Scientists at Klick Applied Sciences have created an artificial intelligence framework that can rapidly identify new use cases for existing therapeutics, according to findings presented Friday at the NeurIPS conference that could greatly improve the drug repurposing process and transform the pharmaceutical industry. The team debuted their algorithm, called LOVENet, a Large Optimized Vector Embeddings Network which integrates two cutting-edge AI technologies: large language model (LLM), and structured knowledge graph technology, which mathematically represents the relationships between drugs and diseases to offer a fresh ...

The efficient storage of clean energy is a critical component to achieving carbon neutrality.  Capacitors are devices that store energy by separating positive and negative electrical charge, and supercapacitors (SC) are capacitors that can store and release large amounts of energy.  A specialized supercapacitor, called a redox electrolyte-enhanced SC (RE-SC), places liquid redox electrolytes, a source of ions that can be electrically charged, next to a carbon-based electrical conductor, or electrode, to achieve high energy storage density and power output.  Despite this increase in performance, RE-SCs suffer from self-discharge of stored energy, limiting their practicality.  ...

COLUMBUS, Ohio – Snacks constitute almost a quarter of a day’s calories in U.S. adults and account for about one-third of daily added sugar, a new study suggests. Researchers analyzing data from surveys of over 20,000 people found that Americans averaged about 400 to 500 calories in snacks a day – often more than what they consumed at breakfast – that offered little nutritional value. Though dietitians are very aware of Americans’ propensity to snack, “the magnitude of the impact ...

Acting as the main interface between the internal and the external world, the skin is the largest and most important organ of the human body. It is frequently exposed to many types of physical injuries or wounds, including cuts, scrapes, scratches, infections, and ulcers. Unfortunately, as one ages, the skin becomes more frail and less capable of healing itself without help. With many countries experiencing a rapid rise in the aging population, the demand for treating such skin wounds has created a greater need for accessible and effective wound ...

Cerebral organoids are three-dimensional, in vitro cultured brains that mimic the activities of the human brain. They have emerged as invaluable tools to comprehend evolution, disease pathogenesis, and neurodevelopmental processes. However, the development of these organoids is still in nascent stages with several limitations that hinder their broad applications. A major obstacle is the absence of a functional vasculature that can restrict the size of organoids, trigger cell death, and prevent cell differentiation in the organoids. To address ...

NEWS RELEASE EMBARGOED UNTIL FRI, DEC. 15 – 5:00 A.M. Eastern   Contact Colleen McDonald - Sr. Consultant, Earned Media 414.801.3146 | cmcdonald@mcw.edu   Trip or Treat? Scientists at the Medical College of Wisconsin make strides in designing non-hallucinogenic psychedelic treatments that may accelerate research on mental health benefits; research findings published in Nature Communications. Milwaukee, Wis. – Dec. 15, 2023 – There is nothing magic about the recent increase ...

CAMBRIDGE, MA — During a chemical reaction, molecules gain energy until they reach what’s known as the transition state — a point of no return from which the reaction must proceed. This state is so fleeting that it’s nearly impossible to observe it experimentally. The structures of these transition states can be calculated using techniques based on quantum chemistry, but that process is extremely time-consuming. A team of MIT researchers has now developed an alternative approach, based on machine learning, that can calculate ...

Child psychologists have long known that play is essential for children’s cognitive development because it boosts their social, physical, and emotional skills. But beginning in the 21st century, specialists repeatedly sounded the alarm that ‘play is under siege’ for US children. Kids were playing less, and – it was feared – with a lesser quality. But are today’s parents sufficiently aware of the importance of letting their children play? Yes, found a team of researchers who tested this through a survey of the opinions of 1,172 US parents. Their results showed that today’s ...

To an everyday consumer, the best gadgets on the market have the highest speed, the largest memory, and the longest battery life. Chasing this demand, the forefront of research often only considers these tangible performance metrics when innovating and designing next-generation electronics. In the wake of this technological stampede, the long-term environmental impacts lie obscured and neglected under the dust.   Researchers at the Singapore University of Technology and Design (SUTD) hope to be the catalyst for sustainability-driven science. Assistant Professor Ang Yee Sin from the Science, Mathematics ...

Transformer architectures have facilitated the development of large-scale and general-purpose sequence models for prediction tasks in natural language processing and computer vision, e.g., GPT-3 and Swin Transformer. Although originally designed for prediction problems, it is natural to inquire about their suitability in another important field, sequential decision-making and reinforcement learning problems, which are typically beset by long-standing issues involving sample efficiency, credit assignment, and partial observability, etc. In recent years, sequence models, especially the Transformer, have attracted increasing interest in the RL communities, spawning ...

Not all discoveries turn out to be actual new discoveries. This was the case for the extremely red objects (EROs) found in James Webb Space Telescope (JWST) data. Analysis shows that they are very similar to blue-excess dust obscured galaxies (BluDOGs) already reported in Subaru Telescope data. Quasars, some of the brightest objects in the Universe, are driven by a supermassive black hole with a mass that can reach more than a billion times that of the Sun. These objects are the focus of much research, but how ...

A research team at the Hong Kong University of Science and Technology (HKUST) has outlined the high-resolution structure of a little-known virus, improving our understanding of viral infection, which could pave the way for more accurate predictions of climate change. With the help of an advanced technique involving cryo-electron microscopy, they managed to capture images of the virus – the cyanophage P-SCSP1u – at near-atomic resolution in its native form and examined it to see how its different parts fit together. This helped show how different proteins work in the virus and how they interact to make the virus ...

In a new study published on 13 November 2023, in the journal Satellite Navigation, researchers from Chang’an University have developed a novel approach using the Precise Point Positioning (PPP) technique combined with a cumulative sum control chart (CUSUM) method. This method enables the analysis of reference station stability and compensates for deformation at monitoring stations. In the study conducted at the Tengqing landslide in Liupanshui, Guizhou Province, Southwest China, an innovative method was applied, showcasing a significant leap in landslide monitoring using GNSS PPP technology. ...

The risk of death from COVID-19 decreases significantly after vaccination but this protection diminishes after six months, providing evidence for continued booster doses, a new study has found.   Researchers from the UK Health Security Agency (UKHSA) analysed more than 10 million cases of COVID-19 in adults between May 2020 and February 2022. Their findings are published in the Journal of the Royal Society of Medicine (JRSM).   The Case Fatality Risk (CFR) - the proportion of cases that resulted in death - was cross-referenced with vaccination ...

In a significant advancement in optical technology, researchers from Tohoku University and Toyohashi University of Technology have developed a new method for creating transparent magnetic materials using laser heating. This breakthrough, recently published in the journal Optical Materials, presents a novel approach to integrating magneto-optical materials with optical devices, a long-standing challenge in the field. "The key to this achievement lies in creating 'Cerium-substituted Yttrium Iron Garnet (Ce:YIG)', ...

When it comes to the Colorado River, history often repeats itself—but it doesn’t have to. That’s the take-home message from CU Boulder hydrologist Shemin Ge, who will present a little-known piece of history from the river this Thursday at the American Geophysical Union (AGU) meeting in San Francisco.   The story of hydrologist Eugene Clyde La Rue, Ge said, may help to explain the current water crisis facing many states in the American West. Ge’s presentation centers around a decision ...

Researchers at the Center for Homelessness, Housing, and Health Equity Research at the University of Southern California released an interim report on the first six months of a randomized controlled trial to study the impact of a basic income and social support intervention for 103 individuals experiencing homelessness in Los Angeles County and the San Francisco Bay Area. Two key findings so far are that participants in the Miracle Money study who received $750 per month were less likely to remain unsheltered and closer ...

UCL researchers have developed a new gene therapy to cure a devastating form of childhood epilepsy, which a new study shows can significantly reduce seizures in mice. The study, published in Brain, sought to find an alternative to surgery for children with focal cortical dysplasia. Focal cortical dysplasia is caused by areas of the brain that have developed abnormally and is among the most common causes of drug-resistant epilepsy in children. It frequently occurs in the frontal lobes, which are important for planning and decision-making. Epilepsy in focal cortical dysplasia is associated with comorbidities, including learning disabilities. Although surgery to remove the affected brain malformation ...

The Icahn School of Medicine at Mount Sinai has received more than $1.3 million from the National Institute of General Medical Sciences of the  National Institutes of Health (NIH) to expand the New York City Virus Hunters program. The program engages high school students from communities historically underrepresented in science in the first large-scale citizen science effort to catalog and map circulating avian influenza and avian paramyxoviruses in New York City’s wild birds. The goal is to track emerging viruses and to prevent future outbreaks. Wild birds can disseminate infectious ...

In an effort to better optimize the triage of patients during mass casualty events, University of Maryland School of Medicine (UMSOM) researchers are receiving up to $7.3 million in funding from the Defense Advanced Research Project Agency (DARPA) for vital new research. The funding will be used to support a study that will collect data over the next 3.5 years on trauma patients with the aim of identifying and implementing lifesaving advancements in medical triage for large-scale mass casualty incidents. “The importance of early interventions in trauma is described as the concept of the ‘golden ...

Freight transportation is a backbone of the US economy — and a significant contributor to US greenhouse gas emissions. In fact, freight accounts for nearly 10% of annual U.S. emissions,ISE Dan Doulet Faculty Fellow and Professor Xueping Li points out. Li and an interdisciplinary, multi-institutional team have been awarded funding from the US Department of Energy to launch a first-of-its-kind, national-scale undertaking to address freight’s impact on climate change — and climate change’s impact on this vital sector. Funding from DOE’s Advanced Research Projects Agency-Energy (ARPA-E) is highly competitive. “Any ...

When looking for ways to reduce their carbon footprint, most people think of first of their car, not their house. Surprisingly, however, buildings make up one of the largest energy-consuming sectors of the US economy, accounting for 39 percent of the country’s total energy use. “Heating and cooling are among the most energy-intensive parts of building operations,” said Associate Professor of Civil and Environmental Engineering Nick Zhou, who leads UT’s Sustainable and Adaptive Built Environment Group in ...

Genome-wide association studies (GWAS) on patient blood samples are useful for identifying the genetic basis of blood cell traits and their links to common diseases. While previous experiments have focused on characterizing clinical parameters such as cell count, few have evaluated the dynamic effects of factors—such as inflammation, microbiome or medications—on blood cell contributions to disease development and progression. This lack of insight into underlying biological mechanisms behind such chronic progressive conditions has hindered ...

MADISON – University of Wisconsin–Madison engineers have used a spray coating technology to produce a new workhorse material that can withstand the harsh conditions inside a fusion reactor. The advance, detailed in a paper published recently in the journal Physica Scripta, could enable more efficient compact fusion reactors that are easier to repair and maintain. “The fusion community is urgently looking for new manufacturing approaches to economically produce large plasma-facing components in fusion reactors,” says Mykola Ialovega, a postdoctoral researcher in nuclear engineering and engineering physics at ...

Tufts University, home to the world’s largest concentration of academic researchers working on cultivated meat, will be hosting its second annual Cellular Agriculture Innovation Day on January 11, 2024. The day-long event will be held at Tufts’ Joyce Cummings Center in Medford, following a year of major developments in the industry — including regulatory approval of cultivated meat in the United States. Bringing together researchers, entrepreneurs, policymakers, and investors, Cellular Agriculture Innovation Day is an opportunity for candid ...