Highlights Messenger RNA (mRNA) is translated into proteins in the cytoplasm of cells. But rather than being a uniform “soup,” the cytoplasm is divided into multiple distinct compartments or regions. Each region is largely responsible for translating functionally similar types of mRNA, a new MSK study finds. And the location of translation determines the amount of protein produced by the mRNA. The movement of mRNA to specific regions is directed by their size and shape, as well as by RNA-binding protein partners. The findings could help develop new approaches to increase ...

Dec. 21, 2023 Contact: Nicole Casal Moore, 734-709-1651, ncmoore@umich.edu  Images and videos Better prosthetics: $3M to develop more natural robotic leg control An effort to create a control model that moves seamlessly between different activities like standing, walking and climbing stairs is renewed by the National Institutes of Health ANN ARBOR—A smoother experience for robotic prosthetic leg users is the aim of a University of Michigan project that has received renewed support from the National Institutes of Health. The R01 grant ...

Glenview, IL – The American College of Chest Physicians (CHEST) was awarded a $100,000 grant from the Council of Medical Specialty Societies (CMSS) to improve diagnostic excellence in interstitial lung disease (ILD). The funded project, called, "'How We Do It': CHEST Experts Weigh In," aims to inform future best practices in reducing the time to diagnosis for ILDs. The activities in the series will prepare the learner to: define symptoms and patient profiles associated with ILD; recognize health inequities that may assist in the diagnosis of ILD; identify the appropriate tests that may help validate a suspicion of ILD; ...

Certain Frequencies Enhance Comprehension New research conducted by the Center for BrainHealth at The University of Texas at Dallas investigates the impact of binaural beat (BB) on language skills. BB is a sound that occurs when two slightly mismatched pure tones are heard. There is a growing interest in using BB as a non-invasive neuromodulation to enhance cognitive performance. The study, Neural consequences of binaural beat stimulation on auditory sentence comprehension: an EEG study, was recently published in Cerebral Cortex.  Led by researchers in the Speech, Language and Music (SLAM) Lab, this EEG ...

Where You Live Matters: A First-of-Its-Kind Study Illustrates How Racism Is Interrelated With Poor Health   Study published in JAMA Network Open points to discrete factors, like voting participation, employment, education, and housing, that may serve as promising targets for interventions   New York, NY (December 21, 2023) – A team of health equity researchers from several institutions has leveraged a complex web of data to test a hypothesis: That structural racism is associated with resources and structures at the neighborhood level that are closely associated with poor health. What they found in an analysis of highly localized, ...

A new methodology that allows for the categorisation and organisation of single-cell data has been launched. It can be used to create a harmonised dataset for the study of human health and disease. Researchers at the Wellcome Sanger Institute, the University of Cambridge, EMBL’s European Bioinformatics Institute (EMBL-EBI), and collaborators developed the tool, known as CellHint. CellHint uses machine learning to unify data produced across the world, allowing it to be accessed by the wider research community, potentially driving new discoveries. In a new study, ...

A pancake stack of radioactivity-sensitive films carried through the sky by a balloon was able to take the world's most accurate picture of a neutron star's gamma ray beam. To achieve this, Kobe University researchers combined the oldest method of capturing radioactive radiation with the newest data capturing techniques and a clever time-recording device. The stars shine their light on us in the full range of the spectrum of light, from infra-red to gamma rays. For each of these bands, different sensing equipment is needed. The most challenging one is gamma rays, famous for being a high-energy product of nuclear fission, ...

A new technology developed by engineers at the University of California San Diego has the potential to make the extended reality (XR) experience smoother and more seamless. The technology consists of an asset localization system that uses wireless signals to track physical objects with centimeter-level accuracy in real time, and then generates a virtual representation of these objects. Applications of this technology range from enhancing virtual gaming experiences to improving workplace safety. The team, led by Dinesh Bharadia, a professor in the Department of Electrical and Computer Engineering at the UC San Diego Jacobs School of Engineering, ...

American Geophysical Union Press Release 23-47 21 December 2023 For Immediate Release This press release is also available online at: https://news.agu.org/press-release/fleeing-drought-vulnerable-populations-face-flood-risk-in-most-african-countries AGU press contact: Liza Lester, +1 (202) 777-7494, news@agu.org (UTC-5 hours) Contact information for the researchers: Serena Ceola, University of Bologna, serena.ceola@unibo.it (GMT+1 hours) WASHINGTON — In 80% of African countries, moved toward rivers and into cities during or following drought, increasing the number of people living in flood-risk areas in ...

Osaka, Japan – Dog owners may need to learn to appreciate their best friend’s urine. Scientists at Osaka Metropolitan University have devised an efficient, non-invasive, and pain-free method to reprogram canine stem cells from urine samples, bringing furry companions one step closer to veterinary regenerative treatment. Induced pluripotent stem cells (iPSCs) have been widely employed in studies on human generative medicine.  With the growing importance of advanced medical care for dogs and cats, there is an expectation that new therapies utilizing iPSCs will ...

Researchers at the Icahn School of Medicine at Mount Sinai have gained a deeper understanding of the nuanced roles of JAK inhibitors, or modulators, in inflammation across various cell types and tissues. Their findings suggest a more precise approach is required to potentially expand JAK inhibitor use to a wider range of allergy and inflammatory disorders. Details on the findings were published in the December 21, 2023, issue of the journal Cell. JAK1 is a key protein in the body that supports cell communication and controls the immune system. It is part of ...

RESEARCHERS DISCOVER KEY TO EPITHELIAL CELL GROWTH Australian researchers have discovered a new way that epithelial cells, which form layers in organs like the skin and stomach, attach to one another, and how they perceive growth signals at these attachments, helping them form tissues of the right size and shape. Epithelial cells cover the surfaces of most organs in the body and must adhere to each other to form both a protective and permeable barrier. They are exquisitely designed to both be tightly sealed against pathogens like bacteria, and to also allow the transport of salts, fluids, and nutrients. Researchers, led by Professor Kieran Harvey and Dr Benjamin Kroeger, at the ...

About The Study: This systematic review of 120 studies with 14,000 participants found that Asian, Black, Hispanic, and Indigenous (e.g., Alaska Native, American Indian, and Native Hawaiian) participants were underrepresented in neonatal clinical trials, while white participants were overrepresented. There was wide variation in the terms used to report race and ethnicity data, and geographic representation was unevenly distributed, with some central and western U.S. regions underrepresented.  Authors: Elliott M. Weiss, M.D., M.S.M.E., of the University of Washington School of Medicine in Seattle, is the corresponding author.  To access the embargoed study: Visit our For ...

About The Study: The results of this study involving 70 youths with autism across four psychiatric inpatient hospitals suggest that wearable biosensing and machine learning may hold promise for identifying objective indicators of impending aggressive behaviors in youths with autism who are psychiatric inpatients. The findings may lay the groundwork for developing just-in-time adaptive intervention mobile health systems that may enable new opportunities for preemptive intervention.  Authors: Matthew S. Goodwin, Ph.D., of Northeastern University in Boston, is the corresponding author.  To access the embargoed study: ...

While physicists continue to argue about whether time is indeed an illusion, as Albert Einstein claimed, biologists have no doubt about its significance for understanding life as a dynamic system. In recent years, they have been gaining an increasingly deeper understanding of complex biological systems using tools enabling the simultaneous analysis of vast amounts of cellular and molecular data and the probing of cellular circuitry that drives disease. However, these in-depth investigations of how cells behave and interact have provided only separate snapshots of what happens inside complex organisms, without accounting ...

Osaka, Japan – Amino acids are the building blocks of life. We obtain them from the food we eat, and the body uses them to make proteins, which in turn are used for growth, development, and a multitude of other functions. However, before the body can build with these blocks, it must first be able to sense their presence. When amino acids are available, a master regulator protein called TORC1 is switched on, causing proteins to be manufactured and cells to grow. If no amino acids are available, TORC1 is switched off, and cells start to recycle themselves in a process known as autophagy. Until now, it was unclear exactly how amino acids triggered the TORC1 switch in yeast. Now, in a study ...

Osaka, Japan – Only recently was it discovered that amino acids, the building blocks of proteins, exist in two different forms: L- and D-forms. While all natural proteins consist exclusively of L-amino acids, the function of D-amino acids remained poorly understood, despite being present in the food we eat every day.   Now, a multi-institutional research team led by Osaka University has revealed a function of one D-form amino acid: D-alanine. So, what does it do, and how did they uncover its function? To understand, we need a little background information.  The circadian clock, a natural ...

Artery calcification is almost twice as common in night owls compared to early birds, according to a study from the University of Gothenburg, Sweden. Circadian function appears to be particularly important during the early stages of cardiovascular disease.  Atherosclerosis involves fatty deposits accumulating on the inside of the arteries, making it harder for blood to pass through. The disease develops over a very long period of time and is not noticed until it leads to blood clots causing angina, heart attack, or stroke. Previous research has shown that people with late-night habits have an increased risk of cardiovascular disease, but this is the first study to show how circadian rhythms ...

A team of scientists has created a chiral assembly by blending inorganic polyoxometalates and organic cyclodextrin molecules. Polyoxometalates are a class of nanomaterials with many useful applications. But the use of polyoxometalates as building blocks to construct chiral POM-based frameworks has been a long-stranding challenge for researchers.  In this research, the team produced a 3D framework, constructed by coordination assembly. The resulting framework features an interlaced organic-inorganic hybrid layer. The team has published their work in the journal, Polyoxometalates, ...

A new study led by scientists at the Smithsonian’s National Museum of Natural History identifies five new species of soft-furred hedgehogs from Southeast Asia. The study, published in the Zoological Journal of the Linnean Society, used DNA analysis and physical characteristics to describe two entirely new species of soft-furred hedgehogs and elevate three subspecies to the level of species. The two new species, named Hylomys vorax and H. macarong, are endemic to the endangered Leuser ecosystem, a tropical rainforest in North Sumatra and Southern Vietnam, respectively. The museum specimens that were vital to describing these two new species came from the natural history collections ...

Osaka, Japan – For many of us, when we think of microbiomes, our first thoughts are probably about the beneficial microorganisms that live in our guts. But now, researchers from Japan and US have discovered how the microbes living in fruit flies can enhance their reproduction. In a recently published study in Communications Biology, the research group has revealed that microbes in the fruit fly microbiome are involved in controlling the germline stem cells that form eggs, as well as subsequent egg maturation, in female fruit ...

Sleep loss does more than just make us tired. It can undermine our emotional functioning, decrease positive moods and put us at higher risk for anxiety symptoms, according to a study published by the American Psychological Association that synthesized more than 50 years of research on sleep deprivation and mood. “In our largely sleep-deprived society, quantifying the effects of sleep loss on emotion is critical for promoting psychological health,” said study lead author Cara Palmer, PhD, of Montana State University. “This study represents ...

A tactile perception system capable of providing human-like multimodal tactile information to objects like robots and wearable devices that require tactile data in real time has been developed. The research team led by Research Director Hyuneui Lim of the Nano-Convergence Manufacturing Systems Research Division and Principle Researcher Youngdo Jung of the Department of Nature-Inspired System and Application of the Korea Institute of Machinery and Materials (Chairman Seog-hyeon Ryu, hereinafter referred to as the “KIMM”), an institute under the jurisdiction of the Ministry of Science and ICT, developed a real-time and ...

While many holiday traditions involve feasts of turkey, soba noodles, latkes or Pan de Pascua, this year, the European Southern Observatory (ESO) is bringing you a holiday chicken. The so-called Running Chicken Nebula, home to young stars in the making, is revealed in spectacular detail in this 1.5-billion-pixel image captured by the VLT Survey Telescope (VST), hosted at ESO’s Paranal site in Chile. This vast stellar nursery is located in the constellation Centaurus (the Centaur), at about 6500 light-years from Earth. Young stars within this nebula emit intense radiation that makes the surrounding hydrogen gas glow in shades ...

Increased sedentary time as a child through adolescence is directly linked to childhood obesity, but new research has found light physical activity may completely reverse the adverse process. The study - conducted in collaboration with between University of Exeter, University of Eastern Finland, University of Bristol, and University of Colorado and published in Nature Communications – is the largest and longest follow-up to objectively measure physical activity and fat mass, using the University of Bristol’s Children of the 90s data (also known as the Avon Longitudinal Study of Parents and Children). ...