Hitherto, the development of valvular heart disease in patients with chronic heart failure has been underestimated and rarely treated. This is the finding of a study conducted at the Division of Cardiology within the Department of Medicine II at Vienna General Hospital and MedUni Vienna and published in the prestigious British Medical Journal (BMJ). Mitral regurgitation was often previously interpreted as part of the progression of heart failure rather than a treatable disease in its own right. Mitral regurgitation is a disease, in which the valve between the left atrium and left ventricle starts to leak, so that blood refluxes with ...

Computer models have been standard tools in basic biomedical research for many years. However, around 70 years after the first publication of an ion current model of a nerve cell by Hodgkin & Huxley in 1952, researchers at Graz University of Technology (TU Graz), in collaboration with the Medical University of Graz and the Memorial Sloan Kettering Cancer Center in New York, have finally succeeded in developing the world's first cancer cell model, thus launching "an essential tool for modern cancer research and drug development," reports a delighted Christian Baumgartner. The head of the Institute of Health Care Engineering with European Testing ...

Chronic fatigue syndrome / myalgic encephalomyelitis (CFS/ME) is a disabling disease, in which people have great difficulties in carrying out their daily activities. Despite its high prevalence, there are still no effective tools for its diagnosis, monitoring and treatment. To better understand and promote follow-up, as well as stratify fatigue in these patients, Vall d'Hebron, the Universitat Autònoma de Barcelona (UAB) and the Universitat Politècnica de Catalunya · BarcelonaTech (UPC) have developed a mobile application that could be useful in the assessment of the severity of fatigue in this syndrome, especially in women. The results of the study in which this technology has been tested have ...

Crystals have fascinated people through the ages. Who hasn't admired the complex patterns of a snowflake at some point, or the perfectly symmetrical surfaces of a rock crystal The magic doesn't stop even if one knows that all this results from a simple interplay of attraction and repulsion between atoms and electrons. A team of researchers led by Atac Imamoglu, professor at the Institute for Quantum Electronics at ETH Zurich, have now produced a very special crystal. Unlike normal crystals, it consists exclusively of electrons. In doing so, they have confirmed a theoretical prediction that was made almost ninety years ago and which has since been regarded as a kind of holy grail ...

When researchers at Lund University in Sweden performed advanced analyses of sputum from the airways of severely ill Covid-19 patients, they found high levels of neutrophil extracellular traps (NETs). It is already a known fact that NETs can contribute to sputum thickness, severe sepsis-like inflammation and thrombosis. After being treated with an already existing drug, the NETs were dissolved and patients improved. The study has now been published in Molecular & Cellular Proteomics. Using advanced fluorescence microscopy, the researchers examined sputum in the airways of three severely ...

There might be fewer bonobos left in the wild than we thought. For the last 40 years, scientists have estimated the abundance of endangered bonobos by counting the numbers of sleeping nests left by the apes in forests of the Congo Basin. Now, researchers from the Max Planck Institute of Animal Behavior report that the rate of sleeping nest "decay" has lengthened by 17 days over the last 15 years as a result of declining rainfall in the Congo Basin. The study warns that longer nest decay times have serious implications for ape conservation: failure to account for these ...

DALLAS - June 30, 2021 - A relative decline in wealth during midlife increases the likelihood of a cardiac event or heart disease after age 65 while an increase in wealth between ages 50 and 64 is associated with lower cardiovascular risk, according to a new END ...

The cells that make up our bodies are constantly exposed to a wide variety of mechanical stresses. For example, the heart and lungs have to withstand lifelong expansion and contraction, our skin has to be as resistant to tearing as possible whilst retaining its elasticity, and immune cells are very squashy so that they can move through the body. Special protein structures, known as "intermediate filaments", play an important role in these characteristics. Researchers at Göttingen University have now succeeded for the first time in precisely measuring which physical effects determine the properties of the individual filaments, and which specific features only occur through the interaction ...

Melbourne researchers have found that liquid chalk, commonly used in gyms to improve grip, acts as an antiseptic against highly infectious human viruses, completely killing both SARS-CoV-2 (the virus that causes COVID-19) and influenza A viruses. University of Melbourne Professor Jason Mackenzie, a laboratory head at the Peter Doherty Institute of Infection and Immunity (Doherty Institute) wanted to investigate whether liquid chalk stopped SARS-CoV-2 transmission after conversations with his daughter - an elite rock climber heading to the Tokyo Olympics. "Both of my daughters were lamenting the closure of gyms at the beginning of the pandemic, particularly my daughter Oceania who was trying to train ...

There are certain rules that even the most extreme objects in the universe must obey. A central law for black holes predicts that the area of their event horizons -- the boundary beyond which nothing can ever escape -- should never shrink. This law is Hawking's area theorem, named after physicist Stephen Hawking, who derived the theorem in 1971. Fifty years later, physicists at MIT and elsewhere have now confirmed Hawking's area theorem for the first time, using observations of gravitational waves. Their results appear in Physical Review Letters. In the study, the researchers take a closer look at GW150914, ...

Exercise training can help support management of overweight and obesity in adults, and can contribute to health benefits beyond "scale victories". The supplement published today in Obesity Reviews, based on the work of an expert group convened under the auspices of the European Association for the Study of Obesity (EASO), provides scientific evidence on health and wellbeing benefits of exercise training for people living with overweight and obesity. Supplement highlights include a summary of key recommendations; additional developed materials provide infographic tools for health care practitioners (HCPs) and people ...

Economists at RMIT University in Melbourne, Australia, economists found passers-by often donated more when paying via a digital platforms like apps, QR codes, PayPal and even Bitcoin, compared to the centuries' old payment method of loose coins. Using data from the online platform The Busking Project, the study analysed individual payments to over three and half thousand active buskers from 121 countries to predict the characteristics of performers who were more likely to receive online donations. The study found North America and Europe were home to the most active buskers and audiences on the platform, with buskers registered ...

Scientists show that an ocean-bottom seismometer deployed close to the calving front of a glacier in Greenland can detect continuous seismic radiation from a glacier sliding, reminiscent of a slow earthquake. Basal slip of marine-terminating glaciers controls how fast they discharge ice into the ocean. However, to directly observe such basal motion and determine what controls it is challenging: the calving-front environment is one of the most difficult-to-access environments and seismically noisy -- especially on the glacier surface -- due to heavily crevassed ice and harsh weather conditions. A team of scientists from Hokkaido University, ...

An invasive species of aphid could put some threatened plant species on Kangaroo Island at risk as researchers from the University of South Australia confirm Australia's first sighting of Aphis lugentis on the Island's Dudley Peninsula. It is another blow for Kangaroo Island's environment, especially following the Black Summer bushfires that decimated more than half the island and 96 per cent of Flinders Chase National Park. Collected by wildlife ecologist Associate Professor Topa Petit and identified by colleagues from the WA Department of Primary Industries and Regional Development, the black aphids were found feeding on seedlings of Senecio odoratus, a native species of daisy, commonly known as the scented groundsel. Of ...

Over the past 20 years, many studies have investigated the effects of acute aerobic exercise on cognitive performance. In recent years, meta-analyses*1 of data from these previous research studies have demonstrated that these a single bout of moderate aerobic exercise temporarily improves cognitive performance. However, close examination of the individual research studies on this topic revealed that in approximately 50% of studies, no beneficial link between acute aerobic exercise and cognitive function was found. An international research collaboration, including Associate ...

Ibaraki, Japan - Flowers come in a multitude of shapes and colors. Now, an international research team led by a researcher from Japan has proposed the novel hypothesis that trade-offs caused by different visitors may play an important role in shaping this floral diversity. In a study published last month, the team explored how the close associations between flowers and the animals that visit them influence flower evolution. Visitors to flowers may be beneficial, like pollinators, or detrimental, like pollen thieves. All of these visitors interact with flowers in different ways and exert different selection pressures on flower traits such as color and scent. For example, a scent that attracts one pollinator may deter other potential pollinators. In this case, the flower would be expected ...

Almost twenty years ago, the process of RNA silencing was discovered in plants, whereby small fragments of RNA inactivate a portion of a gene during protein synthesis. These fragments--called microRNAs (abbreviated as miRNAs)--have since been shown to be essential at nearly every stage of growth and development in plants, from the production of flowers, stems, and roots to the ways plants interact with their environment and ward off infection. The detection and characterization of miRNAs is an active field of research. In the decade following their discovery in plants, over 1,000 bioinformatic tools were used to identify ...

Sophia Antipolis - 1 July 2021: Heart failure patients aged 80 and above are less likely to receive recommended therapies and dosages compared to their younger counterparts, according to research presented today at Heart Failure 2021, an online scientific congress of the European Society of Cardiology (ESC).1 "Guidelines recommend the same treatments for all heart failure patients regardless of age," said study author Dr. Davide Stolfo of the Karolinska Institute, Stockholm, Sweden.2 "Our analysis adjusted for other conditions that might justify withholding ...

As the COVID-19 pandemic exploded across the globe in early 2020, the world's leaders were faced with a flurry of tough moral dilemmas. Should schools and businesses shut down, and if so, for how long? Who should receive scarce resources, such as ventilators, when there wouldn't be enough for everyone? Should people be required to practice contact tracing to control the spread of infection? Should life-saving medicine be held for a country's own citizens or shared with those in greater need? Some global leaders advocated for a utilitarian approach to these dilemmas: impartially maximizing the greatest good for the greatest number of people, even if that would come at the cost of harming a minority of the population. Utilitarianism, however, is a controversial ...

1 July 2021: Despite only limited evidence that fertility add-ons increase the odds of having a baby, the majority of women (82%) have used one or more of these treatments as part of their IVF. This is the conclusion of a retrospective study of 1,590 Australian patients which also found more than seven in 10 (72%) had incurred additional costs for these unproven additional therapies and techniques which range from Chinese herbal medicine to endometrial scratching. The results based on an online survey into prevalence of these optional extras will be presented today by principal investigator Dr Sarah Lensen, a researcher from the University of Melbourne, Australia, at the 37th virtual Annual Meeting of ESHRE. The findings, says Lensen, suggest ...

Bottom Line: For women diagnosed with breast cancer in Florida, breast cancer-specific mortality rates have decreased more among Black and Hispanic women than white women since 1990. Despite these advances, Black women still have double the five- and 10-year mortality rates of non-Hispanic white women. Journal in Which the Study was Published: Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. Author: Robert Hines, PhD, MPH, associate professor of population health sciences at the University of ...

Evidence shows significant reduction in indicators of potential harm over 6-months for smokers switching to exclusive use of glo compared with continuing to smoke cigarettes Gold-standardi indicator supports scientific substantiation of glo's potential as a reduced risk product* First ever long-term study showing sustained reduction in exposure to certain toxicants and indicators of potential harm in smokers switching completely to glo Supports BAT's delivery of A Better TomorrowTM by reducing the health impact of its global business by encouraging ...

New research from marine biologists offers answers to a fundamental puzzle that had until now remained unsolved: why are some fish warm-blooded when most are not? It turns out that while (warm-blooded) fish able to regulate their own body temperatures can swim faster, they do not live in waters spanning a broader range of temperatures. The research therefore provides some of the first direct evidence as to the evolutionary advantage of being warm-blooded as well as underlining that species in this demographic - such as the infamous white shark and the speedy bluefin tuna - are likely just as vulnerable to changing ...

Nanosized molecules of a particular chemical element can inhibit the formation of plaque in the brain tissues. This new discovery by researchers at Umeå University, Sweden, in collaboration with researchers in Croatia and Lithuania, provides renewed hope for novel treatments of, for instance, Alzheimer's and Parkinson's disease in the long run. "This is indeed a very important step that may form the basis of new and efficient treatments of neurodegenerative diseases in the future," says Professor Ludmilla Morozova-Roche at Umeå University. When proteins misfold they form insoluble fibrils called amyloids, which are involved in several serious diseases such as Alzheimer's and Parkinson's, Corino de Andrade's and the mad cow ...

SAN ANTONIO (June 30, 2021) -- In a U.S. and Swiss study, nearly all patients with cancer developed good immune response to the COVID-19 mRNA vaccines three to four weeks after receiving their second dose, but the fact that a small group of the patients exhibited no response raised questions about how their protection against the virus will be addressed moving forward. Among the 131 patients studied, 94% developed antibodies to the coronavirus. Seven high-risk patients did not. "We could not find any antibodies against the virus in those patients," said Dimpy P. Shah, MD, PhD, of the Mays Cancer Center, home to UT Health San Antonio MD Anderson. "That has implications for the future. Should we provide a third dose of vaccine after cancer therapy has completed ...