People who get type 2 diabetes need to gain control of their blood-sugar levels -- fast. The years immediately after diagnosis are strikingly critical in terms of their future risk for heart attacks and death. This is shown by a joint study from the Universities of Gothenburg and Oxford. In a collaboration between the University of Gothenburg in Sweden and the University of Oxford in the UK, the significance of blood sugar levels from the time type 2 diabetes is diagnosed for the risk of heart attacks and death has been studied. The project was led jointly by Professor Marcus Lind in Gothenburg and Professor Rury Holman in Oxford. The research was based on a key trial in type 2 diabetes, the UK Prospective Diabetes Study (UKPDS). This new analysis examined ...

LONDON, ON - Hospital researchers from Lawson Health Research Institute have published a recent study that assessed the use of a specialized treatment for chronic pain and its impact on health care use and opioid prescribing. Paravertebral blocks (PVBs) belong to a broader group of procedures called "nerve blocks." A recent Toronto Star report noted that OHIP has been billed $420 million for nerve block procedures since 2011. PVBs involve injecting medication around the nerves where they exit the bones of the spine, at different locations depending on the patient and the chronic pain they are experiencing. ...

A new study shows that individuals with bipolar disorder who are exposed to significant trauma may be at greater risk for suicide death, suggesting that clinical diagnosis of or genetic predisposition to trauma-related conditions could be important factors to consider in suicide prevention. Suicide is the 10th leading cause of death in the United States, accounting for over 40,000 deaths each year, and suicide death rates are 10 to 30 times higher for people with bipolar disorder than for the general population. The research, spearheaded by Eric Monson, MD, PhD, and Hilary Coon, PhD, from the University of Utah, in collaboration with Virginia Willour, PhD, from the University of Iowa, set out to identify unique risk factors for suicide attempt and death ...

Researchers have made significant advancements in correlating aberrations in specific brain circuits with neuropsychiatric conditions like depression. However, it remains difficult to prove that damage to these circuits causes the symptoms themselves and that targeting them with therapeutics could help patients. By integrating brain lesion datasets with data on how two treatments -- deep brain stimulation (DBS) and transcranial magnetic stimulation (TMS) -- influence neuropsychiatric disorders, researchers from Brigham and Women's Hospital and collaborators developed a new brain mapping approach that may help clarify the cause of a variety of neuropsychiatric conditions and identify promising stimulation sites to target therapeutically. Findings are published ...

As the world continues to warm, many arid regions that already have marginal conditions for agriculture will be increasingly under stress, potentially leading to severe food shortages. Now, researchers at MIT have come up with a promising process for protecting seeds from the stress of water shortage during their crucial germination phase, and even providing the plants with extra nutrition at the same time. The process, undergoing continued tests in collaboration with researchers in Morocco, is simple and inexpensive, and could be widely deployed in arid regions, the researchers say. ...

As atmospheric concentrations of CO2 continue to rise, we are putting future generations at risk of having to deal with a massive carbon debt. IIASA researchers and international colleagues are calling for immediate action to establish responsibility for carbon debt by implementing carbon removal obligations, for example, during the upcoming revision of the EU Emissions Trading Scheme. Over the last several decades, governments have collectively pledged to slow global warming through accords such as the Kyoto Protocol and the Paris Agreement. Despite the ratification of these agreements by a large number of countries, the atmospheric concentration of CO2 continues to rise. At the rate we are going, we are well on our way to using up the remaining quantity of CO2 emissions to limit temperature ...

Doha, Qatar, July 8, 2021: In March 2020, thousands of scientists around the world united to answer a pressing and complex question: which genetic factors influence the wide variation in COVID-19 severity? Why are some patients severely affected while others escape with mild or no symptoms at all? A comprehensive summary of their findings to date, published in Nature - the world's leading multidisciplinary science journal - revealed 13 loci, or locations in the human genome, that are strongly associated with infection or severe COVID-19. The researchers also identified causal factors such ...

In March of 2020, thousands of scientists around the world united to answer a pressing and complex question: what genetic factors influence why some COVID-19 patients develop severe, life-threatening disease requiring hospitalization, while others escape with mild symptoms or none at all? A comprehensive summary of their findings to date, published in Nature, reveals 13 loci, or locations in the human genome, that are strongly associated with infection or severe COVID-19. The researchers also identified causal factors such as smoking and high body mass index. These results come from one of the largest ...

What The Study Did: The SARS-CoV-2 BNT162b2 (Pfizer-BioNTech) vaccine appeared to be safe and achieve satisfactory serologic status in patients with cancer. While there was a lag in antibody production compared with the rate in the noncancer control group, seroconversion occurred in most patients after the second dose. Authors: Irit Ben-Aharon, M.D., Ph.D., of the Rambam Health Care Campus in Haifa, Israel, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamaoncol.2021.2675) Editor's Note: The article includes conflict of interest and funding/support disclosures. Please ...

Tumor fragments in the lab are able to predict whether the corresponding real-life patients will benefit from immunotherapy. "We've solved a major problem many scientists had been facing: preserving a tumors original composition and structure outside of the patient in the lab", says cancer researcher Daniela Thommen from the Netherlands Cancer Institute. On 8 July, the results of her study are published in Nature Medicine. While some cancer patients experience incredible results from immunotherapy, many others do not benefit from this treatment, which puts patients' ...

What The Study Did: A decline in COVID-19 cases after the vaccination of health care workers in a region of California that experienced high rates of COVID-19 disease over the winter is reported in this single-center study. Authors: Shruti K. Gohil, M.D., M.P.H., of the University of California, Irvine School of Medicine, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2021.15980) Editor's Note: Please see the article for additional information, including other ...

A research team at Washington University School of Medicine in St. Louis has identified potential new treatment targets for Alzheimer's disease, as well as existing drugs that have therapeutic potential against these targets. The potential targets are defective proteins that lead to the buildup of amyloid in the brain, contributing to the onset of problems with memory and thinking that are the hallmark of Alzheimer's. The 15 existing drugs identified by the researchers have been approved by the Food and Drug Administration (FDA) for other purposes, providing the possibility of clinical trials that could begin sooner than is typical, according to the researchers. In addition, the experiments yielded seven drugs that may be useful for treating faulty proteins linked to Parkinson's ...

HOUSTON - Researchers from The University of Texas MD Anderson Cancer Center found specific intestinal microbiota signatures correlate with high-grade adverse events and response to combined CTLA-4 and PD-1 blockade treatment. The study, published today in Nature Medicine, also identified a potential new strategy to treat toxicity - while maintaining response - to combined immune checkpoint blockade through either IL-1R inhibition or manipulation of the gut microbiota. Dual immune checkpoint therapy has contributed to progress in overall survival for many cancer types, including ...

One of the things the human brain naturally excels at is recognizing all sorts of patterns, such as stripes on zebras, shells of turtles, and even the structure of crystals. Thanks to our progress in math and the natural sciences, we are not limited to just seeing the patterns; we can also understand how they readily originate out of pure randomness. A notable example of different natural patterns with a single mathematical explanation are Turing patterns. Conceived in 1952 by the renowned mathematician Alan Turing, these patterns arise as the solutions to a set of differential equations that describe the diffusion and reaction of chemicals satisfying a few conditions. Going well beyond pure chemistry, Turing demonstrated ...

Though writing by hand is increasingly being eclipsed by the ease of computers, a new study finds we shouldn't be so quick to throw away the pencils and paper: handwriting helps people learn certain skills surprisingly faster and significantly better than learning the same material through typing or watching videos. "The question out there for parents and educators is why should our kids spend any time doing handwriting," says senior author Brenda Rapp, a Johns Hopkins University professor of cognitive science. "Obviously, you're going to be a better hand-writer if you practice it. But since people are handwriting less then maybe who cares? The real question is: Are there other benefits to handwriting that have to do with reading and spelling and ...

Seismic waves passing through the ground near Longyearbyen in the Adventdalen valley, Svalbard, Norway have been slowing down steadily over the past three years, most likely due to permafrost warming in the Arctic valley. The trend, reported in a new study published in Seismological Research Letters, demonstrates how seismic monitoring can be used to track permafrost stability under global climate change. The study is part of a focus section in an upcoming issue of the journal on Arctic and Antarctic seismology. Julie Albaric of the University of Bourgogne Franche-Comté, while employed at NORSAR (Norway), and colleagues ...

Coastal wetlands - such as salt marshes - provide even more flood protection than previously thought, reducing the risk to lives and homes in estuaries, a new study has revealed. The researchers' simulations showed that wetlands that grow in estuaries, such as salt marshes, can reduce water levels by up to 2 metres and provide protection far inland up estuary channels. This subsequently saved up to $38 (£27) million in avoided flood damage costs per estuary during a large storm thanks to the wetlands' role in preventing storm floods. The research is timely as wetlands are facing growing threats from continued urban development. 22 of the largest 32 cities in the world - including London, New York and Tokyo - are built on low-lying land around estuaries, ...

Populist anti-foreign aid rhetoric works - but only fans of populist politicians are convinced by hostile messages about charity abroad, a new study shows. Those who distrust populist politicians are significantly less susceptible to these messages. The research shows international aid institutions and non-populist politicians should not be unduly worried about the impact of populism on global development cooperation. Those wanting to convince the public about the importance of foreign aid should focus on communicating their message transparently and clearly, and using local partnerships. The research, by A. Burcu Bayram from the University of Arkansas and Catarina Thomson from ...

Concerns have been raised about the AstraZeneca and Johnson & Johnson vaccines regarding very rare but potentially fatal side effects related to low blood platelet counts and blood clots. Recently, reports also emerged that the Pfizer-BioNTech vaccine may cause a rare yet serious side effect: heart inflammation. Concerns about side effects may trigger vaccine hesitancy, which the WHO considers one of 'Ten threats to global health'. Securing sufficient acceptance of vaccines is a key challenge in defeating the coronavirus pandemic, both now and in the future. How ...

What happens when climate change affects the abundance and distribution of fish? Fishers and fishing communities in the Northeast United States have adapted to those changes in three specific ways, according to new research published in Frontiers in Marine Science. Becca Selden, Wellesley College assistant professor of biological sciences, and a team of colleagues examined how fishing communities have responded to documented shifts in the location of fluke and of red and silver hake. The team found that fishers made three distinct changes to their approaches: following the fish to a new location; fishing for a different kind of fish; and bringing their catch to shore at another port of landing. Selden began this research as a postdoctoral ...

July 8, 2021 - Until relatively recently, opioids were a mainstay of treatment for pain following total hip or knee replacement. Today, a growing body of evidence supports the use of multimodal analgesia - combinations of different techniques and medications to optimize pain management while reducing the use and risks of opioids, according to a paper in The Journal of Bone & Joint Surgery. The journal is published in the Lippincott portfolio in partnership with Wolters Kluwer. "Multimodal analgesia has become the standard of care for total joint arthroplasty as it provides superior analgesia with fewer side effects than opioid-only protocols," write Javad Parvizi, ...

Augmented reality (AR) is poised to revolutionise the way people complete essential everyday tasks, yet older adults - who have much to gain from the technology - will be excluded from using it unless more thought goes into designing software that makes sense to them. The danger of older adults falling through the gaps has been highlighted by research carried out by scientists at the UK's University of Bath and the Bath-based charity Designability. A Paper describing their work has received an honourable mention at this year's Human Computer Interaction Conference (CHI2021) - the world's largest conference of its kind. The study concludes that adults aged 50+ are more likely to be successful at completing AR-prompted tasks (such as 'pick up the cube' followed by 'move the cube to the blue ...

Skoltech biologists and their colleagues from Koltzov Institute of Developmental Biology, Russia, and the Chemistry Department of Taras Shevchenko University in Ukraine have discovered fairly unlikely drug candidates for treating liver fibrosis and other pathologies -- among pest control chemicals. In addition, the team looked at modifications of the medication called hymecromone, deeming them promising for anti-fibrotic drugs, too. Published in Glycobiology, the study also sheds light on the possible mechanism of action of the investigated compounds, all of which inhibit the synthesis of hyaluronic acid. Hyaluronic acid is an important biological compound that is a key component ...

The plates of the Earth's crust perform complicated movements that can be attributed to quite simple mechanisms. That is the short version of the explanation of a rift that began to tear the world apart over a length of several thousand kilometers 105 million years ago. The scientific explanation appears today in the journal Nature Geoscience. According to the paper, a super volcano split the Earth's crust over a length of 7,500 kilometers, pushing the Indian Plate away from the African Plate. The cause was a "plume" in the Earth's mantle, i.e. a surge of hot material that wells upwards like an atomic mushroom cloud in super slow motion. It has long been known that the ...

WASHINGTON--Tidal stresses may be causing constant icequakes on Saturn's sixth largest moon Enceladus, a world of interest in the search for life beyond Earth, according to a new study. A better understanding of seismic activity could reveal what's under the moon's icy crust and provide clues to the habitability of its ocean. Enceladus is about 500 kilometers in diameter and almost entirely covered in ice. The moon is nearly 10 times as far away from the Sun as Earth and its bright surface reflects most sunlight, making it very cold, yet researchers have long ...