hydrogen cleanly in the first place. One way to do that is by splitting water via "artificial photosynthesis," a process in which materials called "photocatalysts" leverage solar energy to produce oxygen and hydrogen from water. However, the available photocatalysts are not yet where they need to be to make solar-powered water splitting economically feasible and scalable. ...

Co-authors Bulat Galimzyanov and Anatolii Mokshin (Department of Computational Physics) have developed a unique model that allows for a universal interpretation of experimental data on viscosity for systems of different types, while also proposing an alternative method for classifying materials based on a unified temperature scale. The publication was funded by Russian Science Foundation's grant 'Theoretical, simulation and experimental studies of physical and mechanical features of amorphous systems with inhomogeneous local viscoelastic properties', guided by Professor Mokshin. Using the developed viscosity model, scientists processed experimental data obtained for thirty different ...

A research group led by Prof. PIAO Hailong from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy of Sciences (CAS) identified hepatocellular carcinoma (HCC) subtypes with distinctive metabolic phenotypes through bioinformatics and machine learning methods, and elucidated the potential mechanisms based on a metabolite-protein interaction network and multi-omics data. The study, published in Advanced Science on July 11, provides insights guiding precise personalized HCC medicine. Metabolic reprogramming, which can promote rapid cell proliferation by regulating energy and nutrient metabolism, is considered to be one hallmark of cancer. It can impact other biological processes through complex metabolite-protein ...

The ubiquitous overuse injuries that nag runners may stem from an unlikely culprit: how far you lean forward. Trunk flexion, the angle at which a runner bends forward from the hip, can range wildly--runners have self-reported angles of approximately -2 degrees to upward of 25. A new study from the END ...

DALLAS, July 12, 2021 -- People of South Asian ancestry have more than double the risk of developing heart disease compared to people of European ancestry, yet clinical risk assessment calculators used to guide decisions about preventing or treating heart disease may fail to account for the increased risk, according to new research published today in the American Heart Association's flagship journal Circulation. About a quarter of the world's population (1.8 billion people) are of South Asian descent, and prior research has shown South Asians experience higher rates of heart disease compared to people of most other ethnicities. To better understand the variables surrounding the heart disease risk for people of South Asian ancestry, researchers evaluated ...

A novel method of gene therapy is helping children born with a rare genetic disorder called AADC deficiency that causes severe physical and developmental disabilities. The study, led by researchers at The Ohio State University Wexner Medical Center and The Ohio State University College of Medicine, offers new hope to those living with incurable genetic and neurodegenerative diseases. Research findings are published online in the journal Nature Communications. This study describes the findings from the targeted delivery of gene therapy to midbrain to treat a rare ...

USC researchers have achieved a better way to identify elusive DNA variants responsible for genetic changes affecting cell functions and diseases. Using computational biology tools, scientists at the university's Dornsife College of Letters, Arts and Sciences studied "variable-number tandem repeats" (VNTR) in DNA. VNTRs are stretches of DNA made of a short pattern of nucleotides repeated over and over, like a plaid pattern shirt. Though they comprise but 3% of the human genome, the repetitive DNA governs how some genes are encoded and levels of proteins are produced in a cell, and account for most of the structural variation. Current methods do not accurately detect the variations in genes in some repetitive ...

Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a "stealthy" role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers to uncover potential weaknesses in bacterial arsenals as they seek to develop new therapeutics that may help us win the war against antibiotic resistance. The study, led by scientists from the School of Biochemistry and Immunology and the Trinity Biomedical Sciences Institute (TBSI) at Trinity College Dublin, has just been published by leading international journal Nature Communications. Lipoproteins and their role in ...

Sclerosis, Parkinson's Disease, Alzheimer's and epilepsy are but a few of the central nervous system disorders. They are also very difficult to treat, since the brain is protected by the blood-brain barrier. The blood-brain barrier works as a border wall between the blood and the brain, allowing just certain molecules to enter the brain. And whereas water and oxygen can get through, as can other substances such as alcohol and coffee. But it does block more than 99 percent of potentially neuroprotective compounds from reaching their targets in the brain. Now, ...

In 2015, 170 countries worldwide adopted the Paris Agreement, with the goal limiting the average global temperature increase to 1.5°C. Following the agreement, many countries and cities proposed targets for greenhouse gas mitigation. However, the UNEP Emissions Gap Report 2020 shows that, without drastic and strict actions to mitigate the climate crisis, we are still heading for a temperature increase of more than 3°C by the end of the 21st century. A new study published in the journal Frontiers in Sustainable Cities presents the first global balance sheet of greenhouse gasses (GHGs) emitted by major cities around the world. The aim was to research and monitor the effectiveness of historical GHG reduction ...

A new study published by Wiley early online in CANCER, a peer-reviewed journal of the American Cancer Society, has identified unmet social needs in women with gynecologic cancer that could be addressed to improve care for patients and lessen disparities. For example, identifying patients who reported needing help with reading hospital materials resulted in the use of a cancer care navigator who provided patient education and support, facilitating physician-patient communication and adherence to care recommendations. The prospective survey-based ...

Oncotarget published "Inhibitory effects of Tomivosertib in acute myeloid leukemia" which reported that the authors evaluated the therapeutic potential of the highly-selective MNK1/2 inhibitor Tomivosertib on AML cells. Tomivosertib was highly effective at blocking eIF4E phosphorylation on serine 209 in AML cells. Moreover, combination of Tomivosertib and Venetoclax resulted in synergistic anti-leukemic responses in AML cell lines. Mass spectrometry studies identified novel putative MNK1/2 interactors, while in parallel studies we demonstrated that MNK2 - RAPTOR - mTOR complexes are not disrupted by Tomivosertib. Overall, these Oncotarget findings demonstrate that Tomivosertib exhibits potent ...

Oncotarget published "Epigallocatechin-3-gallate modulates Tau Post-translational modifications and cytoskeletal network" which reported that the chemical modulators of Tau PTMs, such as kinase inhibitors and antibody-based therapeutics, have been developed, but natural compounds, as modulators of Tau PTMs are not much explored. These authors applied biophysical and biochemical techniques like fluorescence kinetics, oligomerization analysis and transmission electron microscopy to investigate the impact of EGCG on Tau glycation in vitro. EGCG inhibited methyl glyoxal -induced Tau glycation in vitro. EGCG potently inhibited MG-induced advanced glycation endproducts formation in neuroblastoma cells as well modulated the localization ...

Oncotarget published "A novel E2F1-regulated lncRNA, LAPAS1, is required for S phase progression and cell proliferation" which reported that long non-coding RNAs are major regulators of many cellular processes, including cell cycle progression and cell proliferation. Inhibition of LAPAS1 expression increases the percentage of S phase cells, and its silencing in synchronized cells delays their progression through S phase. In agreement with its suggested role in cell cycle progression, prolonged inhibition of LAPAS1 attenuates proliferation of human cancer cells. Importantly, knockdown of SPNS2 rescues the effect of LAPAS1 silencing on cell cycle ...